JP4873151B2 - Hair restorer composition - Google Patents

Description

  The present invention relates to a hair restorer composition capable of dramatically improving the hair growth effect by using a specific polymer compound and a specific nonionic surfactant in combination with an active hair growth ingredient.

  Various studies have been conducted so far to improve the hair-growth effect. For example, a hair nourishing agent containing an odd carbon chain length fatty acid or a derivative thereof as an active ingredient (Patent Document 1: Japanese Patent Laid-Open No. 59-27809), a hair restoring agent containing a purine compound or the like as an active ingredient (Patent Document 2: Japanese Patent Application Laid-Open No. 5-320028) has been reported. However, in these, the effect of the hair-growth component was not fully demonstrated.

JP 59-27809 A JP-A-5-320028

  This invention is made | formed in view of the said situation, and it aims at providing the hair restorer composition which has the outstanding hair growth effect.

  The inventor has intensively studied to achieve the above-mentioned object, and evaluated the hair-growth active ingredient using a model animal, and found that a specific hair-growth active ingredient, a specific polymer compound, and a specific nonionic surfactant are included. As a result of the combination, it has been found that the hair-growth effect is dramatically improved as compared with the active ingredient alone, and the present invention has been made.

  Therefore, the present invention comprises (A) a hair-growth active ingredient selected from (A) pentadecanoic acid glyceride, carpronium chloride, nicotinamide, minoxidil, β-glycyrrhetinic acid, isopropylmethylphenol, piroctone olamine, forskolin, and swell thiamarin. (B) N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer and (C) polyoxypropylene polyoxyethylene glyceryl ether and / or polyoxypropylene A hair restorer composition comprising glyceryl ether is provided.

  ADVANTAGE OF THE INVENTION According to this invention, the hair growth effect can be aimed at and the hair restorer composition which has the outstanding hair growth effect can be provided.

  The active ingredient for hair growth (A) used in the present invention is selected from pentadecanoic acid glyceride, carpronium chloride, nicotinamide, minoxidil, β-glycyrrhetinic acid, isopropylmethylphenol, piroctone olamine, forskolin, and swell thiamarin. It can be used individually by 1 type or in combination of 2 or more types as appropriate.

  (A) Although the compounding quantity of a component is an effective amount of various active ingredients, 0.001-10.0 mass% is preferable with respect to the hair restorer composition whole quantity, More preferably, it is 0.01-7.0 mass. %, More preferably 0.05 to 3.0% by mass. If the amount is too small, a sufficient hair-growth effect may not be obtained, and if too much, it may be uneconomical.

  (B) N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer is N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxyl. It is a copolymer of betaine and methacrylic acid alkyl ester, and these ratios in the copolymer are not particularly limited, and can be used singly or in appropriate combination of two or more. Specific examples of N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymers include Yuka Former R205, Yuka Former R205S, Yuka Former 510, Yuka Former SM, manufactured by Mitsubishi Chemical Corporation. Yuka Former 301, Yuka Former AMPHOSET, Yuka Former 104D, Yuka Former 202, Yuka Former 201 (all are trade names).

  (B) The compounding quantity of a component is 0.001-30 mass% normally with respect to the hair restorer composition whole quantity, 0.01-20 mass% is preferable, More preferably, it is 0.1-10 mass%. is there. A blending amount of 0.1 to 10% by mass is more preferable because a hair styling effect is obtained. If the amount is too small, a sufficient hair-growth effect may not be obtained, and if it is too much, the feeling in use may be deteriorated.

  (C) component of this invention is polyoxypropylene polyoxyethylene glyceryl ether and / or polyoxypropylene glyceryl ether, and can be used individually by 1 type or in combination of 2 or more types. As polyoxypropylene (POP) polyoxyethylene (POE) glyceryl ether, POP (24) POE (24) glyceryl ether is preferable, and as polyoxypropylene glyceryl ether, POP (3) glyceryl ether and POP (6) glyceryl ether are preferable. Ether, POP (8) glyceryl ether, POP (10) glyceryl ether, POP (24) glyceryl ether, POP (50) glyceryl ether, POP (55) glyceryl ether, POP (67) glyceryl ether, POP (70) glyceryl ether Is preferred.

  (C) The compounding quantity of a component is 0.001-30 mass% normally with respect to the hair restorer composition whole quantity, More preferably, it is 0.01-20 mass%, More preferably, it is 0.1-20 mass%. It is. A blending amount of 0.1 to 20% by mass is more preferable because a hair styling effect is obtained. If the amount is too small, a sufficient hair-growth effect may not be obtained, and if it is too much, the feeling in use may be deteriorated.

