JP4235267B2 - Syringe - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention is a syringe provided with a liquid leakage prevention mechanism, and in particular, prevents leakage of liquid remaining in the bypass portion that causes the liquid in the rear second chamber divided by the intermediate sliding seal member to flow into the first chamber. It is related with the mechanism to do.
[0002]
[Prior art]
In a two-component prefilled syringe filled with a predetermined medicine and its solution or dispersion, or other chemical liquid, among disposable syringes pre-filled with medicine, so-called prefilled syringes, As shown in FIG. 10, the end seal member 32 is inserted from the rear end opening side in the cylindrical container 31 having the injection needle mounting portion at the distal end portion, and slides in the axial direction into the container 31. A possible intermediate seal member 33 is provided and divided into a first chamber 34 on the front end side and a second chamber 35 on the rear end side. Each chamber contains a drug P, a solution L, etc. There is a structure sealed with a cap 37 (Japanese Patent Publication No. 49-14465).
[0003]
In this type, in the first chamber 34 on the distal end side of the intermediate sliding seal member 33, the side wall of the container 31 is provided with a bypass portion, usually a bypass groove 36 that protrudes outward. By pushing the seal member 32 with a rod, the intermediate seal member 33 is advanced together with the liquid L in the second chamber 35 as shown in FIG. 11, and when the intermediate seal member 33 reaches the bypass groove 36, the groove 36 is formed. Then, the liquid L in the second chamber 35 is caused to flow into the first chamber 34, and thereafter, the intermediate seal member 33 is pressed at the tip of the end seal member 32 as shown in FIG. After dissolution, dispersion, or mixing, the liquid is pushed out from the tip.
[0004]
At this time, since the end seal member passes through the bypass portion, the liquid remaining in the bypass portion leaks behind the end seal member. For this reason, Japanese Patent Laid-Open No. 62-14863 proposes a mechanism in which a partition plate is provided behind the end seal member to prevent the liquid from leaking out of the syringe.
[0005]
[Problems to be solved by the invention]
However, in such a method, chemicals with low viscosity and chemicals with low surface tension may pass through the gap between the partition plate provided on the rod and the inner wall of the container, and when the rod is removed from the container for waste disposal There is a risk that the chemical stored in the diaphragm will be scattered.
Therefore, the present invention provides a syringe equipped with a leakage preventing mechanism that does not pass through a gap with the inner wall of the container or separates the liquid stored in the partition plate when the rod is removed from the container for separation and disposal. The purpose is to do.
[0006]
[Means for Solving the Problems]
The present invention achieves the above object by developing a leakage prevention mechanism having not only a function of blocking the partition plate but also a liquid retention function. A cylindrical container having a rear end opening inserted and sealed by an end sliding seal member positioned at the front end thereof includes at least one intermediate sliding seal member for dividing the inside of the container in the longitudinal direction, A bypass portion formed in the container wall ahead of the initial position of the intermediate sliding seal member and extending in the longitudinal direction longer than the thickness of the intermediate sliding seal member, and the intermediate sliding seal member via the bypass portion A syringe that causes the rear chamber fluid to flow into the front chamber of
The syringe is characterized in that a liquid absorption mechanism capable of absorbing and holding liquid is provided behind the end sliding seal member.
In the present invention, “behind the end sliding seal member” is used to mean including the seal member and all parts behind the syringe, and the liquid absorbing mechanism is used to slide the end slide of the rod end. In addition to the case where the moving seal member is provided in close contact with or behind the moving seal member, the moving seal member includes a case where the rear end opening of the cylindrical container is fitted and sealed.
[0007]
[Operation and effect of the invention]
According to the first application example of the present invention, the liquid is divided into a front chamber and a rear chamber with the intermediate sliding seal member as a boundary, and a predetermined medicine is mixed in the front chamber and a medicine is mixed in the rear chamber. However, the rear end opening side of the rear chamber containing the liquid is closed by inserting an end sliding seal member pressed by the tip of the rod, and the end sliding seal member is closed by the rod. When pressed forward, the intermediate sliding seal member is driven and displaced forward to the bypass area, and causes the rear chamber liquid to flow into the front chamber via the bypass section. When a part or the whole of the end sliding seal member passes the bypass portion, the liquid flowing out behind the end sliding seal member is absorbed and held by the liquid absorption mechanism, so that the liquid leaks to the outside of the injection container. In addition, the chemical solution can be prevented from being dispersed even if the rod after use is removed at the time of disposal.
In general, the injection container is transparent, and if it is simply shielded, the residual liquid can be seen from the outside, giving an anxiety of leakage. However, if it is absorbed and retained, the liquid itself is securely retained. There is no such anxiety.
In particular, when the liquid absorbing material is impregnated with a water retention / absorbing agent, even if there is a clearance between the liquid absorbing material and the inner wall of the syringe, the liquid absorbing retention effect can be achieved completely.
In addition, although the liquid-absorbing material is easy to propagate microorganisms due to its nature, it can contain an antibacterial agent simultaneously with the water-holding / liquid-absorbing agent or alone, thereby preventing the growth of microorganisms that are likely to occur in the liquid-absorbing material. It is possible to improve safety at the time of sorting and disposal.
