JP3977553B2 - Liquid oral composition - Google Patents
Liquid oral composition Download PDFInfo
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- JP3977553B2 JP3977553B2 JP24868599A JP24868599A JP3977553B2 JP 3977553 B2 JP3977553 B2 JP 3977553B2 JP 24868599 A JP24868599 A JP 24868599A JP 24868599 A JP24868599 A JP 24868599A JP 3977553 B2 JP3977553 B2 JP 3977553B2
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- component
- oil
- liquid oral
- oral composition
- soluble
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- 239000007788 liquid Substances 0.000 title claims description 20
- 239000000203 mixture Substances 0.000 title claims description 18
- -1 fatty acid ester Chemical class 0.000 claims description 31
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 17
- 229930195729 fatty acid Natural products 0.000 claims description 17
- 239000000194 fatty acid Substances 0.000 claims description 17
- 239000003945 anionic surfactant Substances 0.000 claims description 8
- 229930006000 Sucrose Natural products 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 239000005720 sucrose Substances 0.000 claims description 7
- 229930182470 glycoside Natural products 0.000 claims description 3
- 239000002736 nonionic surfactant Substances 0.000 claims description 3
- 210000000214 mouth Anatomy 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 description 7
- 229910019142 PO4 Inorganic materials 0.000 description 6
- 150000004665 fatty acids Chemical class 0.000 description 6
- 239000010452 phosphate Substances 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 125000004442 acylamino group Chemical group 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 150000008051 alkyl sulfates Chemical class 0.000 description 4
- 230000007794 irritation Effects 0.000 description 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 239000000551 dentifrice Substances 0.000 description 3
- 239000002324 mouth wash Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 229920000223 polyglycerol Polymers 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 3
- 230000003381 solubilizing effect Effects 0.000 description 3
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 108010077895 Sarcosine Proteins 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
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- 239000003205 fragrance Substances 0.000 description 2
- 235000013922 glutamic acid Nutrition 0.000 description 2
- 239000004220 glutamic acid Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
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- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 229960003080 taurine Drugs 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 241000546188 Hypericum Species 0.000 description 1
