JP3301768B2 - Injectable syringe filled with ready-to-use drug - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a syringe for a drug which is unstable and cannot be stored for a long time in a solution state, and more particularly, dissolves the drug by a simple operation immediately before use. Injectable solutions can be prepared and used for injection, and can be injected in multiple doses if necessary with a portable and convenient syringe.

[0002]

2. Description of the Related Art In recent years, with the advancement of medical treatment, many new injections having high effects have been developed. Some of them
For example, some drugs such as hormones and interferons are unstable, and it is difficult to store them in a solution state that can be used immediately for injection for a long time. These drugs are
Immediately before use, it is necessary to dissolve in a drug solution and use. Some hormones, such as hormonal drugs, need to be carried by the patient and used at regular intervals.

[0003] For use in such applications, there has also been disclosed a syringe in which a drug and a drug solution are separately sealed in a vial, and the two are mixed and dissolved immediately before use so that the syringe can be used as it is. You . For example, JP-A-64-80371 discloses that a drug and a drug solution are separated and sealed in a multi-chamber cylinder ampule having a bypass, and the plunger is pushed in at the time of use, whereby the drug solution passes through the bypass and the drug is passed. Discloses a syringe which flows into a space in which is enclosed to dissolve a drug, and which can be used as it is by attaching a syringe needle.

However, in this mechanism, when the plunger is pushed in during use to dissolve the drug with the drug dissolving solution, a large amount of air or other gas is present in the space in which the drug is sealed in advance, so the dissolving solution is pressurized. Prepared in a state. When dissolving the drug, because of the pressurized state, the volume of the gas is reduced and the generation of bubbles is suppressed, so that the solution is unnecessarily stirred or a large amount of bubbles can be prevented from remaining in the solution, Before injection, it is necessary to release a large amount of air from the needle tip.At that time, even in the pressurized state, extremely small air bubbles return to normal pressure and become large air bubbles. And the operation becomes complicated.

Further, when the plunger is pushed in to dissolve the medicine with the medicine dissolving solution, when an injection needle is attached to the cylinder to remove residual air or the like inside, when the inside of the cylinder is in a pressurized state, the gas is rapidly increased. Are spouted, and there is a problem that a skilled operation is required.

[0006]

DISCLOSURE OF THE INVENTION The present invention relates to a method for preparing an injection solution and a method for injecting hormonal agents, etc., which are used by ordinary people who are not skilled in handling medical equipment. The purpose of the present invention is to provide a syringe which is easy and reliable to operate.

[0007]

SUMMARY OF THE INVENTION The present inventor has disclosed a drug and a drug solution preliminarily separated and sealed in a single vial.
It has been discovered that by pre-encapsulating a mechanism and a drug that can be easily mixed to prepare an injection solution under reduced pressure, an extremely small amount of excess gas can be left when preparing an injection solution. Based on this, the present invention has been achieved.

That is, the vial body 1, the cap 2,
It consists of a front space 3, a connector 4, a rear space 5, a lid 6, a holder body 7, an injection needle 8 and a plunger 9, and a cap 2, a connector 4,
And a lid 6 are attached, a front space 3 is provided between the cap 2 and the connector 4, a rear space 5 is provided between the connector 4 and the lid 6, and the medicine 10 is provided in the front space 3.
A drug solution 11 is sealed in the rear space 5, the inside of both spaces is kept under reduced pressure, a thick portion 12 is provided in the middle part of the vial main body 1, and the distal end of the holder main body 7 is penetrated. Injection needle 8 is attached and needle tips 14 and 15 are provided inside and outside. When using, plunger 9 is inserted into lid 6 and pushed in, drug dissolution solution 11 and connector 4 are pushed in, and connector 4 is inserted. In the rear space, it has a shape that is in close contact with the inner surface of the vial body 1,
When the diameter reaches the thick portion 12, it becomes an oval 13 and a space is formed between the connector 4 and the vial body 1, and the drug solution 11
Flows into the front space 3 through the space, and the drug 10
Is dissolved into an injection solution, and then the holder 7 is placed in the vial 1.
The needle tip 14 inside the holder 7 penetrates the cap 2 and is connected to the front space 3, and the injection solution inside the front space 3 can be injected from the needle tip 15 by pushing the plunger 9. A syringe filled with a medicine for use at the time of use characterized by the above-mentioned features. Alternatively, the connector may be provided with a pressurizing flow mechanism so that the middle part of the vial does not need to be thickened, and an injection volume setting mechanism may be added to these syringes.

