JP5999173B2 - Oral composition - Google Patents

Description

  The present invention relates to a composition for oral cavity containing an ascorbic acid phosphate or a salt thereof. More specifically, the solubility of an ascorbic acid phosphate or a salt thereof in a neutral region is improved, so that -It is related with the composition for oral cavity in which a dust is suppressed and a clear appearance is maintained.

  Ascorbic acid is known to play an important role in the expression of various enzyme activities in the living body and to have various physiological activities. In particular, it acts as a coenzyme for prolyl and lysyl hydroxylase, and is essential for collagen synthesis. For this reason, it is useful for prevention and treatment of gingivitis and periodontitis accompanied by collagen destruction, and various ascorbic acid derivatives have been conventionally developed, and in particular, ascorbic acid phosphates and salts thereof have attracted attention.

  However, when ascorbic acid phosphates are blended in the oral composition in the neutral region, there is a problem that ascorbic acid phosphates are insolubilized and oliage and dust are generated when stored for a long time at a low temperature. In particular, liquid oral compositions such as mouthwashes and liquid dentifrices are liable to deposit oliage and dirt due to insolubilization, and it is very difficult to suppress oliage and dirt after being stored at low temperatures for a long period of time. In addition, ascorbic acid phosphates are stable on the alkali side, but in particular for liquid oral compositions, when the pH exceeds 8, when the mouth contains it, a feeling of discomfort such as nulliness or taste is felt, There is a problem that problems occur in the formulation, such as the occurrence of orientation more easily.

  Although the applicant has proposed Patent Documents 1 to 3 as a technique for blending an ascorbic acid phosphate ester or a salt thereof into the oral composition, Patent Documents 1 to 3 do not mention the above problem.

International Publication No. 2010/143589 JP 2009-149537 A JP 2011-6351 A

Therefore, in the composition for oral cavity containing ascorbic acid phosphate ester or a salt thereof, improvement in solubility of ascorbic acid phosphate ester or a salt thereof in a neutral region, and suppression of occurrence of orientation and dustiness were technical problems. .
The present invention has been made in view of the above circumstances, the solubility of ascorbic acid phosphate ester or a salt thereof is improved in a neutral region, the orientation and dustiness during low-temperature storage is suppressed, and a clear appearance is maintained. It aims at providing the composition for oral cavity.

  As a result of intensive studies to achieve the above object, the present inventors have developed (B) an ascorbic acid phosphate ester or a salt thereof (hereinafter abbreviated as APE) into an oral composition (B). ) Blended with specific polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether and non-ionic surfactant selected from polyglycerin fatty acid ester and (C) aromatic compound selected from isopropylmethylphenol, triclosan and thymol When the blending ratio (A) / (C) of the component (A) and the component (C) is 1 to 50 as a mass ratio, and the pH at 25 ° C. is 6.5 to 8.0. In such a pH range, the solubility of APE is improved, especially in the liquid oral composition, the orientation and dustiness during low-temperature storage is suppressed, and a clear appearance is maintained for a long time immediately after preparation. It was found to be able to equity. Moreover, it discovered that it was excellent in the uncomfortable feeling when a formulation was included in the mouth.

Patent Documents 1 to 3 disclose a composition in which a nonionic surfactant such as polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether and isopropylmethylphenol are blended as an APE-containing oral composition. Yes. However, the techniques disclosed in Cited Documents 1 to 3 do not improve the solubility of APE in the neutral region and do not suppress the occurrence of orientation and dust during low-temperature storage. From these cited references 1 to 3, it is not predictable that the structure of the present invention improves the solubility of APE in the neutral region and can suppress the occurrence of orientation and dust during low-temperature storage.
In the present invention, surprisingly, the aromatic compound (C) has an effect of improving the solubility of APE in the neutral region, and the combined use of the components (B) and (C) results in the APE in the neutral region. It was able to improve solubility, suppress orientation and dirt during low-temperature storage, maintain a clear appearance, and suppress discomfort. In particular, in liquid preparations containing APE, when stored at low temperature, the preparation cannot be recognized only by visually observing the preparation alone. However, according to the present invention, it is possible to suppress such squeeze and to provide a liquid formulation with high clarity. In addition, such suppression of the orientation and dust is specific to the aromatic compound of component (C), and is a special thing that cannot be achieved with other aromatic compounds or fungicides.

  In addition, when (D) sodium alkyl sulfate is further added to the above composition, the effect of suppressing the dirt and dust can be further improved.