- 235000017309 Hypericum perforatum Nutrition 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 150000001545 azulenes Chemical class 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000002772 monosaccharides Chemical group 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 229920001542 oligosaccharide Chemical group 0.000 description 1
- 150000002482 oligosaccharides Chemical group 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 125000005506 phthalide group Chemical group 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
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- 239000003755 preservative agent Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
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- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Description
【０００１】
【発明の属する技術分野】
本発明は保存安定性の良好な液状口腔用組成物に関する。
【０００２】
【従来の技術及び発明が解決しようとする課題】
液状歯磨き、洗口剤等の液状口腔用組成物には、油溶性成分の可溶化剤としてポリオキシエチレン硬化ヒマシ油に代表される非イオン界面活性剤が配合されている（特開昭５９−１２２４１７号、同５９−１２２４１８号）。ポリオキシエチレン硬化ヒマシ油は、可溶化能が高く、広く使用されているが、大量に使用すると粘膜を刺激するおそれがあり、また風味も損なわれる傾向にあった。
一方、ポリグリセリン脂肪酸エステルやショ糖脂肪酸エステルも口腔用組成物の可溶化剤として使用されているが、その可溶化能は充分でなく、特に室温以下の保存時に沈澱物が生じるという問題があった。
従って本発明の目的は、保存安定性が良好で、かつ風味がよく、刺激性の少ない液状口腔用組成物を提供することにある。
【０００３】
【課題を解決するための手段】
そこで本発明者らは、油溶性成分に対して一定量のポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル又はアルキルグリコシドを配合し、さらにこれに少量の陰イオン界面活性剤を配合すれば、低温保存下でも沈澱が生じず安定であり、かつ風味が良好で、刺激等もない液状口腔用組成物が得られることを見出した。
【０００４】
すなわち、本発明は、次の成分（Ａ）、（Ｂ）及び（Ｃ）、
（Ａ）油溶性成分、
（Ｂ）成分（Ａ）に対して２〜７重量倍の、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル及びアルキルグリコシドから選ばれる１種以上の非イオン界面活性剤、
（Ｃ）成分（Ｂ）１００重量部に対して１重量部以上、１０重量部未満の陰イオン界面活性剤
を含有する液状口腔用組成物を提供するものである。
【０００５】
【発明の実施の形態】
本発明の液状口腔用組成物に用いられる（Ａ）油溶性成分としては、香料成分、油溶性薬効剤及び油剤が挙げられる。ここで香料成分としては、メントール、カルボン、アネトール、ペパーミントオイル、メンチルラクテート等が挙げられる。また油溶性薬効剤としては、非水溶性ビタミン（Ａ，Ｄ，Ｅ，Ｆ，Ｋ，Ｐ等）及びその誘導体、グリチルレチン酸、アズレン誘導体、ステロイド、抗プラスミン剤、非水溶性殺菌剤、フタライド類、ニコチン酸誘導体、マロニエ、バーチ、カミツレ、オトギリソウ、センブリ、ヒバマタ等の生薬の有機溶剤抽出物等が挙げられる。さらに油剤としては、スクワラン、パラフィン、シリコーン、各種脂肪酸、エステル油、エーテル油、動植物油等が挙げられる。これらの油溶性成分は１種以上を組み合せて配合することができ、合計で全組成物中に０．０１〜２重量％（以下、単に％で示す）、特に０．１〜１％配合するのが好ましい。
【０００６】
ポリグリセリン脂肪酸エステルとしては、グリセリンが２〜２０個縮合したポリグリセリンに炭素数８〜２４の脂肪酸が１〜４個エステル結合したものが挙げられ、特に５〜１０個縮合したポリグリセリンと炭素数１２〜１４の脂肪酸のモノエステルが好ましい。またショ糖脂肪酸エステルとしては、ショ糖に炭素数８〜２４の脂肪酸がエステル結合したものが挙げられ、特に炭素数１６〜１８の脂肪酸のショ糖エステルが好ましい。アルキルグリコシドとしては、炭素数８〜２４のアルキル基が単糖又はオリゴ糖にエーテル結合したものが好ましく、特にアルキル基の炭素数８〜１６のものが好ましい。これらの成分（Ｂ）の成分は１種以上を組み合せて配合することができ、合計で成分（Ａ）に対して２〜７重量倍配合すると、成分（Ａ）を安定に可溶化できる。また成分（Ｂ）の好ましい配合量は成分（Ａ）に対して２〜５重量倍である。
【０００７】
本発明に用いられる（Ｃ）陰イオン界面活性剤としては、アルキルリン酸エステル、ポリオキシアルキレン化アルキルリン酸エステル、アルキル硫酸エステル、ポリオキシアルキレン化アルキル硫酸エステル、アシルアミノ酸、ポリオキシアルキレン化アシルアミノ酸及びこれらの塩から選ばれる１種以上が挙げられる。ここで、アルキルリン酸エステルとしては、炭素数８〜２４のアルキル又はアルケニル基を１個又は２個有するリン酸エステルが挙げられ、このうちモノＣ8−Ｃ24アルキルリン酸エステル、ジＣ8−Ｃ24アルキルリン酸エステルが好ましい。また、ポリオキシアルキレン化アルキルリン酸エステルとしては、モノ−又はジ−（ポリオキシエチレン化Ｃ8−Ｃ24アルキル）リン酸エステルが好ましい。
【０００８】
アルキル硫酸エステルとしては、Ｃ8−Ｃ24アルキル硫酸エステルが好ましく、ポリオキシアルキレン化アルキル硫酸エステルとしては、ポリオキシエチレン化Ｃ8−Ｃ24アルキル硫酸エステルが好ましい。アシルアミノ酸としては、サルコシン、グリシン、タウリン、グルタミン酸等のアミノ酸のアミノ基が炭素数８〜２４の脂肪酸でアシル化されたものが好ましく、特にＮ−Ｃ8−Ｃ24長鎖アシルサルコシン、Ｎ−Ｃ8−Ｃ24長鎖アシルグルタミン酸、Ｎ−Ｃ8−Ｃ24長鎖アシルメチルタウリン等が好ましい。ポリオキシアルキレン化アシルアミノ酸としては、上記のアシルアミノ酸がポリオキシエチレン化されたものが好ましい。
【０００９】