Although it is described herein that a drug is dissolved in a drug dissolving solution, recent injection solutions are sometimes used in the form of emulsions or suspensions, such as fat emulsions. Can be used as it is. The present invention includes the case where an emulsion or suspension is prepared and used as an injection solution in addition to an aqueous solution. Hereinafter, the present invention will be described in detail.

When an unstable drug is sealed in a vial,
Usually, the drug is placed in a vial, lyophilized, and sealed in a powder state. Next, during the storage period, a connector serving as a partition wall for the drug solution is inserted, and the drug solution is further sealed. Since the drug is in a powder form, it is inevitable that the gas coexists when a large amount of air or inert gas is replaced. Also, when introducing the drug solution into the space in which the drug is enclosed, it is difficult to introduce the remaining gas while extracting the residual gas due to the structure of the vial. It is in a pressurized state coexisting with the existing gas. If the solution is prepared in a pressurized state, the bubbles generated during the dissolution become smaller, and the solution is unnecessarily stirred, and thus there is an advantage that troubles such as deterioration can be prevented.

However, since the space in which the injection solution and a considerably large amount of gas are filled is in a pressurized state, air or the like is blown out when the injection needle is attached, and the pressure drops at that time. In addition, since small bubbles in the liquid, which have not been noticeable until now, become large bubbles, the operation becomes complicated, such as the necessity of degassing again before injection.

If the drug is sealed in a reduced pressure state, even if the solution is introduced, the pressure is hardly increased, and such a trouble that the residual gas amount is very small hardly occurs.

[0013] Further, in such a mechanism, the partition wall is formed by dissolving the solution.
Must be introduced into the space containing the drugTo
However, these days, synthetic rubber or plastics are very extensive.
Since materials with enclosing physical properties have been developed,
Or plastic material or a gap that can be broken by pressing
Use walls, plastic bulkheads with check valves, etc.
Can achieve this goal with a simple mechanism.
You. The present invention has been made from such a viewpoint.

Next, the present invention will be specifically described with reference to the drawings. FIG. 1 illustrates a cross-sectional view of one embodiment of the present invention before use. A cap 2, a connector 4 and a lid 6 are attached to the vial body 1, a front space 3 is formed between the cap 2 and the connector 4, a rear space 5 is formed between the connector 4 and the lid 6, and a front space 3 is formed. In the rear space 5, a drug solution 11 is enclosed. Drugs used in a syringe having such a mechanism are unstable and may be deteriorated when stored in a solution state for a long period of time.
, And freeze-dried to form a powder, and then the connector 4 is introduced to encapsulate the drug 10 in the vial body.
Next, a predetermined amount of the drug solution 11 is injected into the rear space 5 and closed with the lid 6. The cap 2 has a rubber stopper in the center and a periphery covered with aluminum foil, but the periphery of the center line of the vial has no aluminum foil covering and the rubber stopper is exposed. This is so that when the holder is mounted on the vial, the needle tip 14 of the injection needle 8 is connected to the front space 3 through the portion where the rubber stopper is exposed. The material of the central part of the cap does not necessarily need to be a rubber stopper, but may be plastic or foam as long as it has high elasticity. However, when the injection needle is pulled out, the front space 3 is completely shut off from the outside. It must be a material having Therefore, multiple injections can be performed by replacing the holder. Generally, synthetic rubber is preferable, and it is preferable to cover the area other than the vicinity of the center line with a protective aluminum foil or the like.

The vial main body 1 is made of glass and has a shape 12 in which a part of an intermediate portion is thickened as shown in FIG. The material of the vial is not limited to glass, and can be widely used as long as it is transparent and does not contain components eluted in the injection solution, similar to commonly used syringes. Accordingly, plastics and the like can be used in addition to glass. However, since the syringe of the present invention often uses an unstable and sensitive drug, the most chemically stable glass is preferable.

The connector 4 is made of synthetic rubber and has a rear space 5 in the vial main body and a thickened portion 12 in the middle of the main body.
FIGS. 3 (a) and 3 (b) are cross-sectional views of the case in which the device is mounted on the device. As shown in FIG. 3 (b), the connector 4 has an elliptical shape with a gap between the vial inner wall and the rear space 5 having a small inner diameter as shown in FIG. When compressed, it is compressed and
As shown in (a), it is circular and is in close contact with the inner wall.

