JP4283013B2 - Blood component collection circuit - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
  The present invention relates to blood component collection times used in blood component blood collection.On the roadRelated. In more detail, blood component collection times that can reduce the number of wearing times and the occurrence of wearing mistakes.On the roadIt is related.
[0002]
[Prior art]
  At the time of blood collection, for the purpose of effective use of blood and reduction of burden on blood donors, the blood sample is separated into each blood component by centrifugation, etc., and only the components necessary for the transfuser are collected. Ingredients are collected to return the ingredients to the blood donor.
[0003]
  In such component blood collection, when obtaining a platelet preparation, it is necessary to remove blood components (white blood cells) that are not desired to be collected and that are mixed in the collected platelet concentrate. This is to prevent fever, alloantigen sensitization, or viral infection. Thus, in order to remove leukocytes mixed in the platelet concentrate, a blood component collection circuit incorporating a leukocyte removal filter is used.
[0004]
  In such a blood component collection circuit, after collecting a predetermined amount of platelet concentrate, the leukocyte removal filter is filtered at a constant flow rate. For this reason, the blood bag for storing the platelet concentrate before filtration was required. In addition, air exists in the centrifuge before blood collection, and this air moves in the circuit while being cut off from the outside air while collecting blood components. For this reason, an air bag for temporarily storing the air is also necessary.
[0005]
  For this reason, in the blood component collection circuit that has been used conventionally, at least two bags are used in addition to the bag for collecting the blood component to be collected. Another example of a blood component collection circuit that does not have an air bag is described in Japanese Patent Application Laid-Open No. 2002-218772. As shown in FIG. 5, a blood component blood collection circuit disclosed herein includes a centrifuge 520 that separates blood into a plurality of blood components, a first line 521 that introduces blood into the centrifuge 520, A second line 522 that discharges blood components from the centrifuge 520, a temporary storage bag 527 that is connected to the second line 522 and temporarily stores concentrated platelet plasma, and separates white blood cells from the concentrated platelet plasma A leukocyte removal filter 561 to be removed and a platelet collection bag 526 for storing the concentrated platelet plasma after passing through the leukocyte removal filter 561 are provided.
[0006]
  As a result, the concentrated platelet plasma in the temporary storage bag 527 is transferred to the platelet collection bag 526 through the leukocyte removal filter 561, and then the plasma is supplied, and the platelets remaining in the leukocyte removal filter 526 (separate leukocytes are separated). The concentrated platelet plasma after removal is collected in the platelet collection bag 526 together with the plasma.
[0007]
  In this blood component collecting circuit, the temporary storage bag 527 is also used as an air bag without providing an independent air bag, thereby reducing the number of bags constituting the circuit.
[0008]
[Patent Document 1]
  Japanese Patent Laid-Open No. 2002-218772 (pages 4-5, FIG. 1)
[0009]
[Problems to be solved by the invention]
  However, in the blood component collection circuit that has been used conventionally, since there are a large number of bags in the circuit, the circuit configuration is complicated, and the handling thereof is complicated and complicated. Therefore, there is a problem that an operator who collects component blood often makes a mounting mistake.
[0010]
  Moreover, in the blood component collection circuit disclosed in the above-mentioned Japanese Patent Application Laid-Open No. 2002-218772, since the intermediate bag is also used as an air bag, tubes are connected to the top and bottom of the bag. There was a problem in that workability was poor because the tube was in the way when mounted on the component collection device. Moreover, what connected the tube to the upper and lower sides of a bag was disadvantageous also in cost.
[0011]
  Under such circumstances, there is a demand for a blood component collection circuit that can reduce the number of steps of installing the blood component collection circuit at the work site and has good workability for the apparatus.
[0012]
  Accordingly, the present invention has been made to solve the above-described problems, and it is possible to collect blood components that can reduce the number of bags, improve the workability of attachment to the apparatus, and further reduce the occurrence of attachment mistakes. TimesThe roadThe issue is to provide.