Accordingly, the present invention provides the following liquid oral composition.
[1]
(A) A liquid oral composition ascorbic acid phosphate ester magnesium salt containing 0.1 to 2 wt%,
(B) Polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles, polyoxyethylene alkyl having an alkyl group of 16 to 18 carbon atoms and an average addition mole number of ethylene oxide of 20 to 40 moles 0.2 to 1.0% by mass of one or more nonionic surfactants selected from ether and fatty acid esters having 12 to 18 carbon atoms of fatty acid,
(C) One or two or more aromatic compounds selected from isopropylmethylphenol, triclosan, and thymol are contained in an amount of 0.02 to 0.07% by mass, and the components (A) and (C) A composition for liquid oral cavity, wherein the blending ratio (A) / (C) is 3 to 30 as a mass ratio, and the pH at 25 ° C. is 6.5 to 7.8 .
[2]
(C) Liquid oral cavity composition as described in [1] whose component is isopropylmethylphenol.
[3 ]
Furthermore, (D) Liquid oral cavity composition as described in [1] or [2] which contains 0.05-1.0 mass% of sodium alkyl sulfate.
[ 4 ]
Surfactants The total amount of the composition is from 0.2 to 1.3 wt% (1) to the liquid oral composition according to any one of [3].
[5 ]
The liquid oral composition according to any one of [ 1] to [4], which is a liquid dentifrice or mouthwash .
[6]
The liquid oral composition according to any one of [1] to [5], which does not contain an abrasive.
[7]
The liquid oral composition according to any one of [1] to [6], which has a clear appearance.

  According to the present invention, in an oral composition containing an ascorbic acid phosphate or a salt thereof, the solubility of the ascorbic acid phosphate or a salt thereof in the neutral region is improved, so Is suppressed, and a clear appearance can be maintained for a long time immediately after preparation. Moreover, the formulation without a sense of incongruity can be given.

  The present invention will be described in further detail below. The composition for oral cavity of the present invention comprises an aromatic compound selected from (A) ascorbic acid phosphate or a salt thereof, (B) a specific nonionic surfactant, (C) isopropylmethylphenol, triclosan and thymol. And the mixing ratio of component (A) / component (C) and pH are in an appropriate range.

  (A) Ascorbic acid phosphate or a salt thereof is an ester of a compound such as phosphoric acid or polyphosphoric acid in which one or more of the hydroxyl groups at positions 2, 3, 5, and 6 of ascorbic acid For example, ascorbic acid-2-phosphate, ascorbic acid-3-phosphate, ascorbic acid-6-phosphate, ascorbic acid-2-polyphosphate, etc. It is done. Examples of the salts include alkali metal salts such as sodium salt, potassium salt, calcium salt, and magnesium salt, and alkaline earth metal salts. Among these, from the viewpoint of the stability of the composition, a derivative in which the hydroxyl group at the 2-position or 3-position of ascorbic acid is converted to a phosphate ester is preferable, and a magnesium salt of ascorbic acid-2-phosphate is more preferable. Or sodium salt. In particular, the magnesium salt of ascorbic acid-2-phosphate is liable to cause odor and dust when stored at a low temperature when blended in a liquid formulation, but according to the present invention, the occurrence of odor and dust in such a liquid formulation is suppressed and the clarity is improved. Can be maintained.

  (A) The compounding quantity of ascorbic acid phosphate ester or its salt is preferably 0.1 to 2% (mass%, the same applies hereinafter) of the whole composition, more preferably 0.2 to 2%, and still more preferably. 0.2 to 1%. The larger the blending amount, the more the blending effect such as periodontal disease preventive effect is exhibited. However, the content of 2% or less is suitable for suppressing the squeeze and dirt at low temperature storage. Moreover, it is suitable for maintaining a good feeling of use while suppressing a sense of incongruity when it is put in the mouth due to a nasty taste or the like.

The component (B) is a polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide (hereinafter abbreviated as EO added mole number) of 40 to 100 moles, and an alkyl group having 16 to 18 carbon atoms. In E. O. It is a nonionic surfactant selected from polyoxyethylene alkyl ethers having an addition mole number of 20 to 40 moles and polyglycerol fatty acid esters having a fatty acid carbon number of 12 to 18.
The component (B) is blended as a stabilizer. By blending with the component (C), the appearance immediately after preparation of the oral composition containing the component (A) is clarified, and In addition, it has the effect of suppressing the occurrence of orientation and tingling and the appearance of discomfort after low-temperature storage.

