JP4476616B2 - Support with protrusion for patch, method for producing the same, and patch - Google Patents

Description

  The present invention relates to a support with a protrusion for a patch, a method for producing the same, and a patch using the support with a protrusion for a patch.

  BACKGROUND ART Sheet bodies such as non-woven fabrics, knitted fabrics, and films are widely used as a support for external patches to be used by being attached to the skin. Among them, a support with a protrusion that imparts a blood circulation promoting function by physical stimulation is known. As an example of the material of the conventional protrusion, a metal solid material is used, and the protrusion is bonded to the sheet body with an adhesive. However, such solid protrusions are easy to drop off from the sheet body and are stuck with an adhesive, resulting in poor air permeability.

  In order to obtain an appropriate stimulus without pain, the protrusions are preferably made of resin (for example, see Patent Documents 1 and 2). However, in order to obtain a group of projections having a uniform size that gives sufficient stimulation, it is necessary to apply in advance as a resin having a certain degree of shape retention, but in that case, the anchoring property to the sheet body is insufficient. there were. In addition, the conventional support with protrusions has a pressure-sensitive adhesive layer formed on the surface to be used as a patch, but the pressure-sensitive adhesive layer due to the presence of protrusions compared to a conventional flat sheet (a support having no protrusions). There arises a problem that the anchoring property to the support becomes worse. Furthermore, in order to obtain satisfactory uniformity, there is a disadvantage that skill is required.

On the other hand, Patent Document 3 discloses a foam paint in which a foamable resin is mixed with a paint main material obtained by mixing a pigment or paint with a binder. Patent Document 4 discloses an expandable powder coating material comprising a fine powder containing an ethylene / vinyl acetate copolymer, a pyrolytic foaming agent, and a peroxide-based crosslinking agent. It is a use or a covering, and these are not supposed for the purpose of imparting physical stimulation to the human body as in the present invention or the use for a patch for laminating an adhesive layer.
JP 08-260330 A Japanese Utility Model Publication No. 03-038325 JP 54-083524 A Japanese Patent Laid-Open No. 03-093865

  The present invention has been made in view of the above circumstances, and can provide an appropriate physical stimulus to the human body, and the protrusion is difficult to drop off from the sheet body and does not impair the anchoring property with the adhesive. It is an object to provide a support with attachment.

In order to achieve the above object, the present invention employs the following configuration.
The method for producing a support with protrusions for a patch of the present invention comprises a step of applying a slurry-like resin composition containing a base resin and a foaming agent to at least one surface of a sheet body, and an applied resin composition. foaming to, characterized in that it comprises a step of forming a projection soaked the base to the seat body.
In the method for producing a support with protrusions for a patch of the present invention having the above-described configuration, the resin composition may contain an inorganic powder filler.
In the method for producing a support with protrusions for a patch of the present invention having the above-described structure, the resin composition has a viscosity of at least 5000 mPa · s and not more than 30000 mPa · s containing at least a base resin, a foaming agent, and a medium. You may make it apply | coat this highly viscous resin composition to the at least one surface of the said sheet | seat body in the shape of a dot or a line | wire using a resin composition.
Moreover, in the manufacturing method of the support with protrusions for a patch of the present invention having the above-described configuration, the high-viscosity resin composition is applied by transferring onto the at least one surface of the sheet body using a screen having holes. You may do it.
Furthermore, in the method for producing a support with protrusions for a patch of the present invention having the above-described configuration, before transferring the high-viscosity resin composition onto at least one surface of the sheet body, one end of the sheet body It is preferable to correct the positional deviation and / or meandering of the sheet by using a control device that detects the position and corrects the positional deviation and / or meandering.
Moreover, in the manufacturing method of the support body with protrusions for a patch of the present invention having the above-described configuration, it is preferable to form the protrusions by foaming the resin composition at an expansion ratio of 1.1 to 3.0.

In addition, the support with a protrusion for a patch of the present invention is manufactured by the method for manufacturing a support with a protrusion for a patch of the present invention described above.
Further, in the support with a protrusion for a patch of the present invention, a protrusion formed by foaming a resin composition containing a base resin and a foaming agent is formed on at least one surface of the sheet body, and the base of the protrusion Is soaked into the sheet.
Moreover, it is preferable that the support body with a protrusion for patch of this invention is 1.1-3.0 in the foaming magnification of a protrusion.
Further, the patch of the present invention comprises the support with a protrusion for patch of the present invention having any one of the above-described structures, and an adhesive layer formed on the surface of the support having the protrusion. Features.

According to the method for producing a support with protrusions for a patch of the present invention, the resin composition soaks into the sheet body when it is applied to the sheet body. A protrusion is formed from the base) and the protrusion formed on the sheet body. Since such a protrusion is firmly supported by the sheet body because of the presence of the base as described above, it is difficult to drop off from the sheet body, and therefore, no adhesive is required and the use of the adhesive The problem of reduced air permeability can also be improved.
In addition, since the foaming agent is contained in the resin composition, it is possible to produce a support with protrusions that can give an appropriate physical stimulus to the human body by foaming the foaming agent.
Moreover, the support body which has the protrusion formed using the said resin composition can make favorable anchoring property with an adhesive.
According to the support with protrusions for a patch of the present invention, it is possible to give an appropriate physical stimulus to the human body, and it is difficult for the protrusions to come off from the sheet body and the anchoring property with the adhesive is good. it can.

Next, embodiments of the present invention will be described in detail with reference to the drawings.
The present invention is of course not limited to the embodiments described below, and in the following drawings, the constituent parts are shown so that the scale of each constituent part can be easily shown in the drawings. The scale is changed every time.
FIG. 1 is a cross-sectional view showing a schematic configuration of a patch of one embodiment of the present invention, and FIG. 2 is a plan view showing a support with protrusions for a patch provided in the patch of FIG. 3 is an enlarged cross-sectional view showing one of the protrusions provided on the support with protrusions for patch of FIG.