[0013]
[Means for Solving the Problems]
  The blood component collection circuit according to the present invention, which has been made to solve the above problems, is a blood component collection circuit that separates blood into a plurality of blood components by a centrifuge and collects the separated blood components. A first line through which blood flows into the inlet of the separator, a second line connected to the outlet of the centrifuge, and a second line connected to the second line and separated by the centrifuge A blood component reservoir for temporarily storing the first blood component;Connected to the second line;An air storage section for temporarily storing air existing in the centrifuge;A partition wall that divides the blood component reservoir and the air reservoir;A first container comprising: a cell separation filter connected to the first container for separating and removing predetermined cells from the first blood component; and connected to the cell separation filter, A second container for storing the first blood component after passing through the first container, and a second blood component connected to the first line and the second line and separated by the centrifuge And a third container.
[0014]
  By attaching this blood component collection circuit to the blood component collection device, the first blood component and the second blood component can be obtained. The blood component collecting circuit includes only the first container in addition to the second container and the third container for collecting the blood component to be collected. That is, the number of containers (bags) required in the blood component collection circuit is reduced. As a result, the circuit configuration is simplified and the number of circuit mounting steps can be reduced, which facilitates handling. Therefore, it is possible to prevent a mounting error by the operator. As described above, this blood component collection circuit can reduce the number of containers (bags) in the circuit, improve the workability of attachment to the apparatus, and reduce the occurrence of attachment mistakes.
[0015]
  AndThe second1 container has a partitionBloodLiquid component reservoirAnd the skyDividing the air reservoiris doing. This makes it possible to easily manufacture the first container and is advantageous in terms of cost.The
[0016]
  Here, in the first container, the blood component storage part and the air storage part may be completely separated by the partition wall, but the communication part may be formed above the container (upward when mounted on the apparatus). Good. This is because even if the upper part of the container is in communication, one of the storage parts temporarily stores air, so that there is no problem in use.
[0017]
  And when communicating the upper direction of a container, it is desirable for the dimension of the said partition to exist in the range of 40 to 95% with respect to the vertical inner dimension in a said 1st container. More preferably, the dimension of the partition wall is in the range of 60 to 80% with respect to the longitudinal inner dimension of the first container. That is, the lower part of the container is completely divided by the partition wall, while the upper part of the container is communicated. The “vertical inner dimension” means the dimension inside the container in the vertical (vertical) direction when the first container is mounted on the apparatus.
[0018]
  This is because the volume of the air storage part can be increased by forming the partition wall and communicating the upper part of the container, so that the volume of the entire container can be reduced. The partition may be arranged at a position where the lateral dimension of the blood component reservoir is larger than the lateral dimension of the air reservoir. Thereby, the volume of the whole container can be further reduced. The “lateral dimension” means the dimension of each reservoir in the width (horizontal) direction when the first container is mounted on the apparatus.
  And the tube connected to the blood component reservoir and the tube connected to the air reservoir areFirst containerIt is preferable that it is arrange | positioned at the one end side.
[0019]
  Moreover, it is desirable that the tube connected to the first container is disposed on the end side which is the lower side when mounted on the blood component collection device. This is because the workability is improved because the tube does not get in the way when the first container is attached to the apparatus. Moreover, it is because it becomes advantageous also in terms of cost by arrange | positioning a tube to the end (downward) of a container.
  In the blood component collection circuit according to the present invention, it is desirable that the third container has a line for supplying the second blood component to the cell separation filter.
[0020]
  Moreover, in the blood component collection circuit according to the present invention, each tube connecting the first line, the second line, the first container, the second container, and the third container is provided. It is desirable to have a body cassette housing that is partially housed and held.
  Furthermore, the main body cassette housing may hold the tubes so that the first container and the third container are divided on one side, and the cell separation filter and the second container are divided on the other side. desirable.
[0021]
  This is because, by having the main body cassette housing for partially storing and holding each tube in this way, each tube can be arranged at an accurate position simply by mounting the main body cassette housing to the apparatus. Thereby, the mounting workability to the apparatus is further improved, and the occurrence of mounting errors can be further reduced.
