JP7625844B2 - Oral Composition - Google Patents

Description

The present invention relates to an oral composition containing isopropylmethylphenol that provides a high level of effectiveness in the oral cavity, particularly on the gums, even with a single use, and is effective in preventing or inhibiting periodontal disease.

Isopropyl methylphenol has a penetrating bactericidal effect on oral biofilms, penetrating periodontal disease biofilms and killing the bacteria present therein, and therefore has been incorporated into oral compositions as an ingredient for preventing or inhibiting periodontal diseases such as pyorrhea. In Patent Document 1 (WO 2010/143589), isopropyl methylphenol is used in combination with vitamins to prevent or improve periodontal disease.

However, although the preventive or inhibitory effect of isopropyl methylphenol on periodontal disease due to its bactericidal action, such as penetrating and killing oral biofilms, can be gradually felt with continued use, for example as a tightening sensation, it does not immediately give any real feeling to the gums, etc. with a single use, and therefore users may not be able to maintain their motivation to use the product. In order to maximize the effects of isopropyl methylphenol, it is important to maintain the user's motivation to use the product and encourage continued use. To achieve this, it is considered effective to increase the user's motivation by making them feel that the oral composition is working on their mouth, especially their gums, every time they use it.

International Publication No. 2010/143589 Japanese Patent Application Publication No. 8-151324 Japanese Patent Application Publication No. 8-151325 Special table 2019-532946 publication JP 2017-155010 A

The present invention has been made in consideration of the above circumstances, and aims to provide an oral composition containing isopropylmethylphenol that provides a high feeling of effectiveness in the oral cavity, particularly on the gums, even with a single use, and is effective in preventing or inhibiting periodontal disease.

The present inventors conducted extensive research to achieve the above-mentioned objective, and discovered that when an oral composition containing isopropyl methylphenol is combined with a water-soluble tin salt and an amino acid, a unique, long-lasting, and remarkable feeling of firmness is imparted to the oral cavity, particularly to the gums, with a single use, thereby providing a high level of effectiveness that makes the oral composition feel effective on the gums with each use in the oral cavity, and also improving the unpleasant taste to ensure a pleasant taste when used. In other words, the present invention has discovered that an oral composition containing (A) isopropyl methyl phenol, (B) a water-soluble tin salt, and (C) an amino acid not only has a bactericidal effect, but also provides a high level of effectiveness that can be felt in the oral cavity, particularly on the gums, with a single use, has a good taste, and is effective for preventing or suppressing periodontal diseases such as pyorrhea, and has led to the creation of the present invention.

More specifically, in the present invention, by using the component (A) in combination with the component (B) in the oral composition, a unique, long-lasting, and remarkable feeling of gum tightening (a unique feeling that the feeling of gum tightening continues even after a period of time has passed since use, and is felt prominently, hereinafter sometimes abbreviated as "feeling of gum tightening") can be imparted, and a high feeling of effectiveness felt in the gums can be imparted. The feeling of gum tightening is a unique feeling obtained by the specific action of the component (B) on the component (A) as an agent for imparting effectiveness, and is different from the feeling of astringency caused by, for example, other astringents. Furthermore, when the component (A) is used in combination with the component (B), a problem occurs in that a strange taste derived from the component (A) is significantly expressed, resulting in a bad aftertaste. However, by further adding the component (C), the strange taste is improved without being unpleasant as described above, and a good feeling of use is maintained, and a high feeling of effectiveness is imparted by the feeling of gum tightening.
As shown in the comparative examples described later, when the oral composition contained the component (A) but did not contain the components (B) and (C), the feeling of tightness of the gums (the feeling of tightness of the gums immediately after use and 10 minutes after use) was low (Comparative Example 1), and when the oral composition contained the components (A) and (B) but did not contain the component (C), the unpleasant taste (absence of unpleasant taste) after use was poor and the composition was unsuitable for use (Comparative Example 2). In contrast, the oral composition containing the components (A), (B) and (C) of the present invention shown in the examples was excellent in the feeling of tightness of the gums and the unpleasant taste (absence of unpleasant taste) after use.
In addition, Patent Documents 2 and 3 (JP Patent Publication No. 8-151324 and JP Patent Publication No. 8-151325) propose improving antibacterial activity against biofilms by combining lysine or arginine with a compound exhibiting antibacterial activity, and Patent Document 4 (JP Patent Publication No. 2019-532946) combines tranexamic acid or epsilon aminocaproic acid with a stannous ion source to impart gingival wound healing and antibacterial effects to an oral care composition, and Patent Document 5 (JP Patent Publication No. 2017-155010) combines epsilon aminocaproic acid with pyrrolidone carboxylic acid, vitamins, etc. to improve anti-inflammatory effects and discoloration stability, but these are not improvements in the actual feeling of effect. In contrast, the present invention combines components (A), (B) and (C) to impart a unique, long-lasting and noticeable feeling of gum tightening, thereby significantly improving the perceived effect of component (A) and also improving the unpleasant taste.