[0008]
DETAILED DESCRIPTION OF THE INVENTION
The liquid absorbing mechanism M may be provided integrally or detachably in close contact with or spaced from an end sliding seal member which is generally provided integrally or detachably at the tip of the rod. Good. Accordingly, as shown in FIG. 13, a slidable disc-shaped liquid absorbing material D made of a resin such as filter paper having a liquid absorbing function, nylon felt or cotton nonwoven fabric, yarn or woven fabric, or a water-absorbing polymer is used as a rod. 2 is configured to be attached to the tip. As shown in FIGS. 14 and 15, the mounting method is such that the tip protrusion 2a of the rod 2 is threaded, while a screw hole H is provided at the center of the disc-shaped liquid absorbing material D and screwed into the groove 2b. Alternatively, as shown in FIGS. 16 and 17, a twist lock is provided at the tip projecting portion 2a ′ of the rod 2, while a twist hole H ′ is provided at the center of the disc-like liquid absorbing material D, and twisted and screwed into the groove 2b. Can be fitted. In addition, the disk-shaped liquid absorbing material D can be laminated | stacked or arrange | positioned at intervals. On the other hand, the liquid absorbing mechanism M is separated from the end sliding seal member that slides in the cylindrical container by the rod 2 and is fitted to seal the rear end opening of the cylindrical container, and is kept in that position. You may do it. In this case, as shown in FIG. 25, a through hole h of the rod 2 is provided at the center of the disc-like liquid absorbing stopper member S similar to the above D, and the rear end opening of the cylindrical container behind the end sliding seal member 3c is provided. The stopper 2 may be fixed by fitting it into 1b, passing the tip of the rod 2 forward from the through hole h and screwing it to the rear end of the end sliding seal member 3c. As shown in FIG. 3, the liquid absorbing mechanism M fits the stopper member S into a finger grip 100 that can be fitted on the outer periphery of the rear end 1b of the cylindrical container, and the finger grip 100 is attached to open the rear end of the cylindrical container. May be kept to block. The liquid absorbing mechanism M includes a first sliding liquid absorbing mechanism represented by a liquid absorbing material D that slides in the cylindrical container together with the end sliding seal member 3c and the rear end of the cylindrical container. It is also possible to form a combination of both of the second liquid absorption mechanisms represented by the liquid absorption stopper member S that can be retained in the area.
[0009]
Further, as shown in FIG. 18, the liquid absorbing mechanism M is configured to wind a fiber in the form of filter paper, cloth, yarn, or nonwoven fabric around the winding groove 2c formed at the tip of the rod 2, or a water-absorbing polymer or the like. It can be formed by applying a resin (see FIG. 19). In FIG. 19, the wire is wound only at the tip, but it may be wound so as to extend in the longitudinal direction of the rod. In addition, since the outer shape of the liquid-absorbing material defines a gap with the syringe inner wall, the surface gap and the viscosity of the liquid are taken into consideration, and the gap is 0. It can be as small as 2 to 1.0 mm and as large as 0.2 to 1.5 mm when the surface tension is relatively large such as water.
[0010]
Although the liquid absorption mechanism M has shown the liquid absorption performance by the material, it may be absorbed by the capillary phenomenon of the annular or spiral liquid absorption groove C provided at the tip of the rod 2 shown in FIG. . Further, as shown in FIG. 21, a plurality of discs 2e may be laminated in parallel behind the disc 2d at the tip of the rod 2 to form a groove. Also in this case, it is preferable to determine the groove width and depth in consideration of the viscosity and surface tension of the liquid to be absorbed.
[0011]
Further, as shown in FIG. 22, the liquid absorbing mechanism M may be a cylindrical liquid absorbing material R that can slide the cylindrical container, and may be detachably attached to the tip of the rod 2. Specifically, a screw portion to which the end seal member 3c is screwed is projected at the tip 20a of the rod 2, and four shallow grooves for preventing the liquid absorbent R from rotating are formed around the screw portion. In the meantime, four protrusions are formed to prevent the liquid absorbing material R from coming off. The radius of the tip portion 20a is slightly larger than the hole diameter of the liquid absorbing material R. Reference numeral 20b denotes an extruded portion of the rod 2. In this case, as shown in FIG. 23, the cylindrical liquid-absorbing material R is longer in the traveling direction than the disc-shaped liquid-absorbing material D (see FIG. 15). Even if the drop timing of the liquid is slightly delayed, the liquid can be sufficiently retained. Usually, the total length is preferably 10 mm or more. When the end-sliding seal member is pushed to the end, the cylindrical liquid absorbing material R is usually pushed forward beyond the bypass portion, but the rear end blocks the bypass portion and remains as shown in FIG. If this is done, the effect of preventing leakage of the residual liquid is great.
