JP3854034B2 - Drug adhesion method - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a drug attachment method for attaching a drug to an object.
[0002]
[Prior art]
Medical devices and the like include products in which a drug is previously attached (applied) to a part thereof. For example, some blood collection tubes used for specimen blood collection have a blood treatment agent such as a blood anticoagulant applied to the inner peripheral surface of a bottomed cylindrical container.
[0003]
Conventionally, as a method of applying such a medicine, a medicine solution in which the medicine is dissolved is sprayed from a spray nozzle, and a mist-like medicine liquid is applied to an object, or the object is immersed in the medicine liquid. The adhesion method (dipping) is mainly used.
[0004]
However, the spray method has the following drawbacks.
-Since a chemical | medical solution spreads like a mist and there is no directivity in the diffusion direction, a chemical | medical agent cannot be apply | coated only to the position to apply | coat, and a chemical | medical agent adheres to the circumference | surroundings.
[0005]
・ Because it is impossible to control where the sprayed chemical solution scatters, some of it diffuses into the atmosphere and is wasted, making it difficult to attach an accurate amount of drug.
[0006]
-It is difficult to adjust the size of the area to be applied, and in particular, it is impossible to concentrate the drug in a narrow area.
[0007]
・ The chemical solution in the form of mist is easily disturbed by the flow of air, so when spraying in a narrow space such as the inside of an instrument, the turbulent flow occurs due to the rebound of the jet, so the above-mentioned drawback is more prominent. become.
[0008]
・ Since the reach of the sprayed chemical is short, it is necessary to apply the spray nozzle close to the object. For this reason, for example, when applying to the inner peripheral surface of the blood collection tube container, the nozzle must be inserted (inserted) into the inside from the opening of the container and sprayed, and the application operation is complicated and efficient. Absent.
[0009]
-The time required for one spraying, for example, takes a relatively long time of about 0.5 to 2 seconds and cannot be applied quickly.
[0010]
Further, dipping has the following drawbacks.
-The application range cannot be limited, and the drug cannot be partially attached.
-The exact amount of drug cannot be deposited.
・ It is difficult to attach the drug to the inside of the object.
[0011]
[Problems to be solved by the invention]
The present invention eliminates the drawbacks of the prior art, and its purpose is to easily and accurately adjust the attachment position, adhesion region, amount of adhesion, etc., and to attach the drug efficiently and quickly. An object of the present invention is to provide a method of attaching a drug that can be performed.
[0012]
[Means for Solving the Problems]
Such an object is achieved by the present inventions (1) to (10) below.
[0013]
(1) The stored chemical solution is fed by the operation of the piezoelectric pump, the delivered chemical solution is jetted from the nozzle toward the target, and the jetted chemical solution collides with the target. A method of attaching a drug,
The piezoelectric pump includes a pump chamber having a suction port and a discharge port, a suction flow channel connected to the suction port, a discharge flow channel connected to the discharge port, the suction flow channel, and the discharge flow. A check valve provided in at least one of the passages, a diaphragm for increasing or decreasing the volume of the pump chamber, a piezoelectric actuator for driving the diaphragm, and a displacement enlarging mechanism for enlarging the displacement of the piezoelectric actuator and transmitting it to the diaphragm And a biasing member that biases the diaphragm in a direction in which the volume of the pump chamber increases.
[0014]
(2) The method according to (1), wherein the target is an inner wall of a cylindrical container.
[0015]
(3) The method for adhering a medicine according to (2), wherein the chemical liquid is ejected without inserting the nozzle into the cylindrical container.
[0016]
(4) The chemical adhesion method according to (2) or (3), wherein the chemical liquid is sprayed from a direction inclined with respect to the inner wall.
[0017]
( 5 ) The method for adhering a medicine according to any one of (1) to (4) , wherein a speed of the injected chemical liquid is 0.005 to 5 m / s.
[0018]
( 6 ) The method for adhering a drug according to any one of (1) to (5) , wherein the length of the sprayed and linear drug solution is 0.1 to 500 mm.
[0019]
( 7 ) The method for adhering a drug according to any one of (1) to (6) , wherein an average diameter of the sprayed and linear drug solution is 0.1 to 2 mm.
[0020]
( 8 ) The method of attaching a medicine according to any one of (1) to (7) above , wherein the amount of the chemical liquid ejected from one nozzle at a time is 0.1 to 100 μl.