Accordingly, the present invention provides the following oral compositions.
[1]
(A) isopropyl methylphenol,
An oral composition comprising (B) a water-soluble tin salt and (C) an amino acid.
[2]
The oral composition according to claim 1, wherein the water-soluble tin salt (B) is one or more selected from tin chloride and tin fluoride.
[3]
The oral composition according to claim 1 or 2, wherein the amino acid (C) is one or more selected from alanine, tranexamic acid and epsilon-aminocaproic acid.
[4]
The oral composition according to any one of [1] to [3], wherein the mass ratio of (A)/(C) is 0.1 to 5.
[5]
The oral composition according to any one of [1] to [4], wherein the mass ratio of (B) (the amount of tin ions in component (B))/(C) is 0.05 to 30.
[6]
The oral composition according to any one of [1] to [5], wherein the content of the (A) component is 0.01 to 0.2 mass%, the content of the (B) component is 0.02 to 1 mass% as tin ions, and the content of the (C) component is 0.01 to 1 mass%.
[7]
The oral composition according to any one of [1] to [6], further comprising (D) one or more selected from the group consisting of N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate, and menthyl succinate.
[8]
The oral composition according to claim 7, wherein the content of component (D) is 0.00001 to 0.1 mass%.
[9]
The oral composition according to any one of [1] to [8], which is a dentifrice, a mouthwash or a mouth spray.

According to the present invention, it is possible to provide an oral composition that, even with a single use, provides a bactericidal effect, such as penetrating and killing oral biofilms, of component (A) in the oral cavity, as well as a high sense of effectiveness that component (A) is effective on the gums, and that tastes good. The oral composition of the present invention can effectively exert a bactericidal effect, such as penetrating and killing oral biofilms, of component (A), and is effective for preventing or suppressing periodontal diseases such as pyorrhea.

The present invention will now be described in further detail.
The oral composition of the present invention contains (A) isopropylmethylphenol, (B) a water-soluble tin salt, and (C) an amino acid.

(A) Isopropylmethylphenol is a nonionic bactericide that has bactericidal properties such as penetrating and killing oral biofilms, and exerts an effect of preventing or suppressing periodontal disease by killing periodontal pathogens.
The blending amount of (A) isopropylmethylphenol is preferably 0.01 to 0.2% (mass%, hereinafter the same) of the entire composition, more preferably 0.02 to 0.1%. When the blending amount is 0.01% or more, the bactericidal effect and the feeling of firming the gums are sufficiently obtained, and when it is 0.2% or less, the effect of improving the unpleasant taste by the (C) component is sufficiently exhibited, and a pleasant feeling of use is ensured.

The water-soluble tin salt (B), when used in combination with component (A), provides a unique, long-lasting and noticeable feeling of gum tightening, and this feeling of gum tightening provides a sense of actual effectiveness.
(B) Examples of water-soluble tin salts include tin chloride, tin fluoride, tin acetate, tin gluconate, tin oxalate, tin sulfate, tin lactate, tin tartrate, tin citrate, tin malate, tin phosphate, tin pyrophosphate, and tin metaphosphate. Of these, tin chloride and tin fluoride are preferred.
As the tin chloride, tin(II) chloride (stannous chloride) can be used, and it may be a hydrate such as tin(II) chloride dihydrate. As the tin fluoride, tin(II) fluoride (stannous fluoride) or tin(IV) fluoride (stannic fluoride) can be used. In particular, tin(II) fluoride (stannous fluoride) is preferred because it can also impart a caries prevention effect. These may be used alone or in combination of two or more.

The amount of water-soluble tin salt (B) is preferably 0.02-1% of the total composition in terms of tin ions, more preferably 0.03-0.7%, and even more preferably 0.1-0.7%. If the tin ion content is 0.02% or more, a sufficient feeling of firmness of the gums is obtained, and if it is 1% or less, the effect of component (C) in improving unpleasant tastes is fully exerted, ensuring a pleasant usability.

