JP3609945B2 - Automatic analysis method and apparatus - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an automatic analysis method and apparatus, and more particularly to an automatic analysis method and apparatus suitable for performing immunoassay and biochemical analysis on the same specimen.
[0002]
[Prior art]
In an automatic analyzer that analyzes a sample (specimen) such as blood or urine, analysis of biochemical analysis items has been mainstream, but in recent years, analysis of immunological analysis items has also increased. In the biochemical automatic analyzer, analysis is performed by measuring the absorbance at a specific wavelength of a reaction solution that has caused a biochemical reaction. Even in the case of immunoassay, measurement by absorbance is performed for homogeneous immunoassay without B / F separation.
[0003]
On the other hand, immunological analyzers measure fluorescence and luminescence in heterogeneous immunoassay that performs B / F separation in a reaction solution that has caused an immune reaction between an antibody labeled with a fluorescent substance or a luminescent substance and an antigen target substance. By doing so, it is possible to perform more sensitive measurement of immunological analysis items.
[0004]
When highly sensitive measurement is performed by an automatic analyzer, when a sample is dispensed using a dispensing nozzle, there is a problem of sample carry-over in which a previously dispensed sample contaminates the next sample. In the biochemical automatic analyzer, the influence of the sample carryover on the measurement result is not at a level causing clinical problems, and therefore, special measures are rarely taken to avoid the sample carryover when dispensing the sample.
[0005]
On the other hand, there are many immunological analysis items that require high sensitivity, such as infectious disease analysis items, and these analysis items have a great influence on the measurement result of sample carryover and cannot be ignored. Therefore, in the case of an immune analyzer, there is a case where a sample carryover is avoided by attaching a disposable tip to a dispensing nozzle for dispensing a sample and replacing the disposable tip for each sample.
[0006]
[Problems to be solved by the invention]
As the analysis ratio of immunological analysis items in clinical tests increases, there is a need for a device that analyzes biochemical analysis items and immunological analysis items in a single system in order to improve work efficiency in the laboratory. In order to satisfy this requirement, a complex system composed of a combination of an analysis module for analyzing biochemical analysis items and an analysis module for analyzing immune analysis items is conceivable. In such a complex system, a system composed of a biochemical analysis module based on a technique used in a conventional biochemical automatic analyzer and an immune analysis module based on a technique used in a conventional immune analyzer can be configured. .
[0007]
However, there are cases where both biochemical analysis and immunoassay are performed on the same sample. In this case, the immunoassay in the immunoassay module is not affected by the impact of the sample carryover from the biochemical analysis module. It is desirable to prevent. It may also be necessary or desirable to re-analyze, i.e., re-inspect, such as when re-confirmation is necessary or when the analysis results are out of range. In the immunoassay, it is desirable to prevent the influence of the specimen carryover from the biochemical analysis module on the analysis even in such a retest.
[0008]
The object of the present invention is to prevent the influence of the sample carryover from the biochemical analysis module on the immunoassay when both the biochemical analysis in the biochemical analysis module and the immunological analysis module are performed on the same sample. In addition, when retesting the specimen that performs both biochemical analysis in the biochemical analysis module and immunoassay in the immunoassay module, the immune analysis of the sample carryover from the biochemical analysis module is affected. An object of the present invention is to provide an automatic analysis method and apparatus suitable for prevention.
[0009]
[Means for Solving the Problems]
According to one aspect of the present invention, a specimen including both an immunological analysis item and a biochemical analysis item is dispensed into a first analysis unit for immunological analysis and a second analysis unit for biochemical analysis. An automatic analysis method for analysis, in which the sample is dispensed into the first analysis unit, the dispensed sample is subjected to immunoanalysis, and the dispensed sample is placed on standby in a sample standby unit Determining whether or not reexamination of the sample is necessary based on the analysis of the dispensed sample, and when reexamination is necessary as a result of the determination, the waiting sample is analyzed for biochemical analysis. Therefore, the automatic analysis method includes the step of returning to the first analysis unit for immunological analysis prior to dispensing to the second analysis unit.