  As the component (B), E.C. has been disclosed in terms of clarity immediately after preparation, an effect of suppressing orientation and dustiness after low-temperature storage, and a sense of incongruity when contained in the mouth. O. A polyoxyethylene hydrogenated castor oil having an added mole number of 40 to 100 moles, preferably 60 to 100 moles, and an alkyl group having 16 (cetyl) to 18 (stearyl) carbon atoms. O. Polyoxyethylene alkyl ether having an addition mole number of 20 to 40 moles, polyglycerol fatty acid ester having a fatty acid carbon number of 12 (lauric acid) to 18 (stearic acid), preferably 12 (lauric acid) to 14 (myristic acid) And one or more nonionic surfactants selected from these are used.

E. of polyoxyethylene hydrogenated castor oil O. If the number of added moles is less than 40 moles, the solubilizing power and the solubility of the composition itself in the oral cavity are low, and the clarity immediately after preparation of the preparation and the effect of suppressing the squeeze and dusting during low-temperature storage are poor. Those exceeding 100 mol are not commercially available.
E. of polyoxyethylene alkyl ethers O. When the added mole number is less than 20 moles, the solubilizing power is low, the solubility in the oral composition itself is low, the solubilization of the component (A) and the component (C), and the clarity immediately after preparation of the preparation. In addition, it is inferior in the restraint effect on the orientation and dust during low temperature storage. Those exceeding 40 mol are not commercially available. In addition, when the number of carbon atoms of the alkyl group is less than 16 or more than 18 in the polyoxyethylene alkyl ether, it is inferior in the effect of suppressing the orientation and dust during low temperature storage.
Polyglycerin fatty acid esters whose fatty acids have less than 12 or more than 18 carbons have low solubilizing power, solubilization of components (A) and (C), clarity immediately after preparation and low-temperature storage It is inferior to the restraint effect of orientation and dust.

  The blending amount of the component (B) is preferably 0.1 to 1.3% of the entire composition, more preferably 0.2 to 1.3%, and still more preferably 0.2 to 1.0%. The larger the blending amount, the more suitable for solubilization of the component (A) and the component (C) and the suppression of occurrence of dirt and dust during low-temperature storage. Moreover, it is more suitable for obtaining clarity immediately after preparation. When the content is 1.3% or less, it is preferable to suppress an increase in taste and stickiness derived from the component (B) and to suppress a sense of discomfort when included in the mouth.

  The component (C) is an aromatic compound selected from isopropylmethylphenol, triclosan, and thymol. The component (C) is blended as a stabilizer, and when used in combination with the component (B), the oral composition containing the component (A) generates an odor / dirty occurrence and a sense of discomfort after low-temperature storage. There is an inhibitory effect. As the aromatic compound (C), one kind may be used alone, or two or more kinds may be used in combination, but isopropylmethylphenol is particularly preferred.

  The amount of component (C) is preferably 0.01 to 0.12%, more preferably 0.01 to 0.1%, and still more preferably 0.02 to 0.07% of the entire composition. When the blending amount is within the above range, the clarity immediately after the preparation and the effect of suppressing the occurrence of dirt and dust after low-temperature storage are more excellent. Moreover, when it is 0.12% or less, it is suitable for suppressing unpleasant feelings such as bitterness and irritation when it is contained in the mouth.

In the present invention, it is important for the component (A) and the component (C) to be blended at an appropriate ratio in order to suppress the occurrence of effects, particularly the occurrence of orientation and dirt after low-temperature storage.
The blending ratio of the components (A) and (C) is such that the component (A) / component (C) is 1 to 50, particularly 3 to 50, and more preferably 3 to 30. If the blending ratio is less than 1, the clarity immediately after preparation of the preparation is lowered, and the component (C) itself is insolubilized, resulting in the occurrence of orientation and dirt during low-temperature storage. If it exceeds 50, it will not be possible to suppress the occurrence of orientation and dust during low temperature storage.

In the present invention, it is preferable to further blend (D) sodium alkyl sulfate. Sodium alkyl sulfate acts as a stabilizer, and can improve the effect of suppressing the occurrence of dirt and dust after low-temperature storage by blending. In addition, the addition of an anionic surfactant other than sodium alkylsulfate will cause the occurrence of odor and dust, rather than being suppressed, and this improvement in the effect is presumed to be due to the specific action of sodium alkylsulfate. The
As the component (D), an alkyl group having 8 to 18 carbon atoms, particularly 10 to 16 carbon atoms is preferable, and sodium lauryl sulfate is particularly preferable.

