JP3491027B2 - Oral composition - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an oral composition containing an antiplasmin agent, and more particularly to an oral composition having an excellent feeling of use and effective in preventing periodontal disease.

[0002]

2. Description of the Related Art Conventionally, antiplasmin agents have been known to have excellent effects on inflammation and hemostasis, and are known to be effective in preventing periodontal disease. The composition of the composition has been studied and proposed.

However, an oral composition containing an antiplasmin agent typified by tranexamic acid and / or a salt thereof has a peculiar bitterness and pungency, and therefore it is necessary to improve it for practical use. There is a need. Furthermore, an oral composition containing an antiplasmin agent typified by tranexamic acid and / or a salt thereof has poor stability of a fragrance such as deterioration of flavor and the like when stored for a long period of time, and it is necessary to improve it. Is.

Conventionally, as a method for improving the feeling of use of an oral composition containing an antiplasmin agent, carvone and 1-menthol are used in combination (Japanese Patent Publication No. 61-92323).
No.), an aldehyde perfume and the like and one or more cyclic ketones selected from menthone, isomentone and pulegone (Japanese Patent Publication No. 7-74139) are being considered, but carvone is a spearmint oil. 1-Menthol is a main component of peppermint oil, both of which are commonly used as a general-purpose material for (or fragrances) of oral compositions, and also selected from aldehyde fragrances and the like, menthone, isomentone, and pulegone. The compounding of one or more cyclic ketones is also because these are also constituent components of peppermint oil, so if peppermint oil is compounded in the oral composition, it should be possible to implement it. It can be said that it is a general method for preparing an oral composition, but it has a feeling of use and is stable over time only for an oral composition containing an antiplasmin agent. It is not possible to judge that it is a method of improving the property, and it is not sufficient as an effect of suppressing deterioration of flavoring due to long-term storage, and it is desired to develop an oral composition containing this component having a better feeling in use and stability over time. Was there.

[0005]

Means and Actions for Solving the Problems The present inventors have
As a result of repeated intensive studies in view of the above circumstances, an oral composition containing an antiplasmin agent was selected from the group consisting of sodium chloride and star anise oil, sage oil, nutmeg oil, patchouli oil, chamomile oil, and hyssop oil. Surprisingly, when at least one type or two or more types are used in combination, surprisingly, the bitterness of the antiplasmin agent is remarkably masked, the feeling of use is improved, and the deterioration of flavor standing due to long-term storage is suppressed. Discovered and made the present invention. Hereinafter, the present invention will be described in detail.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION Examples of the antiplasmin agent used in the present invention include epsilon aminocaproic acid, tranexamic acid and / or its salt. Tranexamic acid and / or its salt show the most remarkable improving effect. To be The blending amount is not particularly limited, but is preferably 0.01 to 5% by weight, and more preferably 0.03 to 3% by weight based on the entire composition.

As the sodium chloride used in the present invention, in addition to ordinary reagents, edible salt, rock salt, concentrated solution of seawater, etc. can be used. The compounding amount is 0.5 to 0.5 of the whole composition.
It is preferably 30% by weight, particularly preferably 1 to 15% by weight. If the blending amount is more than 30%, saltiness of sodium chloride will occur, and if it is less than 0.5%, a sufficient effect will not be exhibited.

The essential oil used in the present invention is at least one kind or two kinds or more selected from the group consisting of star anise oil, sage oil, nutmeg oil, patchouli oil, chamomile oil, and hyssop oil . Among them, nutmeg oil, Patchouli oil,
Chamomile oil and hyssop oil are preferred. In addition, the blending amount of the composition is more than 1% by weight, bitterness and
In some cases, a sticky feeling may appear, which impairs the feeling of use, and when 0.001% by weight or less, the bitterness-reducing effect is not exhibited, so 0.001 to 1% by weight, particularly 0.001% by weight.
It is preferably 1 to 0.5% by weight. Furthermore, the compounding ratio of at least one or two or more selected from the group consisting of sodium chloride and star anise oil, sage oil, nutmeg oil, patchouli oil, chamomile oil, and hyssop oil is 1:
It is preferably from 2 to 1: 600.