The patch 1 of the present embodiment includes a support 10 with a protrusion for patch as shown in FIGS. 2 to 3 and an adhesive layer 15 formed on the surface of the support 10 having the protrusion 12. It will be.
The support with protrusions for patches 10 is manufactured by the method for manufacturing a support with protrusions for patches according to an embodiment of the present invention. The patch-supported support 10 has a plurality of protrusions 12 formed by foaming a resin composition containing a base resin and a foaming agent on one surface of a sheet body 11, and FIG. As shown, the base (lower part) 12 a of each protrusion 12 is soaked into the sheet body 11. Moreover, the part which is not soaked in the sheet | seat body 11 of each protrusion 12 is the protrusion part (upper part) 12b.

The sheet body 11 is not particularly limited, and a material used for a support layer of a normal patch can be used. As such a material, for example, paper, a fiber sheet, a porous body, a foam, a plastic film, a laminate of a plastic film and a fiber sheet or paper, a plastic film anchor-coated product, and the like can be used.
As the above-mentioned fiber sheet, woven fabrics such as thick weave, yarn weave, gauze, corten, and flannel, knitted fabrics by production methods such as flat knitting, rubber knitting, tuck knitting, double stitch knitting, spun lace, spunbond, A nonwoven fabric produced by a manufacturing method such as thermal bond, chemical bond, needle punch, or the like is appropriately selected and used. Examples of the material of the fiber sheet include, for example, polyester resins such as rayon, polyamide, polyethylene, polyethylene terephthalate, polyolefin resins such as polypropylene, polyester ether, polyurethane resins, acrylic resins, polyvinyl alcohol, polystyrene resins, Examples include cotton and hemp. Among these, polyester resins, polyethylene resins, and polypropylene resins are preferable, and these resins may be used alone or as a blended fiber of two or more.

  Examples of the material of the porous body, foam, and film (sheet) include polyolefin resins such as polyethylene and polypropylene; acrylic resins such as polymethyl methacrylate; polyester resins such as polyethylene terephthalate, polybutylene terephthalate, and polyethylene naphthalate; Cellophane, polyvinyl alcohol, ethylene / vinyl alcohol copolymer, polyvinyl chloride, polyvinylidene chloride, polystyrene, polyurethane resin, polyacrylonitrile, fluorine resin, styrene / isoprene / styrene block copolymer, styrene / butadiene / styrene block Copolymer, styrene / ethylene / propylene / styrene block copolymer, styrene / butadiene rubber, ethylene / vinyl acetate copolymer, polyamide, polysulfur Down, polyester, styrene, and thermoplastic elastomers of polyester or a copolymer rubbers. In addition, these polymerization degrees are not specifically limited, The thing of the polymerization degree normally used for the sheet | seat body as a base material of a patch can be used.

The thickness of the sheet | seat body 11 is about 10-200 micrometers normally, Preferably it is about 15-100 micrometers.
If the thickness of the sheet body 11 is too thin, the film may be cut or difficult to peel off when the patch 1 is peeled from the skin, and if it is too thick, it may be difficult to stick to the curved surface, and the adhesive layer side may not be applied cleanly. Further, the surface of the sheet body 11 (the surface on the side where the adhesive layer is formed and / or the surface opposite to the side where the adhesive layer is formed) may be subjected to surface modification treatment such as corona treatment, It is also possible to use a material that has been embossed or printed.

  The protrusion 12 provided on the support 10 with the patch protrusion is formed of a porous resin obtained by foaming the resin composition applied to the sheet body 11 by heating or the like. The resin composition contains a base resin and a foaming agent as essential components, preferably contains a medium, and may further contain an inorganic powder filler and / or a thickener. The resin composition is preferably a high-viscosity resin composition having a viscosity of 5000 mPa · s to 30000 mPa · s. The porous resin contains a base resin as a main component and a foaming agent as essential components, preferably contains an inorganic powder, and may further contain a thickener.

Examples of the base resin include polyacrylate, ethylene / vinyl acetate, polyethylene, polyvinyl chloride, ethylene / vinyl chloride, acrylic / styrene, polystyrene, polyurethane, polyester, styrene butadiene rubber (SBR). , Acrylonitrile-butadiene rubber (NBR), methacrylate-butadiene synthetic rubber (MBR), polychloroprene, polyisoprene, etc. can be used, but flexibility, light discoloration resistance, safety, heat resistance, price, etc. In view of the above, polyacrylic acid ester type and acrylic / styrene type are preferable.
As content of this base resin, 30-70 mass% of a highly viscous resin composition is desirable.

As the foaming agent, there can be used a microcapsule system in which the volume is increased by expanding the gas contained by heating. Although depending on the encapsulated gas, a type that heats and foams at 100 to 120 ° C. is preferable. As content of this foaming agent, 5-20 mass% of a high-viscosity resin composition is desirable. Fibrin derivatives, alginate, polyacrylic acid, and polyurethane can be used as the above thickeners, but the behavior of structural viscosity varies depending on the type, so it is appropriate considering the effects on film properties and processability. A thickener is selected to obtain viscosity.
As content of this thickener, 0.05-3.0 mass% of a high-viscosity resin composition is desirable.

  Examples of the inorganic powder filler include clay minerals such as smectite and kaolin, oxides such as zinc oxide and titanium oxide, hydroxides such as aluminum hydroxide and calcium hydroxide, carbonates such as calcium carbonate and sodium carbonate, Examples thereof include silicates such as zeolite, and these can be used alone or in combination of two or more. Of these, kaolin, titanium oxide, aluminum hydroxide, and calcium carbonate are particularly preferable.

  The expansion ratio of the protrusion 12 is preferably in the range of 1.1 to 3.0. When the expansion ratio exceeds 3.0, problems such as low protrusion strength and difficulty in sticking to the skin in terms of usability arise.

The protrusion 12 preferably has a hardness of 200 g / mm or more, and more preferably 350 g / mm or more. When the protrusion 12 has the above-mentioned hardness, the pressing effect by the protrusion is particularly excellent, and a good improvement / treatment effect of the affected area can be obtained. In addition, the hardness of a protrusion can be measured with a texture analyzer (made by Stable Microsystem Co., Ltd.), for example.
Moreover, it is preferable that the stress for compressing the protrusion 12 by 1 mm has elasticity having 3N or more. By using protrusions having these physical properties, a particularly good blood flow promoting effect can be obtained.