  When blending a fragrance in the hair restorer composition of the present invention, the fragrance used is similar to the fragrance and fragrance composition described in JP-A No. 2003-1113019. When blending a fragrance composition, the hair restorer composition It is suitable to mix | blend so that a fragrance | flavor composition may be 0.00001-50 mass% with respect to the whole quantity, More preferably, 0.0001-30 mass% is mix | blended.

  In addition to the above-described components, the hair-restoring agent composition of the present invention can be used alone or in combination of two or more as appropriate as long as the effects of the present invention are not impaired. Optional ingredients include, for example, anti-androgen agents, moisturizers, vitamins, amino acids, purified water, ethanol, celluloses, surfactants, fats and oils, ester oils, polymer resins, colorants, fragrances, UV absorption Agents, liquefied gases, compressed gases, and the like.

  The hair restorer composition of the present invention is prepared by, for example, mixing the above components (A) to (C) and the remainder (water or ethanol), and following a conventional method for each dosage form, a uniform solution, lotion, gel, cream, It can be in the form of an aerosol or the like. In addition, when making an aerosol, a combustible gas selected from butane, propane, isobutane, liquefied petroleum gas, and dimethyl ether and / or a compressed gas selected from nitrogen gas, oxygen gas, carbon dioxide gas, and nitrous oxide gas should be blended. Can do. In addition, the gas in the case of making it into aerosol shall not be contained in the hair restorer composition whole quantity in the compounding quantity of said (A)-(C) and arbitrary components.

  The hair-growth composition may be a hair-growth tonic, scalp essence, hair-growth spray, hair-growth hair cream, hair-growth hair gel, or the like.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, unless otherwise specified, “%” in the composition represents mass%.

[Examples 1 to 12, Comparative Examples 1 to 19]
Hair restorer compositions having the compositions shown in Tables 1 to 5 were prepared and evaluated as follows. The results are shown in the table.

[Measurement of hair-growth effect (measurement of hair-growth effect in mice)]
Experiments were carried out using C3H mice (7 weeks old) in the resting period of the hair cycle according to the method of Ogawa et al. (Fragrance Journal, Vol. 17, No. 5, P. 20-29, 1989). Eight mice were used per sample. The entire back of the mouse was removed with an electric clipper and an electric shaver. From the next day, 100 μL was applied once a day, 5 times a week for 16 days. For each mouse, the ratio (%) of the hair regeneration area to the hair removal area on the 16th day after hair removal was determined, and the results were judged to be “effective”, “effective”, “invalid” based on the following evaluation criteria, and the results Is shown by the number of mice.
<Evaluation criteria>
Remarkable: Ratio of hair regeneration area is over 70% Effective: Ratio of hair regeneration area is 50 to 70%
Invalid: Less than 50% of hair regeneration area

  Next, Examples prescribed for each dosage form are shown. The hair restorer compositions of Examples 13 to 26 all showed a good hair growth effect.

[Example 13] (essence for scalp)
Composition%
Pentadecanoic acid monoglyceride 2.0
β-glycyrrhetinic acid 0.02
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaforma R205)
0.5
Polyethylene glycol 400 0.1
DL-α-tocopherol acetate 0.1
POP (24) POE (24) Glyceryl ether 5.0
POP (70) glyceryl ether 10.0
Polyoxyethylene oleyl ether (10EO) 2.0
Sucrose myristic acid ester 0.5
Lauroylglutamate dihexyldecyl 1.5
Coleus extract 0.5
Succinic acid 0.3
L-Menthol 0.3
Fragrance * 0.05
Methylparaben 0.1
99% ethanol remaining
Total 100.0
*: Uses the B composition in Table 2 of JP2003-1113019

[Example 14] (hair growth tonic)
Composition%
β-glycyrrhetinic acid 0.1
Piroctone olamine 0.1
Polyethylene glycol 300 0.1
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaforma R205S)
3.0
POP (24) POE (24) Glyceryl ether 10.0
Stearoyl dioctyldodecyl glutamate 2.0
Polyoxyethylene stearyl ether (20EO) 2.0
POP (70) glyceryl ether 5.0
Isopropyl myristate 3.0
L-Menthol 0.2
Citric acid 0.1
Dibutylhydroxytoluene 0.01
Fragrance * 0.05
99% ethanol 75.0
Purified water balance
Total 100.0
*: Uses the B composition in Table 2 of JP2003-1113019

[Example 15] (Hair nourishing agent)
Composition%
Carpronium chloride 0.1
Nicotinamide 0.5
Glycerin 0.1
Polyoxyethylene stearyl ether (20EO) 2.0
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaformer 510)
0.1
POP (3) glyceryl ether 15.0
L-Menthol 0.2
Dibutylhydroxytoluene 0.01
Malic acid 0.05
Citric acid 0.05
Fragrance * 0.05
99% ethanol 75.0
Purified water balance
Total 100.0
*: Use the D composition in Table 2 described in JP2003-1113019