[0022]
  The blood component collection circuit according to the present invention further includes an air trap chamber for removing bubbles in the middle of the first line, and a filter cassette housing for fixing the air trap chamber and the cell separation filter. Is desirable. Here, the filter cassette housing integrally incorporates the air trap chamber, the connection pipe of the cell separation filter, and the upstream tube and the downstream tube of the cell separation filter.
  AndThe filter cassette housing preferably incorporates the air trap chamber, the connection pipe of the cell separation filter, and the upstream tube and the downstream tube of the cell separation filter.
[0023]
  By having such a filter cassette housing, the upstream tube and the downstream tube of the cell separation filter are bundled, and the position of the second container is determined by attaching the filter cassette housing to the apparatus, so that other circuit configurations are possible. The second container can be mounted at an accurate position without being entangled with the parts. Further, the air trap chamber can be mounted at an accurate position without being entangled with other circuit components. Furthermore, the tube connected to the air trap chamber can be accurately attached to the connection destination. That is, workability can be greatly improved and mounting errors can be reliably prevented.
[0024]
  In the blood component collection circuit according to the present invention, it is desirable that the first blood component is plasma containing platelets. The second blood component is preferably plasma.
[0025]
  In this way, the platelets remaining in the cell separation filter can be collected using plasma as a medium, so that the yield of platelets in the platelet preparation can be increased, and the quality of the platelet preparation with little damage to the platelets It is because it can obtain.
[0026]
  The cell separation filter is preferably a leukocyte removal filter. This is because the removal rate of leukocytes in the blood product can be increased.
[0027]
[0028]
[0029]
[0030]
[0031]
DETAILED DESCRIPTION OF THE INVENTION
  Hereinafter, a most preferred embodiment in which the blood component collection circuit of the present invention is embodied will be described in detail with reference to the drawings. The blood component collection circuit according to the present embodiment is suitable for being attached to a device for collecting a platelet preparation.
[0032]
(First embodiment)
  First, the first embodiment will be described. Therefore, FIG. 1 shows the configuration of the blood component collection circuit according to the first embodiment. FIG. 1 is a circuit configuration diagram of the blood collection circuit 1.
[0033]
  The blood component collection circuit 1 includes a centrifuge 20 for centrifuging blood, a first line 21 connected to the inlet 143 of the centrifuge 20, and a first line 21 connected to the outlet 144 of the centrifuge 20. Two lines 22, a third line 23 connected to the first line 21, a plasma collection bag 25, a platelet collection bag 26, an intermediate bag 28, and an air bag 29. A bag 27 is provided.
[0034]
  The first line 21 includes a blood collection needle side first line 21 a to which the blood collection needle 30 is connected, and a centrifuge side first line 21 b connected to the inlet 143 of the centrifuge 20. The blood collecting means is not limited to the blood collecting needle 30 and may be, for example, a connecting portion (for example, a metal or synthetic resin needle) for connecting to a blood pool such as a blood bag. As this blood collection needle 30, for example, a known metal needle may be used.
[0035]
  The blood collection needle side first line 21a is formed by connecting a plurality of soft resin tubes. The blood collection needle side first line 21a includes a branch connector 21c for connection with the third line 23 from the blood collection needle 30 side, and a chamber 21d for removing bubbles and microaggregates. The other end of the blood collection needle side first line 21 a is connected to a branch connector 21 f for connection with the first tube 25 a of the plasma collection bag 25. The chamber 21d is connected to a filter 21i that is air permeable and impermeable to bacteria. Further, a clamp is attached between the blood collection needle 30 and the branch connector 21c of the blood collection needle side first line 21a.
[0036]
  On the other hand, the centrifuge side first line 21b has a first pump tube 21g. The other end of the first centrifuge-side line 21b is connected to the connecting branch connector 21f.
