JP4742356B2 - Embedded electrode device and electrode embedded device - Google Patents

Description

  The present invention relates to an electrode embedding technique in a living body, and more particularly, to an implantable electrode forming technique for embedding an electrode in the brain parenchyma from the brain dura mater.

Conventionally, studies have been made to temporarily or constantly embed microelectrodes in the brain of a living body, observe the activity of nerve cells, and examine the function of the cells or brain regions to which the cells belong. In recent years, the purpose of improving the recording efficiency of cell activity in such research, the purpose of examining the functional linkage between multiple cells, and also part of the brain machine interface technology that operates external devices in real time Some proposals have been made regarding an apparatus (multi-electrode system; multi-channel cell activity recording system) that can simultaneously record cellular activities from as many neurons as possible. For example, a sword mountain type multi-electrode array using needle-like hard metal electrodes arranged at almost equal intervals like a sword mountain has been proposed (for example, Patent Document 1). Alternatively, a probe card type electrode device provided with a large number of probes has also been proposed (see, for example, Patent Document 2). In addition, the multi-electrode system is used not only for recording cell activity but also for medical use as a part of artificial vision or an artificial hearing device by electrical stimulation of the peripheral and central nervous systems (for example, patents). Reference 3).
US Pat. No. 5,215,088 US Pat. No. 5,563,067 Japanese Patent Application Laid-Open No. 10-137346

  The probe card type electrode device can acquire a signal from a cell, but becomes a large-scale device. For example, when it is applied to a living body, the probe card type electrode device must be installed in a limited position. There are various restrictions.

  Further, the arrangement and number of electrodes in the sword mountain type and probe card type multi-electrode arrays are determined in advance prior to the implantation operation. For this reason, there is a low degree of freedom in flexibly changing the arrangement and number of electrodes in accordance with the movement of the cerebral sulcus and blood vessels in the vicinity of the brain region to be implanted that can be understood for the first time at the time of surgery. In addition, in order to embed these multi-electrode arrays, it is necessary to dissect a biological membrane having a thickness of about 1 mm or less, which is a dura mater covering the brain, and there is a problem that the risk of infection of bacteria or the like to the brain increases. Furthermore, since the Kenyama-type multi-electrode array is composed of a group of hard electrodes having a relatively large diameter, there is a concern about damage to the brain tissue due to impact during implantation and life vibration after implantation. There is also a problem that even if there is no damage to the extent of damage, the electrodes are difficult to follow the movement of the brain tissue due to the vibration, so that the nerve cell activity cannot be recorded stably.

  An object of the present invention is to minimize the invasiveness to a living body and improve the degree of freedom regarding the position and number of electrodes. Another object of the present invention is to construct a radical system that can embed more electrodes at a more appropriate position.

The electrode embedded in the brain of the present invention uses, as a material, an electrode member in the form of a micro wire with low invasiveness, instead of a hard sword mountain type electrode array that requires incision of the dura mater or the like. The wire-like electrode portion is provided with a recording / stimulation point that forms an interface for exchanging signals with the brain. Since the microwire electrode does not have the strength to penetrate the dura by itself, a hard electrode implanter is used. The implanting device has a sharp tip formed so as to easily penetrate the dura mater and holds a linear wire electrode member to guide the electrode into the brain. In addition, a stopper portion is formed in the vicinity of the electrode tip in advance so that the position of the electrode is stabilized after embedding. The stopper portion has a tapered shape that decreases in diameter in the insertion direction (tip direction) of the electrode member. Once the stopper part has entered the brain rather than the dura mater, the electrode part is devised to make it difficult for the electrode member to come off because the stopper part is caught on the inner surface of the dura mater by the reverse taper shape of the stopper part. Yes. Furthermore, by adjusting the positional relationship between the recording / stimulation point and the stopper portion, the recording / stimulation point can be accurately positioned in the brain. In addition to such a linear wire electrode with a stopper, a loop-shaped wire electrode having a stopper function and an embedder for embedding it are also presented. Since the microwire electrode embedded in the brain has a very fine structure regardless of the shape of the tip, it can be embedded in a close brain region at a relatively high density. In addition, since the implanter can make only the minimum necessary holes in the dura mater and the holes heal naturally, special surgical techniques such as incising and suturing the dura mater are also unnecessary.