[Example 16] (Hair nourishing agent)
Composition%
Polyoxyethylene lauryl ether (10EO) 2.0
Piroctone Olamine 1.0
Carpronium chloride 0.5
Isoprene glycol 1.0
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaformer SM)
0.5
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaforma R205S)
3.0
Isotridecyl myristate 2.0
POP (6) glyceryl ether 5.0
POP (24) POE (24) Glyceryl ether 5.0
Methylphenylpolysiloxane 2.0
L-Menthol 0.1
Lactic acid 0.2
Octyl gallate 0.1
Fragrance * 0.05
99% ethanol 60.0
Purified water balance
Total 100.0
*: C composition in Table 2 described in JP2003-1113019 is used.

[Example 17] (Hair nourishing agent)
Composition%
Nicotinamide 3.0
Minoxidil 0.5
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaformer 301)
1.0
Pentanediol 0.5
Polyethylene glycol 300 2.0
Polyoxyethylene lauryl ether (10EO) 2.0
POE (40) hydrogenated castor oil 0.5
Lauroyl glutamic acid POE (2) stearyl ether diester 2.0
POP (70) glyceryl ether 10.0
L-Menthol 0.1
Citric acid 1.0
Fragrance * 0.05
99% ethanol 75.0
Purified water balance
Total 100.0
*: C composition in Table 2 described in JP2003-1113019 is used.

[Example 18] (Hair nourishing agent)
Composition%
Minoxidil 1.0
Isopropylmethylphenol 0.1
Propylene glycol 1.0
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukafoam AMPHOSET) 5.0
Polyoxyethylene oleyl ether (20EO) 2.0
Lauroyl glutamic acid POE (5) stearyl ether diester 1.0
POP (8) glyceryl ether 15.0
Isopropyl palmitate 2.0
Methylphenylpolysiloxane 2.0
L-Menthol 0.1
Citric acid 0.2
Echinashi leaf extract 1.0
Gentian extract 0.2
Fragrance * 0.05
99% ethanol 60.0
Purified water balance
Total 100.0
*: Use the D composition in Table 2 described in JP2003-1113019

[Example 19] (Hair nourishing agent)
Composition%
Forskolin 0.01
Swellcia Marine 0.01
Polyethylene glycol 400 2.0
Isoprene glycol 0.5
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaformer 104D)
0.05
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaforma R205S)
3.0
POP (10) glyceryl ether 10.0
Polyoxyethylene oleyl ether (20EO) 2.0
Pyroglutamic acid isostearic acid POE (30) hydrogenated castor oil 1.5
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaformer SM)
0.1
Isopropyl palmitate 2.0
Methylphenylpolysiloxane 2.0
L-Menthol 0.1
Succinic acid 0.2
Echinashi leaf extract 1.0
Gentian extract 0.2
Fragrance * 0.05
99% ethanol 70
Purified water balance
Total 100.0
*: E composition in Table 2 described in JP-A-2003-113019 is used.

[Example 20] (hair growth spray)
Composition%
(Stock solution)
Isopropylmethylphenol 0.2
Forskolin 0.1
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / alkyl methacrylate ester copolymer (Yukaformer 202)
1.0
Sorbitan laurate 0.5
Pyroglutamic acid isostearic acid POE (40) hydrogenated castor oil 1.5
POP (24) Glyceryl ether 12.0
Ethyl oleate 0.1
Citric acid 0.3
Sucrose laurate 0.5
Fragrance * 0.1
L-Menthol 0.1
99% ethanol remaining
Total stock solution 100.0
Stock solution 80
LPG 20
Total 100
*: Use the D composition in Table 2 described in JP2003-1113019

[Example 21] (Hair nourishing hair cream)
Composition%
Oil phase A
Nicotinamide 0.2
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaformer 201)
5.0
Dimethyl silicone gum (degree of polymerization 12000) 1.0
Dimethyl silicone (degree of polymerization 500) 0.1
Pyroglutamic acid isostearic acid POE (50) hydrogenated castor oil 1.0
Ethyl oleate 2.0
POP (50) glyceryl ether 10.0
Octyldodecyl myristate 1.5
Liquid paraffin 1.0
L-Menthol 0.5
Polyethylene glycol monostearate (40EO) 3.0
Palm oil fatty acid sorbitan 2.0
Glycerol monostearate 1.0
Cetostearyl alcohol 1.0
Pantothenyl ethyl ether 0.5
Propylparaben 0.1
B water phase
N-Myristoylvalin 4.0
Polyethylene glycol 1540 1.0
Polyethylene glycol 1500 1.0
Dipropylene glycol 2.5
Methylparaben 0.25
Gentian extract 0.1
Purified water balance
C: Perfume * appropriate amount
Total 100.0
*: Use D composition of Table 2 of Unexamined-Japanese-Patent No. 2003-113019 The said formulation A and B was melt | dissolved at 70 degreeC, respectively, and A was added to B and emulsified uniformly. Further, C was added while cooling to prepare a hair nourishing hair cream.