It is preferable that the projections 12 as described above are dotted or vertically arranged on one surface of the sheet body 11 and formed in a band shape such as a wave shape or a spiral shape.
As for the shape and size of the protrusions 12, for example, as shown in FIG. 2, the maximum diameter of the protrusions is 2 mm or more and 10 mm or less, preferably a circular shape in plan view with a maximum diameter of 2.5 mm or more and 7 mm or less, or It is a polygonal shape in plan view that circumscribes the circle, and in the case of a strip shape, the maximum width is preferably 2 mm or more and 6 mm or less. Moreover, the height of the protrusion part of the protrusion 12 is 2 mm or more and 7 mm or less, Preferably it is 2.5 mm or more and 5 mm or less, More preferably, it is 3 mm or more, More preferably, it is 3.5 mm or more. The protrusion interval (protrusion portion interval) P is 2 mm or more and 25 mm or less, preferably 4 mm or more and 15 mm or less when scattered, and preferably 2 mm or more and 15 mm or less in the case of a strip.
By setting the maximum diameter and height of the protrusions of the protrusions 12 within the above range, the pressing effect by the protrusions is excellent, and the adhesive can be easily uniformly applied to the protrusion side of the support 10.

Patch projections with support 10, the projections 12, on one surface of the sheet 11, 2 to 14 pieces / 4 cm ^2, preferably from 4 to 12/4 cm ^2, the area of the base of the projections 12, It is preferable that it is 5 to 80%, preferably 10 to 70%, more preferably 20 to 60% of the sheet body area.

It is preferable that the support body 10 with the protrusions for patch according to the present embodiment has a plurality of protrusions 12b (protrusion forming parts) and a flat part (a part without the protrusions) surrounding the protrusions 12b. It is preferable that the area ratio of the projection forming portion (inside the line connecting the outermost projections of the projection group) and the flat portion is projection forming portion: flat portion = 1: 0.5 to 1: 3. Within this range, good adhesion and long-time stickability can be obtained, and good sticking feeling (warm feeling, cool feeling) can be maintained. More specifically, the patch 1 can further enhance the feeling of use of the patch due to the thermal sensation due to the thermal sensation stimulant or the exothermic agent, the cold sensation stimulant or the cooling sensation due to the heat of vaporization of water.
However, when a support having protrusions is used, it becomes difficult to feel the cold feeling and the warm feeling due to the stimulation of the protrusions. In particular, the feeling of warmth / coolness decreases with time. By providing a flat part without protrusions around the protrusion-forming part, even if applied for a long time, it is possible to feel the stimulation by the protrusions and the warmth and coldness of the paste at the same time. It can be used as an agent.

As a method for producing the support with protrusions 10 for a patch, for example, a resin composition in the form of a slurry in which the protrusion component (a resin composition containing a base resin and a foaming agent) is dispersed or dissolved in a medium such as water in advance. (Slurry or resin composition slurry) may be formed on the sheet body so as to form a predetermined pattern, and then dried in hot air or a thermostatic bath, and at the same time promoting foaming of the foaming agent. it can. By applying the slurry-like resin composition and drying by heating, the adhesion of the protrusions 12 to the sheet body 11 can be improved.
Examples of the medium for making the protrusion component into a slurry include water, ethanol, propanol, and the like, and a mixture thereof. A preferable medium is water or a mixture of water and other solvents.
The resin composition slurry is preferably prepared in advance as a slurry having a protrusion component content of 40 to 70% by mass. When the protrusion component content is within this range, the protrusion 12 having good drying efficiency and sufficient strength and height can be obtained. On the other hand, if the water content is too low, production problems such as kogation and discoloration occur during heat drying and foaming.

The slurry viscosity is desirably adjusted to 5000 to 30000 mPa · s, preferably 7000 to 25000 mPa · s, and more preferably 10000 to 20000 mPa · s, to obtain a high-viscosity resin composition.
When the viscosity of the resin composition slurry is lower than 5000 mPa · s, the spread of the composition cannot be controlled when applied onto the sheet body, uniform projections cannot be obtained, and the projection height after heating and foaming cannot be obtained sufficiently. . Further, if the viscosity is higher than 30000 mPa · s, the extrudability of the resin composition slurry from the holes formed in the nozzle and the screen is deteriorated, and a sufficient amount cannot be placed on the sheet body 11, so that the protrusions are sufficient. Are not formed, and a uniform projection cannot be obtained. The viscosity can be adjusted by selecting the type and molecular weight of the base resin, but it is also preferable to adjust the viscosity with a viscosity modifier (thickener / thickener).

A method of applying the slurry to the sheet body 11 is a method of obtaining a predetermined pattern by discharging from a nozzle, a method of extruding and transferring from a screen 32 having holes 32a formed in a predetermined pattern as shown in FIG. 4, or A method of transferring the sheet to a sheet body 11 after placing it on another screen is mentioned, but a method of extrusion transfer from a screen having holes in a predetermined pattern is preferable from the viewpoint of productivity. The slurry used here is preferably a high viscosity resin composition having a viscosity adjusted to the above range.
FIG. 4 is a schematic configuration diagram showing a manufacturing apparatus that is preferably used for manufacturing the support 10 with the protrusions for patch. In the figure, reference numeral 31 denotes a backup roll, and 32 denotes a screen disposed opposite to the backup roll 31. , 33 is a squeegee provided in the screen 32, and 34 is a squeegee support device.

The backup roll 31 supports and supports the screen 32, and the sheet body 11 moves along the backup roll 31 between the backup roll 31 and the screen 32, and the slurry 35 pushed out from the hole 32 a to the sheet body 11. What is transferred in the form of dots or lines is sent to a subsequent process.
The screen 32 is provided with a plurality of holes 32a in a predetermined pattern, and the screen 35 is filled with the slurry 35 as described above. The screen 32 is fixed to a screen mounting device (not shown).
The squeegee 33 is fixed to the squeegee support device 34.
The squeegee support device 34 can adjust the contact angle of the squeegee 33 by rotating. The squeegee support device 34 can manage the amount of rotation by the gage 34a. The squeegee support device 34 can be pushed by the handle 34b that moves the squeegee support device 34 back and forth. The amount of pressing can be managed by the gage 34c.