[0021]
( 9 ) The method of attaching a drug according to any one of (1) to (8) , further including a step of drying the drug solution collided with the target.
[0022]
( 10 ) The method for attaching a drug according to any one of (1) to (9) , wherein the drug is a blood treatment agent such as a blood coagulation promoter, a blood anticoagulant, or a glycolysis inhibitor.
[0025]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, a method for attaching a drug according to the present invention will be described in detail based on a preferred embodiment shown in the accompanying drawings.
[0026]
FIG. 1 is a diagram showing an example of a drug adhering apparatus used for carrying out the drug adhering method of the present invention, FIG. 2 is an enlarged cross-sectional view showing the internal structure of the piezoelectric pump of the drug adhering apparatus 1 shown in FIG. These are the longitudinal cross-sectional views of the blood-collecting blood vessel to which the chemical | medical agent was made to adhere by the chemical | medical agent adhesion method of this invention. In the following description, the upper side in FIGS. 1 to 3 is referred to as “upper” and the lower side is referred to as “lower”.
[0027]
In the present embodiment, a case where a drug is attached (applied) using the inner peripheral surface (inner wall) 61 of the bottomed cylindrical container 6 of the blood collection tube used for sample blood collection as a target will be described representatively. However, it goes without saying that the target is not limited to this.
[0028]
The drug adhesion method of the present invention is achieved by the drug adhesion device 1 shown in FIG. Hereinafter, the medicine adhering apparatus 1 will be described.
[0029]
The drug attachment device 1 includes a piezoelectric pump 2, a nozzle 5, a storage unit 10, a controller 11, a suction tube 12, a discharge tube 13, and a support member 14.
[0030]
The drug to be attached is a chemical solution 7 dissolved (or dispersed) in a solvent and stored in the storage unit 10. As the solvent, for example, water, a volatile organic solvent such as ethanol, or a mixed solution thereof is used. Moreover, for the purpose of adjusting the viscosity of the chemical solution 7, for example, an additive such as PVP (polyvinylpyrrolidone) is added as necessary.
[0031]
One end of a suction tube 12 that sucks up the stored chemical solution 7 is inserted into the storage unit 10, and the other end of the suction tube 12 is connected to a suction flow path 33 of the piezoelectric pump 2 described later.
[0032]
The piezoelectric pump 2 is a diaphragm pump that operates using the piezoelectric actuator 21 as a drive source. The pump chamber 3, the diaphragm 4, the suction flow path 31, the discharge flow path 32, the piezoelectric actuator 21, and a lever (displacement expansion mechanism). ) 22 and a spring (biasing member) 23 (see FIG. 2).
[0033]
The pump chamber (internal space) 3 is a flat space. A suction port 33 is formed at the lower end of the pump chamber 3 and a discharge port 34 is formed at the upper end. A suction flow path 31 is connected to the suction port 33, and a discharge flow path 32 is connected to the discharge port 34.
[0034]
A suction-side check valve 35 is provided at the end of the suction flow path 31 on the suction port 33 side, and a discharge-side check valve 36 is provided at the end of the discharge flow path 32 on the discharge port 34 side. Yes. The suction side check valve 35 and the discharge side check valve 36 have the same configuration, and two ball valves having the same structure are connected in series. The suction side check valve 35 allows the chemical solution 7 to pass only in the direction of flowing into the pump chamber 3, and the discharge side check valve 36 allows the chemical solution 7 to pass only in the direction of flowing out of the pump chamber 3.
[0035]
A part of the inner surface of the pump chamber 3 is constituted by a flexible diaphragm 4, and the volume of the pump chamber 3 is increased or decreased when the diaphragm 4 is deformed. The diaphragm 4 includes a membrane portion 41 made of an elastic material such as various rubbers, and a disc portion 42 provided on the side of the membrane portion 41 that does not face the pump chamber 3. The disc portion 42 receives a force from the piezoelectric actuator 21 and is displaced in the thickness direction, thereby deforming the membrane portion 41 so that the volume of the pump chamber 3 increases or decreases.
[0036]
The piezoelectric actuator 21 is installed in the lower part of the case 24. The piezoelectric actuator 21 is composed of a laminated body in which piezoelectric elements are laminated, and has a columnar shape as a whole. The piezoelectric actuator 21 expands when a voltage is applied, and this expansion (displacement) is expanded by the lever 22, and the disc portion 42 is displaced (pressed) to the pump chamber 3 side via the rod 25. That is, when the piezoelectric actuator 21 is extended, the diaphragm 4 is deformed so as to reduce the volume of the pump chamber 3.
