JP4861650B2 - Liquid oral composition - Google Patents

Description

  The present invention relates to a liquid oral composition having excellent storage stability, particularly low temperature stability.

A nonionic surfactant is blended as a solubilizer in a liquid oral composition such as a toothpaste or mouthwash containing menthol. However, when a sugar fatty acid ester having a good flavor and little irritation is used, its solubilizing ability is not sufficient, and menthol crystallizes during storage at room temperature or lower. In addition, when the amount of menthol is reduced, crystallization of menthol is suppressed, but there is a disadvantage that turbidity is generated in the composition during storage.
As a means for improving the storage stability of a liquid oral composition using such menthol and sugar fatty acid ester, a technique of further adding an anionic surfactant has been proposed (see Patent Document 1). If a large amount of ionic surfactant is used, the mucous membrane may be irritated, and the refreshing feeling of menthol is also impaired by bitterness and astringency.
JP 2001-72559 A

  An object of the present invention is to provide a liquid oral composition having good storage stability, good flavor and less irritation.

  In view of such a situation, the present inventors, in addition to menthol and sugar fatty acid ester, blended both a terpene compound that is liquid at 25 ° C. and a carboxylic acid ester compound having a total carbon number of 12 to 18; However, it has been found that a liquid composition for oral cavity can be obtained which is stable without causing crystal and turbidity, has a good flavor and is free from irritation.

That is, the present invention comprises the following components (A), (B), (C) and (D):
(A) Sugar fatty acid ester (B) Menthol (C) Provided is a liquid oral composition containing a terpene compound (D) having a total carbon number of 12 to 18 which is liquid at 25 ° C.

  The liquid oral composition of the present invention has good storage stability, good flavor, and little irritation.

  The (A) sugar fatty acid ester used in the liquid oral cavity composition of the present invention is a sugar fatty acid ester having 6 to 18 carbon atoms, preferably a sugar fatty acid ester having 12 sugars, and sucrose. Examples thereof include fatty acid esters, maltose fatty acid esters, and lactose fatty acid esters. Examples of the fatty acid portion of the sugar fatty acid ester include saturated or unsaturated fatty acids having 6 to 24 carbon atoms, and specific examples include lauric acid, myristic acid, palmitic acid, oleic acid, stearic acid, and the like. Moreover, (A) sugar fatty acid ester is 0.001-2 mass% (henceforth only shown with%) in the whole composition from the point of the solubilization ability of menthol and a feeling of use, Preferably 0.01-1 %, Particularly 0.1 to 0.5% is preferable.

  (B) Menthol is blended in order to impart a refreshing feeling, and is contained in the entire composition in an amount of 0.01 to 2%, preferably 0.05 to 1%, particularly 0.1 to 0.5%. preferable.

(C) The terpene compound that is liquid at 25 ° C. is a terpene compound that exists in a liquid state at room temperature (25 ° C.), such as hemiterpene, monoterpene, sesquiterpene, diterpene, sesterterpene, triterpene, tetraterpene, and the like Of the alcohol compound. In particular, monoterpenes and monoterpene alcohols are preferable. Specifically, pinene (C ₁₀ H ₁₆ ), limonene (C ₁₀ H ₁₆ ), terpinene (C ₁₀ H ₁₆ ), cineol (C ₁₀ H ₁₈ O), and linalool. Preferred examples include (C ₁₀ H ₁₈ O), isopulegol (C ₁₀ H ₁₈ O), and β-caryophyllene (C ₁₅ H ₂₄ ) farnesol (C ₁₅ H ₂₆ O).

(D) The carboxylic acid ester compound having 12 to 18 carbon atoms is preferably an ester of a linear or branched alcohol having 2 to 12 carbon atoms or a cyclic alcohol having 3 to 12 carbon atoms and a carboxylic acid, and more preferably. Are acetate ester (acetate), lactate ester (lactate), myristic acid ester (myristate), palmitic acid ester (palmitate). Specific examples of the carboxylic acid ester compound having a total carbon number of 12 to 18 include menthyl lactate (C ₁₃ H ₂₄ O ₃ ), menthyl acetate (C ₁₂ H ₂₂ O ₂ ), terpinyl acetate (C ₁₂ H ₂₀ O _2). ), Linalyl acetate (C ₁₂ H ₂₀ O ₂ ), ethyl myristate (C ₁₆ H ₃₂ O ₂ ), and ethyl palmitate (C ₁₈ H ₃₆ O ₂ ) are preferable.

The total amount of (C) terpene compound and (D) carboxylic acid ester compound having a total carbon number of 12 to 18 is preferably 0.01 to 1 times by mass with respect to menthol from the viewpoint of storage stability. It is preferable to set it as 0.05-0.5 mass times.
Moreover, it is preferable that (A) sugar fatty acid ester shall be 1-50 mass times with respect to the total amount of (C) terpene compound and (D) C12-C18 carboxylic acid ester compound, and especially 2- It is preferable to be 20 mass times.
The mass ratio (C) :( D) of (C) terpene compound and (D) carboxylic acid ester compound having a total carbon number of 12-18 is preferably 10: 1 to 1:10, more preferably 5 from the viewpoint of storage stability. : 1 to 1: 5, particularly 3: 1 to 1: 3 is preferable.