[0010]
According to another aspect of the present invention, a first analysis unit for immunoassay, a second analysis unit for biochemical analysis, and a specimen are dispensed into the first and second analysis units. An automatic analyzer including a transport line that transports the sample to be analyzed, the sample standby unit, and the sample to dispense the sample into the first analysis unit and perform immunoanalysis on the dispensed sample The transport line is controlled to transport the sample, and the transport line is controlled to transport the sample, which has been dispensed to the first analysis unit, to wait in the sample standby unit. Based on the analysis of the sample, it is determined whether or not retesting of the sample is necessary. If retesting is necessary as a result of the determination, the waiting sample is used for biochemical analysis. Prior to transport to the analysis unit It is characterized in an automatic analyzer including a computer for controlling the conveying line to return to the first analysis unit for immune analysis.
[0011]
DETAILED DESCRIPTION OF THE INVENTION
FIG. 1 shows an embodiment of an automatic analyzer according to the present invention. 1 includes a sample rack loading unit 1, an ID reading unit 2, a transfer line 3, a return transfer line 4, an analysis module 5 to 8, a sample rack standby unit 9, a sample rack collection unit 10, and an overall management computer 11. Including.
[0012]
The sample rack loading unit 1 is a portion for loading a plurality of sample racks each holding a plurality of samples (samples). The analysis modules 5 to 8 are detachably connected to the transport line 3 along the transport line. The number of analysis modules may be arbitrary, but is four in the drawing. The four analysis modules 5 to 8 constitute two analysis units. That is, the first analysis unit is composed of two units upstream of the conveyance, that is, analysis modules 5 and 6, which are immunological analysis modules. The second analysis unit is composed of two downstream units, that is, analysis modules 7 and 8, which are biochemical analysis modules. Of course, each of the first and second analysis units may be composed of one analysis module, or may be composed of three or more analysis modules.
[0013]
The transport line 3 transports the sample rack from the sample rack input unit 1 to a predetermined analysis module among the analysis modules 5 to 8, and the sample rack that holds the sample that has been analyzed in the analysis module is stored in the sample recovery unit. 10 so as to be housed in the storage. Each of the analysis modules 5 to 8 has service lines 51, 61, 71, and 81, and each transport from the transport line 3 of the sample rack to the analysis modules 5 to 8 moves the sample rack to the service lines 51, 61, 71, and 81. Each is done by pulling in. The return transport line 4 returns the sample rack analyzed by any of the analysis modules 5 to 8 to the entrance side of the transport line 3 when it is necessary to re-examine or to analyze by another analysis module. Is for. When the sample rack standby unit 9 further analyzes the sample analyzed by either of the analysis modules 5 or 6 with another analysis module, the sample rack standby unit 9 determines whether or not to retest after the dispensing by the analysis module 5 or 6 is completed. This is the part that temporarily waits until the result is obtained.
[0014]
Each of the analysis modules 5 to 8 includes computers 12 to 15 that perform control for necessary processing in the analysis module. The sample rack input unit 1 includes a computer 16 that performs necessary control in the sample rack input unit, the transfer line 3, the reexamination transfer line 4, and the sample rack collection unit 10. Further, the sample rack standby unit 9 includes a computer 17 that performs necessary control in the sample rack. These computers and ID reading unit 2 are connected to a computer 11 for overall management. The computer 11 is further connected to an operation unit 18 for inputting necessary information and a display unit 19 for displaying analysis results.
[0015]
The sample held by the sample rack has a sample ID indicating information on the sample (acceptance number, patient name, requested analysis item, etc.), and the sample rack has a rack ID indicating rack identification information such as a rack number. The sample rack in the sample rack loading unit 1 is transported by the transport line 3. When the sample rack moves to the transport line 3, the sample ID and the sample rack ID are read by the ID reading unit 2 and sent to the computer 11. . Based on the information, the computer 11 determines in which analysis module the analysis of the requested analysis item is performed, and gives the information to the computer 16 or the computer of the determined analysis module.