  Thereby, it is possible to embed a large number of electrodes relatively safely and simply in the brain protected by the dura mater.

  That is, according to one aspect of the present invention, there is provided an implantable electrode device embedded in a living body, which is provided at a position in a wire-shaped electrode member and a direction in which the electrode member extends, than the electrode member. An embedding having a stopper portion having a large diameter and an electrical contact provided on the distal end side of the stopper portion of the electrode member and in contact with the measurement target of the living body to exchange signals with the measurement target A mold electrode device is provided.

  Further, it is an intracerebral implantable electrode device that penetrates the dura mater formed in the cranium and is embedded in the brain, and is provided at a position in a direction in which the electrode member extends and the electrode member extends. A stopper portion having a diameter larger than that of the electrode member and contacting the inner wall of the dura mater to prevent the electrode member from being pulled out, and a measurement target of the brain provided on the distal side of the stopper portion of the electrode member There is provided an implantable electrode device in a brain having an electrical contact that contacts a region and exchanges signals with the region to be measured.

  According to the above-described implantable electrode device, since it has a stopper portion that is provided at a position in the extending direction of the electrode member and has a larger diameter than the electrode member, once implanted in a living body (in the brain), It cannot be pulled out easily, and the electrode position can be temporarily fixed. The electrical contact on the brain surface is positioned by the penetrating position, and the distance between the dura mater and the electrical contact can be defined by the distance between the stopper portion and the electrical contact. Therefore, the electrical contact can be accurately temporarily fixed at a preset position.

  According to another aspect of the present invention, a wire-like electrode member and an electric device provided on the distal end side of the electrode member and in contact with the measurement target region of the brain to exchange signals with the measurement target region. And a stopper that is provided at a position in the extending direction of the electrode member and has a larger diameter than the electrode member and abuts against the dura inner wall to prevent the electrode member from being pulled out. A method of disposing an intracerebral implantable electrode device that penetrates the dura formed in the skull and is embedded in the brain, the step of engaging the stopper portion with the engagement portion of the electrode implanting device; Moving the electrode implanting device in a direction penetrating the dura mater, stopping the movement at a position in the brain penetrating the dura mater, and releasing the wire electrode member from the locking portion So that the brain embedded Method comprising the step of withdrawing the write electrode device is provided.

  According to the above method, the step of stopping the movement at a certain position in the brain through the dura mater, and the step of pulling out the implantable electrode device in the brain so that the wire-like electrode member is detached from the locking portion It is possible to efficiently embed an electrode in the brain.

  According to the present invention, it is possible to safely and efficiently arrange a microwire electrode without strength that directly penetrates the dura mater at a target position in the brain. At this time, since it is not necessary to cut the dura widely as in the case of the Kenyama-type electrode, the risk of infection can be minimized.

  In addition, by using a micro wire as a material, the diameter can be made much smaller than that of each hard electrode, and the invasiveness to the brain tissue by the electrode itself can be minimized.

  Furthermore, even when long-term implantation is considered, since the flexible micro-wire electrode follows the movement of the brain due to vibration or the like, it is possible to continue recording nerve cell activity stably.

  In addition, by embedding a large number of wire electrodes with a simple structure and method, it is possible to exchange signals between a large number of neuronal cell populations and the outside, so that more information in the brain can be easily obtained. There is an advantage.

  The embedded electrode forming technique according to the present invention is characterized in that an arbitrary number of electrodes are embedded at arbitrary positions without widely cutting the dura. Hereinafter, an embedded electrode technology according to an embodiment of the present invention will be described with reference to the drawings. FIGS. 1A to 1E are diagrams showing a basic configuration of elemental technology of the embedded electrode forming technology according to the present embodiment, and FIG. 1A shows a state where electrodes are embedded in the brain. FIG. 1B is a cross-sectional view of FIG. 1A, and FIGS. 1C and 1D are diagrams showing a buried electrode and an electrode embedder. (E) is a figure which shows a mode that the loop-shaped wire electrode shown to FIG. 1 (D) was attached to the transplantation needle 3 '.