[0037]
  The second line 22 includes, from the centrifuge 20 side, a branch connector 22a for connecting to the second tube 25b of the plasma collection bag 25, the sixth tube 29a of the air bag 29, and a tube including the bubble removing filter 22f. A branch connector 22b for connection with the fourth tube 28a of the intermediate bag 28 is provided.
[0038]
  One end of the third line 23 is connected to a connecting branch connector 21 c provided on the first line 21. The third line 23 includes a second pump tube 23a, a foreign matter removing filter 23b, a bubble removing chamber 23c, and an anticoagulant container connecting needle 23d from the branch connector 21c side.
[0039]
  The plasma collection bag (third container) 25 is a container for collecting (storing) plasma (second blood component). The plasma collection bag 25 includes a first tube 25a and a second tube 25b. The first tube 25a is connected to the branch connector 25c, one branched tube is connected to the branch connector 21f, and the other branched tube is connected to the branch connector 26b. On the other hand, the second tube 25 b is connected to the branch connector 22 b of the second line 22. Thus, a plasma collection branch line for collecting plasma is constituted by the plasma collection bag 25 and the second tube 25b. A clamp is attached to each of the first tube 25a and the second tube 25b.
[0040]
  The platelet collection bag (second container) 26 is a container for collecting (storing) plasma containing platelets (first blood component) after passing through a leukocyte removal filter 261 described later. The platelet collection bag 26 includes a third tube 26a connected to a branch connector 26b for connecting the first tube 25a of the plasma bag 25 and the fifth tube 28b of the intermediate bag 28, and air in the bag via the tube 263a. And an air bag 262 for storing the air.
[0041]
  In the following description, plasma containing platelets (first blood component) is referred to as “rich platelet plasma”, and concentrated platelet plasma collected (stored) in the platelet collection bag 26 is referred to as “platelet preparation”. To tell.
[0042]
  Further, a leukocyte removal filter (cell separation filter) 261 for separating and removing leukocytes (predetermined cells) from the concentrated platelet plasma is installed in the middle of the third tube 26a. As the leukocyte removal filter 261, for example, in a casing having an inlet and an outlet at both ends, for example, a porous material such as a woven fabric, a nonwoven fabric, a mesh, or a foam made of a synthetic resin such as polypropylene, polyester, polyurethane, and polyamide. A material formed by inserting a filtration member in which one or two or more layers of a material is laminated can be used.
[0043]
  Thus, the 3rd tube 26a is comprised by the two tubes 261a and 262a. The tube 261a connects the branch connector 26b and the leukocyte removal filter 261, and the tube 262a connects the leukocyte removal filter 261 and the platelet (platelet preparation) collection bag 26. Thereby, the third tube 26a (tubes 261a and 262a), the leukocyte removal filter 261, and the platelet collection bag 26 constitute a branch line for collecting platelets for collecting platelets (platelet preparation). A clamp is attached to each of the tube 262a connecting the platelet collection bag 26 and the leukocyte removal filter 261 and the tube 263a connecting the platelet collection bag 26 and the air bag 262.
[0044]
  In this way, the first tube 25a of the plasma collection bag 25 is connected to the tube 261a located on the upstream side of the leukocyte removal filter 261 via the connection branch connector 26b. After separating and removing the plasma, the plasma in the plasma collection bag 25 can be supplied to the leukocyte removal filter 261, and the platelets remaining in the leukocyte removal filter 261 can be collected together with the plasma in the platelet collection bag 26. In other words, the plasma collection bag 25 has a line (first tube 25a) for supplying plasma to the leukocyte removal filter 261. Thereby, the plasma in the plasma collection bag 25 can be directly supplied to the branch line for collecting platelets without going through the multi-chamber bag 27.
[0045]
  The multi-chamber bag (blood bag) 27 is formed by integrally forming an intermediate bag (blood component storage part) 28 and an air bag (air storage part) 29. In the multi-chamber bag 27, as shown in FIG. 2, an intermediate bag 28 and an air bag 29 are completely partitioned by a partition wall 27a. By using such a multi-chamber bag 27, the number of bags is reduced, so that the circuit configuration is simplified and the circuit mounting process can be reduced. FIG. 2 is a plan view showing the configuration of the multi-chamber bag 27.