A surfactant other than the component (A) may be further added to the composition of the present invention as long as the effects of the present invention are not impaired. As such a surfactant, polyglycerol fatty acid ester is preferable. Examples of the polyglycerol fatty acid ester include those obtained by condensing 1 to 4 fatty acids having 8 to 24 carbon atoms with polyglycerol obtained by condensing 2 to 20 glycerols, and particularly those having 5 to 10 condensed polyglycerols and carbon atoms. Monoesters of 12-14 fatty acids are preferred. The polyglycerol fatty acid ester is preferably contained in the entire composition in an amount of 0.01 to 2%, particularly 0.1 to 1%.
Furthermore, in order to improve the solubilizing ability of menthol, an anionic surfactant may be added to the composition of the present invention as long as the effects of the present invention are not impaired. Such anionic surfactants include alkyl phosphates, polyoxyalkylenated alkyl phosphates, alkyl sulfates, polyoxyalkylenated alkyl sulfates, acylamino acids, polyoxyalkylenated acylamino acids and salts thereof. One or more selected may be mentioned. The content of the anionic surfactant is preferably 0 to 0.5%, particularly preferably 0 to 0.2% in the entire composition.

  The composition of the present invention further includes a wetting agent such as water, glycerin, sorbitol, xylitol, trehalose and propylene glycol, a sweetener, a tooth strengthening agent such as sodium monofluorophosphate, sodium fluoride and tin fluoride, and anti-inflammatory. Agents, fungicides, astringents such as zinc chloride, preservatives, pH adjusters, chelating agents, water-soluble ingredients such as ethanol, mint oil, citrus oil, herb oil, spice oil usually used in oral compositions Oil-soluble fragrances such as fruit flavors and water-soluble fragrances that can be easily dispersed in water can be blended.

  The liquid oral composition of the present invention is an aqueous liquid, preferably an aqueous transparent or uniform microemulsion system, and can be used as a liquid dentifrice, mouthwash, mouth freshener, mouthwash, and the like.

Examples 1-4 and Comparative Examples 1-4
Mouthwashes were prepared according to the formulations shown in Table 1, and the liquid properties were evaluated after storage for 2 weeks at room temperature-5 ° C. In addition, as a flavor evaluation, the bitter taste remaining in the mouth when the mouthwash was sprinkled for 30 seconds with 10 mL of the mouthwash was determined according to the sensory criteria shown below.
Sensory criteria ○: not bitter Δ: somewhat bitter ×: bitter The results are shown in Table 1.

  From the results shown in Table 1, the inventive products of Examples 1 to 4 are all transparent and good in flavor evaluation, whereas Comparative Example 1 lacking a terpene compound, a carboxylic acid having a total carbon number of 12 to 18 The composition of Comparative Example 2 lacking an ester compound and the composition of Comparative Example 3 lacking both have good flavor evaluation, but have problems with stability at low temperatures such as turbidity and crystals. In Comparative Example 4 in which sodium lauryl sulfate, which is an anionic surfactant, was added for the purpose of solubilizing menthol, there was no problem in storage stability at low temperatures, but there was a problem in flavor evaluation.

  The composition for liquid oral cavity of the present invention is useful as a liquid dentifrice, mouthwash, mouth freshener, mouthwash and the like because it has good storage stability, good flavor and little irritation.

Claims (5)

The following components (A), (B), (C), (D) and (E):
(A) Sugar fatty acid ester 0.1-0.5 mass%
(B) Menthol 0.1-2% by mass
(C) Terpene compound which is liquid at 25 ° C. (D) Polyglycerin and carbon condensed with 5 to 10 carboxylic acid ester compounds (E) having a total carbon number of 12 to 18 selected from acetate ester, lactate ester and myristic ester Polyglycerin fatty acid ester 0.01 to 1% by mass, which is a monoester of fatty acids of several 12 to 14
A mouthwash containing the component (C) and the component (D) in a mass ratio (C) :( D) of 5: 1 to 1: 5 and containing no anionic surfactant.   (C) The mouthwash according to claim 1, wherein the terpene compound is one or more compounds selected from monoterpenes, monoterpene alcohols, sesquiterpenes and sesquiterpene alcohols. (D) The carboxylic acid ester compound having 12 to 18 carbon atoms in total is one or more compounds selected from menthyl lactate, menthyl acetate, terpinyl acetate, linalyl acetate and ethyl myristate. 2. A mouthwash according to 2.   The content of (A) sugar fatty acid ester is 2 to 20 times by mass with respect to the total amount of (C) terpene compound and (D) carboxylic acid ester compound having 12 to 18 carbon atoms in total. The mouthwash according to any one of the above. The total amount of (C) a terpene compound and (D) a carboxylic acid ester compound having a total carbon number of 12 to 18 is 0.05 to 0.5 times by mass with respect to the content of (B) menthol. The mouthwash of any one of -4.