[0012]
The liquid absorbent material is preferably selected from the group consisting of polyvinyl formal, polyester fiber, pulp, polyester resin containing pulp, polyester fiber containing acetate fiber, acetate fiber, cellulose sponge, and polyvinyl alcohol sponge. . The liquid absorbent material is preferably impregnated with a water retention / absorption enhancer that promotes the liquid absorption function. The water retention / liquid absorption accelerator is glycerin, propylene glycol, polyethylene glycol, D-sorbitol, polyoxyethylene cetyl. The liquid-absorbing material is immersed and impregnated in a liquid selected from the group consisting of ether and benzyl alcohol and contained in a medium such as water in an amount of 1 to 30% by weight. At that time, a surfactant such as polysorbate 80 may be added in combination.
[0013]
The liquid absorbing material preferably contains an antibacterial agent. The antibacterial agent is selected from benzalkonium chloride, benzethonium chloride, dodecyldiaminoethylglycine, dodecyldimethylbenzylammonium chloride, polyhexamethylene biguanide and alkyldiaminoethylglycine hydrochloride, and the amount of impregnation is adjusted according to the use environment.
[0014]
When the solvent liquid which dissolves or disperse | distributes the said chemical | medical agent is colored, it is good for the said liquid absorbing material to color it, and to make a liquid absorption trace visible from the syringe exterior. Colorants include asenyakutannin powder, indigo carmine, turmeric extract, methyl rosaniline chloride, yellow iron oxide, yellow iron sesquioxide, Opalx AS-6178 (trade name of Nippon Colorcon), carbon black, color paste 1, color paste 2, Color paste 3 (Nippon Colorcon company name), caramel, carmine, β-carotene, carotene solution, gold foil, black iron oxide, bucket, zinc oxide, titanium oxide, iron sesquioxide, disazo yellow, edible yellow No. 4, Food Yellow No. 5, Food Blue No. 1, Food Yellow No. 4 Aluminum Lake, Food Red No. 102, Food Red No. 2, Food Red No. 3, Zein, Solar Caramel, Copper Chlorophyllin Sodium, Copper Chlorophyll, Phenol Red, Matcher, Myristin Octyldodecyl acid, methylene blue, medicinal charcoal, ribobutyrate Rabin, riboflavin, green tea powder, ammonium manganese phosphate, riboflavin sodium phosphate, rose oil.
[0015]
Moreover, when the said chemical | medical agent or its solvent liquid has pharmacological activity, it is necessary to deactivate it when discarding the said liquid absorbing material. In that case, it is preferable to contain a quencher. Specific examples of the quenching agent include ethanol, methanol, hydrogen peroxide, sodium hypochlorite, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, sodium bicarbonate, sodium carbonate, boric acid, sulfuric acid At least one of phosphoric acid, trisodium phosphate, disodium phosphate, tripotassium phosphate, dipotassium phosphate, hydrochloric acid, lactic acid, aqueous ammonia, mercury and the like is used.
[0016]
If the liquid absorbent material has substantially no clearance between the outer periphery and the inner wall of the syringe, the leakage preventing effect is greater. However, if the clearance is provided, the slidability of the liquid absorbent material is improved, and the separation and disposal are easy. . Moreover, when it has a finger grip at the rear end of the syringe, it is necessary to provide a clearance depending on its shape. When the liquid absorbent material has a clearance between the outer periphery and the syringe inner wall, the liquid absorption rate of the residual liquid is slightly reduced, but the liquid absorption rate is increased to 100% by containing the water retention / liquid absorption accelerator. Can be improved.
[0017]
The syringe according to the present invention can be applied to the following forms. The liquid absorption mechanism is indicated by M in each drawing. Since the operation mechanism is the same as described above, the description thereof is omitted.
FIG. 1 is a cross-sectional view showing a basic configuration of an embodiment of the present invention.
The cylindrical container 1 has a uniform cylindrical shape as a whole except for a bypass groove 6 that forms a bypass portion described later, and both ends thereof are fully opened.
[0018]
An end sliding seal member 3C to which a rod 2 is attached is inserted from the rear end side of the cylindrical container 1, and the container 1 is partitioned into a first chamber 4 and a second chamber 5 inside thereof. Although the sliding seal member 3 is inserted, the sliding seal member 3 is divided into two parts, a front side sliding seal member 3a and a rear side sliding seal member 3b. The front side sliding seal member 3a and the rear side sliding seal member 3b may be in contact with each other, or may have a predetermined gap as shown. For the purpose of providing such a gap, an appropriate protrusion may be formed on at least one of the mutually opposing surfaces of the front sliding seal member 3a and the rear sliding seal member 3b.
[0019]
A seal member 7 is attached to the distal end opening 1 a of the cylindrical container 1. At the tip of the cylindrical container 1, for example, a cap with a needle is attached at the time of administration of an injection solution to be described later, or a double-ended needle is attached through a holding member and the rear end is inserted into the seal member 7. The injection needle is attached by a known means of passing through.
