JP3681932B2 - Cosmetics for cleansing - Google Patents
Cosmetics for cleansing Download PDFInfo
- Publication number
- JP3681932B2 JP3681932B2 JP24819399A JP24819399A JP3681932B2 JP 3681932 B2 JP3681932 B2 JP 3681932B2 JP 24819399 A JP24819399 A JP 24819399A JP 24819399 A JP24819399 A JP 24819399A JP 3681932 B2 JP3681932 B2 JP 3681932B2
- Authority
- JP
- Japan
- Prior art keywords
- cleansing
- weight
- parts
- cosmetic
- cosmetics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002537 cosmetic Substances 0.000 title claims description 48
- 230000037307 sensitive skin Effects 0.000 claims description 14
- 230000000694 effects Effects 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 9
- 235000003130 Arctium lappa Nutrition 0.000 claims description 8
- 235000008078 Arctium minus Nutrition 0.000 claims description 8
- 229940105990 diglycerin Drugs 0.000 claims description 7
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 7
- WNIFXKPDILJURQ-JKPOUOEOSA-N octadecyl (2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@](C(=O)OCCCCCCCCCCCCCCCCCC)(C)C[C@H]5C4=CC(=O)[C@@H]3[C@]21C WNIFXKPDILJURQ-JKPOUOEOSA-N 0.000 claims description 7
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 claims description 7
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 4
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
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- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- -1 sulfosuccinic acid ester Chemical class 0.000 description 15
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- 241000208843 Arctium Species 0.000 description 7
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 6
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- 239000003921 oil Substances 0.000 description 6
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
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- 206010012438 Dermatitis atopic Diseases 0.000 description 4
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- 238000012360 testing method Methods 0.000 description 4
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 3
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 3
- 235000013871 bee wax Nutrition 0.000 description 3
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- SHZIWNPUGXLXDT-UHFFFAOYSA-N caproic acid ethyl ester Natural products CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 3
- 229940008099 dimethicone Drugs 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
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- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 3
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- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