The (C) amino acid prevents the unpleasant taste caused by the (A) component that occurs when the (A) and (B) components are used in combination, improves the unpleasant taste, and ensures a pleasant taste when used.
The amino acid (C) may be a natural product or an artificially synthesized product, and in particular, alanine, tranexamic acid, and epsilon aminocaproic acid can be used. These may be used alone or in combination of two or more. Among these, alanine is preferred from the viewpoint of improving off-taste, or a combination of tranexamic acid and epsilon aminocaproic acid is also preferred. The combination of alanine and tranexamic acid and/or epsilon aminocaproic acid is more preferred from the viewpoint of further improving the effect of preventing or suppressing periodontal disease by the anti-inflammatory action of tranexamic acid and epsilon aminocaproic acid in addition to the effect of improving off-taste, and the combination of alanine and tranexamic acid is even more preferred.

(C) The amount of amino acid blended is preferably 0.01-1% of the total composition, more preferably 0.03-0.5%, and even more preferably 0.04-0.5%. If the blended amount is 0.01% or more, the effect of improving the unpleasant taste is sufficiently obtained, and if it is 1% or less, the feeling of firmness of the gums is sufficiently maintained. If the blended amount exceeds 1%, the feeling of firmness of the gums may decrease.

In the present invention, the ratio (A)/(C) of the amount of the component (A) to the amount of the component (C) is preferably a mass ratio of 0.1 to 5, more preferably 0.1 to 3, even more preferably 0.1 to 2.5, and particularly preferably 0.3 to 2.5.
Furthermore, (B)/(C), which indicates the ratio of the blending amount of component (B) (blended amount as tin ions) to the blending amount of component (C), is preferably 0.05 to 30, more preferably 0.1 to 20, and even more preferably 0.3 to 20, in terms of mass ratio.
When either the mass ratio of (A)/(C) or the mass ratio of (B)/(C) is within the above range, the gums will feel firmer and the unpleasant taste will be improved. When the mass ratio of (A)/(C) is less than 0.1 or the mass ratio of (B)/(C) is less than 0.05, the gums may not feel firmer. When the mass ratio of (A)/(C) is more than 5 or the mass ratio of (B)/(C) is more than 30, the unpleasant taste improvement effect may not be fully achieved.
It is particularly preferable in terms of exerting the effects of the present invention that the mass ratio of (A)/(C) and the mass ratio of (B)/(C) are both within the above ranges.

The oral composition of the present invention preferably further contains a cooling agent (D). By including the component (D), the feeling of firmness of the gums is further enhanced, and the effect of the composition is further improved.
Examples of component (D) include N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate, and menthyl succinate. Of these, N-(4-cyanomethylphenyl)-p-menthanecarboxamide and N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide) are more preferred. These may be used alone or in combination of two or more.
Specifically, the following commercially available products can be used.
N-Ethyl-p-menthane-3-carboxamide; Symrise, WS-3
Ethyl 3-(p-menthane-carboxamide) acetate; Toyotama Fragrance Co., Ltd., WS-5
N-(4-cyanomethylphenyl)-p-menthanecarboxamide: EVERCOOL 180, manufactured by Givaudan Japan Ltd.
N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide); EVERCOOL 190, manufactured by Givaudan Japan Ltd.
2-Isopropyl-N,2,3-trimethylbutyramide; WS-23, manufactured by Givaudan Japan Ltd.
Menthone glycerol acetal; MGA, manufactured by Symrise
Menthoxypropane-1,2-diol; manufactured by Takasago International Corporation, CA10
Menthyl lactate: manufactured by Symrise Menthyl succinate (monomenthyl succinate): manufactured by Vimanfis

When component (D) is included, the amount is preferably 0.00001 to 0.1% of the total composition, more preferably 0.00003 to 0.07%, and particularly preferably 0.00005 to 0.05%.

The oral cavity composition of the present invention can be prepared in the form of a paste, gel, liquid, etc., and used as a dentifrice such as toothpaste, gel dentifrice, liquid dentifrice, lubricant dentifrice, etc., a mouthwash, a mouth spray, etc. Among them, it is suitable as a dentifrice, a mouthwash, or a mouth spray, particularly as a dentifrice. The preparation method can be a conventional method according to the form and dosage form.
In this case, other optional components may be added as necessary in addition to the above-mentioned components depending on the purpose, dosage form, etc. of the oral composition. Examples of optional components include surfactants, abrasives, thickeners, humectants, solvents, sweeteners, flavorings, preservatives, colorants, active ingredients, etc.
Specific examples of optional components are shown below. These optional components may be blended alone or in combination of two or more, and the blend amount of each optional component may be a normal amount within a range that does not impair the effects of the present invention.