[0046]
  The intermediate bag 28 is a container for temporarily storing concentrated platelet plasma. The intermediate bag 28 includes a fourth tube 28a connected to the branch connector 25c and a fifth tube 28b connected to the branch connector 22b. On the other hand, the air bag 29 is a container for temporarily storing the air existing in the centrifuge 20 before blood collection. The airbag 29 includes a sixth tube 29a connected to the branch connector 22a.
[0047]
  These fourth to sixth tubes 28a, 28b, 29a are provided on one end side of the multi-chamber bag 27, and a suspension hole 27b is provided on the opposite end thereof. This prevents the tube from getting in the way when the multi-chamber bag 27 is attached to the apparatus. In addition, it is advantageous in terms of cost to arrange the tube below the bag.
[0048]
  Here, a modified example of the multi-chamber bag will be described. The multi-chamber bag 27 used in the present embodiment is a multi-chamber bag of the type in which the intermediate bag 28 and the air bag 29 are completely separated by the partition wall 27a but are not completely separated in this way. Also good. An example of this type of multi-chamber bag is shown in FIG. FIG. 3 is a plan view of the multi-chamber bag 37.
[0049]
  Similar to the multi-chamber bag 27, the multi-chamber bag 37 includes an intermediate bag 28 and an air bag 29, but the intermediate bag 28 and the air bag 29 are not completely separated by the partition wall 37a. That is, the communication part is formed above the multi-chamber bag 37 (the side that is the upper side when attached to the apparatus). In such a multi-chamber bag 37, when the bag is inverted, the concentrated platelet plasma may move into the airbag 29. However, in the circuit 1 according to the present embodiment, the multi-chamber bag 37 (27) is used while being fixed in the vertical direction, so that the concentrated platelet plasma does not move into the airbag 29. Further, one side of the multi-chamber bag 37 is the air bag 29, and air is temporarily stored, so there is no problem in use.
[0050]
  The size (height) H2 of the partition wall 37a is within a range of 40 to 95% (0.4 * H1 ≦ H2 ≦ 0.95 * H1) with respect to the longitudinal inner dimension H1 of the multi-chamber bag 37. Preferably, it may be within a range of 60 to 80% (06 * H1 ≦ H2 ≦ 0.8 * H1). Since the volume of the air storage portion can be increased by forming the partition wall 37 a and communicating the upper portion of the multi-chamber bag 37, the volume of the multi-chamber bag 37 is smaller than that of the multi-chamber bag 27. ing.
[0051]
  In the multi-chamber bag 37, the partition wall 37a is disposed at a position where the lateral dimension W1 of the intermediate bag 28 is larger than the lateral dimension W2 of the airbag 29 (W1> W2). Thereby, the multi-chamber bag 37 can be further reduced.
[0052]
  The multi-chamber bag 27, the leukocyte removal filter 261, and the platelet collection bag 26 are further placed at a position where the leukocyte removal filter 261 is lower than the multi-chamber bag 27 with the circuit 1 mounted on the blood component collection device. The collection bag 26 is set at a position lower than the leukocyte removal filter 261.
[0053]
  Here, each tube used for forming the above-described first to third lines 21 to 23, each pump tube 21g, 23a, and each tube 25a, 25b, 26a connected to each bag 25-27. , 28a, 28b and 29a are preferably polyvinyl chloride. If these tubes are made of polyvinyl chloride, sufficient flexibility and softness can be obtained, so that they are easy to handle and are suitable for clogging with a clamp or the like. In addition, as each pump tube 21g and 23a, what has the intensity | strength of the grade which is not damaged even if it presses with each liquid feeding pump (for example, roller pump etc.) is used.
[0054]
  Moreover, the same constituent material as each tube can be used also about the constituent material of each branch connector 21c, 21f, 22a, 22b, 25b, 26c mentioned above, respectively.
