JP5672716B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition useful for prevention of caries and periodontal disease.

  The cause of dental caries and periodontal disease, which are the two major diseases in the oral cavity, are dental plaque (dental plaque), which is a lump of bacteria. Oral fluid is used.

  Mastic resin and / or mastic oil (also simply referred to as mastic) has an antibacterial action against bacteria that cause dental caries and periodontal disease (Patent Document 1). And in the mouthwash. In addition, in order to improve the peculiar taste and irritation of mastic, a technology related to oral composition in which mastic and tea tree oil are blended simultaneously (Patent Document 2), oral composition in which mastic and ethanol are blended simultaneously (patent Document 3), a technique related to an oral composition (Patent Document 4) in which mastic and l-menthol and / or carvone are simultaneously blended has been reported.

JP 2002-029982 A JP 2004-182649 A JP 2003-012483 A JP 2002-205930 A

However, the antibacterial activity against periodontopathic bacteria etc. of the conventional mastic-containing oral composition is not yet satisfactory, and further improvement in anti-bacterial action, suppressive action against gingivitis, feeling of use, etc. is desired. It was.
Therefore, the subject of this invention is providing the composition for oral cavity which contains a mastic and was excellent in the antibacterial effect, the bad breath prevention effect, the gingivitis suppression effect, etc.

  Therefore, the present inventor conducted various studies to improve the antibacterial action and the like of mastic, and surprisingly, if a certain amount of sodium fluoride and / or sodium monofluorophosphate is mixed with mastic, It has been found that the antibacterial action is remarkably enhanced, and if citric acid and / or a salt thereof is further added thereto, the antibacterial action is further enhanced and the bad breath prevention action and refreshing feeling are improved. Furthermore, it has also been found that the composition of the present invention is particularly excellent in suppressing gingivitis when a surfactant is not blended.

That is, the present invention includes the following components (a) to (c):
(A) Mastic resin and / or mastic oil 0.01 to 10 w / w%,
(B) 0.02 to 0.44 w / w% sodium fluoride and / or 0.07 to 1.52 w / w% sodium monofluorophosphate, and (c) citric acid and / or its salt 0.005 1.0w / w%
The composition for oral cavity containing this is provided.

  The present invention also provides an agent for enhancing the antibacterial action of mastic resin and / or mastic oil containing sodium fluoride and / or sodium monofluorophosphate as an active ingredient.

  ADVANTAGE OF THE INVENTION According to this invention, the antibacterial effect with respect to the causative agent of a dental caries or periodontal disease is strong, and it can provide the oral cavity composition which is excellent in a bad breath prevention effect and a gingivitis suppression effect, and without irritation.

  The composition for oral cavity of this invention contains (a) mastic resin and / or mastic oil. The component (a) has an antibacterial action against bacteria that cause caries and periodontal disease. The mastic resin is sap collected from Pistachia Lentiscus of Anacardiaceae. On the other hand, mastic oil is an essential oil extracted from the mastic resin. For example, Patent Document 1 describes the following method as a method for producing mastic oil. 1,000 g of mastic resin and 1,000 g of medium chain fatty acid triglyceride are mixed and stirred in a hot water bath at 60 ° C. for about 30 minutes to completely dissolve the mastic resin, and then this is about 50 μm. After passing through a mesh of openings and filtering to remove impurities, the mixture is cooled to about 25 ° C. to obtain mastic oil as an oil solution in which mastic resin is dissolved.

  Content in the composition for oral cavity of this invention of a component (a) is 0.01-10 w / w% from the point of an antibacterial effect, a bad breath prevention effect, a gingivitis suppression effect, and a taste. If the content of the component (a) is less than 0.01 w / w%, sufficient antibacterial action and bad breath prevention action cannot be obtained, and if it exceeds 10 w / w%, it is not preferable in terms of taste and irritation. More preferable content of a component (a) is 0.03-5 w / w%, More preferably, it is 0.05-3 w / w%.

  The composition for oral cavity of the present invention contains (b) sodium fluoride and / or sodium monofluorophosphate. These components (b) are usually used in oral compositions as caries inhibitors due to the promotion of dental calcification, etc., but component (b) is a mastic resin or mastic of component (a). It has never been known to have an effect of enhancing the antibacterial action of oil. The content of sodium fluoride in the composition for oral cavity of the present invention is 0.02 to 0.44 w / w%, more preferably 0.02 to 0%, from the viewpoint of the antibacterial action enhancing effect of component (a). .21 w / w%. Moreover, it is preferable that the compounding quantity of a component (a) and sodium fluoride adjusts a component (a) / sodium fluoride within the range of 0.02-500 by mass ratio, More preferably, it is 0.15-. 250. The content of sodium monofluorophosphate in the composition for oral cavity of the present invention is 0.07 to 1.52 w / w%, more preferably 0.07, from the viewpoint of the antibacterial action enhancing effect of component (a). -0.72 w / w%. Further, the blending amount of component (a) and sodium monofluorophosphate is preferably adjusted so that component (a) / sodium monofluorophosphate is within a range of 0.005 to 150 by mass ratio, more preferably. 0.04 to 75.