The lid 6 is made of a circular rubber and has a shape which is in close contact with the inner wall of the vial body. The connector 4 and the lid 6 are not limited to those made of rubber, and plastics or foams can be widely used as long as they are high elastic materials.

The injection needle 8 extends through the tip of the holder body 7.
Is attached, and both inside and outside ends of the needle are
14 and 15. When the vial is inserted so as to be inserted into the holder, the needle tip 14 passes through the cap 2 and the needle tip 14
Are connected to the front space 3. A collar 20 is provided at the rear end of the holder and can be used to hang a finger during injection. When the holder is attached to the vial, the distance between the flange and the rear end of the vial is preferably at least 10 mm or more in use. Further, the material of the holder is not particularly limited, and it is preferable that the material is transparent and its internal state can be easily understood, and transparent plastic or glass is suitable.

The plunger 9 is used by being attached to the lid 6, but may be attached in advance, or may be attached only when used. The material is not particularly limited, but a plastic molded product is preferable in consideration of the shape of the joint portion with the lid 6 .

In the syringe of the present invention, the drug and the drug solution are separately sealed in the vial. Therefore, when the syringe is used, the drug is dissolved in the drug solution and the injection solution is prepared as a preparation step. Need to be prepared. Therefore, when the plunger 9 is attached to the lid 6 and pushed into the inside, the drug solution 11 is hardly compressed because it is a liquid,
The drug solution 11 and the connector 4 are simultaneously pushed in to transmit the pressure. At this time, the connector 4 is in close contact with the inner surface of the vial body 1 in the rear space as shown in FIG.
Since arising is between gap between the inner surface shape and becomes connector 4 and vial oval 13 shown in, the drug solution 11 flows into the front space 3 through which between gap, and injections by dissolving agents 10 Become.

FIG. 2 shows that when the lid 6 is pushed in, the connector 4 is pushed in at the same time, and the thick portion of the middle portion of the vial is pushed.
FIG. 4 shows a state in which the drug solution 11 sealed in the rear space 5 has flowed into the front space 3 in which the drug has been sealed through the gap between the connector 4 and the inner surface of the vial 1 because the solution has reached 12. Since the whole amount of the drug solution 11 has flowed into the front space 3, the lid 6 comes into close contact with the connector 4,
This shows a state in which the preparation of the injection solution is completed by dissolving the drug. At this time, a small amount of residual gas is present in the front space 3 together with the injection solution.

Next, when the holder 7 is attached to the vial body 1 for injection, the needle tip 14 inside the holder 7 penetrates the cap 2 and is connected to the front space 3. At this time, it is necessary to attach the holder 7 to the vial 1 with the vial body 1 with the cap 2 up. This is to prevent leakage of the injection solution and to remove a small amount of gas remaining with the injection solution. FIG. 5 shows a state where the holder 7 is attached to the vial body 1.

If the vial 1 is held in the state shown in FIG. 5 with the cap 2 facing upward, a small amount of residual gas has accumulated in the upper part of the injection solution. Is ready for injection. FIG. 6 shows the state of the syringe at that time.

At this time, in FIG. 5, if the opening at the tip of the needle tip 14 penetrates the cap 2 and completely enters the inside of the front space 3, it is collected between the needle tip and the inner surface of the cap. Residual gas cannot be removed. However, if a part of the opening at the tip of the needle tip 14 reaches the inner surface of the cap, the residual gas can be completely removed. For this purpose, for example, the length from the inner surface of the holder to the needle tip can be adjusted so that a part of the opening of the needle tip reaches the inner surface of the cap. The needle tip 14 and the inner surface of the cap 2 in FIG. 5 show such a state. In addition, the angle of the needle tip 14 is made more acute to make the opening longer, or in FIG.
If the upper end of the opening of the needle tip 14 is extended in an elongated slit shape, a part of the opening can easily reach the inner surface of the cap.

Next, the needle tip 15 is pierced into the skin at the part to be injected,
By pushing the plunger 9, the front space 3
The injection solution inside is injected into the body from the needle tip 15.