  As shown in FIG. 1A, a hole H having a predetermined shape is formed in the skull 33 that wraps the brain, and the dura mater 35 is exposed in the opening in which the hole H is formed. As shown in FIG. 1 (B), for example, a flexible thread-like or needle-like electrode member 21 having a diameter of about 0.03 to 0.2 mm diameter so as to penetrate the dura 35 exposed from the opening. Is formed. In order to fix the electrode member 21 in the brain, for example, in the embodiment shown on the right side of FIG. 1B, a stopper portion S is formed near the tip of the electrode member 21. The stopper portion S has a tapered shape that decreases in diameter in the insertion direction (tip direction) of the electrode member 21. With this shape, the electrode member 21 is devised so that it is difficult for the brain to come out while suppressing the invasiveness of the brain. Further, the way in which the electrode member 21 enters the brain 37 can be adjusted by the position of the stopper portion S.

Next, a configuration example of an electrode implanter used for embedding the electrode member 21 in the brain will be described. It is roughly divided into a linear wire electrode embedder shown in FIG. 1 (C) and a loop type wire electrode embedder shown in FIG. 1 (D). In the configuration shown in FIG. 1C, for example, a cylindrical member 3 ′ that accommodates the linear wire electrode 3e has a sharpened shape in which the tip 3a is cut obliquely. In this shape, the straight wire electrode 3e can be advanced in the direction of the brain 37 through the dura mater 35 in FIG. 1 (B) by the sharpened shape of the tip 3a in a state in which the straight wire electrode 3e is accommodated. it can. In this case, a recording / stimulation point that constitutes an interface for signal exchange with the brain is provided at the tip of the linear wire electrode 3e. This interface unit enters or contacts the brain 37 and exchanges information (signals) with the brain. By adjusting the positional relationship between the recording / stimulation point and the stopper portion S, the positioning of the recording / stimulation point in the brain can be made accurate.

On the other hand, as shown in FIGS. 1D and 1E, in the case of the loop-shaped wire electrode 21 ′ having the loop shape 21a ′ at the tip, for example, a sharp portion at the tip of the solid rod-shaped portion 3 ′ 3a ′ and a hook portion 3b ′ for hooking the loop shape 21b ′ are provided, and the loop wire electrode 21 ′ can be hooked as shown in FIG. A recording / stimulation point 21a 'is formed at the tip of the loop shape 21a'. This configuration is also devised so that the dura 35 can be penetrated by the sharp portion 3a ′. The loop electrode is not provided with the stopper portion 5 of the linear electrode 3e. However, after embedding, the tissue enters the rope and has the effect of increasing the stability of the electrode.

  When forming a plurality of wire electrodes, one wire may be embedded at a plurality of locations, or an electrode embedding device including a plurality of electrode embedders may be used. Hereinafter, the embedded electrode forming technique will be described more specifically based on the following examples.

  The embedded electrode forming technique according to this embodiment relates to a technique in which a stopper is formed on a linear wire electrode. 2A and 2B are diagrams showing a configuration example of the electrode implanter A according to the present embodiment. 2C, 2D, and 2E are diagrams showing a configuration example of a wire electrode with a stopper.

  As shown in FIGS. 2A and 2B, the electrode embedder A according to this embodiment has a first cylindrical portion 73 on the distal end side and a second cylindrical portion 71 that follows the first cylindrical portion 73. Both cylindrical portions 71 and 73 are formed with passages communicating with each other. In this passage, stainless steel columnar parts (stainless steel cores) 73b and 71a (which may actually be integrated) are movably inserted, and the columnar parts 73b and 71a are connected to the distal end side by the gripping part 75 of the base, It can be moved to the base end side. The first cylindrical portion 73 has a tapered tip, and a portion of the first cylindrical portion 73 extending from the tapered base side further to the base side is cut out in the radial direction. A notch 77c (slit) is formed. The width of the slit is preferably substantially equal to the thickness of the wire described later.