[0016]
Now, assume that the same sample rack stops at two places, the immunological analysis module 5 and the biochemical analysis module 7, and analyzes the immunological analysis item and the biochemical analysis item for the sample held by the sample rack. The sample rack is transported to the immune analysis module 5 by the transport line 3, where it is dispensed and subjected to immunoanalysis. When the dispensing is completed, the sample rack is transported to the biochemical analysis module 7 by the transport line 3 when the sample held in the sample rack is not designated for automatic reexamination. The specimen held in the specimen rack is subjected to biochemical analysis. The sample rack holding the sample for which biochemical analysis has been completed is transported to the sample rack recovery unit 10 by the transport line 3 and recovered.
[0017]
When the sample held in the sample rack is a sample for which automatic reexamination is designated and includes an immunological analysis item for which automatic reexamination is designated, the sample rack is transported line 3 after completion of dispensing for immunological analysis. Therefore, the sample is transferred to the sample rack standby unit 9 without being stopped by the analysis modules 6 to 8, and is temporarily standby. In the meantime, the computer 11 determines whether or not retesting is necessary according to a predetermined algorithm or logic. If retesting is necessary as a result of the determination, the sample rack is transported by the transport line 3 and the return transport line 4. The sample is returned to the inlet side of the sample and further conveyed to the analysis module 5 by the conveyance line, and the sample held in the sample rack is again dispensed, and re-examination, that is, immunoassay is performed again. After dispensing for the second immunoanalysis in the analysis module 5, the sample rack is transported to the analysis module 7, where the sample is dispensed and biochemically analyzed. Thereafter, the sample rack is transported to the sample rack collection unit 10 by the transport line 3 without stopping at the analysis module 8 and the sample rack standby unit 9 when the sample held in the sample rack is a sample that is not designated for retesting. And recovered.
[0018]
For the sample rack dispensed by the analysis module 7, if the sample held in the sample rack is a sample designated for reexamination and includes a biochemical analysis item designated for reexamination, the sample rack is dispensed by the analysis module 5. For a sample rack that has already been processed, the same steps are executed as in the case where the sample held in the sample rack is a sample that has been designated for retesting and includes an immunological analysis item that has been designated for retesting.
[0019]
If there is another sample rack to be subjected to biochemical analysis in the analysis module 8 during the immunological analysis process in any of the analysis modules 5 to 8, for example, the analysis module 5, the sample rack is transferred to the transport line. 3 may be directly transported to the analysis module 8 without stopping at any of the analysis modules 5 to 7. In this sense, the transport line 3 can also be called an overtaking transport line.
[0020]
In the case of performing both biochemical analysis in the biochemical analysis module and immunological analysis in the immunological analysis module, in the embodiment, the immunological analysis in the immunochemical analysis module is performed prior to the biochemical analysis in the biochemical analysis module. . In addition, samples that have been dispensed for immunoassay will temporarily wait in the sample rack standby section until a determination is made as to whether or not retesting is necessary, and a determination result will be displayed that retesting is necessary. In this case, the sample rack is transported so that the immune analysis in the immune analysis module is executed again prior to the biochemical analysis in the biochemical analysis module. For this reason, the influence of the specimen carryover from the biochemical analysis module on the immunoassay is prevented.
[0021]
FIG. 2 shows details of the immunoassay module 5 of FIG. The plurality of reagent containers 20 are arranged in a circle on the reagent disk 21, and the reagent disk 21 is rotated by a motor. The plurality of reaction vessels 22 are arranged in a circular shape on a thermostat 23, and the thermostat 23 is rotated by a motor. The reaction container 22 is moved from the reaction container installation position 24 to the sample dispensing position 25, the reagent dispensing position 26, and the reaction liquid suction position 27 by the rotation operation of the constant temperature bath 23.
[0022]
The sample dispensing pipettor 28 can be moved from the sample suction position 29 to the sample dispensing position 25 by a motor. When the sample rack 30 is drawn into the lead-in line 51 and is held by the sample rack and the sample (sample) positioned at the sample suction position 29 is dispensed into the reaction container 22 at the sample dispensing position 25, The disposable tip 31 is attached to the tip end of the pipetter 28.