In the syringe of the present invention, the drug and the drug solution are sealed in the vial under reduced pressure, and the inside of the vial needs to be kept at reduced pressure even during the storage period. When the injection solution is prepared inside the front space 3, the drug is sealed under reduced pressure in advance, so that the dissolution is completed,
The amount of residual gas coexisting with the injection solution is only a small amount, and the inside is almost at normal pressure. Therefore, even when the holder 7 is mounted and the needle tip 14 is connected to the front space 3, the gas inside does not spout suddenly, and bubbles are generated in the injection solution due to the pressure drop accompanying the gas spouting. Not even.

When a drug and a drug solution are sealed in a usual manner, the drug and the air at normal pressure are sealed in the front space 3, so that when the drug solution is injected, the inside of the front space 3 is considerable. It is under pressure. Therefore, if the needle tip is connected to the front space with the holder attached for injection, the gas in the pressurized state inside will suddenly squirt, and air bubbles in the injection solution will be generated due to the decrease in internal pressure. appear. For this reason, operations such as air removal at the time of injection become complicated.

Although the syringe of the present invention can be applied to subcutaneous injection, intramuscular injection, or injection into blood vessels, many drugs that need to be prepared immediately before injection are used for subcutaneous injection.

FIG. 7 is a cross-sectional view of a connector provided with the pressurizing flow mechanism 16 . Inside the connector fluid passageway 21 is provided for, and pressurized circulation mechanism 16 is attached to the middle. Only when a certain pressure or more is applied to the rear space 5, the drug solution inside the rear space 5 can flow to the front space 3 through this valve .

[0030]

In FIG. 7, a liquid passage 21 is provided inside the connector, and a pressurized flow distribution mechanism 16 to which a plastic film 22 is attached, which is damaged so as to be easily broken when pressure is applied thereto, is provided. Is installed . However, before the film is ruptured under pressure, the flaw does not penetrate the film and does not leak. When a certain pressure or more is applied to the rear space 5, the plastic film 22 inside the connector is broken, and the liquid inside the rear space 5 flows into the front space 3 through this valve. The film is not particularly limited as long as it has a structure and a material that can be broken only when a predetermined pressure or more is applied. Usually, a plastic film is preferred.

[0032] In the case of using a connector with such function of this is, it is not necessary to provide a portion 12 which became thicker in the middle of the vial body 1. A drug and a drug solution can be sealed with a connector in the same thickness. Therefore, there is an advantage that the structure of the vial is significantly simplified.

The dissolution of the drug in the drug solution, the removal of residual gas, and the actual operation of the injection, etc., as preparation stages for injection, are substantially the same as those shown in FIGS.

FIG. 8 is a sectional view of an injection amount setting device attached to the rear portion of the vial body 1 and the plunger 9 in another embodiment, and FIG. 9 is an exploded view of the device. An intermediate portion of the plunger 9 a stopper 19 is provided, the injection amount setting sleeves 23 are fitted to the rear of the vial body 1. As shown in FIG. 8 , the sleeve 23 is made up of a double cylinder inside and outside, and the rear portions of the two cylinders are connected by a donut-shaped flange 25 having an injection amount setting dial 17. In order to clarify the structure of the sleeve, FIG. 9 shows a state in which the inner cylinder and the outer cylinder are separated by broken lines.

An injection amount setting dial 17 is provided at the rear end of the sleeve 23, and a stepped cut 18 corresponding to the injection amount setting dial is provided on the inner cylinder of the sleeve 23. Further, a screw 24 is engraved on the outside of the vial body and a part of the inner surface of the outer cylinder of the sleeve 23 which comes into contact with the vial body. When the screws of the holder and the sleeve are engaged with each other, the sleeve 23 and the holder 7 are locked. It cannot move in the axial direction of the syringe.

When dissolving the drug in the drug solution at the stage of preparation for injection, the sleeve 23 is fitted to the rear end of the vial body 1 and the plunger 9 is attached to the lid 6. At that time, the stopper 19 of the plunger 9 is inserted into the notch 26 of the lid 25 of the sleeve.
The stopper 19 is engaged with the first step engraved on the sleeve, so that when the plunger is pushed in, the sleeve is pushed in at the same time. In this state, the screw of the vial and the sleeve are not engaged with each other, so that the sleeve can move freely in the axial direction of the syringe. When the plunger 9 is pushed in to dissolve the drug, the sleeve 23 is pushed by the stopper 19 and moves toward the end of the vial. By this operation, the medicine in the front space 3 is dissolved by the medicine dissolving solution , and when the preparation of the injection solution is completed, the front surface of the lid 6 comes into close contact with the rear surface of the connector 4. At this time, the sleeve 23 is fitted into the upper end of the vial body 1 considerably deeply. Next, the holder 7 is attached to the vial main body 1 and an injection needle is attached, and the plunger 9 is gradually pushed in with the needle point upward to release some gas remaining inside the syringe, whereby preparation for injection is completed. .