On the other hand, as shown in FIG. 2 (C), the wire electrode B with a stopper according to the present embodiment is provided with a conical stopper 83 which is reduced in diameter toward the tip in the vicinity of the tip of the wire electrode 81 and coaxial with the wire. Yes. The stopper forms a hump with an insulating material, for example. At the tip of the wire electrode B with a stopper, a recording / stimulation point is formed at the tip of the wire cut. 2 (D) and 2 (E) are diagrams showing a modified example of the stopper, and when the shape 83-1 similar to FIG. 2 (C) is formed by a member different from the insulating material (FIG. 2). (D)), the case where the cylindrical stopper 83-2 is formed by a member different from the insulating material is shown. In order to bond the wire electrode and the separate member, heat melting may be used, or an appropriate adhesive may be used.

FIG. 3 is a diagram showing a process of attaching a wire electrode B with a stopper to the electrode implanter A and implanting the electrode in the brain. First, as shown in FIG. 3A, the stopper 83 is inserted from the tip of the electrode embedder A, and the wire electrode B with the stopper is disposed so as to lock the stopper 83 in the slit 77c. As shown in FIG. 3B, in this state, the electrode implanter A and the wire electrode B with the stopper are moved from the skull opening toward the brain 97. At this time, the central axis of the electrode embedder A is moved in a slightly oblique direction with respect to the radial direction of the dura 95 (FIG. 3C). The dura mater 95 is perforated by the tip of the electrode implanter B, and the first cylindrical portion 73 enters the brain 97 through the formed through hole. When the movement of the brain 97 is stopped at a predetermined position and the electrode implanter A is pulled back upward while pushing the grasping portion 75, only the wire electrode B with a stopper remains in the brain (FIG. 3D to FIG. 3). E)). When embedding a plurality of wire electrodes in one opening, the operations of FIGS. 3A to 3E are repeated. Thereafter, as shown in FIG. 3 (F), the opening is closed with artificial bone, filler 101, etc., and the base of the wire electrode is pulled out in the connector direction (L2). At this time, one surface of the stopper 83 is brought into contact with the inner surface of the dura mater (not shown) to prevent the wire electrode from returning.

  As described above, according to the embedded electrode forming technique according to this embodiment, the position of the wire electrode can be fixed by attaching the stopper to the wire electrode. The “stopper” is not sharp like a fishhook, for example, and can pass through the dura mater (relatively elastic) when a certain amount of force is applied. Further, since the stopper itself is not inside the brain tissue, damage to the tissue is very small when it is pulled out.

  Next, the embedded electrode technology according to the second embodiment of the present invention will be described with reference to the drawings. FIG. 4 is a view showing a structural example of a stainless steel electrode implanter according to a second embodiment of the present invention. FIG. 4A shows a cylindrical member constituting the implanter C. The first cylindrical portion 101 on the proximal end side, the second cylindrical portion 103 on the distal end side, and the inner portions 101a and 103b in the cylindrical portion. A core portion 105 made of, for example, stainless steel that can be inserted into the cylindrical portion, and includes a core portion 105 having a core portion 105a inserted into the cylindrical portion and a proximal end side grip portion 105b. As shown in FIG. 4A, when the gripping portion 105b is pushed toward the distal end, the distal end of the stainless steel core 105a is aligned with the distal end of the cylindrical member. On the other hand, as shown in FIG. 4B, when the gripping portion 105b is pulled toward the proximal end, the tip of the stainless steel core 105a is retracted from the tip of the cylindrical member, and the electrode formed on the tip side wall of the cylindrical member is attached. The hook portion 103c that can be hooked is opened (in the state shown in FIG. 4A, the hook portion 103c is blocked by the tip of the stainless steel core 105a, and the hook function is lost. 4 (D) is a view of the front end of the cylindrical member as viewed from above, and as shown in these drawings, the front end of the cylindrical member includes It can be seen that the hook portion 103c is provided at a substantially equal position in the horizontal direction.

FIG. 5 is a diagram showing a configuration example of a loop-shaped wire electrode D suitable for use with the cylindrical member. As shown in FIG. 5, the loop-like wire electrode D according to the present embodiment has a columnar base 121 and a loop-shaped stopper / measurement unit 111 formed at the tip of the base 121. The stopper / measurement unit 111 forms a loop shape by bending the vicinity of the tip of the wire in a loop shape and bonding the tip end portion 117 back to the base 121 side. As shown in the figure on the right, the entire wire is covered with an insulator such as parylene resin and has a diameter of 0.05 m.
m metal wire (for example, an alloy made by mixing platinum and iridium is included as a material) 125. The recording / stimulation point 115 has a configuration in which the insulator is removed from the tip of the loop 111 to expose the fine metal wire. Thereby, an electrical signal from the brain and an electrical signal to the brain can be transmitted.