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- 235000011076 sorbitan monostearate Nutrition 0.000 description 3
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- 230000001629 suppression Effects 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- XSEPZWCXUIAKNQ-PMDAXIHYSA-N [3-[2,3-bis[[(Z)-octadec-9-enoyl]oxy]propoxy]-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COCC(COC(=O)CCCCCCC\C=C/CCCCCCCC)OC(=O)CCCCCCC\C=C/CCCCCCCC)OC(=O)CCCCCCC\C=C/CCCCCCCC XSEPZWCXUIAKNQ-PMDAXIHYSA-N 0.000 description 2
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- 150000002148 esters Chemical class 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000037311 normal skin Effects 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- GECRRQVLQHRVNH-MRCUWXFGSA-N 2-octyldodecyl (z)-octadec-9-enoate Chemical compound CCCCCCCCCCC(CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC GECRRQVLQHRVNH-MRCUWXFGSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 229940082483 carnauba wax Drugs 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 125000005131 dialkylammonium group Chemical group 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
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- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical class C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- 238000011597 hartley guinea pig Methods 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
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- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- 235000019271 petrolatum Nutrition 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
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- 239000000344 soap Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
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- 239000002689 soil Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
【０００１】
【発明の属する技術分野】
本発明は、敏感肌の人に好適な、クレンジング用の化粧料に関する。
【０００２】
【従来の技術】
クレンジング化粧料は、化粧品の分野に於いては、メークアップ化粧料等の石鹸などの水性洗浄料で落としにくい、油性の汚れを落とすのに用いられる化粧料であり、通常高内相の水中油乳化剤形のものが使用され、内相に存在する油性液体成分の溶剤効果により、この様な油性の汚れを落とすものである。この様なクレンジング化粧料に於いて、最大の課題は油性成分が多いため、この様な油剤自身の溶剤としての刺激と使用時の塗擦に起因する刺激の発現である。この様な刺激発現は通常は殆ど観察されないが、近年その数が急増している、アトピー性皮膚炎患者のような敏感肌の人に於いては、この出現の可能性は高く、この対応が求められていた。
【０００３】
一方、クレンジング化粧料に抗炎症成分を含有させる試みは全く為されておらず、この様な抗炎症成分を含有するクレンジング化粧料が敏感肌の人に好適であることも全く知られていなかった。又、ジグリセリンテトラオレートはその溶剤特性より、クレンジング化粧料の成分として好適であることは知られているが、このものが使用時の刺激発現を軽減することも、このものと抗炎症成分を組み合わせることも全く知られていなかった。
【０００４】
【発明が解決しようとする課題】
本発明は、この様な状況下為されたものであり、アトピー性皮膚炎患者のような敏感肌の人であっても、刺激発現の可能性が低いクレンジング用の化粧料を提供することを課題とする。
【０００５】
【課題の解決手段】
本発明者らは、この様な状況に鑑みて、アトピー性皮膚炎患者のような敏感肌の人であっても、刺激発現の可能性が低いクレンジング用の化粧料を求めて、鋭意研究努力を重ねた結果、クレンジング用の化粧料に抗炎症作用を有する成分を含有させることにより、この様なクレンジング用の化粧料が得られることを見いだし、発明を完成させるに至った。即ち、本発明は、抗炎症作用を有する成分を含有するクレンジング用の化粧料を提供するものである。
【０００６】
【発明の実施の形態】
（１） 本発明のクレンジング用の化粧料の必須の成分である抗炎症作用を有する成分