  Examples of the material of the squeegee 33 for extruding the slurry 35 in the extrusion method from the screen 32 include metals such as aluminum, titanium, carbon steel, and stainless steel, or plastics such as acrylic, Bakelite (trademark), and polyester. From the viewpoint of properties and the like, a polyester type is preferable.

When the slurry 35 is pushed out from the hole 32a by the squeegee 33, the position and angle of the squeegee are adjusted so that the tip of the squeegee 33 is aligned with the intersection of the line segment connecting the center of the backup roll 31 and the screen 32 and the screen 32. It is preferable to do. Moreover, it is preferable that the pressing amount is about 3 to 6 mm / time.
In order to dry and foam the slurry 35 applied on the sheet member 11, a method using hot air or hot wire can be used, but hot air is preferable in consideration of productivity. As hot air conditions, temperature is 120-210 degreeC, More preferably, it is 120-180 degreeC, More preferably, it is 130-170 degreeC.
In addition, since the resin composition extruded from the nozzle or the screen 32 is in the form of a slurry, a part of the slurry applied to the sheet body 11 soaks into the sheet body 11, and the remainder is a protrusion on the sheet body 11. Therefore, by drying and foaming as described above, a protrusion (projection) is formed on the sheet body 11, and a soaking part (base 12a) is formed on the sheet body 11.
In this way, the support 10 with the protrusions for patch is obtained.

Before transferring the slurry 35 onto the sheet body 11, the position shift of the sheet body 11 is detected by using a control device 50 that detects the position of one end of the sheet body 11 and corrects the position shift and / or meandering. And / or to correct meandering.
The misalignment and / or meandering correction of the sheet body 11 is detected by using various sensors 40 to detect the deviation amount and the meandering amount and send the signal to the control device 50, and the electric drive device 55 uses the newly issued signal. A method of correcting to an ideal position can be used.

  Examples of the sensor 40 include an optical transmission sensor, a reflective line sensor, a sound wave sensor, and a contact sensor. An example of the signal controller (control device) 50 is an EPC (edge position controller). Further, as the electric drive device 55 for correcting the position of the sheet body 11 based on a signal output from the control device 50, the unwinding sheet (sheet body 11) is moved left and right by an electric cylinder to perform position control. Or, a roll guider that corrects the position by changing the angle of the two rolls with a fulcrum that remains parallel may be used. These devices can be used in any combination, but it is desirable that the position serving as the reference of the workpiece is one end of the original fabric. That is, when the center of the original fabric is aligned with the center of the workpiece, there may be a problem that the slurry transfer position shifts when the original fabric width changes.

When the adhesive layer 15 is formed by applying an adhesive to the surface of the support body 10 with the protrusions formed as described above on which the protrusions 12 are formed, the patch 1 of this embodiment is obtained.
Examples of the pressure-sensitive adhesive include polyhydric alcohol pressure-sensitive adhesives, rubber pressure-sensitive adhesives (SIS pressure-sensitive adhesives, acrylic pressure-sensitive adhesives, and silicone-based pressure-sensitive adhesives), water-containing pressure-sensitive adhesives, and the like. In view of promoting blood circulation by stimulating the protrusions, an anti-inflammation, fatigue recovery, and edema improvement effect by cooling of the applied part can be obtained, and a hydrous patch is preferably used.

<Polyhydric alcohol adhesive>
The polyhydric alcohol-based pressure-sensitive adhesive is a substantially non-aqueous pressure-sensitive adhesive containing a polyhydric alcohol and a polyhydric alcohol-soluble or swellable polymer compound as essential components. (It is possible to contain a small amount of water derived from the raw material, but from the viewpoint of the effect of the present invention, the water content in the pressure-sensitive adhesive should be 10% or less, preferably 5% or less, more preferably 3%. Is the following)

  As the polyhydric alcohol, glycols (including glycol ethers), glycerins, and sugar alcohols are preferably used. Specifically, for example, alkylene glycols such as 1,3-butanediol, ethylene glycol, propylene glycol, butylene glycol, isoprene glycol, and amylene glycol, glycerins such as glycerin, diglycerin, triglycerin, and polyglycerin, Examples include dialkylene glycols such as diethylene glycol, dipropylene glycol and diethylene glycol monoalkyl ether, polyethylene glycols, polypropylene glycols, polyethylene glycol / polypropylene glycols, hydrogenated castor oils, sugar alcohols such as sorbitol, and the like.

  Among these, ethylene glycol, propylene glycol, isoprene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol / polypropylene glycol, diethylene glycol monoalkyl ether, glycerin, diglycerin, triglycerin, polyglycerin, and the like are preferable. Particularly preferred are diethylene glycol monoalkyl ether, isoprene glycol, polyethylene glycol, polyethylene glycol / polypropylene glycol, polypropylene glycol and glycerin. From the viewpoint of exothermicity, polyethylene glycol having a molecular weight of 200 to 6000, particularly 200 to 2000 is most preferable. Further, when two or more kinds of polyethylene glycols having different average molecular weights, that is, those having an average molecular weight of less than 350 and 350 or more are used in combination, the initial exothermic property and the exothermic sustainability are very good. Further, by combining the above polyethylene glycol with another polyhydric alcohol, a patch with particularly good exothermic property, usability and stability can be obtained.

  The blending amount of the polyhydric alcohol is not particularly limited and can be appropriately selected, and is usually 10 to 95% by mass, preferably 20 to 93% by mass, more preferably 30 to 90% by mass of the whole pressure-sensitive adhesive composition. % By mass. When the blending amount is within this range, the physical properties such as adhesiveness, cohesiveness and flexibility, manufacturability and usability are particularly good.

