JP3120375U - Microchannel sensor test piece capable of simultaneously examining various types of human physiological information - Google Patents

Abstract

Disclosed is a microchannel sensor test piece capable of detecting various types of biochemical substances sequentially or simultaneously.
In a microchannel sensor test piece capable of simultaneously inspecting various types of human body physiological information, an electrically insulating substrate, a lid plate facing and facing the substrate, and an inspection object feed opening at one end thereof, and an inspection object A specimen delivery storage area facing the delivery opening, one end of which is connected to the test specimen storage area and the other end is connected to each reaction enzyme area, a plurality of communicating microchannels, and affixed to the substrate. One end is connected to the reaction enzyme zone, and the other end is extended to one end of the test piece.
[Selection] Figure 3

Description

  The present invention relates to a microchannel sensor test piece that can examine multiple types of human physiological information at the same time, and in particular, a variety of physiological information including human body fluids (blood, etc.) due to the structure of a plurality of microchannel sensor test pieces. Is detected. The test piece is provided with a plurality of microchannels, and the body fluid is introduced into each enzyme zone connected to the microchannel by the action of the capillary, reacts with each enzyme sealed in the enzyme zone, and the biochemical substance of the object to be measured The present invention relates to a microchannel sensor test piece capable of simultaneously examining various types of human physiological information.

  In recent years, with economic development and modern civilization, modern civilization diseases (also called chronic diseases) such as diabetes, hypertension, hyperlipidemia and gout are approaching our lives, and pose a great threat to health. Yes. For this reason, in addition to daily dietary management and proper exercise, it is necessary to visit a medical institution and receive a health check to understand their own health status. The concept of home care is gradually increasing, and there is an increasing number of products that are fast, inexpensive, self-detecting while staying at home without the need for specialized operations. Among them, when users want to know their health using medical instruments such as blood glucose meters, electronic thermometers, electronic sphygmomanometers, cholesterol meters, etc., they bother to spend time and money in medical facilities. There is no need to measure under the cooperation of solicited medical personnel. If you have a medical instrument on hand, you can keep track of your health wherever you are, and you can avoid worsening your illness. In addition, diseases such as diabetes, hypertension, hyperlipidemia, and gout are all related and have a high possibility of co-occurrence. Therefore, the user can grasp his / her medical condition through various types of tests.

  As shown in FIG. 1, the above-mentioned normal chronic disease is often examined by blood, and a user collects blood from a finger or earlobe and attaches the blood to the electrode test piece opening of the biosensor. A reaction enzyme zone that reacts to the opening is provided, and one type of enzyme can test only one type of physiological information. The electrode test piece of a known biological sensor is composed of a flat insulating substrate, and is usually provided with electrical insulation and heat resistance characteristics in order to prepare for the heat fixation treatment of the biological reaction film and the conductive layer. A polycarbonate plate, a vinyl chloride plate, a polypropylene plate, a glass fiber plate, a bakelite plate, a ceramic, a glass plate, or the like is used. Among them, an electrode signal circuit, a working electrode circuit, and a pair of separated electrode signal circuits are provided in the conductive layer. One end of the electrode signal circuit is connected to the reaction enzyme zone, and the other end of the electrode signal circuit is connected to the electrochemical biosensor device (not shown). Physiological information in blood can be examined by electrochemical reaction.

However, blood must be collected for each item. In addition, it causes pain every time blood is collected. Especially for patients with prolonged chronic disease, the pain is repeated for many years.
As an example, in human biological information such as blood glucose, each electrode test piece has only one specimen attachment port and a single biological reaction enzyme. For this reason, when examining other people's biological information such as total cholesterol, high density lipoprotein, low density lipoprotein or uric acid content, it is necessary to collect blood again, and to use different electrode specimens and biosensors. Must be used.

  In order to reduce the number of blood collections and pains of the user, and to realize multi-item inspection, the present invention provides a plurality of microchannels in the specimen feed opening of the biosensor electrode test piece, and uses the function of capillary diffusion for inspection. Blood inside the material feed opening is transmitted to each enzyme reaction zone, and a reaction enzyme corresponding to the test object is provided in each enzyme reaction zone. Thereby, the test value of many kinds of biological information is obtained by one test.

  In other words, the first device of the present application is a microchannel sensor test piece capable of simultaneously examining a kind of multi-body human physiological information for inspecting the content of a biochemical substance in an inspection object. , A cover plate provided with a specimen feed opening at one end thereof, a specimen feed accommodation area facing the specimen feed opening, one end thereof connected to the specimen accommodation area, and the other end to each reaction enzyme area Consists of multiple connected microchannels and one or more work, reference electrodes, attached to the substrate, one end connected to the reaction enzyme zone and the other end extended to one end of the test piece Provided is a microchannel sensor test piece capable of simultaneously examining various types of human physiological information.

  A second device of the present application provides a microchannel sensor test piece capable of simultaneously examining multi-type human physiological information according to the first device, wherein microchannels are sequentially connected to each reaction enzyme zone. .

  A third device of the present application provides a microchannel sensor test piece capable of simultaneously examining multi-type human physiological information according to the first device, wherein the microchannel maintains the same distance as each reaction enzyme zone.

  A fourth device of the present application is a microchannel sensor test capable of simultaneously examining multi-type human physiological information according to the second or third device, characterized in that the connection to the microchannel is performed, and the reference electrode is distributed on both sides of the substrate. Provide a piece.

  As described above, the present invention utilizes the action of capillary diffusion from a plurality of channels, and transmits blood attached to the test object feed opening to each enzyme reaction zone, thereby allowing multiple types of human bodies in one test. Because biological information measurement values can be obtained, more economical and more efficient inspection is realized.