本発明のクレンジング用の化粧料は、抗炎症作用を有する成分を含有する事を特徴とする。この様な抗炎症作用を有する成分としては、例えば、グリチルリチン酸ジカリウム、グリチルレチン酸ステアリル等のグリチルリチン酸関連物質、ゴボウのエキスやシラカバのエキス等のような抗炎症生薬のエキス類等が例示できる。これらの内、本発明のクレンジング用の化粧料に於いて特に好ましいものは、グリチルレチン酸ステアリルとゴボウのエキスである。これらの成分はクレンジングのような擦過を伴う使用形態に於いて、物理的動作によって刺激が発現するのを抑制する作用に優れる。これにより、クレンジング用の化粧料が敏感肌の人に化粧動作時、刺激が発現することを抑制する。本発明のクレンジング化粧料に於ける、抗炎症作用を有する成分の好ましい含有量は、総量で０．００５〜１重量％であり、更に好ましくは、０．０５〜０．５重量％である。これは、少なすぎると、刺激発現を抑制しない場合があり、多すぎても効果が頭打ちになり経済的効果が少ない場合があるからである。
【０００７】
（２） 本発明のクレンジング用の化粧料
本発明のクレンジング用の化粧料は、上記抗炎症成分を必須成分として含有することを特徴とする。本発明で言う、クレンジング用の化粧料とは、油性の成分を落とすための化粧料であって、その剤形としては、油中水乳化クリーム、油中水乳化乳液、水中油乳化クリーム、水中油乳化乳液、多相エマルション、非水エマルション等何れも適用可能である。本発明のクレンジング用の化粧料に於いては、上記抗炎症作用を有する成分以外に、本発明の効果を損なわない範囲に於いて、通常この様な化粧料で使用される任意の成分を含有することができる。この様な任意成分としては、例えば、スクワラン、ワセリン、マイクロクリスタリンワックス等の炭化水素類、ホホバ油、カルナウバワックス、オレイン酸オクチルドデシル、ジグリセリンテトラオレート等のエステル類、オリーブ油、牛脂、椰子油等のトリグリセライド類、ステアリン酸、オレイン酸、リチノレイン酸等の脂肪酸、オレイルアルコール、ステアリルアルコール、オクチルドデカノール等の高級アルコール、スルホコハク酸エステルやポリオキシエチレンアルキル硫酸ナトリウム等のアニオン界面活性剤類、アルキルベタイン塩等の両性界面活性剤類、ジアルキルアンモニウム塩等のカチオン界面活性剤類、ソルビタン脂肪酸エステル、脂肪酸モノグリセライド、これらのポリオキシエチレン付加物、ポリオキシエチレンアルキルエーテル、ポリオキシエチレン脂肪酸エステル等の非イオン界面活性剤類、ポリエチレングリコール、グリセリン、１，３−ブタンジオール等の多価アルコール類、増粘・ゲル化剤、酸化防止剤、紫外線吸収剤、色剤、防腐剤、粉体、ビタミン等の有効成分等を含有することができる。これらの任意の成分の内、特に、エステル系油剤として、ジグリセリンテトラオレートを含有することが好ましい。このものは既に、高融点ワックス等の通常のクレンジング用の化粧料でも落としにくい成分を、相溶させて落とす作用に優れていることが既に知られている。本発明者の検討によれば、後記実施例に示す如く、この油剤は擦過時において、皮膚へ与える刺激が少なく、本発明の効果を著しく高める作用を有する。本発明のクレンジング用の化粧料に於ける、ジグリセリンテトラオレートの好ましい含有量は、１０〜４０重量％であり、更に好ましくは、２０〜３０重量％である。これは、少ないと摩擦刺激低減化効果やクレンジング作用が認められない場合があり、多すぎると効果が頭打ちになるばかりか処方の自由度を損なう場合があるからである。更に、本発明のクレンジング用の化粧料に於いては、Ｎ−ラウロイル−Ｌ−グルタミン酸ジ（コレステリル・オクチルドデシル）を含有することも有利である。このものも肌への刺激を与えることなくクレンジング作用を増強させるからである。本発明のクレンジング用の化粧料における、前記Ｎ−ラウロイル−Ｌ−グルタミン酸ジ（コレステリル・オクチルドデシル）の好ましい含有量は、０．１〜１０重量％であり、更に好ましくは、０．５〜５重量％である。これは、クレンジング効果と費用効果の兼ね合いからである。更にのびを軽くし、摩擦係数を小さくする観点から、２−エチルヘキサン酸セチルのような分岐脂肪酸のエステルを１０〜４０重量％、より好ましくは１５〜２５重量％含有させることも好ましい。本発明のクレンジング用の化粧料は、これらの成分を常法に従って処理することにより製造することができる。かくして得られたクレンジング用の化粧料は擦過動作を含む化粧動作下使用されても刺激を発現することなく油性汚れを落とすことができるので、敏感肌の人でもトラブル無く使用することができる。従って、本発明のクレンジング用の化粧料は、アトピー性皮膚炎などの敏感肌の人用のクレンジングとしても好適である。勿論、本発明のクレンジング用の化粧料は普通の肌の人が用いても何ら不利な点を有さず、普通肌の人が使用する場合も本発明の技術的範囲に属する。
【０００８】
【実施例】
以下に、実施例を挙げて、本発明について更に詳細に説明を加えるが、本発明が、これら実施例にのみ、限定を受けないことは言うまでもない。
【０００９】
＜実施例１＞
以下に示す処方に従って、クレンジング用の化粧料（水中油エマルション）を作製した。即ち、イ、ロの成分をそれぞれ７０℃に加熱し、イの成分に徐々にロの成分を加え、攪拌冷却し、クレンジング用の化粧料を得た。
イ
ベヘニルアルコール １ 重量部
２−エチルヘキサン酸セチル ２０ 重量部
Ｎ−ラウロイル−Ｌ−グルタミン酸
ジ（コレステリル・オクチルドデシル） ５ 重量部
流動パラフィン ２５ 重量部
ブチルパラベン ０．１重量部
ポリオキシエチレン（４５）ステアレート ２ 重量部
ソルビタンモノステアレート １ 重量部
自己乳化型グリセリルモノステアレート １ 重量部
ポリオキシエチレン（１２０）イソステアレート １ 重量部
ミツロウ ２ 重量部
オリーブオイル ２５ 重量部
ジメチコン１０ｃ．ｓ． ２ 重量部
グリチルレチン酸ステアリル ０．１重量部
ロ
１，３−ブタンジオール ３ 重量部
ゴボウのエキス ０．１重量部
水 １１．７重量部
【００１０】
＜実施例２＞