Surfactants:
Examples of the surfactant include anionic surfactants, nonionic surfactants, and amphoteric surfactants, and specific examples thereof are shown in (i) to (iii) below.
(i) Anionic Surfactants Examples of anionic surfactants include alkyl sulfates such as lauryl sulfate, acyl sarcosine salts, acyl methyl taurine salts, acyl glutamate salts, and α-olefin sulfonate salts (tetradecene sulfonate salts). As the above salts, alkali metal salts such as sodium salts and potassium salts are preferred.
(ii) Nonionic Surfactants Examples of nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyglycerin fatty acid ester, sorbitan fatty acid ester, and fatty acid monoglyceride.
(iii) Amphoteric Surfactants Examples of amphoteric surfactants include fatty acid amidopropyl betaines such as coconut oil fatty acid amidopropyl betaine, and N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts.
The amount of the surfactant to be blended is preferably 0.001 to 10%, and more preferably 0.1 to 5%, of the total composition.

Abrasives:
Examples of the abrasive include silica-based abrasives such as silicic anhydride, zeolite, calcium carbonate, aluminum hydroxide, and aluminum oxide.
The amount of the abrasive blended is usually from 2 to 50%, particularly from 10 to 40%, of the entire composition.

Thickener:
Examples of the thickener include organic thickeners such as xanthan gum, sodium alginate, hydroxyethyl cellulose, carrageenan, sodium carboxymethyl cellulose, polyvinylpyrrolidone, sodium polyacrylate, and carboxyvinyl polymers, and inorganic thickeners such as thickening silica.
The amount of the thickener blended is usually from 0.1 to 10%, particularly from 0.1 to 8%, of the entire composition.

Wetting Agent:
Examples of the alcohol include sugar alcohols such as sorbitol, xylitol, and erythritol, and polyhydric alcohols such as glycerin, propylene glycol, and polyethylene glycol (PEG).
The amount of the wetting agent is usually 2 to 50% of the total composition.

solvent:
Examples of the alcohol include purified water and lower alcohols having 1 to 3 carbon atoms, such as ethanol. When ethanol is added, it may be 25% or less of the total composition, or it may not be added at all.
Sweeteners:
Examples include saccharin, sodium saccharin, and sucralose.

Fragrance:
Examples of such oils include menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, and eucalyptus oil. These oils may be used alone or in combination of two or more.
The amount of the fragrance blended is usually 0.01 to 2% of the total composition.

Preservatives:
Examples include paraoxybenzoic acid esters and sodium benzoate.
Colorants:
Examples include Blue No. 1, Blue No. 2, Green No. 3, Yellow No. 4, Yellow No. 5, Red No. 106, Red No. 227, caramel, titanium oxide, and titanium mica.

Optional Active Ingredients:
Examples of such additives include fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, enzymes such as dextranase, sodium pyrrolidone carboxylate, allantoin, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, vitamin E, copper gluconate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, pyrophosphate, polyphosphate, metaphosphate, zeolite, aluminum lactate, potassium nitrate, calcium glycerophosphate, and Phellodendron Bark extract.

The present invention will be specifically explained below with examples, comparative examples, and formulation examples, but the present invention is not limited to the following examples. In the following examples, % indicates mass % unless otherwise specified.

[Examples and Comparative Examples]
Dentifrice compositions having the compositions shown in Tables 1 to 4 were prepared by conventional methods and evaluated by the following methods. The results are also shown in the tables.
In addition, all of the dentifrice compositions of the examples containing (A) isopropylmethylphenol had a bactericidal effect, such as penetrating bactericidal effect on oral biofilms, derived from component (A).