また、これらの陰イオン界面活性剤の塩としては、ナトリウム塩、カリウム塩などのアルカリ金属塩、アルギニン、リジン、ヒスチジン等の塩基性アミノ酸塩、アンモニウム塩、アルカノールアミン塩等が好ましい。
【００１０】
これらの陰イオン界面活性剤は、成分（Ｂ）１００重量部に対して１重量部以上１０重量部未満配合すると、成分（Ｂ）による油溶性成分の可溶化能を向上させることができるため、成分（Ｂ）を大量に配合することなく、低温保存条件でも長期間安定な液状口腔用組成物が得られる。また成分（Ｂ）の配合を大量必要としないため刺激や風味の点でも改善される。より好ましい陰イオン界面活性剤の配合量は成分（Ｂ）に対し３〜９．５％である。
【００１１】
本発明の液状口腔用組成物は、水性液状であり、好ましくは水性の透明又は均一なマイクロエマルション系であり、液状歯磨、洗口剤、口中清涼剤、含嗽剤等として使用することができる。
【００１２】
本発明液状口腔用組成物には、さらに水、グリセリン、ソルビトール、キシリトール、トレハロース、プロピレングリコールなどの湿潤剤、甘味剤、モノフルオロリン酸ナトリウム、フッ化ナトリウム、フッ化スズ等の歯質強化剤、抗炎症剤、殺菌剤、塩化亜鉛等の収斂剤、保存料、pH調整剤、キレート剤、エタノール等の水溶性成分を配合することができる。
【００１３】
【実施例】
実施例１〜６及び比較例１〜３
表１記載の処方で液状歯磨剤を調製し、製造直後に外観を観察し、次いで室温、５℃及び−５℃条件下に１ケ月保存後に安定性を評価した。結果を表１に示す。
【００１４】
【表１】
表１から明らかなように、油溶性成分に対して２〜７重量倍の成分（Ｂ）（ポリグリセリン脂肪酸エステル）と、成分（Ｂ）１００重量部に対して１重量部以上１０重量部未満の陰イオン界面活性剤を配合すれば、室温〜低温下で長期間安定な液状口腔用組成物が得られることがわかる。また、実施例１〜６の液状歯磨剤は、風味も良好で、かつ口腔内への刺激もなかった。
【００１６】
【発明の効果】
本発明の液状口腔用組成物は、室温〜低温条件下での長期安定性に優れる。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a liquid oral composition having good storage stability.
[0002]
[Prior art and problems to be solved by the invention]
Liquid oral compositions such as liquid toothpastes and mouthwashes are blended with nonionic surfactants typified by polyoxyethylene hydrogenated castor oil as solubilizers for oil-soluble components (Japanese Patent Laid-Open No. Sho 59-). 122417, 59-122418). Polyoxyethylene hydrogenated castor oil has a high solubilizing ability and is widely used. However, when used in a large amount, the mucous membrane may be irritated and the flavor tends to be impaired.
On the other hand, polyglycerin fatty acid esters and sucrose fatty acid esters are also used as solubilizers for oral compositions, but their solubilizing ability is not sufficient, and there is a problem that precipitates are generated particularly during storage at room temperature or lower. It was.
Accordingly, an object of the present invention is to provide a liquid oral composition having good storage stability, good flavor and less irritation.
[0003]
[Means for Solving the Problems]
Therefore, the present inventors blended a certain amount of polyglycerin fatty acid ester, sucrose fatty acid ester or alkylglycoside with the oil-soluble component, and further blended with a small amount of an anionic surfactant to preserve it at low temperature. However, the present inventors have found that a liquid oral composition that is stable without precipitation and has a good flavor and no irritation can be obtained.
[0004]
That is, the present invention includes the following components (A), (B) and (C),
(A) oil-soluble component,
(B) one or more nonionic surfactants selected from polyglycerin fatty acid ester, sucrose fatty acid ester, and alkyl glycoside, 2 to 7 times by weight with respect to component (A),
(C) A liquid oral composition containing 1 part by weight or more and less than 10 parts by weight of an anionic surfactant with respect to 100 parts by weight of the component (B).