Next, when the injection amount setting dial 17 is rotated to set the injection amount in accordance with the injection amount, the sleeve on which the stairs are cut also rotates at the same time, and a predetermined interval is set between the stopper 19 and the notch of the stairs facing the stopper. The rotation of the sleeve causes the screw 24 cut in the sleeve and the vial to engage, so that the sleeve cannot move in the axial direction of the syringe.

The injection solution is injected into the body by inserting the needle tip 15 of the syringe into the skin and pushing the plunger 9.
Since that time injection is a stopper 19 of the plunger 9 is pushed until reaching to that <br/> stepped notch in conjunction with the scale set by the injection quantity setting dial 17 is stopped,
Injection of pre-set amount is accurately injected into the body.

The notch of the sleeve connected to the injection amount setting dial is not limited to the shape of the stairs, but may be any shape as long as the stopper of the plunger can be stopped at a predetermined position.
The nicks in the sleeve may be of any shape.

In the case where the same vial is used and a number of injections are performed at a fixed time interval, when the first injection is completed, the holder is removed from the vial body, and the holder to which the injection needle is attached is removed. Discarded. Alternatively, depending on the structure of the holder tip, only the needle tip can be removed and discarded. When the needle tip is removed from the cap 2 at the tip of the vial, the tip of the cap is made of a material having a self-sealing property, so that the needle hole is completely closed. A new needle can be used for each injection.

With such an apparatus, a desired amount of injection solution can be accurately injected by an extremely simple operation.

The syringe of the present invention is particularly suitable for the case of using an unstable drug which cannot be stored for a long time in the state of a solution which can be used as it is as an injection solution.
Such drugs include various polypeptide injections,
For example, growth hormone, interferon and the like. Furthermore, many of these drugs are extremely sensitive, and if they are stirred vigorously during dissolution, the chemical structure may partially change,
The reduced-pressure encapsulation of the present invention is suitable for use of particularly sensitive drugs because the injection solution is not agitated at all until the injection after dissolution.

[0043]

In recent years, with the advancement of medical treatment, many new injections having excellent effects have been developed. Some of these are difficult to store for a long time in a solution state that can be used immediately for injection because the drugs themselves are unstable, such as hormones. These drugs need to be dissolved in a drug solution immediately before use. In some cases, the patient needs to carry the medicine at all times and inject it at regular intervals.

When the syringe of the present invention is used, the drug can be dissolved and the injection solution can be prepared and injected by a simple operation immediately before use. It is also convenient to carry, and if necessary, injection can be divided into multiple injections, and the amount of injection solution can be accurately controlled.

[Brief description of the drawings]

FIG. 1 shows a cross-sectional view of one embodiment of the vial body of the syringe of the present invention.

FIG. 2 is a cross-sectional view showing a state during dissolution of a drug in one embodiment of the syringe of the present invention.

FIGS. 3 (a) and (b) are cross-sectional views of the vial body of one embodiment of the syringe of the present invention in a direction perpendicular to the axis of the syringe.

FIG. 4 is a cross-sectional view of a vial body according to an embodiment of the syringe of the present invention in which the dissolution of a drug is completed.

FIG. 5 shows a cross-sectional view of an embodiment of the syringe of the present invention with a holder attached to the vial body.

FIG. 6 is a cross-sectional view of one embodiment of a state of being injected with the syringe of the present invention.

FIG. 7 shows a cross-sectional view of one embodiment of the connector of the syringe of the present invention.

FIG. 8 is a cross-sectional view of the injection volume setting device of the rear portion of the vial body and the plunger 9 according to an embodiment having the injection volume setting device of the syringe of the present invention.