  (D) When mix | blending a component, the compounding quantity has preferable 0.05-1.0% of the whole composition, More preferably, it is 0.1-0.5%. When blended within the above range, it is possible to further improve the ability to suppress the occurrence of orientation and dirt after low-temperature storage. Moreover, when it is 1.0% or less, it is difficult to give an uncomfortable feeling such as bitterness or irritation when it is contained in the mouth.

  In the present invention, it is more preferable that the total amount of the surfactant in the composition is an appropriate amount in terms of suppressing the occurrence of orientation and dirt after low-temperature storage, and also suppressing the uncomfortable feeling, and the component (D) is blended. In this case, the total amount of the components (B) and (D) is preferably 0.1 to 1.3%, more preferably 0.2 to 1.3%, and still more preferably 0.2 to 1.0%. Addition within the range is desirable. When the total amount is within the above range, the effects of solubilization of the component (A) and the component (C) and the restraint of dirt and dust during low-temperature storage are more excellent. Moreover, when it is 1.3% or less, it is suitable for suppressing the taste and stickiness derived from these components, and suppressing the uncomfortable feeling when included in the mouth.

The pH (25 ° C.) of the composition is 6.5 to 8.0, preferably 7.0 to 7.8. If the pH is less than 6.5, the decomposition of the component (A) is promoted, so that it becomes easy to generate dirt and dust when stored at low temperatures, and if the composition has a pH exceeding 8.0, it cannot be suppressed. Even if (B) and (C) component are mix | blended, generation | occurrence | production of orientation and dust cannot be suppressed. Moreover, when pH exceeds 8.0, when it is included in the mouth, a sense of incongruity such as nulliness or a nasty taste increases.
In addition, although the pH of a composition may become 6.5-8.0 in some ways, you may adjust in the said range using a pH adjuster as needed. As the pH adjusting agent, a pH adjusting agent such as sodium hydroxide, hydrochloric acid, sodium carbonate, sodium hydrogen carbonate, boric acid or a salt thereof can be used, and among them, sodium hydroxide, potassium hydroxide and hydrochloric acid are preferably used. The blending amount of these pH adjusters only needs to be able to adjust the pH to the above range.

  The composition of the present invention is particularly suitably prepared as a liquid oral composition, and specifically can be suitably prepared as a liquid formulation such as liquid dentifrice and mouthwash. Here, the liquid oral composition is a transparent or translucent preparation in which a compounding component is solubilized, and a solid component that is not solubilized such as an abrasive is generally not compounded.

  Moreover, in addition to the said component, the well-known arbitrary component according to the dosage form etc. can be mix | blended with the composition for oral cavity of this invention in the range which does not impair the effect of this invention. As an optional component, for example, a solvent, a wetting agent, a thickening agent, a surfactant, and, if necessary, a preservative, a sweetening agent, a fragrance, a coloring agent, an active ingredient, and the like can be added to the liquid oral composition.

As the solvent, purified water is generally used. Moreover, although C2-C4 lower monohydric alcohols, such as propylene glycol and ethanol, can be mix | blended, normally the compounding quantity of these solvents is 0-30% of the whole composition, and especially 2 ~ 20% is preferred.
In addition, even if the composition for oral cavity of this invention is a composition which does not contain ethanol substantially (namely, ethanol content in a composition is 0.01% or less, especially 0-0.0001%). The effects of the present invention can be obtained.

  Examples of the wetting agent include sugar alcohols such as sorbitol, xylitol, and erythritol, and polyhydric alcohols such as glycerin, ethylene glycol, and polyethylene glycol. A compounding quantity is 0 to 20% of the whole composition normally.

As the surfactant, a surfactant other than the component (B) and the component (D) may be blended as long as the effects of the present invention are not hindered. For example, anionic surfactants such as lauroylmethyl taurine, acylamino acid salt, sodium dodecylbenzenesulfonate, α-sulfo fatty acid alkyl ester sodium, alkyl phosphate ester salt, alkyldimethylaminoacetic acid betaine, fatty acid amidopropyldimethylaminoacetic acid betaine Amino acid-type amphoteric surfactants such as betaine acetate-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts and imidazoline-type amphoteric surfactants such as N-fatty acid acyl-L-alginate salts Activator, sucrose fatty acid ester, sorbitan fatty acid ester, polyoxyethylene polyoxypropylene block copolymer type nonionic surfactant, polyoxyethylene fatty acid ester, fatty acid monoglyceride Etc., and the like.
When these surfactants are blended, the total amount of the surfactant including the component (B) and further the component (D) is 0.1 to 1.3%, particularly 0.2 to 1.3%. In particular, it is desirable to add in the range of 0.2 to 1.0%.