[0023]
The reagent dispensing pipetter 32 can be moved from the reagent suction position 33 to the reagent dispensing position 26. The sipper 34 is movable between a reaction solution suction position 27, a buffer solution suction position 35, and a flow cell internal cleaning position 36. Further, the sipper 34 has a function of sending the reaction solution to the flow cell in the detection unit 37 through the tube.
[0024]
The chip and reaction container transfer mechanism 38 transfers the disposable chip 31 from the chip storage position 39 to the chip mounting position 55 and the reaction container 22 from the reaction container storage position 40 to the reaction container installation position 24. The reagent dispensing pipettor 32 and the sipper 34 wash their nozzles at their respective washing positions (not shown).
[0025]
To explain the operation of the immunological analysis module 5, first, the chip and reaction container transfer mechanism 38 transfers the disposable chip 31 to the chip mounting position 55 and the reaction container 22 to the reaction container installation position 24. When the sample is positioned at the sample aspirating position 29, the reagent disk 21 rotates so as to position the reagent container 20 containing the reagent used for analyzing the sample at the reagent aspirating position 33, and the sample dispensing pipetter 28 has its own nozzle. After the disposable tip 31 is mounted, the sample is moved to the sample suction position 29 and the sample (specimen) is sucked. After sample suction, the sample dispensing pipetter 28 is moved to the sample dispensing position 25 and discharges the sucked sample to the reaction vessel 22. After the release, the sample dispensing pipetter 28 is moved to the tip discarding position 41 and the tip at the tip is discarded.
[0026]
The reaction container 22 from which the sample has been released is moved to the reagent dispensing position 26 by the rotation of the reaction disk 23. The reagent dispensing pipettor 32 sucks the reagent at the reagent suction position 33 and releases it to the reaction container 22 moved to the reagent dispensing position 26. The reaction container 22 containing the immune reaction liquid of the reagent and the sample is moved to the reaction liquid suction position 27 by the rotation of the reaction disk 23 after a predetermined time has elapsed. The sipper 34 sucks the reaction solution, further moves to the buffer solution suction position 35 to suck the buffer solution, and transfers it to the flow cell in the detection unit 37 through the tube. As a result, optical measurement is performed, and an analysis result of the immunological analysis item is obtained. Thereafter, the sipper 34 is moved to the flow cell internal cleaning position 36 to suck the flow cell internal cleaning liquid and flow it through the tube to the flow cell to clean the flow cell.
[0027]
The details of the immunoassay module 6 of FIG. 1 are the same as those shown in FIG. Therefore, the description is omitted to avoid duplication.
[0028]
FIG. 3 shows details of the biochemical analysis module 7 of FIG. The biochemical analysis module 7 includes a first reagent disk 43 and a second reagent disk 44 in which a plurality of first reagents 41 and second reagents 42 are arranged in a circle, and first and second reagent dispensing. A reagent system including pipettes 45 and 46, a sample system including sample dispensing pipettor 47, a reaction system in which a plurality of reaction vessels 50 are arranged on a reaction disk 49 through which constant temperature water from a constant temperature bath 48 circulates, A measurement system (analysis system) including a wavelength photometer 52 is provided.
[0029]
The sample rack 30 is drawn into the lead-in wire 71, held in the sample rack, and the sample (sample) positioned at the sample suction position is sucked by the sample dispensing pipettor 47 and dispensed into the reaction container 50 of the reaction disk 49. Released in position. The reaction container 50 from which the sample has been released is moved to the first reagent dispensing position by the rotation of the reaction disk 49, where the first reagent 41 held on the first reagent disk 43 is stored in the reaction container 50. Dispensed by the first reagent pipetter 45. The reaction vessel 50 into which the first reagent has been dispensed is moved to the stirring position, where the sample and the first reagent are stirred at the stirring position 53.