[0037]
A spring 23 that urges the diaphragm 4 in a direction to increase the volume of the pump chamber 3 is installed so as to connect the rod 25 and the case 24. This spring 23 assists the force of the piezoelectric actuator 21 in the contracting direction. In addition, a lead wire 26 from an external controller 11 is connected to the piezoelectric actuator 21, and a drive voltage is applied from the controller 11.
[0038]
The controller 11 can generate a pulsed voltage that rises from 0 [V] to a set voltage value (hereinafter referred to as “applied voltage”). Further, the controller 11 has a width [ms] of one pulse (hereinafter referred to as “pulse width”), a time [ms] (hereinafter referred to as “rise time”) until the pulse rises from 0 [V] to the applied voltage. ”), The interval [s] between pulses when the pulses are output continuously can be set. By changing these settings, the amount of the chemical liquid 7 injected by one injection (hereinafter referred to as “injection amount”) and the speed of the injected chemical liquid 7 (hereinafter referred to as “linear velocity”). .), The injection interval in the case of continuous injection can be changed.
[0039]
One end of the discharge tube 13 is connected to the discharge flow path 32 of the piezoelectric pump 2. The nozzle 5 is connected to the other end of the discharge tube 13. The nozzle 5 has a tapered inner surface whose inner diameter gradually decreases toward the tip. Thereby, the chemical | medical solution 7 is sprayed from the nozzle 5 at linear form.
[0040]
The nozzle 5 is installed by being fixed by a fixing member (not shown) so that a tip 51 thereof faces obliquely downward. For this reason, the medicinal solution 7 is jetted obliquely downward and collides with the collision center position 70 on the inner peripheral surface 61 at an angle inclined with respect to the inner peripheral surface 61 of the blood collection tube 6. The drug solution 7 that has collided spreads from the collision center position 70 to the periphery thereof on the inner peripheral surface 61, but obliquely collides with the inner peripheral surface 61, so that the drug solution 7 moves from the collision center position 70 to the back (downward) inside the blood collection tube 6. The spread in the direction of heading is larger (see FIG. 3). Further, the collision center position 70 can be freely set according to the direction of the nozzle 5, and the chemical solution 7 can be adhered deeply into the blood collection tube container 6.
[0041]
Further, the average diameter (hereinafter referred to as “wire diameter”) of the chemical liquid 7 ejected in a linear manner is determined by the shape of the nozzle tip 51 and the size of the inner diameter.
[0042]
The target blood collection tube 6 constitutes a part of the blood collection tube used for specimen blood collection, and is a bottomed cylindrical container made of substantially transparent glass, various plastics, or the like. After the drug is attached to the inner peripheral surface 61 of the blood collection tube 6, the blood collection tube is formed by sealing the opening 62 with a sealing member (not shown) such as a film or a rubber plug, for example.
[0043]
The blood collection tube 6 is supported by the support member 14 so as to stand upright, for example. The nozzle 5 and the blood collection tube container 6 are in a positional relationship such that the opening 62 of the blood collection tube container 6 is positioned slightly below the nozzle tip 51.
[0044]
The support member 14 may be attached to a transport mechanism (not shown) so that the blood collection tube 6 can be moved.
[0045]
The drug adhesion method of the present invention is carried out using the drug adhesion device 1 as described above. Hereinafter, a method for attaching a medicine using the medicine adhering apparatus 1 will be described.
[0046]
[1] A drug solution 7 is prepared by dissolving a drug in a solvent and stored in the storage unit 10. The drug attached to the inner peripheral surface 61 of the blood collection tube 6 is a blood treatment agent, and a drug such as a blood coagulation promoter, a blood anticoagulant, or a glycolysis inhibitor is used. Examples of the blood coagulation promoter include thrombin, snake venom, and silica powder. Examples of the blood anticoagulant include heparin, citric acid, and ethylenediaminetetraacetic acid. Examples of the glycolysis inhibitor include fluorination. Sodium etc. are mentioned. Examples of the heparin neutralizing agent include drugs such as protamine sulfate.
[0047]
Furthermore, for medical instruments other than blood collection tubes, various drugs such as antithrombotic agents, thrombolytic agents, nutrients, anesthetics, anticancer agents, water-repellent coating agents, hydrophilic coating agents are used depending on the purpose. Is done. Moreover, you may make a different chemical | medical agent adhere to each of several places as needed.