  The composition for oral cavity of the present invention contains (c) citric acid and / or a salt thereof. These components (c) are usually used as buffering agents in oral compositions, but when the component (c) is used in combination with the component (b), the antibacterial of the mastic resin or mastic oil of the component (a) It has never been known to have an effect of enhancing the action. Citric acid and / or a salt thereof is preferably citric acid and / or an alkali metal citrate (particularly sodium citrate). The content of the citric acid and / or salt thereof in the oral cavity composition of the present invention is 0.005 to 1.0 w / w%, more preferably from the viewpoint of antibacterial action enhancing effect of the component (a) and taste-masking. Is 0.01 to 0.5 w / w%.

  In addition to the above components, the composition for oral cavity of the present invention includes, as an optional component, other components usually blended in the oral composition, for example, other medicinal components, wetting agents, cleaning agents or bases, viscosity modifiers. In the range which does not impair the effect of this invention, appropriate components, such as a pH adjuster, a flavoring agent, a corrigent, a coloring agent, a solvent, and a detergent, may be included.

  Medicinal ingredients include sodium azulenesulfonate, ε-aminocaproic acid, allantoin, allantoinchlorohydroxyaluminum, allantoindihydroxyaluminum, epidihydrocholesterin, dihydrocholesterol, sodium chloride, glycyrrhizic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, Trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, β-glycyrrhetinic acid, ascorbic acid, sodium ascorbate, pyridoxine hydrochloride, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, zeolite, dihydrogen pyrophosphate Disodium, sodium pyrophosphate, anhydrous sodium pyrophosphate, sodium monohydrogen phosphate, phosphorus Trisodium, sodium polyphosphate, polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol 600, polyethylene glycol 1000, polyethylene glycol 1500, polyethylene glycol 1540, polyethylene glycol 4000, polyethylene glycol 6000, polyethylene glycol 2000, polyvinyl pyrrolidone, Examples include, but are not limited to, polyvinylpyrrolidone K25, polyvinylpyrrolidone K30, polyvinylpyrrolidone K90, lysozyme chloride, copper chlorophyllin sodium, hinokitiol, and the like.

  Examples of the wetting agent include, but are not limited to, glycerin, concentrated glycerin, glycerol, propylene glycol, polyethylene glycol, 1,3-butylene glycol, sorbitol (sorbite liquid), and the like.

  Examples of the cleaning agent include, but are not limited to, anhydrous silicic acid, sodium polyphosphate, light anhydrous silicic acid, calcium hydrogen phosphate, sodium hydrogen carbonate, calcium carbonate, hydroxyapatite, calcium pyrophosphate, and the like.

  Examples of the viscosity modifier include, but are not limited to, xanthan gum, carrageenan, sodium polyacrylate, bentonite, sodium alginate, polyvinyl pyrrolidone, carboxymethyl cellulose, carboxyvinyl polymer, and hydroxyethyl cellulose.

  Examples of the pH adjuster include, but are not limited to, sodium hydroxide, sodium hydrogen phosphate, sodium phosphate and the like.

Examples of flavoring agents include, but are not limited to, menthol and peppermint.
Examples of the corrigent include, but are not limited to, sodium chloride, xylitol, sodium saccharin, xylit, glycyrrhizic acid, dipotassium glycyrrhizinate, and the like.
Examples of the colorant include, but are not limited to, titanium oxide.
Examples of the solvent include, but are not limited to, purified water, ethanol, polyethylene glycol, and 1,3-butylene glycol.
Examples of the detergent include, but are not limited to, erythritol.

  Among the above components, the wetting agent is preferably contained in the composition for oral cavity of the present invention in an amount of 1 to 30 w / w%, more preferably 5 to 15 w / w%. It is preferable to contain 0.1-50 w / w% of cleaning agents, More preferably, it is 1-30 w / w%. It is preferable to contain 0.1-10 w / w% of a viscosity modifier, More preferably, it is 1-7.5 w / w%.

  In general oral compositions, a surfactant is blended as a foaming agent and a cleaning agent, but the oral composition of the present invention has a strong antibacterial action, so even if a surfactant is not blended, Due to the sufficient cleaning action, the action of suppressing gingivitis and the like is good. Therefore, in the present invention, it is preferable not to add a surfactant.

  Examples of the dosage form of the oral composition of the present invention include dentifrices such as toothpastes and liquid dentifrices, mouthwashes, and gum massage agents, but dentifrices are preferred.

  The composition for oral cavity of the present invention can be produced by blending the essential component and the optional component according to the dosage form, and mixing these components with water. The material in particular of the container which stores the dentifrice of this invention is not restrict | limited, Usually, the container used for a dentifrice can be used. Specifically, plastic containers such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used.