[0055]
  As the plasma collection bag 25, the platelet collection bag 26, and the multi-chamber bag 27, a flexible sheet material made of resin is laminated, and the peripheral portions thereof are fused (heat fusion, high frequency fusion, ultrasonic fusion). Or the like, or a bag-like one bonded with an adhesive or the like. As a material used for each bag 25, 26, 27, for example, soft polyvinyl chloride is preferably used.
[0056]
  In addition, as a sheet material used for the platelet collection bag 26, it is more preferable to use a material excellent in gas permeability in order to improve platelet storage stability. As such a sheet material, for example, polyolefin, DnDP plasticized polyvinyl chloride, or the like is used, and a sheet material of the above-described material is used without using such a material. What was thin (for example, about 0.1-0.5 mm, especially about 0.1-0.3 mm) is suitable. In addition, a platelet storage solution such as GAC, PAS, or PSM-1 may be placed in the platelet collection bag 26 in advance.
[0057]
  The main part of such a blood component collection circuit 1 is a cassette type as shown in FIG. That is, the blood component collection circuit 1 includes each line (first line 21, second line 22, third line 23) and each tube (first tube 25a, second tube 25b, third tube 26a, first tube 4 tube 28a, 5th tube 28b, 6th tube 29a) are partially accommodated, and they are hold | maintained partially, In other words, the main body cassette housing 31 to which they were partially fixed is provided. Each branch connector 21 f, 22 a, 22 b, 25 c, 26 b is housed in the main body cassette housing 31.
  This main cassette housing 31 has a multi-chamber bag 27 (first container) and a plasma collection bag 25 (third container) on one side, a leukocyte removal filter 261 (cell separation filter) and a platelet collection bag 26 (second container). Each line and each tube are held so that the container is divided into the other side.
[0058]
  As a result, the connecting portions of the tubes having the most complicated configuration in the circuit 1 are all accommodated in the main body cassette housing 31. Therefore, by providing the main body cassette housing 31, the circuit 1 can be easily attached to the apparatus without causing the tubes to be entangled with each other. That is, the mounting workability to the apparatus is further improved, and mounting errors can be reliably prevented.
[0059]
  Further, both ends of the first pump tube 21g and the both ends of the second pump tube 23a are fixed to the main body cassette housing 31, and these pump tubes 21g and 23a are respectively supplied from the main body cassette housing 31 with each liquid feed. It protrudes in a loop shape corresponding to the shape of a pump (for example, a roller pump). Thereby, the 1st and 2nd pump tubes 21g and 23a are easy to attach to each liquid feed pump, respectively, and workability is improved.
[0060]
  Furthermore, the main cassette housing 31 includes a plurality of openings located in the housing. And each tube is arrange | positioned on these opening parts. Thereby, when the main body cassette housing 31 is attached to the apparatus, each tube is set in a tube opening / closing device provided in the apparatus.
[0061]
  A procedure for mounting the blood component collection circuit 1 on the apparatus will be described. First, the main cassette housing 31 is set at a predetermined position on the apparatus side. Thereby, the tube set of the most complicated part in the circuit 1 can be performed very easily. Next, the centrifuge 20 is set in a centrifuge on the apparatus side. Next, each of the plasma collection bag 25, the platelet collection bag 26, and the multi-chamber bag 27 is set at a predetermined position. At this time, since the number of bags is reduced, the mounting process is reduced as compared with the conventional case. That is, the mounting workability is improved. Finally, the tubes 25a, 25b, 26a, 28a, 28b, and 29a connected to the tubes of the first to third lines 21 to 23 and the bags 25 to 27 are set at predetermined positions. The blood component collection circuit 1 can be attached to the apparatus by the above procedure.
[0062]
  In the blood component collecting circuit 1, since the number of bags is reduced and the main body cassette housing 31 is provided, no complicated mounting work is involved. The occurrence of mistakes can be reduced.
[0063]
  Thereafter, the platelet product is collected by executing the blood collection process, the plasma collection process, the plasma circulation process, the platelet collection process, and the blood return process by the apparatus equipped with the blood component collection circuit 1.