  Examples of the thickener include sodium carboxymethyl cellulose and hydroxyethyl cellulose. The blending amount of the thickener is usually 0 to 5%.

Examples of the preservative include benzoates such as sodium benzoate, potassium sorbate and the like. Examples of the sweetener include saccharin, saccharin sodium, steviosite, sucralose, aspartame and the like.
As perfumes, natural perfumes such as spearmint oil and mint oil, and single perfumes such as carvone and anethole, as well as well-known perfumes used in oral hygiene products such as single perfumes and / or blended perfumes including natural perfumes are used. Can do. The blending amount is usually in the range of 0.00001 to 1%.
Examples of the coloring agent include highly safe water-soluble pigments such as Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105.

  As active ingredients, ascorbic acid phosphates and salts thereof, isopropylmethylphenol, triclosan, and known ingredients other than thymol, such as anti-inflammatory agents, enzymes, fluorides, bactericides, and the like, in a range that does not interfere with the effects of the present invention. An effective amount may be blended.

EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples,% indicates mass% unless otherwise specified.
In the polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether, the numerical value in parentheses indicates the average number of moles of ethylene oxide added. In the table, POE is an abbreviation for polyoxyethylene. The pH was measured immediately after preparation using a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd., and showed a value after 3 minutes at 25 ° C.

[Examples and Comparative Examples]
Liquid oral compositions having the compositions shown in Tables 1 to 3 were prepared by the following method. The obtained liquid oral composition was evaluated by the following methods. Moreover, the liquid oral cavity composition of the composition shown in Table 4 was similarly prepared, and the clarity immediately after preparation preparation and the effect of suppressing scumming were evaluated in the same manner. The results are shown in Tables 1-4.

Preparation method of liquid oral composition The liquid oral composition is prepared by dissolving the water-soluble raw material in purified water according to the composition in the table and then adding the wetting agent or solvent to the wetting agent or solvent. A solution in which the oil-soluble raw material and the nonionic surfactant were dissolved was added with stirring to be uniformly dissolved. A three-one motor (BL1200, manufactured by HEIDON) was used for manufacturing.

Clarity test immediately after preparation of preparation The composition immediately after preparation was filled in 250 mL of a colorless and transparent PET container having a full injection amount of 250 mL, and compared with a PET container (control product) filled with purified water, and visually judged according to the following criteria.
Evaluation criteria for clarity immediately after preparation ◎: No dust is observed ○: Slight dust is observed, but there is no problem because there is no control product △: Scratch is clearly recognized and control product Slight dust is observed even if there is no X ×: Slightly dust is observed without comparison with the control product, and it is difficult to see through the PET container.

Evaluation of Ori-Nigori Suppression Effect 250 mL of the composition was filled in a 250 mL PET container, stored at −10 ° C. for 1 month, returned to room temperature, and when the PET container was in a dirty state or gently displaced The orientation was visually determined according to the following criteria in comparison with a PET container (control product) filled with purified water. B or higher was accepted.
Evaluation criteria for the effect of restraint against dirt and dust A-1: No dirt or dust is observed. A-2: Almost no dirt or dust is observed. At first, the orientation is recognized, but there is no problem. C: Even if there is no reference product, the orientation is slightly recognized by the judgment alone. D: The orientation is judged by the judgment alone. Clearly recognized E: Significant odor and dust are recognized by independent judgment

Evaluation of no discomfort when in the mouth Ten subjects with sensitive oral mucosa evaluated the discomfort felt in the mouth while rinsing for about 20 seconds containing about 10 mL of the composition immediately after preparation. . Sensory evaluation was carried out according to the following criteria, with two control products (compositions having the same composition as in Example 1 and the pH of the composition adjusted to pH 9 with sodium hydroxide as a pH adjusting agent). The average value was obtained and judged according to the following criteria.
Evaluation Criteria for No Discomfort When Ingested 4: No Discomfort 3: Little Discomfort 2: Discomfort Equivalent to Control 1: Feeling Conspicuous Discomfort Stronger than Control Standard ◎: 3.5 points or more ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