[0020]
The first chamber 4 is filled with the powdered medicine P, and the second chamber 5 is filled with a solution or dispersion thereof, or various kinds of chemical liquids L, and the first chamber 4 of the cylindrical container 1 is filled. A bypass groove 6 protruding outward with a predetermined width is formed on the side wall, and the length of the bypass groove 6 in the axial direction of the container 1 is determined by the front side sliding seal member 3a and the rear side sliding seal. It is longer than the total thickness of the members 3b by a predetermined amount. Furthermore, the total length in the axial direction of the sliding seal members 3a and 3b and the end seal member 3c is set to be longer than the axial length of the bypass groove 6 by a predetermined amount. This length can be easily adjusted by adjusting the length of the end sliding seal member 3c.
[0021]
When the embodiment of the present invention having the above-described configuration is used, the second chamber 5 is pressed by pressing an end sliding seal member 3c (hereinafter referred to as a plunger) to which the rod 2 is mounted as in the conventional case. Both the front side sliding seal member 3a and the rear side sliding seal member 3b move forward via the liquid L inside, and these reach the formation position of the bypass groove 6 so that the first chamber 4 and the second chamber 5 communicate with each other. At that time, the liquid L in the second chamber 5 flows into the first chamber 4, and after the inflow is completed, the end of the end seal member 3c comes into contact with the rear end of the rear side sliding seal member 3b. Directly press this to advance the front and rear sliding seal members 3a and 3b, at least the first half of the front sliding seal member 3a reaches the front of the tip of the bypass groove 6, and At least the second half of the plunger seal member 3c The pressing is stopped at a position where the inner wall of the cylindrical container 1 is held in a sliding state without reaching the ipass groove 6, and after mixing the drug by shaking the cylindrical container 1, The dissolved, dispersed or mixed injection solution is ejected through the attached injection needle. At this time, the liquid leakage prevention mechanism M absorbs and holds the residual liquid in the bypass groove.
[0022]
Next, FIG. 2 shows a procedure for assembling the syringe main body including filling of the powder medicine, the solution, etc. in the embodiment of the present invention as described above.
First, as shown in (A), in the state where the rear side sliding seal member 3b is inserted into the cylindrical container 1, the second chamber 5 is filled with a solution, a dispersion or a chemical solution L, and end seals are made. The member 3c is inserted. In this state, after steam sterilization is performed on the solution, dispersion or chemical L, the inner surface of the first chamber 4 is dried. In the steam heat sterilization treatment here, when the solution, dispersion liquid or chemical liquid L in the second chamber 5 contains an active substance, the temperature does not destroy the active substance, for example, a temperature of 50 to 60 ° C. or less. To process.
[0023]
Thereafter, as shown in (B), the front side sliding seal member 3a is inserted from the front end opening 1a of the cylindrical container 1 in a sufficiently dried state, and is brought into close contact with the rear side sliding seal member 3b. Alternatively, a slight gap is provided to make it approach. In this state, after filling the powder medicine P in the first chamber 4 from the tip opening 1a, the fixed seal member 7 is attached to the tip opening 1a to obtain the two-component prefilled syringe having the structure shown in FIG. . In this case, the rod 2 may be attached from the beginning or attached later.
[0024]
In the assembly procedure as described above, moisture adheres or permeates into the rear sliding seal member 3b during the steam heat sterilization of the solution, dispersion or chemical liquid L in the second chamber 5, but this steam heat sterilization is performed. Further, by inserting the dry front sliding seal member 3a after the drying / cooling step and then filling the powder medicine P into the first chamber 4, it is possible to prevent moisture from moving to the powder medicine P side. .
[0025]
Further, when a structure is provided in which gaps are provided between the front and rear sliding seal members 3a and 3b, moisture from the second chamber 5 side passes through the rear sliding seal member 3b in the storage state after assembly. Thus, the time required to enter the front side sliding seal member 3a is increased, and the period until moisture reaches the medicine on the first chamber 4 side can be increased.
[0026]
As described above, the two-component prefilled syringe according to the present invention is used in a state where the injection needle is attached to the tip of the cylindrical container 1. Hereinafter, the injection needle mounting mechanism and the cylindrical container will be described. A more specific configuration example of the seal member 7 and the sliding seal member 3a of the front end opening 1a will be described.
[0027]
【Example】
FIG. 3 is a cross-sectional view showing an example in which a sliding type member is used as the seal member 7 inserted into the distal end opening of the cylindrical container 1.
In this example, a cap 8 with a needle is attached to the tip of the cylindrical container 1. The cap 8 with a needle has an injection needle 82 fixed to the tip of a cup-shaped cap body 81, and the inner periphery of the body 81. Has a structure in which a groove 81 a communicating with the injection needle 82 is formed. Further, the main body 81 has a gap 81b protruding from the front end opening 1a of the cylindrical container 1 to the front end side by a predetermined length so that the seal member 7 can enter therein.
[0028]
In such a configuration, when the plunger is pressed during use, the solution or dispersion liquid in the second chamber 5 or another kind of chemical solution flows into the first chamber 4 through the bypass groove 6, or the inflow is completed. Then, as shown in FIG. 4, the seal member 7 moves into the gap of the main body 81 of the cap 8 with the needle. When the plunger is further pressed in this state, the injected solution dispersed or dissolved in the first chamber 4 enters the injection needle 82 via the groove 81a formed in the main body 81 of the needle-equipped cap 8, and is injected. It can be done. In addition, the cap 8 with a needle | hook may be either the thing attached to the injection needle 81 at the time of administration, or the structure already attached before that.