  Embodiments according to the present invention will be described below with reference to the drawings.

  2 and 3, FIG. 2 is a schematic diagram of the first embodiment of the present invention, and FIG. 3 is an exploded schematic diagram of the first embodiment. In this example, four types of biological information are examined at the same time. However, when used, inspection areas corresponding to various items can be provided as necessary.

  The microchannel sensor test piece 10 capable of simultaneously examining multi-type human physiological information of the present invention is provided with a cover plate 17, and an inspection object feed opening 11 is provided on one side of the cover plate 17.

  Corresponding to the inspection object feeding accommodation area 14 below the inspection object feeding opening 11, the inspection object feeding accommodation area 14 is connected to the microchannel 12, and a first reaction enzyme area 13 is provided at one end of the microchannel 12. Each channel is sequentially connected to the second reaction enzyme zone 132, the third reaction enzyme zone 133, and the fourth reaction enzyme zone 134.

  Among them, the first reaction enzyme zone 13, the second reaction enzyme zone 132, the third reaction enzyme zone 133, and the fourth reaction enzyme zone 134 depend on the reaction enzyme to be attached, the blood glucose enzyme reaction zone, the total cholesterol enzyme reaction zone, the high density lipoprotein. It can be divided into an enzyme reaction zone or a uric acid reaction zone.

  The substrate 18, which is an electrically insulating flat plate, has a first pair work, a reference electrode 19, a second pair work, a reference electrode 192, a third pair work, a reference electrode 193 and a fourth pair work on the substrate 18. A reference electrode 194 is provided.

  The first reaction enzyme zone 13 is the first pair operation, the reference electrode 19, the second reaction enzyme zone 132 is the second pair operation, the reference electrode 192, the third reaction enzyme zone 133 is the third pair operation, the reference electrode 193, and the first The fourth reaction enzyme zone 134 is connected to the reference electrode 194 in the fourth counter work, and the electrochemical reaction of the first reaction enzyme zone 13, the second reaction enzyme zone 132, the third reaction enzyme zone 133, and the fourth reaction enzyme zone 134 is performed. The reaction is transmitted from the first pair work, the reference electrode 19, the second pair work, the reference electrode 192, the third pair work, the reference electrode 193 and the fourth pair work, and the reference electrode 194.

  4 and 5, FIG. 4 is a schematic view of another embodiment of the present invention, and FIG. 5 is a cross-sectional view of another embodiment of the present invention.

  In this example, a three-dimensional scientific test piece is illustrated. Among them, the first reaction enzyme zone 13 and the first pair work, the reference electrode 19, the second reaction enzyme zone 132 and the second pair work, and the reference electrode 192 are provided on one side of the substrate 18, and the third reaction enzyme zone 133 and the third pair work. The counter work, the reference electrode 193, the fourth enzyme reaction zone 134 and the fourth counter work, the reference electrode 194 are provided on the other surface of the substrate 18. For this reason, the width | variety of an electrode test piece can be reduced.

FIG. 6 is a schematic view of the state of reading the biochemical substance content of the test object by the human biological signal sensor 20 using the microchannel biosensor test piece 10.
After the measurement person inserts the electrode test piece 10 into the human biological signal sensor 20, a test object is attached, and the human biological signal sensor 20 performs arithmetic processing, and blood sugar, total cholesterol, high density lipoprotein, uric acid, etc. of the test object The inspection value can be displayed.

  The above description is a preferred embodiment of the present invention and does not limit the scope of implementation of the present invention. Accordingly, equivalent effects changes or modifications according to the claims of the present invention shall be included in the scope of the present invention.

It is the schematic of the biosensor electrode test piece of a well-known technique. It is the schematic of Example 1 of this invention. 1 is an exploded schematic view of Embodiment 1 of the present invention. FIG. 3 is a schematic view of another embodiment of the present invention. It is sectional drawing of another Example of this invention. It is a use mode schematic of the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Electrode test piece 11 Test object delivery opening part 12 Microchannel 13 1st reaction enzyme area 132 2nd reaction enzyme area 133 3rd reaction enzyme area 134 4th reaction enzyme area 17 Lid 18 Substrate 19 First pair work, reference electrode 192 Second pair work, reference electrode 193 Third pair work, reference electrode 194 Fourth pair work, reference electrode 20 Human biological signal sensor

Claims (4)

In a microchannel sensor test piece that can inspect a variety of human body physiological information at the same time to inspect the biochemical substance content of the test substance,
An electrically insulating substrate;
A cover plate that is pasted to face the substrate and has an inspection object feed opening at one end thereof,
An inspection object feeding storage area facing the inspection object feeding opening,
A plurality of communicating microchannels, one end of which is connected to the specimen containing area and the other end is connected to each reaction enzyme area;
Affixed to the substrate, one end of which is connected to the reaction enzyme zone and the other end is extended to one end of the test piece, characterized by comprising one or more operations, a reference electrode,
A microchannel sensor test piece that can examine multiple types of human physiological information at the same time.   The microchannel sensor test piece capable of simultaneously examining multi-type human physiological information according to claim 1, wherein the microchannel is connected to each reaction enzyme zone in a sequential manner.   The microchannel sensor test piece according to claim 1, wherein the microchannel maintains the same distance as each reaction enzyme area. 4. The microchannel sensor test piece capable of simultaneously examining multi-type human physiological information according to claim 2 or 3, wherein the operation of connecting to the microchannel and the reference electrode are distributed on both sides of the substrate.

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