実施例１のクレンジングクリームを用いて、刺激発現抑制試験を行った。即ち、ハートレー系白色種モルモットの背部（雄性、３００〜４００ｇ、１群５匹）を剃毛し、ガムテープで３回ストリッピングした後、１％酢酸エタノール溶液でふき取り、更にエタノールでふき取って敏感肌モデルを作製した。このモデルの背部４ｃｍ×４ｃｍの部位に０．１ｇのクレンジング料を塗布し、５回擦過した後、脱脂綿でふき取り、その３０分後に皮膚の状態を観察・判定した。判定基準は、＋＋：明瞭な赤みを部位の多くに認める、＋：明瞭な赤みが部位に点状に散在する、±：不明瞭ではあるが赤みの印象がある、−：赤みを認めないを用いた。比較例１は実施例１のグリチルレチン酸ステアリルとゴボウのエッセンスを水に置換したものを用いた。結果は表１に出現例数として示す。これより本発明のクレンジング料は敏感肌の人でも安心して使用できることがわかる。
【００１１】
【表１】
＜実施例３＞
以下に示す処方に従って、クレンジング用の化粧料（水中油エマルション）を作製した。即ち、イ、ロの成分をそれぞれ７０℃に加熱し、イの成分に徐々にロの成分を加え、攪拌冷却し、クレンジング用の化粧料を得た。
イ
ベヘニルアルコール １ 重量部
２−エチルヘキサン酸セチル ２０ 重量部
Ｎ−ラウロイル−Ｌ−グルタミン酸
ジ（コレステリル・オクチルドデシル） ５ 重量部
流動パラフィン ２５ 重量部
ブチルパラベン ０．１重量部
ポリオキシエチレン（４５）ステアレート ２ 重量部
ソルビタンモノステアレート １ 重量部
自己乳化型グリセリルモノステアレート １ 重量部
ポリオキシエチレン（１２０）イソステアレート １ 重量部
ミツロウ ２ 重量部
ジグリセリンテトラオレート ２５ 重量部
ジメチコン１０ｃ．ｓ． ２ 重量部
グリチルレチン酸ステアリル ０．１重量部
ロ
１，３−ブタンジオール ３ 重量部
ゴボウのエキス ０．１重量部
水 １１．７重量部
【００１３】
＜実施例４＞
実施例２と同様に、モルモット敏感肌モデルでの検討を、実施例３のクレンジングのグリチルレチン酸ステアリルとゴボウのエキスとを水に置換した比較例２と共に行った。実施例２とも比較すると、本発明のクレンジング化粧料に於いては、ジグリセリンテトラオレートを含有することにより、更に、刺激発現が抑制されていた。
【００１５】
＜実施例５＞
以下に示す処方に従って、クレンジング用の化粧料（水中油エマルション）を作製した。即ち、イ、ロの成分をそれぞれ７０℃に加熱し、イの成分に徐々にロの成分を加え、攪拌冷却し、クレンジング用の化粧料を得た。このものも優れた刺激抑制作用を有していた。
イ
ベヘニルアルコール １ 重量部
２−エチルヘキサン酸セチル ２０ 重量部
Ｎ−ラウロイル−Ｌ−グルタミン酸
ジ（コレステリル・オクチルドデシル） ５ 重量部
流動パラフィン ２５ 重量部
ブチルパラベン ０．１重量部
ポリオキシエチレン（４５）ステアレート ２ 重量部
ソルビタンモノステアレート １ 重量部
自己乳化型グリセリルモノステアレート １ 重量部
ポリオキシエチレン（１２０）イソステアレート １ 重量部
ミツロウ ２ 重量部
ジグリセリンテトラオレート ２５ 重量部
ジメチコン１０ｃ．ｓ． ２ 重量部
グリチルレチン酸ステアリル ０．１重量部
ロ
グリチルリチン酸ジカリウム ０．１重量部
１，３−ブタンジオール ３ 重量部
ゴボウのエキス ０．１重量部
水 １１．６重量部
【００１６】
＜実施例６＞
実施例１、３、５のクレンジングクリームについて、敏感肌の人をパネラーに用い（１群１５人計４５人）、８週間の使用テストを行った。使用方法は通常のクレンジング化粧料の使用法に準じた。使用テスト終了後、アンケートにより、使用感（なめらかさと使用に於ける心地よさ）とクレンジング力をアンケートによって評価してもらった。評価基準は＋＋：非常によい、＋：良い、±：やや良い、−：やや悪い、−−：悪いを用いた。結果を表２に示す。これにより、本発明のクレンジング化粧料は敏感肌の人でも安心して使用できるほどに刺激発現が抑制されていること及び優れたクレンジング力を有することがわかる。更に、使用テスト時に於ける、実施例１と３の刺激抑制の程度の差が動物実験の時に比し、更に開いていることから、使用に於けるなめらかさ、言い換えれば、摩擦感の無さが刺激発現抑制、言い換えれば心地よさに大きく寄与することがわかり、その意味でジグリセリンテトラオレートの有用性がわかる。
【００１７】
【表２】
【発明の効果】
本発明によれば、刺激発現の可能性が低いクレンジング用の化粧料を提供することができる。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a cleansing cosmetic suitable for people with sensitive skin.
[0002]
[Prior art]
In the cosmetics field, cleansing cosmetics are cosmetics that are difficult to remove with soaps such as make-up cosmetics, and are used to remove oily stains. An emulsifier type is used, and this oily soil is removed by the solvent effect of the oily liquid component present in the internal phase. In such cleansing cosmetics, the biggest problem is that there are many oily components, and therefore, the stimulation of such an oil agent itself as a solvent and the expression of the irritation caused by the coating during use. This kind of irritation is usually rarely observed, but in people with sensitive skin, such as patients with atopic dermatitis, whose number has increased rapidly in recent years, the possibility of this occurrence is high, and this response is It was sought after.