[0048]
The solvent of the chemical solution 7 may be any solvent that dissolves the drug, and is preferably a volatile organic solvent such as water or ethanol depending on the solubility of the drug (whether it is water-soluble or fat-soluble). Used. Two or more mixed solvents such as a mixed solution of water and an organic solvent can also be used.
[0049]
When a solvent containing a relatively large amount of organic solvent is used, the chemical solution 7 is excellent in quick drying. Further, since the surface tension of the drug solution 7 is reduced, the drug solution 7 that has collided with the inner peripheral surface 61 of the blood collection tube 6 is greatly spread and can be adhered to a wide range. As a result, when the blood collection tube is used, the adhered drug (blood treatment agent) comes into contact with the collected blood over a wide area and quickly dissolves.
[0050]
When a solvent containing a relatively large amount of water is used, the surface tension of the drug solution 7 increases, and the drug solution 7 that collides with the target can be formed into droplets without spreading. Can be made.
[0051]
Moreover, the magnitude | size which the chemical | medical solution 7 which collided with the target spreads can be adjusted by adjusting the viscosity of the chemical | medical solution 7. FIG. When other conditions are the same, the smaller the viscosity of the chemical solution 7, the greater the spread on the target. The viscosity of the chemical solution 7 can be adjusted using, for example, a viscosity modifier such as PVP (polyvinylpyrrolidone).
[0052]
The concentration of the chemical solution 7 is appropriately determined depending on the use and type of the drug. The absolute amount of the adhered drug is determined by the concentration of the chemical solution 7 and the injection amount. Therefore, when the same amount of medicine is attached, if the concentration of the chemical solution 7 is lowered and the injection amount is increased, the injection amount can be increased. Conversely, the concentration of the chemical solution 7 is increased and the injection amount is reduced. Then, it can adhere to a narrow range.
[0053]
[2] The nozzle 5 is removed from the discharge tube 13, and a syringe (not shown) or the like is attached instead to suck in the chemical solution, and the pump chamber 3 is filled with the chemical solution 7 (priming operation to the piezoelectric pump 2). Then, the nozzle 5 is attached as it was.
[0054]
[3] The controller 11 is operated to set the applied voltage, pulse width, and rise time. The linear velocity can be adjusted mainly by changing the settings of applied voltage and rise time. In addition, the injection amount can be adjusted mainly by changing the settings of the applied voltage and the pulse width.
[0055]
[4] The controller 11 generates the pulsed drive voltage set in [3] and applies the voltage to the piezoelectric actuator 21. The piezoelectric actuator 21 extends when a voltage is applied, and presses the disc portion 42 via the lever 22 and the rod 25. Thereby, the diaphragm 4 is deformed so as to protrude toward the pump chamber 3, and the volume of the pump chamber 3 is reduced.
[0056]
[5] When the volume of the pump chamber 3 is reduced, the chemical liquid 7 filled in the pump chamber 3 does not pass through the suction side check valve 35 but passes through only the discharge side check valve 36 and enters the discharge flow path 32. Discharge (liquid feeding). Then, the chemical liquid 7 that has been in each of the discharge flow path 32, the discharge tube 13, and the nozzle 5 is sequentially fed, and the chemical liquid 7 is ejected from the nozzle tip 51 in a linear shape.
[0057]
At this time, since the piezoelectric actuator 21 quickly expands and feeds liquid at a high speed, it can be ejected instantaneously and rapid application is possible.
[0058]
Moreover, since the chemical | medical solution 7 is sprayed in one direction linearly with liquid form, the chemical | medical solution 7 can be made to collide with a target correctly, and can be made to adhere to the set position correctly.
[0059]
The linear velocity is preferably 0.005 to 5 m / s, and more preferably 0.1 to 1 m / s. Within such a range, the injected chemical liquid 7 flies in a straight line, so that it can collide with the target more accurately. Further, the colliding chemical solution 7 does not bounce back and scatter. Further, when other conditions such as the injection amount are the same, the larger the linear velocity, the larger the chemical solution 7 spreads. Therefore, the size of the chemical solution 7 can be adjusted by setting the linear velocity.
[0060]
The length of the sprayed chemical solution 7 (hereinafter referred to as “line length”) is preferably 0.1 to 500 mm, and more preferably 1 to 10 mm. Within such a range, the straightness of the injected chemical liquid 7 becomes higher, and the chemical liquid 7 can be more reliably prevented from diffusing. Further, the wire length can be adjusted by changing the setting of the wire diameter and the injection amount.