[0005]
DETAILED DESCRIPTION OF THE INVENTION
Examples of the (A) oil-soluble component used in the liquid oral composition of the present invention include a fragrance component, an oil-soluble medicinal agent and an oil agent. Here, examples of the fragrance component include menthol, carvone, anethole, peppermint oil, menthyl lactate and the like. Oil-soluble medicinal agents include water-insoluble vitamins (A, D, E, F, K, P, etc.) and their derivatives, glycyrrhetinic acid, azulene derivatives, steroids, antiplasmin agents, water-insoluble fungicides, phthalides And organic solvent extracts of herbal medicines such as nicotinic acid derivatives, maronier, birch, chamomile, hypericum, assembly, and hibamata. Furthermore, examples of the oil agent include squalane, paraffin, silicone, various fatty acids, ester oil, ether oil, animal and vegetable oils. These oil-soluble components can be blended in combination of one or more, and the total amount is 0.01 to 2% by weight (hereinafter simply indicated by%), especially 0.1 to 1%. Is preferred.
[0006]
Examples of the polyglycerol fatty acid ester include those obtained by condensing 1 to 4 fatty acids having 8 to 24 carbon atoms with polyglycerol condensed with 2 to 20 glycerol, and particularly those having 5 to 10 condensed polyglycerol and carbon number. Monoesters of 12-14 fatty acids are preferred. Examples of the sucrose fatty acid ester include sucrose in which a fatty acid having 8 to 24 carbon atoms is ester-bonded, and a sucrose ester of a fatty acid having 16 to 18 carbon atoms is particularly preferable. As the alkyl glycoside, an alkyl group having 8 to 24 carbon atoms in which an ether group is bonded to a monosaccharide or oligosaccharide is preferable, and an alkyl group having 8 to 16 carbon atoms is particularly preferable. These components (B) can be blended in combination of one or more. When blended in total 2 to 7 times by weight with respect to component (A), component (A) can be stably solubilized. Moreover, the preferable compounding quantity of a component (B) is 2-5 weight times with respect to a component (A).
[0007]
Examples of the (C) anionic surfactant used in the present invention include alkyl phosphate ester, polyoxyalkylenated alkyl phosphate ester, alkyl sulfate ester, polyoxyalkylenated alkyl sulfate ester, acylamino acid, and polyoxyalkylenated acyl. 1 or more types chosen from an amino acid and these salts are mentioned. Here, examples of the alkyl phosphate ester include phosphate esters having one or two alkyl or alkenyl groups having 8 to 24 carbon atoms. Among them, mono C 8 -C 24 alkyl phosphate ester, di-C 8 -C 24 alkyl phosphoric acid ester is preferred. The polyoxyalkylenated alkyl phosphate ester is preferably a mono- or di- (polyoxyethylenated C 8 -C 24 alkyl) phosphate ester.
[0008]
The alkyl sulfates, preferably C 8 -C 24 alkyl sulfates, polyoxyalkylene alkyl sulfates, polyoxyethylenated C 8 -C 24 alkyl sulfates are preferred. The acylamino acid is preferably one in which the amino group of an amino acid such as sarcosine, glycine, taurine, glutamic acid is acylated with a fatty acid having 8 to 24 carbon atoms, and particularly N—C 8 -C 24 long chain acyl sarcosine, N— C 8 -C 24 long chain acyl glutamic acid, N—C 8 -C 24 long chain acylmethyl taurine and the like are preferred. As the polyoxyalkylenated acylamino acid, those in which the acylamino acid is polyoxyethylenated are preferable.
[0009]
Further, as salts of these anionic surfactants, alkali metal salts such as sodium salt and potassium salt, basic amino acid salts such as arginine, lysine and histidine, ammonium salts and alkanolamine salts are preferable.
[0010]
When these anionic surfactants are blended in an amount of 1 part by weight or more and less than 10 parts by weight with respect to 100 parts by weight of the component (B), the solubilizing ability of the oil-soluble component by the component (B) can be improved. Without blending a large amount of the component (B), a liquid oral composition that is stable for a long time even under low-temperature storage conditions can be obtained. Further, since a large amount of the component (B) is not required, it is improved in terms of irritation and flavor. A more preferable amount of the anionic surfactant is 3 to 9.5% based on the component (B).