[0003]
On the other hand, no attempt has been made to include an anti-inflammatory component in cleansing cosmetics, and it has never been known that cleansing cosmetics containing such anti-inflammatory components are suitable for people with sensitive skin. . In addition, it is known that diglycerin tetraoleate is suitable as a cleansing cosmetic ingredient because of its solvent properties. There was no known combination.
[0004]
[Problems to be solved by the invention]
The present invention has been made under such circumstances, and it is intended to provide a cleansing cosmetic that has a low possibility of irritation even if it is a person with sensitive skin, such as a patient with atopic dermatitis. Let it be an issue.
[0005]
[Solution to Problem]
In view of such a situation, the present inventors have sought for cleansing cosmetics that have a low possibility of irritation, even for people with sensitive skin such as atopic dermatitis patients. As a result, the inventors have found that such cleansing cosmetics can be obtained by adding an anti-inflammatory component to the cleansing cosmetics, and have completed the invention. That is, the present invention provides a cleansing cosmetic containing a component having an anti-inflammatory action.
[0006]
DETAILED DESCRIPTION OF THE INVENTION
(1) The component which has an anti-inflammatory action which is an essential component of the cleansing cosmetic composition of the present invention The cleansing cosmetic composition of the present invention is characterized by containing a component having an anti-inflammatory action. The component having such anti-inflammatory effect, for example, dipotassium glycyrrhizinate, glycyrrhizinic acid-related substances such as grayed Richirurechin stearyl, extracts, anti-inflammatory herbal such as extracts such as burdock extracts and birch, etc. can be mentioned . Of these, the particularly preferred cosmetics for cleansing of the present invention are stearyl glycyrrhetinate and burdock extract. These components are excellent in the action of suppressing the occurrence of stimulation by physical action in usage forms involving scrubbing such as cleansing. Thereby, the cosmetic for cleansing suppresses that a stimulus is expressed at the time of a makeup operation to a person with sensitive skin. In the cleansing cosmetic composition of the present invention, the total content of the components having anti-inflammatory action is 0.005 to 1% by weight, more preferably 0.05 to 0.5% by weight. This is because if the amount is too small, the stimulus expression may not be suppressed, and if the amount is too large, the effect may reach a peak and the economic effect may be small.