(1) Evaluation method for gum tightness: A sensory evaluation was carried out by 10 expert panelists. The dentifrice composition filled in a laminated tube was pressed out 1 cm onto a toothbrush, and the toothbrush was brushed for 3 minutes in the same manner as usual. The gum tightness immediately after use and 10 minutes after use were evaluated according to the following criteria.
The feeling of tight gums is a distinctive sensation that is noticeable and lasts for a long time after use, in which the feeling of tight gums continues.
Evaluation criteria: 5 points: Very strong feeling of tightness of gums immediately after use and after 10 minutes 4 points: Strong feeling of tightness of gums immediately after use and after 10 minutes 3 points: Slight feeling of tightness of gums immediately after use and after 10 minutes 2 points: Not much feeling of tightness of gums immediately after use and after 10 minutes 1 point: No feeling of tightness of gums immediately after use and after 10 minutes The average of the evaluation results of 10 people was calculated and evaluated according to the following evaluation criteria. Those that secured the evaluations of ◯, ◎, and ☆ were judged to be dentifrice compositions that gave a feeling of tightness of gums and were excellent in the feeling of effect on the gums.
Evaluation criteria: ☆: Average score of 4.5 points or more ◎: Average score of 4.0 points or more and less than 4.5 points ○: Average score of 3.0 points or more and less than 4.0 points △: Average score of 2.0 points or more and less than 3.0 points ×: Average score of 1.0 points or more and less than 2.0 points

(2) Evaluation method for off-flavor (absence of off-flavor) after use: A sensory evaluation was carried out by 10 expert panelists. The dentifrice composition filled in a laminated tube was pressed out 1 cm onto a toothbrush, and the subjects brushed their teeth for 3 minutes in the same way as usual. The off-flavor remaining in the mouth 10 minutes after use was evaluated according to the following criteria.
Evaluation criteria: 4 points: no unpleasant taste at all 3 points: slight unpleasant taste 2 points: unpleasant taste 1 point: very strong unpleasant taste The average of the evaluation results of 10 people was calculated and rated according to the following evaluation criteria. Those that secured the evaluations of ◎ and ○ were judged to be dentifrice compositions that left no unpleasant taste after use, had a suppressed unpleasant taste, and were good tasting.
Evaluation criteria: ☆: Average score of 4 points ◎: Average score of 3.5 points or more and less than 4.0 points ○: Average score of 3.0 points or more and less than 3.5 points △: Average score of 2.0 points or more and less than 3.0 points ×: Average score of 1.0 points or more and less than 2.0 points

Details of the raw materials used are shown below.
(A) Isopropylmethylphenol; manufactured by Osaka Kasei Co., Ltd. (B) Tin chloride; manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., tin(II) chloride dihydrate (B) Tin fluoride; manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., tin(II) fluoride
(C) Alanine; DL-alanine, manufactured by Ajinomoto Healthy Supply Co., Ltd. (C) Tranexamic acid; epsilon-aminocaproic acid, manufactured by Kyowa Pharma Chemical Co., Ltd. (C) N-(4-cyanomethylphenyl)-p-menthanecarboxamide, manufactured by Daiichi Sankyo Co., Ltd.
Givaudan Japan Co., Ltd., Evercool 180
(D) N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide);
Givaudan Japan Co., Ltd., Evercool 190
The composition of fragrance A will be described in detail below.

注；（Ｂ）／（Ｃ）は、（（Ｂ）成分のスズイオンとしての配合量）／（（Ｃ）成分の配合量）の質量比である（以下同様）。

Note: (B)/(C) is the mass ratio of (the amount of component (B) blended as tin ions)/(the amount of component (C) blended) (the same applies below).

Composition of fragrance A:
Peppermint oil 50
Peppermint refined oil (20% pre-distillate cut) 5
Peppermint refined oil (15% front and rear part cut) 5
Spearmint oil 1
Spearmint refined oil (20% pre-distillate cut) 1
Japanese peppermint oil 1
Japanese peppermint refined oil (30% of the front part cut) 1
Menthol 10
Carbone 1
1,8-cineole 1
Anethole 5
Cinnamic aldehyde 1
Eugenol 1
Methyl Salicylate 1
Flavor 1 (Table 5) 1
Flavor 2 (Table 6) 1
Flavor 3 (Table 7) 1
Flavor 4 (Table 8) 1
Flavor 5 (Table 9) 1
Flavor 6 (Table 10) 1
Flavor 7 (Table 11) 1
Solvent (Table 12) Remainder
Total 100%

An example prescription is shown below.