[0061]
The wire diameter is preferably 0.1 to 2 mm, and more preferably 0.2 to 1 mm. Within such a range, the straightness of the injected chemical liquid 7 becomes higher, and the chemical liquid 7 can be more reliably prevented from diffusing.
[0062]
The injection amount is appropriately determined according to the use and type of the drug, but in the case of the blood treatment agent, it is preferably 0.1 to 100 μl, and more preferably 1 to 10 μl. Within such a range, the straightness of the injected chemical liquid 7 becomes higher, and the chemical liquid 7 can be more reliably prevented from diffusing. Furthermore, the chemical solution 7 can be more uniformly attached, and it is easier to make the chemical solution 7 thinner.
[0063]
[6] The drug solution 7 ejected obliquely downward from the nozzle 5 enters the inside of the blood collection tube 6 through the opening 62 and collides with the collision center position 70 on the inner peripheral surface 61 from the oblique direction. It spreads and adheres to a certain range around the position 70. At this time, since the colliding chemical solution 7 has a momentum to move downward, the downward spread is large (see FIG. 3).
[0064]
At this time, the injected liquid 7 accurately collides with the set position (collision center position 70). Therefore, the injected chemical liquid 7 does not diffuse and adhere to portions other than the target, and can be attached to a region where almost the entire injection amount is set, and an accurate amount of medicine can be attached.
[0065]
Moreover, since the flight distance of the injected chemical liquid 7 is large, it is not necessary to bring the nozzle 5 close to the target. Furthermore, when the surface tension of the chemical solution 7 is set to be small or the injection amount is set to be large, the distance over which the attached chemical solution 7 spreads downward can be made longer. Therefore, the medicine can be adhered to the inner peripheral surface 61 of the blood collection tube 6 up to the inner portion without inserting the nozzle 5 into the blood collection tube 6. This eliminates the need for an operation for moving the nozzle 5 relative to the blood collection tube 6 in order to insert the nozzle 5 into the blood collection tube 6 and a mechanism therefor, which is efficient and simple. Drugs can be attached.
[0066]
Further, since it is not necessary to insert the nozzle 5 and the time required for injection is extremely short, there are the following advantages when mass-producing the blood collection tubes on the production line. It is not necessary to stop the blood collection tube 6 once in the step of sequentially attaching the drug to the blood collection tubes 6 that are successively conveyed by a conveyance device such as a conveyor, and the nozzle 5 is kept moving. That is, the chemical solution 7 is ejected and adhered in accordance with the timing when the positional relationship becomes appropriate. For this reason, it can adhere very efficiently and quickly, and simplification of an apparatus can also be achieved.
[0067]
In addition, the portion to which the drug is adhered by the method for adhering a drug according to the present invention can have higher light transmittance than the case where the drug is adhered by spraying. This is because, in the method using spraying, droplets having a small particle diameter are attached, so that the attached surface scatters light, whereas in the method of the present invention, the chemical solution 7 is attached in the form of a film. This is because light scattering is small. Therefore, even if the medicine adheres to the inner peripheral surface 61 of the blood collection tube 6, it is possible to increase the internal visibility.
[0068]
[7] After the chemical solution 7 is adhered, it is dried as necessary. Drying may be natural drying, air drying, or warm air drying.
[0069]
FIG. 4 is a longitudinal sectional view showing a syringe to which a medicine is attached by the same method as the medicine attaching method described above. In the following description, the upper side in FIG. 4 is referred to as “base end” and the lower side is referred to as “tip”.
[0070]
The syringe 8 shown in FIG. 4 has a substantially cylindrical shape, and has an open end 81 at the proximal end and a protruding portion 82 at the distal end. A tip opening 83 is formed at the tip of the protruding portion 82.
[0071]
The drug 71 is attached to the tip of the inner peripheral surface 84 of the syringe 8. By adjusting the direction of the nozzle 5, the drug 71 can be attached to the back of the syringe in this way.
[0072]
The syringe 8 is used after a drug 71 is attached thereto and a plunger with a gasket (not shown) is inserted from the open end 81. An injection needle, a tube, a connector, a catheter, or the like can be connected to the protruding portion 82.
[0073]
As mentioned above, although the chemical | medical agent adhesion method of this invention was demonstrated based on embodiment of illustration, this invention is not limited to this.