The oral composition of the present invention is a toothpaste such as toothpaste, moisturized toothpaste, liquid toothpaste, mouthwash, troche, chewing gum, oral pasta, gingival massage cream, liquid mouth freshener, solid mouth freshener. It can be adjusted as an agent, and in addition to the above, various known ingredients corresponding to the respective types can be added within a range in which the effects of the present invention are not impaired. For example, surfactants such as sodium lauryl sulfate, sodium lauroyl sarcosine, diethanolamide laurate, sucrose fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, block copolymer of polyoxyethylene and polyoxypropylene ( Blending amount 0-5%) Wetting agents such as glycerin, sorbit, polyethylene glycol, propylene glycol, hexylene glycol (blending amount 1-40%), hydroxyethyl cellulose, carboxymethyl cellulose, methyl cellulose, carboxypropyl cellulose, propyl cellulose, carrageenan, Caking agents such as sodium alginate, xanthan gum, polyvinyl alcohol, polyvinylpyrrolidone (compounding amount 0.1-5.0 ), In some cases, dicalcium phosphate, calcium carbonate, silica abrasives such as aluminum hydroxide, precipitated silica,
In addition, sweeteners such as sodium saccharin, stevioside, xylitol, menthol, carvone, anethole, eugenol, methyl salicylate, peppermint oil, spearmint oil, wintergreen oil, clove oil, eucalyptus oil, lemon oil, orange oil and other flavors, Dyes, preservatives and pH adjusters can be added. Also, as an active ingredient,
Enzymes such as dextranase, mutanase, lysozyme,
Fluorine compounds such as sodium monofluorophosphate and sodium fluoride, triclosan, chlorhexidines,
One or more of quaternary ammonium such as cetylpyridinium chloride, hinokitiol, sodium copper chlorophyllin, tranexamic acid, glycyrrhetinic acid, glycyrrhizinate, azulene and polyphosphate can be blended.

[0011]

EXAMPLES Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these. Examples and Comparative Examples The mouthwashes shown in Formulation Examples 1 and 2 were prepared according to a conventional method, and the bitterness and the flavor were evaluated for stability over time. The results are shown in Table 1. The evaluation results are shown by rounding off the average score of 10 panelists.

[0012]   Prescription 1 (prescription with sodium chloride)     Ingredient amount (% by weight)   Tranexamic acid 0.05   Sodium chloride 1.5   Essential oil shown in Table 1 0.05   Glycerin 13.00   Ethanol 7.00   Saccharin sodium 0.005   Polyoxyethylene hydrogenated castor oil (60) 0.35   Perfume 0.20   Remaining water   100.0 in total

[0013]   Prescription 2 (prescription without sodium chloride)     Ingredient amount (% by weight)   Tranexamic acid 0.05   Essential oil shown in Table 1 0.05   Glycerin 13.00   Ethanol 7.00   Saccharin sodium 0.005   Polyoxyethylene hydrogenated castor oil (60) 0.35   Perfume 0.20   Remaining water   100.0 in total

Bitterness Evaluation Method About 20 ml of the prepared mouthwash was rinsed for 30 seconds, and the degree of bitterness remaining in the mouth after being contained in the mouth was sensory-evaluated according to the following evaluation criteria in four stages. (Evaluation criteria) No bitterness 4 Almost no bitterness 3 Somewhat inferior 3 Somewhat bitterness 2 Some bitterness 1

Evaluation of Stability of Flavor Using the mouthwash immediately after preparation and the mouthwash left at 40 ° C. for 1 month, the mouth was rinsed with about 20 ml for 30 seconds, and sensory evaluation was performed in four stages according to the following evaluation criteria. (Evaluation Criteria) The flavoring after one month left is almost the same as that before leaving. 4 The flavoring after one month left is slightly inferior to that before leaving. 3 The flavor standing after one month is inferior to before leaving for two months. The flavor afterward is considerably inferior to that before leaving 1

(Comprehensive evaluation) Evaluation of bitterness and stability over time All are 3 or more and either is 4 ◎ All are 3 ○ Either is 2 △ Either 1x

[0017]

[Table 1]

As is clear from the results of Table 1, the oral composition containing the antiplasmin agent has a peculiar bitterness, but sodium chloride and star anise oil, sage oil, nutmeg oil, patchouli oil, chamomile oil, When used in combination with at least one or two or more selected from the group consisting of hyssop oil, bitterness is suppressed, and further deterioration of flavoring due to long-term storage is effectively suppressed, and stability over time, It has a high usability. In addition, even if the examples and the comparative examples are compared, the addition of sodium chloride does not improve the bitterness and stability over time, and star anise oil, sage oil, nutmeg oil, patchouli oil, chamomile oil, and hyssop It has been confirmed that the bitterness and the temporal stability are efficiently improved only when sodium chloride is used in combination with at least one or two or more selected from the group consisting of oils.

[0019]

EFFECTS OF THE INVENTION The oral composition of the present invention has little bitterness and pungency peculiar to the conventional anti-plasmin agents, has an excellent feeling in use, and is excellent in flavor stability over time. It is suitable for preventing and improving periodontal diseases.

Claims (2)

(57) [Claims] 1. An antiplasmin agent and sodium chloride and at least one kind selected from the group consisting of star anise oil, sage oil, nutmeg oil, patchouli oil , and hyssop oil, in combination, Composition for oral cavity. 2. The oral composition according to claim 1, wherein the antiplasmin agent is tranexamic acid and / or a salt thereof.