[0030]
When the second reagent needs to be added, the stirred reaction vessel 50 is moved to the second reagent dispensing position, where the reaction vessel 50 is held by the second reagent disk 44. The second reagent 42 is dispensed by the second reagent pipetter 46. The dispensed reaction container 50 is moved to the stirring position, where the sample, the first reagent, and the second reagent in the reaction container 50 are stirred by the stirring device 53, and the reaction liquid is generated. The
[0031]
The reaction vessel 50 containing the reaction solution is moved to the measurement position, where the multi-wavelength photometer 52 measures the multi-wavelength absorbance of the reaction solution, and the analysis result of the biochemical analysis item is obtained.
[0032]
The details of the biochemical analysis module 8 of FIG. 1 are the same as those shown in FIG. Therefore, the description is omitted to avoid duplication.
[0033]
FIG. 4 shows a system operation flow of the automatic analyzer according to the present invention. The operator first installs the reagent at a predetermined position in each analysis module, and stores in the storage device in the computer 11 information on which analysis module each reagent is in and for which analysis item. And register (S401). This registration may be performed by the operator operating the operation unit 18 or may be performed by automatically reading the reagent ID of the reagent.
[0034]
Next, the operator operates the operation unit 18 to designate whether or not the automatic reinspection logic is to be activated for each analysis item, and if so, which reinspection logic is to be activated (S402). This is to automatically perform re-inspection only for analysis items that really require re-inspection, and greatly contributes to minimizing the reduction in processing capacity of the entire apparatus. The automatic re-inspection logic specifically indicates the following conditions, for example. These are stored in advance in the storage device of the computer 11 and registered, and the operator can select and select one.
[0035]
(1) Always carry out automatic re-inspection unconditionally.
[0036]
(2) When the analysis (measurement) range that is set in advance for the deviation of the analysis item is deviated, an automatic reexamination is performed (for example, for TSH (Thyrotropin Thyroid Stimulating Hormone), the analysis result is 0.27 IU / ml or more If there is a deviation from the condition of 4.2 IU / ml or less).
[0037]
(3) If the difference between the current analysis value and the previous analysis value for a sample derived from the same subject exceeds a preset field value, an automatic reexamination is performed (for example, the current measurement value is the same as the previous measurement value). If it is more than 50% different).
[0038]
Thereafter, the operator operates the operation unit 18 to designate an analysis (measurement) channel use algorithm in the case of performing automatic reexamination (S403). The analysis channel use algorithm in the case of performing automatic re-examination specifically shows the following conditions, for example. These are stored in advance in the storage device of the computer 11 and registered, and the operator can select and select one.
[0039]
(1) Use the same analysis (measurement) channel as in the analysis (measurement) before the retest.
[0040]
(2) Use an analysis channel that is different from the one used before the retest. This is effective when the analysis channel before retesting is abnormal.
[0041]
(3) Use a plurality of analysis channels including the same analysis channel as in the analysis before the retest. This is effective when it is desired to obtain a highly reliable analysis result.
[0042]
(4) Use a plurality of analysis measurement channels that do not include the same analysis channel as in the analysis before the retest. This is effective when the analysis channel before retesting is abnormal and it is desired to obtain a highly reliable analysis result.
[0043]
Each analysis module has only one analysis (measurement) channel in the embodiment, but may have a plurality of analysis channels. Further, the plurality of analysis channels in the above (3) and (4) may be a plurality of analysis channels within one analysis module, or a plurality of analysis channels spanning a plurality of analysis modules within the same analysis unit. It may be an analysis channel.
[0044]
The automatic recheck logic information and the analysis channel use algorithm may be stored and registered not in the storage device in the computer 11 but in a storage device provided outside the computer 11.
[0045]
The operator then inserts a sample rack into the sample rack input unit 1 and registers in the computer 11 which analysis item is analyzed for which sample, that is, performs an analysis item request by operating the operation unit 18 (S404). . The operator then operates the operation unit 18 to determine whether or not to execute the above-described automatic reexamination logic for each specimen (S405). This is effective in that, for example, consumption of an important minute sample can be prevented by omitting automatic reexamination. When the operation by the operator as described above is completed, the analysis is started (S407), the analysis result is output (S407), and the analysis is completed (S408).