[0029]
In place of the above structure, the seal member 7 is disposed inside the container 1 at a distance from the tip of the cylindrical container 1, and the liquid in the second chamber 5 is moved into the first chamber 4 by pressing the plunger 3 c. When the inflow is completed, the sealing member 7 may be configured to remain at the tip portion of the cylindrical container 1. By doing so, coupled with the function of the locking mechanism described later, the front and rear in the first chamber 4 are completely sealed, so that no liquid leaks from anywhere even if the container 1 is vibrated during dissolution and dispersion.
[0030]
FIG. 5 is a sectional view showing an example in which a non-movable type seal member 7 is used. In this type, a cap 9 that also serves as a needle holding member is attached to the distal end portion of the cylindrical container 1, and the double-ended needle 10 is inserted to a predetermined position via the cap 9, thereby the rear end portion of the double-ended needle 10. Is structured so as to penetrate the seal member 7 and protrude into the first chamber 4.
[0031]
In this structure, when the double-ended needle 10 is attached, the needle immediately communicates with the first chamber 4 and the injection solution dissolved or dispersed in the first chamber 4 is directly injected through the double-ended needle 10 as described above. be able to.
[0032]
In the system using the double-ended needle 10, the rear end portion of the needle 10 penetrates the seal member 7 and enters the first chamber 4, so that the first chamber 4 of the seal member 7 as shown in FIG. By forming the depression 7a capable of accommodating the protrusion of the needle on the side end face, the amount of injection solution (loss amount) remaining in the cylindrical container 1 at the time of administration can be reduced.
[0033]
Now, in the two-component prefilled syringe, prior to actual administration, the plunger L is pressed so that the liquid L in the second chamber 5 is changed into the first chamber 4 so that the two components are uniformly dissolved, dispersed or mixed in the first chamber 4. It is necessary to stop the plunger and shake the syringe well in such a state that the plunger 1 has almost completely flowed into the chamber 4 and has not yet flowed out of the tip of the container 1. In addition, during this vibration application operation, the dissolved liquid or dispersion liquid that has moved into the first chamber 4 flows back through the bypass groove 6 and passes through the inside of the original second chamber 5, that is, beyond the plunger seal member 3c. In order not to flow out to the rear part of the container 1, the plunger is temporarily stopped at an optimum position.
After the above operation, when the plunger 3c is further advanced, the chemical solution is injected through the needle 82. When the rear end of the plunger seal member 3c begins to pass through the bypass groove 6, the liquid remaining in the bypass groove 6 leaks backward. In the present invention, a leakage preventing mechanism M is provided at the rear end of the seal member 3c of the plunger.
[0034]
6 to 7 show an embodiment in which such an operation is simplified.
In the example shown in FIG. 6, a convex portion 101 that protrudes in a circumferential manner to the inner side of the inner peripheral surface of the cylindrical container 1 is provided on the inner peripheral surface of the finger grip 100 attached to the rear end portion of the cylindrical container 1. The rod 2 is formed with a plurality of protrusions 201 on the same circumference at a predetermined position in the axial direction. The positions of the protrusions 201 on the axial direction of the rod 2 are such that the front end surface of the front side sliding seal member 3a reaches the front side from the front end portion of the bypass groove 6 and the rear side slides. The rear end surface of the seal member 3b comes into contact with the front end surface of the seal member of the plunger 3c, and further, the rear half of the seal member 3c of the plunger does not reach the bypass groove 6 and keeps sliding with the inner wall of the cylindrical container 1. In the state where the protrusion 201 is in contact with the convex portion 101 of the finger grip 100, the distance between the central axis of the rod 2 and the tip of each protrusion is based on the inner diameter of the convex portion 101 of the finger grip 100. Is also slightly larger. Furthermore, the finger grip 100 is made of a flexible material such as synthetic resin.
[0035]
According to the above configuration, when the rod 2 is pushed in from the non-use state of FIG. 6 (A), the front side sliding seal member 3a moves to the tip of the bypass groove 6 as shown in FIG. The rod 2 and the seal member 3c are temporarily stopped by the resistance caused by the protrusion 201 coming into contact with the convex portion 101 as shown in FIG. In this state, the liquid in the second chamber 5 is completely injected into the first chamber 4, and both the front end and the rear end of the bypass groove 6 are closed so that the backflow and loss of the liquid are completely prevented. In this state, the syringe is shaken to uniformly dissolve, disperse or mix the two components. Thereafter, when the rod 2 is pushed strongly, the finger grip 100 is bent and the projection 201 passes through the convex portion 101, so that the injection solution after dissolution, dispersion or mixing can be administered to the living body.