[0011]
The liquid oral composition of the present invention is an aqueous liquid, preferably an aqueous transparent or uniform microemulsion system, and can be used as a liquid dentifrice, mouthwash, mouth freshener, mouthwash, and the like.
[0012]
The liquid oral composition of the present invention further includes a wetting agent such as water, glycerin, sorbitol, xylitol, trehalose and propylene glycol, a sweetener, a tooth enhancer such as sodium monofluorophosphate, sodium fluoride and tin fluoride. , Anti-inflammatory agents, bactericides, astringents such as zinc chloride, preservatives, pH adjusters, chelating agents, ethanol and other water-soluble components can be blended.
[0013]
【Example】
Examples 1-6 and Comparative Examples 1-3
A liquid dentifrice was prepared according to the formulation shown in Table 1, the appearance was observed immediately after production, and then the stability was evaluated after storage for 1 month at room temperature, 5 ° C and -5 ° C. The results are shown in Table 1.
[0014]
[Table 1]
As apparent from Table 1, 2 to 7 times by weight of component (B) (polyglycerin fatty acid ester) with respect to the oil-soluble component, and 1 part by weight or more and less than 10 parts by weight with respect to 100 parts by weight of component (B) It can be seen that a liquid oral composition that is stable for a long period of time at room temperature to low temperature can be obtained by adding an anionic surfactant. Moreover, the liquid dentifrice of Examples 1-6 also had favorable flavor, and there was no irritation | stimulation in an intraoral area.
[0016]
【The invention's effect】
The liquid oral composition of the present invention is excellent in long-term stability under room temperature to low temperature conditions.
Claims (3)
（Ａ）油溶性成分、
（Ｂ）成分（Ａ）に対して２〜７重量倍の、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル及びアルキルグリコシドから選ばれる１種以上の非イオン界面活性剤、
（Ｃ）成分（Ｂ）１００重量部に対して１重量部以上、１０重量部未満の陰イオン界面活性剤
を含有する液状口腔用組成物。The following components (A), (B) and (C),
(A) oil-soluble component,
(B) one or more nonionic surfactants selected from polyglycerin fatty acid ester, sucrose fatty acid ester, and alkyl glycoside, 2 to 7 times by weight with respect to component (A),
(C) Liquid oral cavity composition containing 1 weight part or more and less than 10 weight part anionic surfactant with respect to 100 weight part of component (B).
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| JP24868599A JP3977553B2 (en) | 1999-09-02 | 1999-09-02 | Liquid oral composition |
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|---|---|---|---|
| JP24868599A JP3977553B2 (en) | 1999-09-02 | 1999-09-02 | Liquid oral composition |
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| JP3977553B2 true JP3977553B2 (en) | 2007-09-19 |
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| US20210244636A1 (en) * | 2018-10-24 | 2021-08-12 | Sunstar Inc. | Composition for oral cavity |
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| JP2005029513A (en) * | 2003-07-07 | 2005-02-03 | Kobayashi Pharmaceut Co Ltd | Breath cool-refreshing preparation and method for producing the same |
| JP4918973B2 (en) * | 2005-08-12 | 2012-04-18 | ライオン株式会社 | Dentifrice composition |
| JP5043588B2 (en) * | 2007-10-12 | 2012-10-10 | 花王株式会社 | Liquid oral composition |
| MX2010005006A (en) * | 2008-02-08 | 2010-05-27 | Colgate Palmolive Co | Oral care product and methods of use and manufacture thereof. |
| WO2009099453A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| JP5930953B2 (en) * | 2011-12-14 | 2016-06-08 | 花王株式会社 | Method for producing antibacterial agent composition |
| JP6800936B2 (en) * | 2018-10-24 | 2020-12-16 | サンスター株式会社 | Oral composition |
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| US20210244636A1 (en) * | 2018-10-24 | 2021-08-12 | Sunstar Inc. | Composition for oral cavity |
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