  The dentifrice of the present invention is usually prepared by the operation of Production Example 1 described later, but any preparation method capable of achieving the present invention may be used, and is not particularly limited.

  Next, although an Example is given and this invention is demonstrated, this invention is not limited to this at all.

Production Example 1
The dentifrice used for the postscript test example was manufactured as follows. Concentrated glycerin and xanthan gum were added to purified water and stirred. Separately, a solution obtained by adding sodium citrate, sodium fluoride, dipotassium glycyrrhizinate, titanium oxide, and hydroxylethyl cellulose to purified water was added and stirred. Then, a solution in which hydroxyethyl cellulose is dispersed in sorbitol, ethanol, purified water, anhydrous silicic acid, mastic oil, fragrance, a solution in which l-menthol is dispersed in ethanol, light anhydrous silicic acid is added, and further stirred. A composition was obtained. In the following evaluation, a laminate tube tube filled with about 50 g was used.

[Test Example 1]
(Antimicrobial action)
The dentifrices of Examples 1 to 25 and Comparative Examples 1 to 13 were prepared, and 1% of the prepared bacterial solution of Actinomyces naeslundii (1 × 10 ⁷ cfu / mL) was inoculated on the sample. A sample diluted with a brain heart infusion agar medium supplemented with yeast extract and sterile defatted blood of sheep was mixed, and after culturing under anaerobic conditions, the number of colonies was measured. The results are shown in Tables 1 and 2.
A: The number of villages is less than 10.
○: The number of villages is 10 or more and less than 1,000.
Δ: The number of villages is 1,000 or more and less than 100,000.
X: The number of villages is 100,000 or more.

[Test Example 2]
(Usability test 1)
Dentifrices of Examples 1 to 25 and Comparative Examples 1 to 13 were prepared, and 20 males and females were panelists, and the effectiveness when each oral composition was used was evaluated according to the following evaluation criteria.
(Evaluation criteria)
"Preventing bad breath"
1: The bad breath was not reduced at all 2: The bad breath was hardly reduced 3: The bad breath was slightly reduced 4: The bad breath was reduced 5: The bad breath was remarkably reduced. Height (fresh feeling) "
1: There was no cleaning feeling (fresh feeling) 2: There was almost no cleaning feeling (fresh feeling) 3: Cleaning feeling (fresh feeling) was slightly high 4: Cleaning feeling (fresh feeling) was high 5: The feeling of cleaning (fresh feeling) was remarkably high. Each feeling of use was evaluated as shown below from the average value of the scores of 20 people, and the results are shown in Tables 1 and 2.
"Average score of 20 people"
×: 1 to less than 2 △: 2 to less than 3 ○: 3 to less than 4 ◎: 4 or more

[Test Example 3]
(Usability test 2)
Dentifrices of Examples 5 to 8, 21 to 25, and Comparative Examples 9 to 13 were prepared, and 12 persons with awareness of gingivitis (gum swelling and bleeding) were used as panelists, and each oral composition was used. The effectiveness was evaluated according to the following evaluation criteria.
(Evaluation criteria)
"Alleviation of gingival inflammation (gum swelling and bleeding)"
1: Feeling that gingival inflammation (gum swelling and bleeding) was not alleviated 2: Feeling that gingival inflammation (gum swelling and bleeding) was hardly alleviated 3: Gingival inflammation (gingival gingiva) Swelling and bleeding) felt slightly reduced 4: Gingival inflammation (gingival swelling and bleeding) felt 5: Gingival inflammation (gingival swelling and bleeding) was remarkably reduced The mitigating effect of the gingival inflammation symptoms (gum swelling and bleeding) was evaluated as shown below from the average of the 12 scores, and the results are shown in Table 3.
"Average score of 12 people"
×: 1 to less than 2 △: 2 to less than 3 ○: 3 to less than 4 ◎: 4 or more

  As is apparent from Table 1, it can be seen that sodium fluoride and / or sodium monofluorophosphate enhances the antibacterial action of the mastic resin and mastic oil. As is apparent from Table 2, the composition for oral cavity containing specific amounts of components (a), (b) and (c) has an antibacterial action, has a bad breath prevention action, and has a refreshing feeling. I understand that. Further, as is apparent from Table 3, it can be seen that the oral composition of the present invention is particularly excellent in gingivitis-inhibiting action when no surfactant is blended.

Claims (3)

The following components (a) to (c):
(A) mastic resin and / or mastic oil 0.03 ~ 5 w / w%,
(B) sodium fluoride 0.02 to 0.4 w / w% and / or sodium monofluorophosphate 0.07~ 1.5 w / w%, and (c) citric acid and / or salts thereof 0. 01 ~ 0.5 w / w%
The composition for oral cavity containing this.   The composition for oral cavity of Claim 1 which does not contain surfactant.   The composition for oral cavity according to claim 1 or 2, which is a dentifrice.