[Formulation Example 1] Dentifrice (A) Isopropyl methylphenol 0.05
(B) Tin fluoride (stannous fluoride) 0.4
(C) Tranexamic acid 0.05
Sodium monofluorophosphate 0.38
Tocopherol acetate 0.1
Aluminum lactate 2
Potassium nitrate 5
Sodium citrate 0.5
Sodium hexametaphosphate 1
Abrasive Silica 18
Sodium lauryl sulfate 0.6
Sodium methyl lauroyl taurate 0.6
Polyoxyethylene (20) hydrogenated castor oil 1
Sodium lauroyl glutamate 0.1
70% sorbitol solution 30
Propylene glycol 3
Xanthan gum 0.3
Sodium carboxymethylcellulose 1.0
Polyethylene glycol 4000 0.5
Copper gluconate 0.1
Viscosifying Silica 1
Titanium oxide 0.4
Sodium saccharin 0.08
Sodium hydroxide (adjust pH to 7.0)
Fragrance A 1.3
Purified water Balance
Total 100%

[Formulation Example 2] Dentifrice (A) Isopropyl methylphenol 0.05
(B) Tin fluoride (stannous fluoride) 0.4
(C) epsilon aminocaproic acid 0.05
Sodium fluoride 0.11
Tocopherol acetate 0.1
Aluminum lactate 2
Potassium nitrate 5
Sodium citrate 0.5
Sodium hexametaphosphate 1
Abrasive Silica 15
Sodium lauryl sulfate 0.6
Sodium tetradecene sulfonate 0.5
Sodium lauroyl sarcosine 0.2
Coconut oil fatty acid amidopropyl betaine solution (30%) 0.9
85% glycerin solution 28
Propylene glycol 3
Carrageenan 0.3
Xanthan gum 0.3
Sodium carboxymethylcellulose 0.7
Sodium pyrrolidone carboxylate 3.0
Cationic cellulose 0.05
Viscosifying Silica 2
Titanium oxide 0.3
Sodium saccharin 0.1
Sodium hydroxide (adjust pH to 6.1)
Fragrance A 1.3
Purified water Balance
Total 100%

[Formulation Example 3] Mouthwash (A) Isopropyl methylphenol 0.05
(B) Tin fluoride (stannous fluoride) 0.1
(C) Tranexamic acid 0.05
Tocopherol acetate 0.1
70% sorbitol solution 5
85% glycerin solution 1
Xylitol 1
Sodium lauroyl sarcosine 0.1
Propylene glycol alginate 0.1
Polyoxyethylene (60) hydrogenated castor oil 0.3
Polyoxyethylene (15) cetyl ether 0.1
Propylene glycol 3
Ethanol 10
Citric acid 0.05
Sodium citrate 0.3
Sodium hydroxide (adjust pH to 6.0)
Fragrance A 0.1
Purified water Balance
Total 100%

[Formulation Example 4] Mouth spray (A) Isopropyl methylphenol 0.05
(B) Tin fluoride (stannous fluoride) 0.1
(C) Tranexamic acid 0.05
Tocopherol acetate 0.1
Sodium hexametaphosphate 0.01
85% glycerin solution 30
70% sorbitol solution 4
Polyethylene glycol 400 2
Xylitol 1
Cetylpyridinium chloride 0.05
Ethanol 25
Polyoxyethylene (60) hydrogenated castor oil 2
Copper gluconate 0.01
Citric acid 0.05
Sodium citrate 0.3
Sodium hydroxide (adjust pH to 6.0)
Fragrance A 0.5
Purified water Balance
Total 100%

Claims (9)

(A) isopropyl methylphenol,
An oral composition comprising (B) a water-soluble tin salt and (C) an amino acid. The oral composition according to claim 1, wherein (B) the water-soluble tin salt is at least one selected from tin chloride and tin fluoride. The oral composition according to claim 1 or 2, wherein the amino acid (C) is one or more selected from alanine, tranexamic acid, and epsilon aminocaproic acid. The oral composition according to any one of claims 1 to 3, wherein the mass ratio of (A)/(C) is 0.1 to 5. The oral composition according to any one of claims 1 to 4, wherein the mass ratio of (B) (the amount of tin ions in component (B))/(C) is 0.05 to 30. The oral composition according to any one of claims 1 to 5, wherein the content of component (A) is 0.01 to 0.2% by mass, the content of component (B) is 0.02 to 1% by mass as tin ions, and the content of component (C) is 0.01 to 1% by mass. The oral composition according to any one of claims 1 to 6 further contains (D) one or more selected from N-ethyl-p-menthane-3-carboxamide, ethyl-3-(p-menthane-carboxamide) acetate, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)-3-p-menthanecarboxamide), 2-isopropyl-N,2,3-trimethylbutyramide, menthone glycerol acetal, menthoxypropane-1,2-diol, menthyl lactate, and menthyl succinate. The oral composition according to claim 7, wherein the content of component (D) is 0.00001 to 0.1% by mass. The oral composition according to any one of claims 1 to 8, which is a dentifrice, a mouthwash or a mouth spray.