[0036]
On the other hand, in the example shown in FIG. 7, a convex portion 101 is formed in the same manner on the inner peripheral surface of the finger grip 100 attached to the rear end portion of the cylindrical container 1. As shown in FIG. 5, a plurality of notch grooves 102 are formed, and the same number of blades 202 are formed on the rod 2. The distance from the center of the rod 2 to the tip of each blade 202 is larger than the inner diameter dimension of the convex portion 101 of the finger grip 100 and more than the distance between the center of the finger grip 100 and the bottom surface of each notch groove 102. It is shortened. Further, the end face position on the front end side of each blade 202 is such that the front end face of the front side sliding seal member 3a reaches the front side from the front end portion of the bypass groove 6 by pressing of the plunger, and the rear end face of the rear side seal member 3b. And the distal end surface of the plunger seal member 3c are in contact with each other, and the latter half of the plunger seal member 3c does not reach the bypass groove 6 and remains in a sliding state with respect to the inner wall of the container 1. The position 202 is in contact with the rear end surface of the finger grip 100.
[0037]
In the above configuration, in the state before use shown in (A), the rod 2 is in a state in which each blade 202 does not coincide with the formation position of the notch groove 102 of the finger grip 100 as shown in (C). Then, it is inserted into the cylindrical container 1. In use, the plunger is first pushed in the state of (C). As a result, while the liquid moves, the front side sliding seal member 3a is stopped at the tip of the bypass groove 6 as shown in (D), but when pushed further, as shown in (E), the blade 202 is moved to the finger grip. The plunger stops when it contacts the rear end surface of 100. In this state, as described above, the liquid in the second chamber 5 is completely injected into the first chamber 4 and is prevented from flowing back through the bypass groove 6, so that the syringe is shaken in that state. The two components are uniformly dissolved, dispersed or mixed. Thereafter, when the rod 2 is rotated so that each blade 202 is aligned with the position where each notch groove 102 is formed, the entire rod can be pushed in as shown in (F). Therefore, injection after dissolution, dispersion, or mixing The liquid can be injected into the living body.
[0038]
In addition, without adopting the structure shown in FIG. 6 or FIG. 7 as described above, a cylindrical container at a predetermined position ahead of the tip of the bypass groove 6, for example, about 2 mm ahead of the tip of the bypass groove 6. It is also effective to simply provide a line-shaped mark along the circumferential direction on the outer periphery or inner peripheral surface of 1. That is, when the plunger is pressed so that the front end surface of the front sliding seal member 3a does not exceed the mark, the liquid in the second chamber 5 is almost completely injected into the first chamber 4. What is necessary is just to shake a syringe in the state.
[0039]
By the way, in each of the above-described embodiments, each of the sliding seal members 3a and 3b on the front side and the rear side, or the plunger 3c has a plurality of ribs protruding circumferentially on its outer peripheral surface, that is, a plurality of circular shapes. As a structure having a rib, the liquid tightness between the first chamber 4 and the second chamber 5 or the liquid tightness between the second chamber 5 and the outside of the container 1 is maintained, and the sliding property in the container 1 is good. Is considered to be. In such a structure, when each sliding seal member 3a, 3b or seal member 3c passes through the bypass groove 6 due to the pressure of the rod 2, the liquid accumulated in the bypass groove 6 is transferred to each seal member 3a, 3b. Or, it enters the annular recess formed between the circular ribs of the seal member 3c of the plunger, and the injection solution is not administered by that amount, resulting in a loss. In order to solve this, it is conceivable to make the recess shallow enough not to impede the slidability of the seal member, but measures for further reducing the loss will be described below.
[0040]
FIG. 8 shows a cross-sectional view of an embodiment in which the countermeasure is taken.
A plurality of circular ribs 300 are formed on the front side sliding seal member 3a, the rear side sliding seal member 3b, and the end seal member 3c, respectively. A plurality of vertical ribs 301 having a height are formed, and the vertical ribs 301 divide the gaps formed between the circular ribs 300 into a plurality of small gaps.
[0041]
In this example, four vertical ribs 301 are formed in each gap at positions where the outer circumferences of the respective seal members 3a, 3b and 3c are divided into four equal parts, whereby each gap between the circular ribs 300 is formed. Each is divided into four equal parts (see FIG. 9).
[0042]
By adopting such a configuration, when the front side sliding seal member 3a, the rear side sliding seal member 3b, and the plunger 3c pass through the bypass groove 6 due to the pressing of the plunger, each injection solution passes through the bypass groove 6. Of the gaps between the circular ribs 300, the gaps enter any of the small gaps partitioned by the vertical ribs 301, but cannot enter the adjacent small gaps due to the presence of the vertical ribs 301. Compared with the case where only 300 is provided, the injection solution remaining in the gap of each seal member is reduced to about ¼.
[0043]
In addition, the number of the vertical ribs 301 provided in each gap between the circular ribs 300 is not limited to four, and can be an arbitrary number of two or more. As the number increases, the loss amount of the injection solution decreases. However, since the slidability of each seal member is lowered accordingly, it is desirable that the number of seal members be an appropriate number in consideration of these factors. Further, the vertical rib 301 may be formed only on the sliding seal members 3a and 3b on the front side and the rear side.