[0007]
(2) Cleansing cosmetic of the present invention The cleansing cosmetic of the present invention is characterized by containing the anti-inflammatory component as an essential component. The cosmetic for cleansing referred to in the present invention is a cosmetic for removing oily components, and its dosage form includes a water-in-oil emulsified cream, a water-in-oil emulsified emulsion, an oil-in-water emulsified cream, Any of oil emulsions, multiphase emulsions, non-aqueous emulsions and the like can be applied. The cleansing cosmetic composition of the present invention contains, in addition to the above-mentioned components having anti-inflammatory action, any component that is usually used in such cosmetics within a range not impairing the effects of the present invention. can do. Such optional components include, for example, hydrocarbons such as squalane, petrolatum, microcrystalline wax, jojoba oil, carnauba wax , octyldodecyl oleate, esters such as diglycerin tetraoleate , olive oil, beef tallow, coconut oil Triglycerides such as, fatty acids such as stearic acid, oleic acid, lithinoleic acid, higher alcohols such as oleyl alcohol, stearyl alcohol, octyldodecanol, anionic surfactants such as sulfosuccinic acid ester and sodium polyoxyethylene alkyl sulfate, alkyl Amphoteric surfactants such as betaine salts, cationic surfactants such as dialkylammonium salts, sorbitan fatty acid esters, fatty acid monoglycerides, their polyoxyethylene adducts, polyoxyethylene amines Nonionic surfactants such as kill ethers, polyoxyethylene fatty acid esters, polyhydric alcohols such as polyethylene glycol, glycerin, 1,3-butanediol, thickening / gelling agents, antioxidants, UV absorbers, It can contain coloring agents, preservatives, powders, active ingredients such as vitamins, and the like. Of these optional components, in particular, as an ester-based oil preferably contains diglycerol tetraoleate. This is already known to be excellent in the action of dissolving and removing components that are difficult to remove even with ordinary cleansing cosmetics such as high melting point waxes. According to the study of the present inventor, as shown in the examples described later, this oil agent has a function of remarkably enhancing the effects of the present invention with little irritation to the skin during rubbing. The preferred content of diglycerin tetraoleate in the cleansing cosmetic of the present invention is 10 to 40% by weight, more preferably 20 to 30% by weight. This is because, if the amount is too small, the frictional stimulus reducing effect and cleansing action may not be recognized, and if the amount is too large, the effect may reach a peak and the degree of freedom of prescription may be impaired. Furthermore, the cleansing cosmetic composition of the present invention advantageously contains di-N-lauroyl-L-glutamate (cholesteryl octyldodecyl). This is because it also enhances the cleansing action without causing irritation to the skin. In the cleansing cosmetic composition of the present invention, a preferable content of the di-cholesteryl octyldodecyl N-lauroyl-L-glutamate is 0.1 to 10% by weight, and more preferably 0.5 to 5%. % By weight. This is because of the balance between cleansing effect and cost effectiveness. From the viewpoint of further reducing the elongation and reducing the friction coefficient, it is also preferable to contain 10 to 40% by weight, more preferably 15 to 25% by weight, of a branched fatty acid ester such as cetyl 2-ethylhexanoate. The cleansing cosmetic composition of the present invention can be produced by treating these components according to a conventional method. Thus cosmetic for the resulting cleansing since it is possible to slow down the oily dirt without having to express the stimulus be used under makeup operations, including the scraping operation, it is possible to use also no trouble with people of sensitive skin. Therefore, the cleansing cosmetic of the present invention is also suitable as a cleansing for people with sensitive skin such as atopic dermatitis. Of course, the cleansing cosmetic of the present invention does not have any disadvantages even when used by a person with normal skin, and even when used by a person with normal skin, it belongs to the technical scope of the present invention.
[0008]
【Example】
Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to these examples.
[0009]
<Example 1>
In accordance with the formulation shown below, it was cosmetic for cleansing the (oil-in-water emulsion) to create made. That is, the ingredients of A and B were each heated to 70 ° C., the ingredient of B was gradually added to the ingredient of A , and stirred and cooled to obtain a cleansing cosmetic.