  The polyhydric alcohol-soluble polymer means that a 1% by mass polyhydric alcohol solution of the polymer becomes transparent or clear and uniform. Polyhydric alcohol swellable polymer means that when mixed with polyhydric alcohol, the polymer absorbs polyhydric alcohol to increase the volume, and the mass of the polymer-polyhydric alcohol body is the mass of the polymer before mixing. That is more than twice the A preferred polymer compound has a property of gelling by dissolving or swelling in a polyhydric alcohol, and among them, a nonionic polymer can be suitably used. Further, a polymer compound having hydrophilicity and a thermoplastic compound are desirable.

  Specifically, for example, hydroxypropylcellulose, polyvinylpyrrolidone, carboxyvinyl polymer, (meth) acrylic acid / (meth) acrylic acid ester copolymer, N-methacryloylethyl-N, N-dimethylammonium-α-N-methylcarboxy Betaine polymer, polyacrylic acid, polyvinyl acetate, alkyl vinyl ether / maleic anhydride copolymer, polyvinyl alcohol, poly N-vinylacetamide, polymethoxypolyethylene glycol (meth) acrylate, polyphenoxypolyethylene glycol (meth) acrylate, polyhydroxyethyl And one or more polymers selected from the group consisting of (meth) acrylate, polyhydroxypropyl (meth) acrylate, polyacrylamide, and mixtures thereof. That. Further, these polymer compounds may be cross-linked products in which a part thereof is cross-linked.

  The hydroxypropyl cellulose preferably has a substitution degree of 50% or more. Here, the degree of substitution means mass% of the etherified hydroxypropoxyl group content with respect to the hydroxypropylcellulose mass. A high degree of substitution is preferable because compatibility with the polyhydric alcohol can be sufficiently obtained. Hydroxypropyl cellulose has a hydroxypropoxyl group content of 20 to 90%, preferably 50 to 80%, for example. The polyvinyl pyrrolidone may be a copolymer mainly composed of a vinyl pyrrolidone monomer, such as 2-ethylhexyl acrylate / vinyl pyrrolidone copolymer, vinyl pyrrolidone / vinyl acetate copolymer and vinyl pyrrolidone / vinyl caprolactone / vinyl imidazole copolymer. Is mentioned.

  Examples of the (meth) acrylic acid / (meth) acrylic acid ester copolymer include methacrylic acid / methyl acrylate copolymer, methacrylic acid / ethyl acrylate copolymer, acrylic acid / octyl acrylate copolymer, and methacrylic acid / acrylic acid n. -A butyl copolymer etc. are mentioned. The N-methacryloylethyl-N, N-dimethylammonium-α-N-methylcarboxybetaine polymer is a copolymer mainly composed of N-methacryloylethyl-N, N-dimethylammonium-α-N-methylcarboxybetaine monomer. For example, N-methacryloylethyl-N, N-dimethylammonium-α-N-methylcarboxybetaine / octadecyl methacrylate copolymer and N-methacryloylethyl-N, N-dimethylammonium-α-N-methyl And carboxybetaine / 2-ethylhexyl methacrylate copolymer.

The polyacrylic acid may be unneutralized or partially neutralized. A partially neutralized polyacrylic acid having a neutralization rate of less than 20 mol% is preferable because it is easily dissolved in a polyhydric alcohol. More preferably, it is unneutralized polyacrylic acid. The polyvinyl acetate may be a copolymer mainly composed of a vinyl acetate monomer. For example, vinyl acetate / crotonic acid copolymer, vinyl acetate / itaconic acid copolymer and the like can be mentioned.
Examples of the polyvinyl alcohol include complete / partially saponified products of polyvinyl acetate. The alkyl vinyl ether / maleic anhydride copolymer may be an alkyl vinyl ether / maleic anhydride copolymer and a hydrolyzate thereof, or a neutralized product or a half ester of the hydrolyzate. An example is a methyl vinyl ether / maleic anhydride copolymer.

  In the polymethoxypolyethyleneglycol (meth) acrylate and polyphenoxypolyethyleneglycol (meth) acrylate, the number of moles of ethylene glycol added to the side chain of polyethyleneglycol contained in methoxypolyethyleneglycol (meth) acrylate and phenoxypolyethyleneglycol (meth) acrylate (n ) Is, for example, n = 2 to 50, preferably n = 2 to 23. The polymethoxypolyethylene glycol (meth) acrylate and polyphenoxypolyethylene glycol (meth) acrylate may be a copolymer with, for example, an alkyl (meth) acrylate. Particularly preferred polymer compounds are hydroxypropylcellulose, polyvinylpyrrolidone, polyacrylic acid and methacrylic acid copolymer.

  The molecular weight of the polymer compound is preferably high enough to obtain good gel-forming properties, and is, for example, 10,000 to 10,000,000, preferably 100,000 to 5,000,000. The blending amount of the polyhydric alcohol-soluble or swellable polymer compound is not particularly limited and can be appropriately selected, and is usually 1 to 50% by mass of the entire pressure-sensitive adhesive composition. When the blending amount is out of this range, problems such as a decrease in shape retention, cohesiveness and tackiness occur. Preferably it is 1-45 mass%, More preferably, it is 1-40 mass%, Most preferably, it is 3-25 mass%.

<Rubber adhesive>
The rubber-based pressure-sensitive adhesive is a substantially anhydrous pressure-sensitive adhesive in which a synthetic resin, a softening agent, a tackifying resin, and other optional components are blended as necessary.
Specific examples of the synthetic resin include styrene-isoprene-styrene (SIS) block copolymer rubber, styrene-butadiene-styrene block copolymer rubber, styrene-butadiene rubber, polybutene rubber, polyisoprene rubber, Examples thereof include rubbers such as butyl rubber, silicone rubber, natural rubber, and synthetic isoprene rubber; and synthetic resins such as poly (meth) acrylate, polyvinyl ether, polyurethane, polyester, polyamide, and ethylene copolymer. These may be used alone or in combination. Among these, styrene-isoprene-styrene, natural rubber, and acrylic are preferable. The compounding quantity of the said synthetic resin is not restrict | limited in particular, It can select suitably, Usually, 5-45 mass% of the whole adhesive composition, Preferably it is 10-30 mass%. When the blending amount is out of this range, physical properties such as adhesiveness, cohesiveness, flexibility and shape retention are poor, and manufacturability and usability are lowered.