[0044]
In addition, the front and rear sliding seal members 3a and 3b and the circular ribs 300 and the vertical ribs 301 of the plunger 3c are linearly formed along the inner wall surface of the cylindrical container 1 as shown in the figure. In addition, in order to further reduce the frictional resistance with the cylindrical container 1, a so-called crowning shape in which a curved bulge is appropriately provided in the axial direction can be used.
[0045]
Moreover, as the said liquid absorption mechanism M, as shown in FIG. 22, the cylindrical liquid absorption material R which can slide the said cylindrical container may be comprised, and it may be detachably mounted | worn with the front-end | tip part of the said rod. This liquid absorbent material R is a material sheet selected from the group consisting of polyvinyl formal, polyester fiber, pulp, polyester resin containing pulp, polyester fiber containing acetate fiber, acetate fiber, cellulose sponge, glycerin, propylene Manufactured by dipping and impregnating in a water retention / absorption promoter-containing liquid selected from the group consisting of glycol, polyethylene glycol, D-sorbitol, polyoxyethylene cetyl ether, and benzyl alcohol, and punching it into a predetermined shape. . Moreover, it is good also as a cylindrical shape by superimposing the said disk shaped liquid absorbing material D (refer FIG. 15). The liquid absorbing material is impregnated with an antibacterial agent selected from benzalkonium chloride, benzethonium chloride, dodecyldiaminoethylglycine, dodecyldimethylbenzylammonium chloride, polyhexamethylene biguanide, cetylbiridinium chloride and alkyldiaminoethylglycine hydrochloride. is there.
[0046]
In this case, as shown in FIG. 23, the cylindrical liquid-absorbing material R is longer in the traveling direction than the disc-shaped liquid-absorbing material D (see FIG. 15) (normally, the total length is 10 mm or more). Even when the fall timing of the residual liquid is slightly delayed when passing through the bypass passage, the liquid can be sufficiently retained. When the plunger 3c is pushed down to the end, the cylindrical liquid absorbent R is usually pushed forward beyond the bypass groove. In particular, as shown in FIG. 24, if the rear end of the cylindrical liquid absorbent R remains beyond the bypass groove. Great effect of preventing leakage of residual liquid. In the figure, the same members as those in FIG.
[Brief description of the drawings]
FIG. 1 is a sectional view showing a basic configuration of an embodiment of the present invention.
FIG. 2 is an explanatory diagram of an assembly process of a syringe body including filling of the medicine and the like.
FIG. 3 is a cross-sectional view showing the configuration of a specific embodiment of the present invention in the case where a sliding type seal member is used at the tip opening of a cylindrical container.
FIG. 4 is a diagram for explaining the operation when the example of FIG. 3 is used.
FIG. 5 is a cross-sectional view showing the configuration of another embodiment of the present invention when a non-movable type seal member is used at the distal end opening of a cylindrical container and a double-ended needle is used as an injection needle.
FIG. 6 is an explanatory diagram of an example of a locking mechanism between the rod 2 and the cylindrical container 1 and a release mechanism thereof in the present invention.
FIG. 7 is also an explanatory view of an example of a release mechanism about the locking mechanism between the rod 2 and the cylindrical container 1 in the present invention.
FIG. 8 is a cross-sectional view showing an example in which measures are taken to reduce the dose loss of the injection solution in the two-component prefilled syringe of the present invention.
FIG. 9 is an external perspective view of the seal members 3a, 3b and 3c.
FIG. 10 is a cross-sectional view showing a configuration of a conventional two-component prefilled syringe.
FIG. 11 is an explanatory diagram of the first work.
FIG. 12 is a diagram illustrating the second work.
FIG. 13 is a schematic view showing the arrangement of the first embodiment of the leakage preventing mechanism used in the present invention.
FIG. 14 is a side view showing a first attachment mechanism of the first embodiment.
FIG. 15 is a front view showing a first attachment mechanism of the first embodiment.
FIG. 16 is a side view showing a second attachment mechanism of the first embodiment.
FIG. 17 is a front view showing a second attachment mechanism of the first embodiment.
FIG. 18 is a side view showing the attachment mechanism of the second embodiment.
FIG. 19 is a schematic view showing the arrangement of a second embodiment of the leakage preventing mechanism used in the present invention.
FIG. 20 is a schematic view showing the arrangement of a third embodiment of the leakage preventing mechanism used in the present invention.
FIG. 21 is a schematic view showing a modification of the third embodiment of the liquid leakage preventing mechanism used in the present invention.
FIG. 22 is a perspective view showing a fourth embodiment of the liquid leakage preventing mechanism used in the present invention.
FIG. 23 is a cross-sectional side view showing a pushed state of the first form of the fourth embodiment of the liquid leakage preventing mechanism used in the present invention.
FIG. 24 is a cross-sectional side view showing a pushed state of a second form of the fourth embodiment of the liquid leakage preventing mechanism used in the present invention.
FIG. 25 is a sectional side view of a syringe using a first liquid absorption stopper member as a liquid leakage preventing mechanism used in the present invention.
FIG. 26 is a cross-sectional side view of a syringe using a second liquid absorbing stopper member as a liquid leakage preventing mechanism used in the present invention.