FIG. 6 is a diagram showing an electrode embedding process in the brain using the electrode embedding technique according to the present embodiment. As shown in FIG. 6A, first, the loop-shaped wire electrode D is hooked on a hook portion (103c in FIG. 4C) formed in the vicinity of the tip of the stainless steel electrode implanter C. In this state, as shown in FIG. 6B, an opening is formed in the scalp 131 and the skull 133, and the stainless steel electrode implanter C is brought closer to the brain 137. Next, as shown in FIG. 6 (C), the sharp tip of the stainless steel electrode implanter C penetrates the brain membrane 135 as if by skin injection, and moves the stopper / measurement unit 111 into the brain. The movement is stopped at the position of. As shown in FIG. 6 (D), when the gripping part (105b in FIG. 4) is pushed toward the tip side, it is pushed by the stainless steel core (105a), so that the loop-shaped wire electrode B is removed from the hook part (103c). Comes off. Next, stainless steel electrode implanter C
Is pulled in the original direction (the direction away from the brain 137), only the loop electrode D is left in the brain 137 as shown in FIG. Next, as shown in FIG. 6 (F), an artificial bone / filler 141 is disposed to close the opening, and the base of the wire electrode is pulled out in the connector direction (L1). The loop 111 does not easily come off the dura mater 135 and functions as a stopper in the brain. However, since the loop 111 is formed by wire bonding, the wire electrode D can be pulled out from the brain by pulling the wire electrode D against the adhesive force after the measurement is completed for some reason.

Thereby, the recording / stimulation point (115 in FIG. 5) can be arranged in the brain 137, and the wiring can be drawn from the brain 137 by the wire, and a signal from the brain 137 can be obtained via the recording / stimulation point 115 or the brain 137 can be given a signal. Further, similarly to the first embodiment, it is possible to embed a plurality of wire electrodes from one skull opening.

As described above, according to the implantable electrode technique according to the present embodiment, the loop-shaped wire electrode B can be disposed at a desired position in the brain while reducing the damage to the dura mater 135. By making the loop itself larger than the through-hole formed in the dura mater 135, it is caught by the dura mater 135 at the bonding portion (117) of the loop 111. Even if D is pulled, the loop electrode does not come off easily. Therefore, by estimating the distance between the dura mater 135 and the measurement target part in advance, the recording / stimulation point 115 can be aligned and fixed to the measurement part. This also applies to the embodiment using the stopper member shown in the third embodiment. As described above, the use of the technique according to the present embodiment has an advantage that the loop-like wire electrode can be easily embedded in the brain and damage to the dura mater can be reduced.

The implantable electrode formation technique according to this embodiment is a partial modification of the technique described in Embodiment 2 so as to be suitable for implantation in the deep brain. FIG. 7A is a diagram illustrating a configuration example of the electrode embedder E according to the present embodiment. Compared to the implanters of Examples 1 and 2, the structure of the tip 253 that enters the brain is simple (solid, not hollow), and its diameter is small. As a result, the structure is such that even if it is inserted into the deep brain, damage is reduced. FIG. 7B is a diagram illustrating a configuration example of a loop-shaped wire electrode. As shown in FIG. 7B, the loop-shaped wire electrode E according to the present embodiment forms a loop-shaped portion 258 by turning the tip portion of the wire electrode 255 toward the base portion, and turns back. Glue in place (257). At this time, the recording / stimulation point 259 is set to face the base direction. As shown in FIG. 7A, a concave portion 253b for hooking the loop-shaped portion 258 of the loop-shaped wire electrode D has a sharp cylindrical portion 253 formed in the vicinity of the tip 253a, and a gripping portion 251 following it. . If a strict depth relationship from the deep brain, especially from the brain surface, is not necessary, it is sufficient to use the original cut as the recording / stimulation point, not the vicinity of the loop shape of the wire electrode as in this embodiment. It is thought that the purpose can be achieved. On the other hand, in the case of implantation into the deep brain, it is difficult to prevent the electrode from coming off in the relationship between the dura mater and the stopper as in the first and second embodiments. However, by making the wire electrode an α-type loop, it becomes possible to increase the resistance to extraction and stabilize the electrode in the brain. Even if the wire electrode is removed from the implanter as in Examples 1 and 2, if the α-type loop is used, when the implanter is pulled out deep in the brain, only the electrode is naturally It is thought that it can be left in. Furthermore, by setting the recording / stimulation point with this α-type electrode at the loop turn-back position as in the loop electrode of the second embodiment, the position on the brain surface or stereo coordinates can be controlled more strictly.