Ibehenyl alcohol 1 part by weight 2-ethylhexanoate cetyl 20 parts by weight N-lauroyl-L-glutamate di (cholesteryl octyldodecyl) 5 parts by weight liquid paraffin 25 parts by weight butylparaben 0.1 part by weight polyoxyethylene (45) stear Rate 2 parts by weight sorbitan monostearate 1 part by weight Self-emulsifying glyceryl monostearate 1 part by weight polyoxyethylene (120) isostearate 1 part by weight beeswax 2 parts by weight olive oil 25 parts by weight dimethicone 10c. s. 2 parts by weight stearyl glycyrrhetinate 0.1 parts by weight 1,3-butanediol 3 parts by weight burdock extract 0.1 parts by weight water 11.7 parts by weight
<Example 2>
Using the cleansing cream of Example 1, a stimulus expression suppression test was performed. That is, the back of male Hartley guinea pigs (male, 300-400 g, 5 per group) was shaved, stripped 3 times with gummed tape, then wiped with 1% ethanol acetate solution, and then wiped with ethanol for sensitive skin. the model was created made. A 0.1 g cleansing material was applied to a 4 cm × 4 cm portion of the back of this model, and after rubbing 5 times, wiped with absorbent cotton, and 30 minutes later, the skin condition was observed and judged. Judgment criteria are: ++: clear redness is recognized in many parts, +: clear redness is scattered in the form of dots, ±: unclear but red impression,-: no redness is recognized Using. In Comparative Example 1, the essence of stearyl glycyrrhetinate and burdock of Example 1 was replaced with water. The results are shown in Table 1 as the number of appearance cases. Thus, it can be seen that the cleansing material of the present invention can be used with peace of mind even by people with sensitive skin.
[0011]
[Table 1]
<Example 3>
In accordance with the formulation shown below, it was cosmetic for cleansing the (oil-in-water emulsion) to create made. That is, the ingredients of A and B were each heated to 70 ° C., the ingredient of B was gradually added to the ingredient of A , and stirred and cooled to obtain a cleansing cosmetic.
Ibehenyl alcohol 1 part by weight 2-ethylhexanoate cetyl 20 parts by weight N-lauroyl-L-glutamate di (cholesteryl octyldodecyl) 5 parts by weight liquid paraffin 25 parts by weight butylparaben 0.1 part by weight polyoxyethylene (45) stear Rate 2 parts by weight sorbitan monostearate 1 part by weight Self-emulsifying glyceryl monostearate 1 part by weight polyoxyethylene (120) isostearate 1 part by weight beeswax 2 parts by weight diglycerin tetraoleate 25 parts by weight dimethicone 10c. s. 2 parts by weight Stearyl glycyrrhetinate 0.1 parts by weight 1,3-butanediol 3 parts by weight Burdock extract 0.1 parts by weight Water 11.7 parts by weight
<Example 4>
As in Example 2, the guinea pig sensitive skin model was examined together with Comparative Example 2 in which the cleansing stearyl glycyrrhetinate and burdock extract of Example 3 were replaced with water. Comparing actual施例2 both are at the cleansing cosmetic composition of the present invention, by containing the diglycerol tetraoleate, further stimulated expression was suppressed.
[0015]
<Example 5>
In accordance with the formulation shown below, it was cosmetic for cleansing the (oil-in-water emulsion) to create made. That is, the ingredients of A and B were each heated to 70 ° C., the ingredient of B was gradually added to the ingredient of A , and stirred and cooled to obtain a cleansing cosmetic. This also had an excellent stimulus suppressing action.