Details of the raw materials used are as follows.
Ascorbic acid phosphate magnesium: manufactured by Wako Pure Chemical Industries, Ltd., phosphoric acid-L-ascorbyl magnesium, biochemical ascorbic acid sodium phosphate ester: manufactured by DSM Nutrition Japan, Stay C50
Polyoxyethylene (40) hydrogenated castor oil:
NIKKOL HCO-40, manufactured by Nikko Chemicals
Polyoxyethylene (60) hydrogenated castor oil:
NIKKOL HCO-60, manufactured by Nikko Chemicals
Polyoxyethylene (100) hydrogenated castor oil:
NIKKOL HCO-100, manufactured by Nippon Emulsion Co., Ltd.
Polyoxyethylene (20) cetyl ether:
NIKKOL BC-20 manufactured by Nikko Chemicals
Polyoxyethylene (20) stearyl ether:
NIKKOL BS-20, manufactured by Nikko Chemicals
Polyoxyethylene (40) cetyl ether:
NIKKOL BC-40, manufactured by Nikko Chemicals
Polyglyceryl monolaurate:
NIKKOL Decaglyn 1-L, manufactured by Nikko Chemicals
Decaglyceryl monomyristate:
NIKKOL Decaglyn 1-M, manufactured by Nikko Chemicals
Isopropylmethylphenol: Osaka Chemical Co., Ltd. Triclosan: Ciba Japan Co., Ltd. Timor: Osaka Kasei Co., Ltd. sodium lauryl sulfate: Toho Chemical Industry Co., Ltd. Sodium hydroxide: Kanto Chemical Co., Ltd. Ethylene (5) hydrogenated castor oil:
NIKKOL HCO-5, manufactured by Nikko Chemicals
Polyoxyethylene (20) hydrogenated castor oil:
NIKKOL HCO-20, manufactured by Nikko Chemicals
dl-α-tocopherol: manufactured by Wako Pure Chemical Industries, Ltd. phenol: manufactured by Wako Pure Chemical Industries, Ltd. methyl salicylate: manufactured by Wako Pure Chemical Industries, Ltd., Wako primary benzethonium chloride: manufactured by Kanto Chemical Co., Inc.

  From the results shown in Table 3, when the component (B) or (C) is missing or the nonionic surfactant or the aromatic compound is inappropriate (Comparative Examples 1 to 8), it is not possible to suppress the occurrence of dirt and dust. It was. Even if the components (B) and (C) are blended, if the blending ratio of the components (A) and (C) is inappropriate (Comparative Examples 9 and 10), it is not possible to suppress the occurrence of clogging. When the composition had a pH outside the specific range, the occurrence of orientation and dust could not be suppressed (Comparative Examples 11 and 12). In contrast, (A), (B), (C) component, (A) / (C) ratio, liquid oral composition (Examples in Tables 1 and 2) with appropriate pH are as follows: Clarity immediately after preparation, excellent curbing effect when stored at -10 ° C for 1 month, and uncomfortable feeling. It was confirmed that the occurrence of orientation and dust could be suppressed, and the clarity could be maintained for a long time immediately after preparation. Further, as shown in Table 4, it was confirmed that when the component (D) was further blended, the effect of suppressing the occurrence of dirt and dust was improved.

Claims (7)

(A) A liquid oral composition ascorbic acid phosphate ester magnesium salt containing 0.1 to 2 wt%,
(B) Polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles, polyoxyethylene alkyl having an alkyl group of 16 to 18 carbon atoms and an average addition mole number of ethylene oxide of 20 to 40 moles 0.2 to 1.0% by mass of one or more nonionic surfactants selected from ether and fatty acid esters having 12 to 18 carbon atoms of fatty acid,
(C) One or two or more aromatic compounds selected from isopropylmethylphenol, triclosan, and thymol are contained in an amount of 0.02 to 0.07% by mass, and the components (A) and (C) A composition for liquid oral cavity, wherein the blending ratio (A) / (C) is 3 to 30 as a mass ratio, and the pH at 25 ° C. is 6.5 to 7.8 . The liquid oral composition according to claim 1, wherein the component (C) is isopropylmethylphenol. Furthermore, 0.05 to 1.0 mass% of (D) sodium alkyl sulfate is contained , The composition for liquid oral cavity of Claim 1 or 2 characterized by the above-mentioned. The liquid oral composition according to any one of claims 1 to 3 , wherein the total amount of the surfactant in the composition is 0.2 to 1.3% by mass. Any one liquid oral composition as claimed in claim 1 which is a liquid dentifrice or mouthwash. The composition for liquid oral cavity of any one of Claims 1-5 which does not contain an abrasive | polishing agent. The composition for liquid oral cavity according to any one of claims 1 to 6, which has a clear appearance.