  Examples of the softening agent include liquid paraffin, polybutene, castor oil, cottonseed oil, palm oil, coconut oil, process oil, almond oil, olive oil, camellia oil, versic oil, peanut oil, lanolin and the like. These may be used alone or in combination. Among these, liquid paraffin is preferable. The blending amount of the softening agent is not particularly limited and can be appropriately selected, and is usually 10 to 80% by mass, preferably 25 to 60% by mass based on the entire pressure-sensitive adhesive composition. When the blending amount is out of this range, physical properties such as adhesiveness, cohesiveness, flexibility and shape retention are poor, and manufacturability and usability are lowered.

  Examples of the tackifying resin include alicyclic saturated hydrocarbon resins, rosin esters, hydrogen alicyclic hydrocarbons, terpene hydrogenated resins, hydrogenated rosin esters, dibasic acid-modified rosin esters, and the like. These may be used alone or in combination. The compounding amount of the tackifying resin is not particularly limited and can be appropriately selected, and is usually 15 to 50% by mass, preferably 20 to 45% by mass, based on the entire pressure-sensitive adhesive composition. When the blending amount is out of this range, physical properties such as adhesiveness are poor and usability is lowered.

<Water-containing adhesive>
The water-containing pressure-sensitive adhesive is a water-containing gel containing a pressure-sensitive polymer and water. The water-soluble polymer is preferably cross-linked by a curing agent or radiation irradiation. In addition, arbitrary components can be mix | blended with a hydrous gel.

Adhesive polymers include polyacrylic acid, sodium polyacrylate, carboxyvinyl polymer, partially neutralized polyacrylic acid, polyacrylic acid polymethacrylic acid copolymer, methyl vinyl ether / maleic anhydride copolymer, sodium carboxymethyl cellulose , Etc. These may be used alone or in combination. Among these, polyacrylic acid, carboxyvinyl polymer, sodium polyacrylate, and sodium carboxymethylcellulose are preferable.
The compounding quantity of the said adhesive polymer is not restrict | limited in particular, It can select suitably, Usually, 0.1-40 mass% of the whole adhesive composition, Preferably it is 1-30 mass%. If the amount is too small, the adhesive strength and cohesiveness may be insufficient. If the amount is too large, the viscosity will be high, causing problems in workability during production, and when using as a patch, if you feel pain when peeling. There is.

Examples of the crosslinking agent include polyvalent metal ion crosslinking agents and organic cation crosslinking agents.
Examples of the polyvalent metal ions include magnesium ions, calcium ions, zinc ions, cadmium ions, aluminum ions, titanium ions, tin ions, iron ions, chromium ions, manganese ions, cobalt ions, nickel ions, and the like. Among them, compounds that release polyvalent metal ions, such as magnesium compounds, calcium compounds, zinc compounds, cadmium compounds, aluminum compounds, titanium compounds, tin compounds, iron compounds, chromium compounds, manganese compounds, cobalt compounds, nickel compounds, etc. However, the water-containing pressure-sensitive adhesive composition used in the present invention is applied to the skin, and it is particularly preferable to use an aluminum compound, a magnesium compound, a calcium compound, etc. in consideration of safety to the skin. . Specifically, alums such as potassium alum, ammonium alum, and iron alum, aluminum hydroxide, aluminum sulfate, aluminum chloride, aluminum glycinate, aluminum acetate, aluminum oxide, aluminum silicate, aluminum metasilicate, calcium hydroxide , Calcium carbonate, calcium sulfate, calcium nitrate, calcium chloride, calcium acetate, calcium oxide, calcium phosphate, magnesium hydroxide, magnesium carbonate, magnesium sulfate, magnesium acetate, magnesium silicate, magnesium oxide, magnesium hydroxide aluminate, aluminate metasilicate Magnesium, magnesium aluminate silicate, synthetic hydrotalcite, water soluble compounds such as double salts containing these metals, 1 of poorly water soluble compounds Or may be used two or more. An antacid containing aluminum and magnesium can also be blended as a polyvalent metal salt.

The organic cation crosslinking agent is not particularly limited as long as it has at least two cation groups such as N ⁺ and S ⁺ in the molecule, but those having a cation group of N ⁺ group are preferred, and more preferably, Examples thereof include those in which the cationic group is a trimethylammonium group or a polydimethyldiallylammonium group. Further, the main chain is preferably a polysaccharide polymer. For example, vinyl-based cationic polymers and cationized polysaccharides, specifically poly-4 (2) -vinylpyridine, ionene polymer (manufactured by Aldrich), N-trialkylaminomethyl polystyrene, aminoacetalized polyvinyl alcohol, poly-4 (5) - vinylimidazole, linear polyethylene imine, polyethylene imine, poly dialkyl diallyl ammonium salts, dialkyl diallyl ammonium salt -SO ² copolymer, cationic dextran, cationic starch, cationized polyvinyl pyrrolidone (cationized PVP), trimethylammonium type cationized cellulose, polydimethyldiallylammonium type cationized cellulose, cationized PVA, dimethyldiallylammonium salt-acrylamide copolymer, dimethyldia Examples include lylammonium salt-acrylamide copolymer, dimethyl lauryl ammonium type cationized cellulose, cationized guar gum, chitosan, gelatin or salts thereof such as fluoride, chloride, bromide, iodide and the like. These may be used alone or in combination of two or more.

The molecular weight of the organic cation crosslinking agent is, for example, 1000 to 100 million. In order to obtain particularly good elasticity and shape retention for good gel formation, the molecular weight is preferably 10,000 to 10,000,000, more preferably 50,000 to 10,000,000.
Preferred crosslinking agents are magnesium aluminate silicate, magnesium aluminate metasilicate, aluminum glycinate, synthetic hydrotalcite, alum. Organic cationic crosslinking agents include cationized starch, cationized PVP, cationized celluloses, and cationized guar gum.

  The blending amount of the cross-linking agent may be appropriately adjusted depending on the type of each cross-linking agent, but is usually in the range of 0.001 to 40% by mass, preferably 0.05 to 20% by mass of the entire pressure-sensitive adhesive composition. If the blending amount is too small, the cohesiveness may be insufficient. If the blending amount is too large, the viscosity becomes high, causing problems in tackiness and workability during production.