Ibehenyl alcohol 1 part by weight 2-ethylhexanoate cetyl 20 parts by weight N-lauroyl-L-glutamate di (cholesteryl octyldodecyl) 5 parts by weight liquid paraffin 25 parts by weight butylparaben 0.1 part by weight polyoxyethylene (45) stear Rate 2 parts by weight sorbitan monostearate 1 part by weight Self-emulsifying glyceryl monostearate 1 part by weight polyoxyethylene (120) isostearate 1 part by weight beeswax 2 parts by weight diglycerin tetraoleate 25 parts by weight dimethicone 10c. s. 2 parts by weight stearyl glycyrrhetinate 0.1 parts by weight dipotassium loglicyrrhizinate 0.1 part by weight 1,3-butanediol 3 parts by weight burdock extract 0.1 part by weight water 11.6 parts by weight
<Example 6>
About the cleansing creams of Examples 1, 3, and 5, a person with sensitive skin was used as a panelist (15 people per group, 45 people in total), and a use test was conducted for 8 weeks. Use method was according to the use of normal cleansing cosmetic. After the use test was completed, a questionnaire was used to evaluate the feeling of use (smoothness and comfort in use) and cleansing power. The evaluation criteria used were ++: very good, +: good, ±: slightly good, −: slightly bad, −—: bad. The results are shown in Table 2 . Thereby, it turns out that irritation | stimulation expression is suppressed and the cleansing cosmetics of this invention have the outstanding cleansing power so that even the person with sensitive skin can use it in comfort. Furthermore, since the difference in the degree of suppression of stimulation between Examples 1 and 3 in the use test is more open than in the animal experiment, it is smoother in use, in other words, no friction feeling. Can be said to greatly contribute to suppression of stimulation expression, in other words, comfort, and in that sense, the usefulness of diglycerin tetraoleate can be understood.
[0017]
[Table 2]
【The invention's effect】
ADVANTAGE OF THE INVENTION According to this invention, the cosmetics for cleansing with low possibility of irritation | stimulation expression can be provided.
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24819399A JP3681932B2 (en) | 1999-09-02 | 1999-09-02 | Cosmetics for cleansing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24819399A JP3681932B2 (en) | 1999-09-02 | 1999-09-02 | Cosmetics for cleansing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005096648A Division JP2005194290A (en) | 2005-03-30 | 2005-03-30 | Cleansing cosmetic |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001072548A JP2001072548A (en) | 2001-03-21 |
| JP2001072548A5 JP2001072548A5 (en) | 2004-12-09 |
| JP3681932B2 true JP3681932B2 (en) | 2005-08-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP24819399A Expired - Lifetime JP3681932B2 (en) | 1999-09-02 | 1999-09-02 | Cosmetics for cleansing |
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| JP (1) | JP3681932B2 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10223486A1 (en) * | 2002-05-27 | 2003-12-11 | Beiersdorf Ag | Cosmetic and / or dermatological preparation with 2,3-dibenzylbutyrolactones |
| JP4409164B2 (en) * | 2002-11-20 | 2010-02-03 | ポーラ化成工業株式会社 | Foam external preparation |
| JP2006306780A (en) * | 2005-04-28 | 2006-11-09 | Kao Corp | Liquid cleansing composition |
| CN104379122B (en) * | 2012-09-28 | 2018-10-26 | 富士胶片株式会社 | Cosmetics and emulsification composition containing Enoxolone derivative |
| JP6448376B2 (en) * | 2015-01-16 | 2019-01-09 | 株式会社マンダム | Lotion |
| JP6478651B2 (en) * | 2015-01-16 | 2019-03-06 | 株式会社マンダム | Cleansing lotion |
| JP6448378B2 (en) * | 2015-01-16 | 2019-01-09 | 株式会社マンダム | Beauty method |
| JP6448377B2 (en) * | 2015-01-16 | 2019-01-09 | 株式会社マンダム | Cleansing lotion |
| CN106999398B (en) * | 2015-01-16 | 2020-02-07 | 株式会社漫丹 | Makeup removing lotion, sheet cosmetic and cosmetic method |
| JP6448379B2 (en) * | 2015-01-16 | 2019-01-09 | 株式会社マンダム | Anti-acne lotion for wiping |
-
1999
- 1999-09-02 JP JP24819399A patent/JP3681932B2/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| JP2001072548A (en) | 2001-03-21 |
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