[Example 22] (hair growth tonic)
Composition%
β-glycyrrhetinic acid 0.5
Forskolin 0.05
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaforma R205)
5.0
Polyethylene glycol 400 1.0
Ethylene glycol 0.2
POP (55) glyceryl ether 20.0
Pyroglutamic acid isostearate POE (25) glyceryl 1.0
POE (40) hydrogenated castor oil 0.2
Vinyl acetate / vinyl pyrrolidone copolymer 0.1
L-Menthol 0.1
Rosemary extract 1.0
Tartaric acid 0.05
Ethanol 70.0
Purified water balance
Total 100.0

[Example 23] (hair growth tonic spray)
Composition%
Undiluted solution
β-glycyrrhetinic acid 0.05
Swellcia Marine 0.1
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaforma R205S)
10.0
Diglucosyl gallic acid 0.5
Stearyltrimethylammonium chloride 0.1
POP (67) glyceryl ether 20.0
Polyethylene glycol 300 0.5
Pyroglutamate glyceryl oleate 1.5
L-Menthol 0.5
Fumaric acid 0.05
Fragrance * Appropriate amount of ethanol 65.0
Purified water balance
Total stock solution 100.0
Stock solution 84.5
DME 15
Nitrogen 0.5
Total 100.0
*: E composition in Table 2 described in JP-A-2003-113019 is used.

[Example 24] (hair growth tonic spray)
Composition%
Undiluted solution
Piroctone olamine 0.05
Minoxidil 0.5
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaformer 510)
0.5
Propylene glycol 0.5
Lauroylglutamate dihexyldecyl 1.0
POP (70) glyceryl ether 17.0
L-Menthol 0.2
Citric acid 0.05
Ethanol 75.0
Purified water balance
Total stock solution 100.0
Stock solution 84.5
LPG 15
Nitrogen 0.5
Total 100.0

[Example 25] (hair growth tonic spray)
Composition%
Undiluted solution
Pentadecanoic acid monoglyceride 2.0
Piroctone Olamine 0.2
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer (Yukaformer SM)
1.0
POP (24) POE (24) Glyceryl ether 15.0
Glycerin 1.0
Pentaglyceryl monomyristate 2.0
POE (40) hydrogenated castor oil 0.2
Octyldodecyl lactate 2.5
Propylene glycol 0.1
Lauric acid sucrose ester 0.2
Lauroyl glutamate dihexyldecyl 0.5
Pyroglutamate glyceryl oleate 1.5
L-Menthol 1.0
Succinic acid 0.05
Perfume * appropriate amount
99% ethanol remaining
Total stock solution 100.0
Stock solution 70
DME 30
Total 100
*: Uses the B composition in Table 2 of JP2003-1113019

[Example 26] (hair growth spray)
Composition%
Isopropylmethylphenol 0.1
Nicotinamide 0.1
β-glycyrrhetinic acid 0.05
POP (70) glyceryl ether 10.0
N-methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / methacrylic acid alkyl ester copolymer 2.0
POP (24) POE (24) grayed Li glyceryl ether
2.0
Citric acid 0.02
Perfume appropriate amount ethanol 60.0
Purified water balance
Total 100.0
*: C composition in Table 2 described in JP2003-1113019 is used.

Claims (2)

  (A) Pentadecanoic acid glyceride, carpronium chloride, nicotinic acid amide, minoxidil, β-glycyrrhetinic acid, isopropylmethylphenol, piroctone olamine, forskolin, and swell thiamarin, and (B) N— Contains methacryloyloxyethyl N, N-dimethylammonium-α-N-methylcarboxybetaine / alkyl methacrylate ester copolymer and (C) polyoxypropylene polyoxyethylene glyceryl ether and / or polyoxypropylene glyceryl ether A hair restorer composition characterized by that. Component (C) is POP (24) POE (24) glyceryl ether, POP (3) glyceryl ether, POP (6) glyceryl ether, POP (8) glyceryl ether, POP (10) glyceryl ether, POP (24) glyceryl The hair restorer composition according to claim 1, which is one or more selected from ether, POP (50) glyceryl ether, POP (55) glyceryl ether, POP (67) glyceryl ether, and POP (70) glyceryl ether. .