[Explanation of symbols]
1 cylindrical container
1a Tip opening
100 finger grip
101 protrusion
102 Notch
2 Rod
201 Convex
202 blades
3 Intermediate sliding seal member
3a Front side sliding seal member
3b Rear sliding seal member
3c End sliding seal member
300 round ribs
301 Vertical rib
4 Room 1
5 Room 2
6 Bypass groove
7 Seal member
7a hollow
8 Needle cap
81 Cap body
81a groove
81b gap
82 Injection needle
9 Cap
10 Double-headed needle
Drugs such as P powder
L Dissolution, dispersion or other chemicals
M liquid absorption mechanism
D Disk-shaped absorbent material
R Cylindrical liquid absorbing material
S Absorption stopper member.

Claims (23)

A cylindrical container having a front end opening portion to which the injection needle is attached and a rear end opening in which a rod is inserted and sealed by an end sliding seal member positioned at the front end divides the inside of the container in the longitudinal direction. At least one intermediate sliding seal member, and a bypass portion formed in the container wall ahead of the initial position of the intermediate sliding seal member and extending in the longitudinal direction longer than the thickness of the intermediate seal member,
A syringe that causes the rear chamber liquid to flow into the front chamber of the intermediate sliding seal member through the bypass portion,
A syringe having a liquid absorption mechanism capable of absorbing and holding liquid behind the end sliding seal member.   The syringe according to claim 1, wherein the liquid absorbing mechanism is provided in close contact with an end sliding seal member at a tip of the rod or at an interval behind the end sliding seal member.   The syringe according to claim 2, wherein the liquid absorption mechanism is provided integrally or detachably on an end sliding seal member formed integrally with the tip of the rod.   The syringe according to claim 2, wherein the liquid absorbing mechanism is provided integrally or detachably behind the end sliding seal member that is removable from the rod tip.   The syringe according to any one of claims 1 to 4, wherein the liquid absorbing mechanism is made of a liquid absorbing material selected from paper, fiber or resin having a liquid absorbing function.   6. The syringe according to claim 5, wherein the liquid absorbing material comprises at least one selected from the group consisting of polyvinyl formal, polyester fiber, pulp, pulp fiber or polyester fiber containing acetate fiber, acetate fiber, sponge and absorbent resin.   The syringe according to claim 5 or 6, wherein the liquid-absorbing material is impregnated with a water retention / liquid absorption accelerator that promotes the liquid absorption function.   The syringe according to claim 7, wherein the water retention / absorption accelerator is one or more selected from the group consisting of glycerin, propylene glycol, polyethylene glycol, D-sorbitol, polyoxyethylene cetyl ether, and benzyl alcohol.   The syringe according to claim 5, wherein the liquid absorbent material contains a water retention / liquid absorption accelerator and a surfactant.   The syringe according to any one of claims 5 to 9, wherein the liquid-absorbing material contains an antibacterial agent.   The syringe according to any one of claims 5 to 9, wherein the liquid-absorbing material contains a water retention / liquid absorption accelerator and an antibacterial agent.   The syringe according to claim 10 or 11, wherein the antibacterial agent is at least one selected from benzalkonium chloride, benzethonium chloride, dodecyldiaminoethylglycine, dodecyldimethylbenzylammonium chloride, polyhexamethylene biguanide and alkyldiaminoethylglycine hydrochloride. .   The syringe according to any one of claims 5 to 11, wherein the liquid absorbing material is colored with a colorant.   The syringe according to claim 5, wherein the liquid absorbing material contains a quenching agent.   The syringe according to any one of claims 5 to 11, wherein the liquid-absorbing material contains a colorant and a quencher.   The syringe according to any one of claims 1 to 4, wherein the liquid absorption mechanism has substantially no clearance between the outer periphery and the syringe inner wall.   The syringe according to any one of claims 1 to 4, wherein the liquid-absorbing material has a clearance between the outer periphery and the inner wall of the syringe, and contains the water retention / liquid absorption accelerator.   The syringe according to claim 5 or 6, wherein the liquid-absorbing material has a hollow cylindrical shape that can be fitted to a tip of the rod that is removable from the end sliding seal member.   The syringe according to any one of claims 1 to 5, wherein the liquid absorption mechanism includes an annular or spiral liquid absorption groove having a liquid absorption function.   The syringe according to any one of claims 1 to 5, wherein the liquid-absorbing mechanism is made of a liquid-absorbing material that is wound around at least the rod tip in a ring shape.   The syringe according to claim 1, wherein the liquid absorption mechanism is a liquid absorption member that has a through-hole of the rod and can be fitted and retained in a rear end opening of the cylindrical container.   The liquid-absorbing mechanism is a liquid-absorbing member that has a through-hole of the rod, is fitted into a finger grip that can be fitted to the outer periphery of the rear end of the cylindrical container, and can be retained in the rear-end opening of the cylindrical container. Item 2. The syringe according to Item 1.   The syringe according to claim 1, wherein the liquid absorbing mechanism includes a liquid absorbing member that slides in the cylindrical container together with the end sliding seal member, and a liquid absorbing member that can be retained at the rear end of the cylindrical container.

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