FIG. 8 is a diagram showing a process of placing the loop-shaped wire electrode F in the brain (for example, the nucleus below the white matter) by the electrode implanter E shown in FIGS. 7 (A) and 7 (B). First, as shown in FIG. 8A, an opening is formed in the scalp 211 and the skull 233, and the loop wire electrode F is hooked on the concave portion (253b in FIG. 7A) toward the opening. The electrode embedder E is moved. Next, as shown in FIG. 8B, the dura 235 is penetrated by the tip of the electrode implanter E, and the tip of the electrode implanter E is moved to a predetermined position in the deep brain 237. As shown in FIG. 8C, when the electrode embedder E is pulled back in the base direction, the loop-shaped wire electrode F is detached from the concave portion 253b, and only the loop-shaped wire electrode F remains at a predetermined position. At this time, since a recording / stimulation point is formed at the tip of the wire forming the loop 258, a signal in the brain 237 can be acquired or a signal can be given into the brain 257.

  As described above, the electrode can be embedded deep in the brain by the embedded electrode forming technique according to the present embodiment, that is, the combination of the embedder having a simple structure and the electrode having the α-type loop structure. Also in this embodiment, a plurality of wire electrodes can be embedded from one opening as in the other embodiments. Further, by combining this embodiment with the first or second embodiment, it is possible to embed electrodes both near the brain surface and deep in the brain from one opening.

  As described above, according to the wire electrode forming technique according to the present embodiment, it is possible to efficiently arrange the wire electrode in the brain while suppressing relatively little damage to the living body at the time of implantation. Compared with a hard electrode, a microwire electrode is less invasive to the brain even when vibration occurs in the brain, and can function stably for a long period of time. If a large number of such fine wire electrodes can be embedded in the brain according to the present invention, there is an advantage that more information in the brain can be easily obtained. In addition, since the implanting device itself used for carrying out the present invention has a simple structure such that the injection core is slightly modified, it can be produced at a relatively low cost. Furthermore, since the implantation method itself such as injection is simpler than the arrangement of the array electrode accompanied by the incision of the dura mater, even a beginner can learn the technology smoothly.

  In addition, although the example which arrange | positions a wire electrode in a brain was demonstrated in the said Example, it can be applied also to various in-vivo tissues, such as a spinal cord and a muscle. In addition, the stopper is formed of an elastic member, for example, so that the diameter of the stopper is reduced when inserted into the brain, and once inserted into the brain, the stopper is returned to the original position so that the wire is less likely to be pulled back. It is also possible to devise such that. Even in this case, it is preferable that the stopper is reduced in diameter when pulled strongly so that the wire can be pulled out from the brain.

  The present invention can be used as a technique for exchanging signals with a living body, particularly the brain.