  In addition to the crosslinking agent, it is preferable to incorporate a curing regulator. As a hardening regulator, a citric acid, malic acid, tartaric acid etc. can be mentioned, for example, These can be used individually by 1 type or in combination of 2 or more types. Although the compounding quantity of a hardening regulator can be selected suitably, it is 0.001-10 mass% normally with respect to the whole composition, Preferably, it is 0.005-2 mass%.

  The water content of the water-containing pressure-sensitive adhesive in the present invention is not particularly limited and can be appropriately selected, and is usually 20 to 90% by weight, preferably 30 to 80% by weight, based on the whole pressure-sensitive adhesive composition. If the amount of water is too small, the tackiness and cohesion will be reduced, and if too much, the shape retention and cohesion will be reduced.

In addition to the above components, water-soluble or water-absorbing polymers, and other components usually added to a patch composition or the like similar to a polyhydric alcohol-based pressure-sensitive adhesive can also be appropriately blended. For example, surfactants, humectants, refreshing agents, inorganic powders, preservatives, solubilizers, stabilizers, percutaneous absorption accelerators, fragrances, pigments and the like can be mentioned.
Water-soluble or water-absorbing polymers include gelatin, pectin, polyvinyl pyrrolidone, vinyl acetate copolymer, polyethylene oxide, hydroxypropyl cellulose, polyvinyl pyrrolidone, (meth) acrylic acid / (meth) acrylic acid ester copolymer, N-methacryloyl Ethyl-N, N-dimethylammonium-α-N-methylcarboxybetaine polymer, polyvinyl acetate, polyvinyl alcohol, N-vinylacetamide copolymer, crosslinked polyvinylpyrrolidone, crosslinked polyalkylene oxide, crystalline cellulose, cellulose powder Alginic acid, gelatin, croscarmellose sodium, sodium polyacrylate, hydroxyethyl cellulose, methyl cellulose, methyl vinyl ether-maleic anhydride copolymer Na Cross-linked product, corn starch, xanthan gum, gum arabic, tragacanth, karaya, etc. guar gum and the like.

Each of the above-mentioned adhesives has anti-inflammatory analgesics (indomethacin, ketoprofen, flurbiprofen, glycol salicylate, methyl salicylate, glycyrrhetinic acid, stearyl glycyrrhetinate, glycyrrhizic acid (salt) for the purpose of treatment. )), Blood circulation promoters (capsicum, capsaicin, gingerone, tocopherol acetate, nonyl acid vanillylamide, vanillyl butyl ether, etc.), moisturizers (amino acids, urea, heparin analogs and other mucopolysaccharides, fats / hydrocarbons / high grades) Various active ingredients such as oily components such as fatty acids, higher alcohols and higher fatty acid esters, seaweed extracts such as dabilia, and the like, and essential oils (rosemary, sage, etc.) having an edema-inhibiting action can be blended.
These drugs can be used singly or in appropriate combination of two or more. The compounding amount can be selected as an appropriate amount of each drug, but is usually in the range of 0.001% by mass to 30% by mass.
Furthermore, in addition to the above components, other components that are usually added to the adhesive composition of a patch can be appropriately blended as necessary. For example, superabsorbent polymers, surfactants, inorganic powders, preservatives, solubilizers, stabilizers, fragrances, pigments and the like can be mentioned.

  The said adhesive composition of this invention can be prepared by kneading each adhesive component until it becomes uniform by a well-known method.

EXAMPLES Hereinafter, although an Example is shown and this invention is demonstrated more concretely, this invention is not limited to the following Example.
[Example 1]
A support with protrusions for a patch was produced by the following production method. The projection components used in the production of the support with projections for patches are shown in Tables 1 to 3 below.

  Sample Nos. Shown in Tables 1 to 3 were used. The various protrusion components 1 to 20 were prepared by dispersing and mixing the filler in an aqueous emulsion of a resin base (base resin) in advance with a mixer and then mixing the foaming agent and balance water. Then, it added slowly, mixing a thickener, and adjusted to the predetermined | prescribed viscosity. The obtained slurry was poured into a cylindrical screen having holes in a predetermined pattern in advance, and the slurry was pushed from the inside through the holes to the outside with a squeegee, and transferred to a nonwoven fabric (sheet body). After the transfer, drying and foaming were carried out in a predetermined hot air to obtain various protrusions for the patch-supported support.

(Comparative Example 1)
Sample No. Using the composition of No. 8, a filler was dispersed and mixed in a resin-base aqueous emulsion with a mixer in advance, and then the foaming agent and balance water were mixed. Thereafter, the thickener was slowly added while mixing to adjust to a predetermined viscosity. The obtained slurry is poured into a cylindrical screen having holes in a predetermined pattern in advance, and the slurry is pushed out from the inside through the holes so that the slurry is applied to the entire surface of the nonwoven fabric (sheet body). Transcribed. After the transfer, drying and foaming were carried out in a predetermined hot air to obtain a support with a protrusion for patch in which a protrusion was partially formed.

(Comparative Example 2)
Sample No. A support with protrusions was produced from No. 8 using a composition not using a foaming agent. A filler was dispersed and mixed in a resin-base aqueous emulsion with a mixer in advance, and then water of balance was mixed. Thereafter, the thickener was slowly added while mixing to adjust to a predetermined viscosity. The obtained slurry was poured into a cylindrical screen having holes in a predetermined pattern in advance, and the slurry was pushed from the inside through the holes to the outside and transferred to a nonwoven fabric (sheet body). After the transfer, drying was performed in a predetermined hot air to obtain a support with a protrusion for patch, in which protrusions were partially formed.

(Comparative Example 3)
Sample No. A support with protrusions was produced using the composition of No. 21. A filler was dispersed and mixed in a resin-base aqueous emulsion with a mixer in advance, and then water of balance was mixed. Thereafter, the thickener was slowly added while mixing to adjust to a predetermined viscosity. The obtained slurry was poured into a cylindrical screen having holes in a predetermined pattern in advance, and the slurry was pushed from the inside through the holes to the outside and transferred to a nonwoven fabric (sheet body). After the transfer, drying was performed in a predetermined hot air to obtain a support with a protrusion for patch, in which protrusions were partially formed.