[0074]
Target objects are not limited to blood collection tubes and syringes, but include, for example, capillaries, bags, bottles, tubes, catheters, drip chambers, filters, dialyzers, artificial lungs, heat exchangers, cardiotomy Reservoirs and their inner surfaces, petri dishes, multi-hole plates and the like may be used.
[0075]
【The invention's effect】
As described above, according to the present invention, the chemical liquid is linearly ejected with directivity in a predetermined direction, and the chemical liquid is caused to collide accurately with the set position. Can be adjusted.
[0076]
In addition, by appropriately setting the injection amount, viscosity, linear velocity, type and concentration of the solvent, etc., the chemical adhesion amount and adhesion region can be freely adjusted.
[0077]
Further, since almost the entire amount of the injected chemical liquid can be attached to the attachment region, an accurate amount of medicine can be attached, and there is no waste of medicine.
[0078]
Furthermore, it can be deposited quickly and efficiently, which is advantageous for continuous injection, and simplification of the apparatus used for implementation.
[Brief description of the drawings]
FIG. 1 is a side view showing an example of a drug adhering device used for carrying out a drug adhering method of the present invention.
2 is an enlarged cross-sectional view showing an internal structure of a piezoelectric pump of the medicine adhering apparatus shown in FIG. 1. FIG.
FIG. 3 is a vertical cross-sectional view of a blood collection tube with a drug adhered to the inner peripheral surface by the drug deposition method of the present invention.
FIG. 4 is a longitudinal sectional view of a syringe having a drug attached to the inner peripheral surface by the drug attaching method of the present invention.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Drug adhesion apparatus 2 Piezoelectric pump 21 Piezoelectric actuator 22 Lever 23 Spring 24 Case 25 Rod 26 Conductor 3 Pump chamber 31 Suction flow path 32 Discharge flow path 33 Suction port 34 Suction port 35 Suction side check valve 36 Suction side check valve 4 Diaphragm 41 Membrane part 42 Disk part 5 Nozzle 51 Nozzle tip 6 Blood collection vessel 61 Inner peripheral surface 62 Opening 7 Drug solution 70 Collision center position 71 Adhering drug 8 Syringe 81 Open end 82 Protruding part 83 Tip opening 84 Inner peripheral surface 10 Storage Part 11 Controller 12 Suction tube 13 Discharge tube 14 Support member

Claims (10)

The stored chemical solution is fed by the operation of the piezoelectric pump, the delivered chemical solution is ejected from the nozzle toward the target, and the ejected chemical solution is made to collide with and adhere to the target. A method of attaching a drug,
The piezoelectric pump includes a pump chamber having a suction port and a discharge port, a suction flow channel connected to the suction port, a discharge flow channel connected to the discharge port, the suction flow channel, and the discharge flow. A check valve provided in at least one of the passages, a diaphragm for increasing or decreasing the volume of the pump chamber, a piezoelectric actuator for driving the diaphragm, and a displacement enlarging mechanism for enlarging the displacement of the piezoelectric actuator and transmitting it to the diaphragm And a biasing member that biases the diaphragm in a direction in which the volume of the pump chamber increases.   The method of claim 1, wherein the target is an inner wall of a cylindrical container.   The chemical | medical agent adhesion method of Claim 2 which sprays the said chemical | medical solution, without inserting the said nozzle into the inside of the said cylindrical container.   The method of attaching a medicine according to claim 2 or 3, wherein the chemical liquid is sprayed from a direction inclined with respect to the inner wall. The method of attaching a medicine according to any one of claims 1 to 4 , wherein a speed of the sprayed chemical liquid is 0.005 to 5 m / s. The method for adhering a medicine according to any one of claims 1 to 5 , wherein the length of the sprayed and linear chemical solution is 0.1 to 500 mm. The method of attaching a medicine according to any one of claims 1 to 6 , wherein an average diameter of the sprayed and linear chemical liquid is 0.1 to 2 mm. The method of attaching a medicine according to any one of claims 1 to 7 , wherein the amount of the chemical liquid ejected from one nozzle at a time is 0.1 to 100 µl. The method of attaching a drug according to any one of claims 1 to 8 , further comprising a step of drying the drug solution collided with the target. 10. The method of attaching a drug according to claim 1 , wherein the drug is a blood treatment agent such as a blood coagulation promoter, a blood anticoagulant, or a glycolysis inhibitor.

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