[0046]
FIG. 5 shows a sample rack transport process flow according to the present invention. The sample rack is loaded into the sample rack loading unit 1 (S501). When the loaded sample rack is transferred to the transport line 3 (S502), the sample ID and the rack ID are read by the ID reading unit 2 (S503). The information is sent to the computer 11.
[0047]
The computer 11 determines whether there is a sample requested to be analyzed for the immunological analysis item on the sample rack (S504). If the result is “YES”, the sample rack is based on a command from the computer 11 to the computer 16. Is transferred to a predetermined immune analysis module by the transfer line 3 (S505), dispensing is performed based on a command from the computer 11 to the computer of the immune analysis module, and an immune analysis is performed on the immune analysis items ( S506).
[0048]
After the end of the dispensing, the computer 11 determines whether or not the dispensed sample is the sample with the automatic reexamination designation performed in step S405 in FIG. 4 (S507), and the result is “YES”. If so, it is determined whether or not the sample includes the immunological analysis item designated in step S405 in FIG. 4 and designated for automatic reexamination (S508). If the result is “YES”, the sample rack is transported to the sample rack standby unit 9 by the transport line 3 based on a command from the computer 11 to the computer 16 (S509), and waits there until the analysis result is obtained (S510). ).
[0049]
The computer 11 determines whether the automatic reexamination is necessary after the analysis result is obtained based on the reexamination logic designated in step S402 in FIG. 4 (S511). For example, the sample rack is transported to a predetermined immune analysis module by the transport line 3 and the return transport line 4 in accordance with the selected analysis channel use algorithm based on a command from the computer 11 to the computer 16 (S512). Dispensing is performed based on a command from the computer 11 to the module computer, the immunoassay is performed again (S513), and the process is terminated (S514).
[0050]
If the determination result in steps S507, S508, and S511 is “NO”, the flow proceeds to step S514.
[0051]
When step S514 is completed or when the determination result in step 504 is “NO”, steps S515 to S525 for biochemical analysis corresponding to steps S504 to S514 for immunoassay are respectively performed in the same manner. When the analysis is completed or when the analysis is necessary, the sample rack is recovered by the sample rack recovery unit 10 (S526).
[0052]
In the above embodiment, when both biochemical analysis in the biochemical analysis module and immunoassay in the immunological analysis module are performed, the immunoanalysis in the immunochemical analysis module precedes the biochemical analysis in the biochemical analysis module. Done. In addition, samples that have been dispensed for immunoassay temporarily wait in the sample rack standby section until the determination of whether or not retesting is necessary, and the determination result that retesting is necessary When it comes out, the sample rack is transported so that the immune analysis in the immune analysis module is executed again prior to the biochemical analysis in the biochemical analysis module. For this reason, the influence of the specimen carryover from the biochemical analysis module on the immunoassay is prevented.
[0053]
FIG. 6 shows part of another embodiment of an automatic analyzer according to the present invention. This embodiment differs from the embodiment of FIG. 1 in that each analysis module does not have a lead-in line as shown in FIG. Therefore, in this embodiment, the sample rack remains on the transport line 3 even during sample dispensing.
[0054]
In the embodiment of FIG. 6, sample rack standby units 9 a to 9 d are provided at the rear of each of the analysis modules 5 to 8, and the sample rack can be returned to the rear by the return conveyance line 4 from any of them. It is different from the embodiment of FIG. The embodiment of FIG. 6 is otherwise substantially the same as the embodiment of FIG.
[0055]
【The invention's effect】
According to the present invention, when both the biochemical analysis in the biochemical analysis module and the immunological analysis module are performed on the same specimen, the influence of the specimen carryover from the biochemical analysis module on the immunological analysis is prevented. In addition, when retesting the specimen that performs both biochemical analysis in the biochemical analysis module and immunoassay in the immunoassay module, the immune analysis of the sample carryover from the biochemical analysis module is affected. An automated analysis method and apparatus suitable for prevention is provided.