A water-based pressure-sensitive adhesive gel mainly composed of cross-linked polyacrylic acid is applied to the surface on which the protrusions of the obtained support with protrusions for various patches are formed to form an adhesive layer. Various patches were prepared. The various patches prepared were evaluated for the uniformity of the protrusions, the irritation by the protrusions, the presence or absence of protrusions when sticking and peeling, and the anchoring properties of the adhesive layer. The results are shown in Tables 4 to 7 below.
In the evaluation of the uniformity of the protrusions in Tables 4 to 7, ◎ is uniform (less than about 5% visually non-uniform protrusion), ○ is almost uniform (about 5 to 10% visually uneven protrusion) Less than) and Δ are slightly non-uniform (the visually non-uniform protrusion is less than about 10 to 30%), and x is non-uniform (the visually non-uniform protrusion is about 30% or more). Moreover, in the stimulus evaluation score by protrusion, 5 is very strong, 4 is quite strong, 3 cannot be said at all, 2 is quite weak, and 1 is very strong.

From the results shown in Tables 4 to 7, the patch using the support with protrusions of Comparative Example 1 in which the protrusion component was transferred to the entire surface of the nonwoven fabric had a poor anchoring property of the adhesive layer. In addition, the patch using the support with protrusions of Comparative Example 2 in which the protrusion component not containing the foaming agent was transferred to the nonwoven fabric has insufficient protrusion height, and almost no irritation caused by the protrusion is obtained. It was not. In addition, the patch using the protrusion component having a viscosity of 100000 mPa · s and using the support with protrusions of Comparative Example 3 which is not foamed has insufficient protrusion heights, Dropout was observed.
On the other hand, the patch in which the adhesive layer was formed on the support with protrusions using the protrusion components of Sample Nos. 1 to 20 felt good physical irritation in skin attachment. Also, no protrusions were observed at the time of sticking or peeling.

[Example 2]
Sample No. Before transferring the protrusion components of 15 to 16 to the nonwoven fabric, set the sheet body position correction device equipped with an optical sensor, EPC and roll guider and align the reference position with the nonwoven fabric right end and center respectively. The results of evaluating the deviation are shown in Table 8.

[Reference Example 1]
Sample No. Table 8 shows the results of evaluating the deviation of the protrusion position when the sheet body position correcting device before transferring the protrusion component of 21 to the nonwoven fabric was removed.
In the projection position deviation rating in Table 8, ◯ indicates that the positional deviation is 5 mm or less, Δ indicates that the positional deviation is 5 mm to 10 mm, and x indicates that the positional deviation has exceeded 10 mm.

  From the results shown in Table 8, before transferring the projection component to the nonwoven fabric, the position of the nonwoven fabric is obtained by manufacturing the support with projections using a sheet body position correcting device that detects the position of the nonwoven fabric and detects and corrects misalignment. It can be seen that the misalignment can be reduced, and that the misalignment detection position can be made smaller by setting the detection position of the misalignment to the end than the center of the nonwoven fabric.

Sectional drawing which shows schematic structure of the patch of one Embodiment of this invention. The top view which shows the support body with the processus | protrusion for patch with which the patch of FIG. 1 was equipped. The expanded sectional view which shows one of the protrusions with which the support body with the protrusion for patch of FIG. 2 was equipped. The schematic block diagram which shows the manufacturing apparatus used suitably for the manufacturing method of the support body with a processus | protrusion for patch of embodiment.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1 ... Patch, 10 ... Support body with protrusion, 11 ... Sheet body, 12 ... Projection, 12a ... Base part (lower part), 12b ... Projection part (upper part), 15 ... Adhesive layer, 31 ... Backup roll, 32 ... Screen, 32a ... Hole, 33 ... Squeegee, 34 ... Squeegee support device, 34a ... Gage, 34b ... Handle 34c ... Gage 35 ... Slurry 40 ... Sensor 50 ... Controller (control device) 55 ... Electric drive

Claims (10)

A step of applying a slurry-like resin composition containing a base resin and a foaming agent to at least one surface of the sheet body, and foaming the applied resin composition to form a protrusion having a base soaked in the sheet body method for producing a plaster for nubbed support, characterized in that it comprises a step. The said resin composition contains an inorganic powder filler, The manufacturing method of the support body with a processus | protrusion for patchs of Claim 1 characterized by the above-mentioned. As the resin composition, a high-viscosity resin composition having a viscosity of 5000 mPa · s or more and 30000 mPa · s or less containing at least a base resin, a foaming agent, and a medium is used, and the high-viscosity resin composition is used as at least one of the sheet bodies. 3. The method for producing a support with a protrusion for patch according to claim 1 or 2, wherein the support is applied in the form of dots or lines on the surface. The production of the support with protrusions for patch according to claim 3 , wherein the high-viscosity resin composition is applied by transferring onto the at least one surface of the sheet using a screen having holes. Method. Before transferring the high-viscosity resin composition onto at least one surface of the sheet body, using a control device that detects a position of one end of the sheet body and corrects misalignment and / or meandering, The method for producing a support with protrusions for patch according to claim 4 , wherein the positional deviation and / or meandering of the sheet body is corrected. The support with a protrusion for a patch according to any one of claims 1 to 5, wherein the protrusion is formed by foaming the resin composition at an expansion ratio of 1.1 to 3.0. Production method. A support with a protrusion for a patch, which is manufactured by the method for manufacturing a support with a protrusion for a patch according to any one of claims 1 to 6 .   A protrusion formed by foaming a resin composition containing a base resin and a foaming agent is formed on at least one surface of the sheet body, and a base portion of the protrusion is infiltrated into the sheet body. Support with protrusion for agent. The support according to claim 8, wherein the protrusion has an expansion ratio of 1.1 to 3.0. A patch comprising the support with a protrusion for patch according to any one of claims 7 to 9 , and an adhesive layer formed on a surface of the support having a protrusion.

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