FIGS. 1A to 1E are diagrams showing a basic configuration of elemental technology of the embedded electrode forming technology according to the present embodiment, and FIG. 1A shows a state where electrodes are embedded in the brain. FIG. 1B is a cross-sectional view of FIG. 1A, and FIGS. 1C and 1D are diagrams showing a buried electrode and an electrode embedder. 1 (E) is a diagram showing a state in which the embedded electrode is hooked on the electrode embedder. 2A and 2B are diagrams showing a configuration example of the linear electrode embedder according to the first embodiment. 2C, 2D, and 2E are diagrams showing a configuration example of a wire electrode with a stopper. FIGS. 3A to 3F are diagrams illustrating a process of attaching a wire electrode with a stopper to a linear electrode implanter and implanting the electrode in the brain. It is a figure which shows one structural example of the loop-shaped electrode embedding device by 2nd Example of this invention. It is a figure which shows one structural example of a loop-shaped wire electrode suitable for using with a cylindrical member. It is a figure which shows the electrode embedding process to the brain using the loop electrode embedding technique by 3rd Example of this invention. FIG. 7A is a diagram illustrating a configuration example of a deep brain electrode implanter. FIG. 7B is a diagram illustrating a configuration example of a loop-shaped wire electrode. FIGS. 8A to 8C are diagrams showing a process of placing a loop-shaped wire electrode in the deep brain using the electrode implanter shown in FIGS. 7A and 7B.

Explanation of symbols

  S ... stopper part, H ... hole, 3 '... cylindrical member, 3a ... tip part, 3b ... linear wire electrode, 21 ... electrode member, 33 ... skull, 35 ... dura mater, 37 ... brain, A ... electrode Embedder, 71 ... second cylindrical portion 71, 73 ... first cylindrical portion, 75 ... gripping portion 77c ... notch portion, B ... wire electrode with stopper, 81 ... wire electrode, 83 ... conical shape Stopper.

Claims (6)

An implantable electrode device embedded in a living body,
A wire-like electrode member having a conductive core and an insulating coating layer covering the core;
A stopper portion provided at a predetermined position in the extending direction of the electrode member, and having a larger diameter than the electrode member;
An electrical contact formed by exposing the core portion on the tip side of the stopper portion of the electrode member and abutting on the measurement target of the living body and exchanging signals with the measurement target; Have
The embedded electrode device according to claim 1, wherein the stopper portion has a conical shape coaxial with the electrode member and having a diameter reduced toward the tip. An implantable electrode device embedded in a living body,
A wire-like electrode member having a conductive core and an insulating coating layer covering the core;
A stopper portion provided at a predetermined position in the extending direction of the electrode member, and having a larger diameter than the electrode member;
An electrical contact formed by exposing the core portion on the tip side of the stopper portion of the electrode member and abutting on the measurement target of the living body and exchanging signals with the measurement target; Have
The stopper portion is a loop-shaped structure formed in a larger diameter than the electrode member by a part of the electrode member,
It said electrical contacts are implantable electrode device, wherein the covering layer is removed at the distal end of said loop-like structure is obtained by exposing the core. An implantable electrode device in the brain that penetrates the dura mater formed in the cranium and is embedded in the brain,
A wire-like electrode member having a conductive core and an insulating coating layer covering the core;
A stopper portion that is provided at a predetermined position in the extending direction of the electrode member, has a larger diameter than the electrode member, and abuts against the dura inner wall to prevent the electrode member from being pulled out;
An electrical contact between the measurement target site and the contact with the measurement target site of the brain, which is formed by exposing the core portion on the tip side of the stopper portion of the electrode member Contact point,
The embedded electrode device according to claim 1, wherein the stopper portion has a conical shape coaxial with the electrode member and having a diameter reduced toward the tip. An implantable electrode device in the brain that penetrates the dura mater formed in the cranium and is embedded in the brain,
A wire-like electrode member having a conductive core and an insulating coating layer covering the core;
A stopper portion that is provided at a predetermined position in the extending direction of the electrode member, has a larger diameter than the electrode member, and abuts against the dura inner wall to prevent the electrode member from being pulled out;
An electrical contact between the measurement target site and the contact with the measurement target site of the brain, which is formed by exposing the core portion on the tip side of the stopper portion of the electrode member Contact point,
The stopper portion is a loop-shaped structure formed in a larger diameter than the electrode member by a part of the electrode member,
It said electrical contacts are implantable electrode device, wherein the covering layer is removed at the distal end of said loop-like structure is obtained by exposing the core. A rod-shaped electrode embedded device to place the implantable electrode device according to any one of claims 1 to 4,
A locking portion for locking the stopper portion;
An electrode embedding device, comprising: a release unit that releases the locking of the embedded electrode device locked to the locking portion. The electrode embedding apparatus according to claim 5, further comprising a sharp tip for penetrating the dura mater.

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