[Brief description of the drawings]
FIG. 1 is an overall conceptual diagram of an automatic analyzer showing an embodiment according to the present invention.
FIG. 2 is a detailed plan view of the immune analysis module of FIG.
3 is a detailed plan view of the biochemical analysis module of FIG. 1. FIG.
FIG. 4 is a system operation flowchart of the automatic analyzer according to the present invention.
FIG. 5 is a flow chart of a sample rack transport process according to the present invention.
FIG. 6 is a conceptual diagram of a part of an automatic analyzer showing another embodiment according to the present invention.
[Explanation of symbols]
1: sample rack input unit, 2: ID reading unit, 3: transport line: 4: return transport line, 5-8: analysis module, 9: sample rack standby unit, 10: sample rack recovery unit, 11: for overall management Computer, 12-17: Computer, 18: Operation part, 19: Display part, 51, 61, 71, 81: Lead-in line.

Claims (10)

An automatic analysis method for analyzing a sample containing both an immunological analysis item and a biochemical analysis item by dispensing the sample into a first analysis unit for immunological analysis and a second analysis unit for biochemical analysis. Based on the analysis of the dispensed sample, the sample is dispensed into the first analysis unit, and the dispensed sample is immunoanalyzed, the sample that has been dispensed is made to wait in the sample standby unit Determining whether or not retesting of the sample is necessary, and when retesting is necessary as a result of the determination, the waiting sample is dispensed to the second analysis unit for biochemical analysis. Prior to doing so, an automated analysis method comprising the step of returning to the first analysis unit for immunoassay. 2. The automatic analysis method according to claim 1, further comprising a step of directly transporting the waiting sample to the second analysis unit when re-examination is unnecessary as the determination result. 3. The automatic analysis method according to claim 1, wherein the determination is performed based on a predetermined reinspection logic. The re-examination logic according to claim 3, wherein the re-examination logic always performs an automatic re-examination unconditionally, a condition that an automatic re-examination is performed when a predetermined analysis range is deviated, and the same subject An automatic analysis method characterized by including at least one of the conditions that a retest is performed when a difference between a current analysis value and a previous analysis value of a sample exceeds a predetermined value. 5. The automatic analysis method according to claim 1, wherein the specimen returned to the first analysis unit is analyzed based on a predetermined analysis channel use algorithm. 6. The analysis channel use algorithm according to claim 5, wherein the analysis channel use algorithm uses the same analysis channel as the analysis before the retest, the condition that the analysis channel is different from the analysis before the retest, and the analysis before the retest. Automatic including at least one of a condition for using a plurality of analysis channels including the same analysis channel and a condition for using a plurality of analysis channels not including the same analysis channel as at the time of analysis before retesting Analysis method. An automatic including a first analysis unit for immunological analysis, a second analysis unit for biochemical analysis, and a transport line for transporting a sample to be dispensed and analyzed in the first and second analysis units An analyzer that controls the transport line so as to transport the specimen to a specimen standby section and to dispense the specimen into the first analysis unit and perform immunoanalysis on the dispensed specimen; The transport line is controlled to transport the sample that has been dispensed to the first analysis unit so that the sample standby unit waits, and the sample is re-inspected based on the analysis of the dispensed sample. And if a retest is required as a result of the determination, an immunoassay is performed prior to transporting the waiting sample to the second analysis unit for biochemical analysis. For the first analysis unit Automatic analyzer which comprises a computer for controlling the conveying line to return to Tsu and. 8. The computer according to claim 7, wherein the computer controls the transport line so as to transport the waiting sample directly to the second analysis unit when the re-examination is unnecessary as the determination result. Automatic analyzer to do. 9. The automatic analyzer according to claim 7, further comprising means for preliminarily storing retest logic for making the determination. The automatic analyzer according to any one of claims 7 to 9, further comprising means for previously storing an analysis channel use algorithm for reexamination of the specimen returned to the first analysis unit.

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