[0064]
  As described above, in the blood component collection circuit 1 according to the first embodiment as described in detail, since the multi-chamber bag 27 is provided, the number of bags conventionally required is reduced. As a result, the circuit configuration is simplified and the number of circuit mounting steps can be reduced, which facilitates handling. Therefore, it is possible to prevent a mounting error by the operator. As described above, the blood component collection circuit 1 can reduce the number of containers (bags) in the circuit, improve the workability of attachment to the apparatus, and reduce the occurrence of attachment mistakes.
[0065]
  In the multi-chamber bag 27, since the intermediate bag 28 and the air bag 29 are partitioned by providing the partition wall 27a, it can be easily manufactured and is advantageous in terms of cost. Further, the tubes 28a, 28b, 29a connected to the multi-chamber bag 27 are disposed on the lower end side when mounted on the blood component collection device, so that each tube 28a, 28b, 29a does not get in the way.
[0066]
  Further, the blood component collection circuit 1 has a main body cassette housing 31 that partially stores and holds each tube and each branch connector, so that each tube can be accurately connected only by mounting the main body cassette housing 31 to the apparatus. Can be placed in position. Thereby, the mounting workability to the apparatus is further improved, and the occurrence of mounting errors can be further reduced.
[0067]
(Second Embodiment)
  Next, a second embodiment will be described. The blood component collection circuit according to the second embodiment has almost the same basic configuration as that of the first embodiment, except that a filter cassette housing is newly provided. Therefore, in the following description, the same components as those in the first embodiment are denoted by the same reference numerals in the drawings, the description thereof will be omitted, and differences will be mainly described.
[0068]
  FIG. 4 shows the configuration of the blood component collection circuit according to the second embodiment. FIG. 4 is a circuit configuration diagram of the blood component collection circuit 1a. As shown in FIG. 4, the blood component collection circuit 1a is obtained by providing a filter cassette housing 32 to the blood component collection circuit 1 according to the first embodiment. The filter cassette housing 32 fixes the air trap chamber 21d and the leukocyte removal filter 261. Specifically, in the filter cassette housing 32, an air trap chamber 21d provided in the first line 21, a connection tube (Y-shaped tube) 262b of the leukocyte removal filter 261, a tube 261a and a tube 262a are integrated. Built in.
[0069]
  When such a blood component collection circuit 1a is attached to the apparatus, the main body cassette housing 31 and the filter cassette housing 32 are set at predetermined positions, and most of the attaching work of each tube is completed. . That is, by providing the filter cassette housing 32, the tubes 261a and 262a connected to the leukocyte removal filter 261 are bundled, and the position of the platelet collection bag 26 is fixed and the platelet collection bag 26 is not entangled with other circuit components. Can be mounted at an accurate position. Also, the air trap chamber 21d can be mounted at an accurate position without being entangled with other circuit components. Furthermore, the tube connected to the air trap chamber 21d can be accurately attached to the filter 21i.
[0070]
  According to the blood component collection circuit 1a according to the second embodiment as described above, since the above-described multi-chamber bag 27 is provided, it is the same as the blood component collection circuit according to the first embodiment described above. An effect can be obtained. Further, since the blood component collection circuit 1a is provided with the filter cassette housing 32, it is possible to greatly improve the mounting workability of the circuit and more reliably prevent the occurrence of mounting errors.
[0071]
  It should be noted that the above-described embodiment is merely an example and does not limit the present invention in any way, and various improvements and modifications can be made without departing from the scope of the invention. In the above-described embodiment, the circuit for collecting the platelet preparation is exemplified, but the present invention can be applied to a circuit for collecting other blood components.