FIG. 9 shows a diffusion exploded view of the injection volume setting device of the rear portion of the vial body and the plunger 9 in one embodiment having the injection volume setting device of the syringe of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Vial body 2 Cap 3 Front space 4 Connector 5 Rear space 6 Lid 7 Holder 8 Injection needle 9 Plunger 10 Drug 11 Drug solution 12 Thickened part of vial body middle part 13 Residual gas 14 Needle tip inside holder 15 Needle tip outside holder 16 Pressurizing flow mechanism 17 Injection volume setting dial 18 SleeveStepped cut  19 Plunger stopper 20 Holder flange 21Passage inside the connector  22 Scratched Film 23Injection volume settingSleeve 24 Screw 25 DonutFlange  26 DonutFlangeNotch

Claims (4)

(57) [Claims] (1) vial body (1), cap (2), front space (3), connector (4), rear space (5), lid
(6), holder body (7), injection needle (8) and plunger
(9), the vial body (1) is fitted with a cap (2), a connector (4), and a lid (6).
There is a front space (3) between (2) and connector (4),
There is a rear space (5) between the connector (4) and the lid (6), a drug (10) in the front space (3) and a rear space.
A drug solution (11) is sealed in (5), the insides of both spaces are kept under reduced pressure, a thick part (12) is provided in the middle part of the vial body (1), and a holder body (7)
A needle (8) is attached through the tip of the needle, and there are needle tips (14) and (15) on the inside and outside.When using, insert the plunger (9) into the lid (6) and push it inside. The drug solution (11) and the connector (4) are pushed in, and the connector (4) is in close contact with the inner surface of the vial body (1) in the rear space, but is inserted into the thicker portion (12). When it reaches, an oval (13) forms a gap between the connector (4) and the vial body (1), and the drug solution (11) flows into the front space (3) through the gap, and the drug (10) ) Is dissolved to form an injection solution, and then the holder (7) is attached to the vial (1).
The needle tip (14) inside the holder (7) passes through the cap (2) and is connected to the front space (3), and by pushing the plunger (9), the injection inside the front space (3) A syringe filled with a drug for dissolving at the time of use, characterized in that a liquid can be injected from the needle tip (15). 2. The vial body (1), cap (2), front space (3), connector (4), rear space (5), lid
(6), holder body (7), injection needle (8) and plunger
(9), the vial body (1) is fitted with a cap (2), a connector (4), and a lid (6).
There is a front space (3) between (2) and connector (4),
There is a rear space (5) between the connector (4) and the lid (6), a drug (10) in the front space (3) and a rear space.
A drug solution (11) is sealed in (5), the inside of both spaces is kept under reduced pressure, and the space is provided inside the connector (4) .
The passage (21) has a plastic
Stick film is provided (22), a rear space (5) applying pressure to the said space inside the drug solution (11) pressurized distribution system you flowing into the front space (3) through the connector (16) is attached, also the needle (8) is mounted through the front end of the holder body (7), the inner and tip outward (14), (15) there, a plunger for use when the lid (6) (9)
Is inserted and pushed in, the drug solution (11) and connector (4) are pushed in, the rear space (5) is pressurized, and the pressurizing flow mechanism (16) of the connector (4) operates. The drug solution (11) flows into the front space (3) and the drug (10)
To dissolve into the injection solution, and then vial the holder (7).
When attached to (1), the needle tip (14) inside the holder (7) passes through the cap (2) and is connected to the front space (3),
Depress plunger (9) to remove front space
(3) A syringe filled with a dissolving-for-use type drug, wherein the injection solution inside can be injected from the needle tip (15). 3. A donut on the rear of the vial body (1)
Inner and outer layers connected coaxially through a flange (25)
Concentric / cylindrical injection volume setting sleeve (23)
It is fitted coaxially with the body (1), and the outside of the sleeve (23)
The cylinder is provided with an injection volume setting dial (17).
The inner cylinder of the valve (23) has a floor corresponding to the injection volume setting dial.
A stepped cut (18) is provided and a plunger (9)
Has a stopper (19) on the inner surface of the outer cylinder of the sleeve (23).
And the locking screw facing the outer surface of the vial body (1)
(24), and axially slide the plunger (9) during injection.
The topper (19) has a step-like shape corresponding to the setting of the dial (17).
Go straight to the position where it is stopped by the notch (18)
Thereby, it was configured to be able to inject a predetermined amount of liquid,
3. The syringe filled with a drug for use when used according to claim 1 or 2. 4. The opening of the tip of the inner needle tip (14) attached to the holder body (7) reaches the inner surface of the cap (2), and the front space (3) is closed before injection. Residual gas (13)
Any of claims 1, 2, and 3 wherein
A syringe filled with a drug for use at the time of use according to the present invention.