[0072]
【The invention's effect】
  As described above, according to the blood component collection circuit of the present invention, in the blood component collection circuit that separates blood into a plurality of blood components by the centrifuge and collects the separated blood components, the flow of the centrifuge A first line through which blood flows into the inlet, a second line connected to the outlet of the centrifuge, and a first blood connected to the second line and separated by the centrifuge A blood component reservoir for temporarily storing the components;Connected to the second line;An air storage section for temporarily storing air existing in the centrifuge;A partition wall that divides the blood component reservoir and the air reservoir;A first container comprising: a cell separation filter connected to the first container for separating and removing predetermined cells from the first blood component; and connected to the cell separation filter, A second container for storing the first blood component after passing through the first container, and a second blood component connected to the first line and the second line and separated by the centrifuge Therefore, it is possible to reduce the number of containers (bags) in the circuit, to improve the mounting workability to the apparatus, and to reduce the occurrence of mounting errors.
[0073]
[Brief description of the drawings]
FIG. 1 is a circuit configuration diagram showing a blood component collection circuit according to a first embodiment.
FIG. 2 is a plan view showing a multi-chamber bag.
FIG. 3 is a plan view showing a multi-chamber bag according to another embodiment.
FIG. 4 is a circuit configuration diagram showing a blood component collection circuit according to a second embodiment.
FIG. 5 is a circuit configuration diagram showing a conventional blood component collection circuit.
[Explanation of symbols]
  1 Blood component collection circuit
  20 Centrifuge
  21 First line
  22 Second line
  25 Plasma collection bag
  26 Platelet collection bag
  27 Double room bag
  28 Intermediate bag
  29 Airbag
  261 Leukocyte removal filter

Claims (10)

In a blood component collection circuit that separates blood into a plurality of blood components by a centrifuge and collects the separated blood components,
A first line for flowing blood into the inlet of the centrifuge;
A second line connected to the outlet of the centrifuge;
A blood component reservoir for temporarily storing a first blood component separated by the centrifuge connected to the second line; and connected to the second line and present in the centrifuge A first container comprising: an air storage part that temporarily stores air; and a partition that partitions the blood component storage part and the air storage part;
A cell separation filter connected to the first container and separating and removing predetermined cells from the first blood component;
A second container connected to the cell separation filter and storing the first blood component after passing through the cell separation filter;
A third container connected to the first line and the second line and storing a second blood component separated by the centrifuge;
A blood component collecting circuit comprising: In the blood component collection circuit according to claim 1,
The blood component collection circuit according to claim 1, wherein a dimension of the partition wall is in a range of 40 to 95% with respect to a longitudinal inner dimension of the first container. In the blood component collecting circuit according to claim 1 or 2,
The blood component collecting circuit, wherein the partition wall is disposed at a position where a lateral dimension of the blood component reservoir is larger than a lateral dimension of the air reservoir. The blood component collection circuit according to any one of claims 1 to 3,
The blood component collection circuit, wherein the tube connected to the blood component storage part and the tube connected to the air storage part are arranged on one end side of the first container . The blood component collection circuit according to any one of claims 1 to 4,
The blood component collection circuit according to claim 1, wherein the tube connected to the first container is disposed on an end side which is a lower side when the tube is attached to the blood component collection device. The blood component collection circuit according to any one of claims 1 to 5,
The blood component collection circuit, wherein the third container has a line for supplying the second blood component to the cell separation filter. In the blood component collection circuit according to claim 1,
A main body cassette housing for partially storing and holding each tube connecting the first line, the second line, the first container, the second container, and the third container; The blood component collection circuit characterized by the above-mentioned. The blood component collection circuit according to claim 7,
The main body cassette housing holds the tubes on one side of the first container and the third container so as to partition the cell separation filter and the second container on the other side. Blood component collection circuit. In the blood component collecting circuit according to claim 1 or 6,
An air trap chamber for removing bubbles in the middle of the first line;
A blood component collection circuit comprising a filter cassette housing for fixing the air trap chamber and the cell separation filter. The blood component collection circuit according to claim 9,
The blood component collection circuit, wherein the filter cassette housing integrally incorporates the air trap chamber, a connection pipe of the cell separation filter, and an upstream tube and a downstream tube of the cell separation filter.

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