JP2941880B2 - Emulsified cosmetic - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention contains an emulsified cosmetic, more specifically a hydroxyalkylated cyclodextrin (hereinafter abbreviated as HACD) as an emulsifier, and is particularly suitable as a cosmetic for skin and hair. The present invention relates to an emulsified cosmetic having excellent stability and safety which can be used for cosmetics.

[Prior art] Conventionally, in an emulsified cosmetic containing oil and water,
Various surfactants have been used alone or in combination. However, for example, ionic surfactants such as alkyl sulfates and higher fatty acid salts may cause skin irritation when used at a high concentration, and when polyoxyethylene type nonionic surfactants are used. Have problems in compatibility, such as inactivating preservatives such as parabens.

[Problem to be Solved by the Invention] In order to solve such a problem, a technique using cyclodextrin or a derivative thereof has been developed. JP-A-58-58139 discloses a technique in which cyclodextrin is used in combination with an oil-soluble surfactant and emulsified by a specific method. JP-A-63-194726 discloses a technique using methylated β-cyclodextrin as an emulsifying aid.

However, these techniques use a conventional surfactant in combination, so that problems such as skin irritation have not been completely solved.

The present inventors have conducted research to obtain a conventional emulsified cosmetic that does not use a surfactant at all, and as a result, have found that among the derivatives of cyclodextrin, the above problem can be solved particularly when HACD is used as an emulsifier. Completed the invention.

[Means for Solving the Problems] That is, the present invention comprises a hydroxyalkylated cyclodextrin, water and an oil, does not contain any cyclodextrin polymer and lecithin, and converts the oil to the hydroxyalkylated cyclodextrin. The present invention relates to an emulsified cosmetic characterized by being blended in an equal amount (weight ratio) or more.

 Hereinafter, the configuration of the present invention will be described in detail.

The HACD used in the present invention is obtained by introducing a hydroxyalkyl group into a hydroxyl group of cyclodextrin, which is conventionally well known as a cyclic oligosaccharide.

As the hydroxyalkyl, substituents such as hydroxymethyl, hydroxyethyl, and hydroxypropyl are mainly used.As a result of these substitution reactions, hydroxymethylcyclodextrin, hydroxyethylcyclodextrin, hydroxypropylcyclodextrin, hydroxybutylcyclodextrin, An HACD such as dihydroxypropylcyclodextrin can be obtained.

 The substitution degree of the hydroxyalkyl group is preferably from 1 to 14.

Cyclodextrin (hereinafter abbreviated as CD) is known to have a structure of α, β, and γ (hereinafter abbreviated as α-CD, β-CD, and γ-CD) depending on the number of glucoses. However, the present invention uses one or more of these CDs after hydroxyalkylation. Usually, β-CD is used, but α, γ-CD may be used as a mother nucleus. α, β, γ
And a starch hydrolyzate containing the same CD simultaneously.

Among these HACDs, hydroxyethylated β-CD or hydroxypropylated β-CD is preferable in consideration of price, ease of production, usability, and water solubility, but is not limited thereto. In addition, hydroxyethylated CD or hydroxypropylated CD is α,
Although the mixture is a mixture of β and γ, it is possible to use the mixture as it is, or to isolate the hydroxypropylated CD of α, β, and γ.

As a method for producing HACD, several methods have been conventionally known, and an example is shown below.

β-CD (Nippon Shokuhin Kako, brand name: Celldex N)
100 g was dissolved in 150 ml of a 20% aqueous NaOH solution, and while maintaining the temperature at 30 ° C., 50 ml of propylene oxide was gradually added dropwise, followed by stirring for 20 hours to continue the reaction. After completion of the reaction, the mixture was neutralized to pH 6.0 with hydrochloric acid, placed in a dialysis membrane tube, and desalted under running water for 24 hours.
Thereafter, drying was performed with a freeze dryer to obtain about 90 g of hydroxypropylated β-CD. The substitution degree per CD of this hydroxypropylated β-CD was 5.1.

Examples of the oil used in the emulsified cosmetic of the present invention include natural animal and vegetable oils and fats such as macadamia nut oil, evening primrose oil, olive oil, mink oil, jojoba oil, lanolin and squalene, and liquid hydrocarbons such as paraffin, paraffin wax and squalane. , Waxes such as whale wax, beeswax, candelilla wax, carnauba wax, higher alcohols such as cetanol, isocetanol, stearyl alcohol, isostearyl alcohol, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid, etc. Esters such as higher fatty acids, isopropyl myristate, isopropyl palmitate, isopropyl isostearate, and glyceryl 2-ethylhexanoate;
Other examples include polar oils such as diethylene glycol monopropylene pentaerythritol ether, ethyl linoleate, and polyoxypropylene butyl ether, and silicone oils.

The emulsified cosmetic of the present invention is prepared by blending oil and water and emulsifying according to a conventional method except that HACD is used as an emulsifier. The emulsion type may be any of an oil-in-water type and a water-in-oil type.

The preferred composition of the emulsified cosmetic of the present invention is as follows.

Blending amount (% by weight) Preferred amount (% by weight) Oil 1 to 60 5 to 35 HACD 2 to 10 3 to 5 Water 25 to 95 40 to 90 The emulsified cosmetic of the present invention does not impair the effects of the present invention. Various optional components can be further blended within the range, for example, soluble powder bases such as D-mannitol and lactose, humectants such as glycerin and hyaluronic acid, drugs such as vitamin C and vitamin E, anti-inflammatory agents, ultraviolet absorption Agents, antioxidants, preservatives, viscosity modifiers, pigments, crude drugs, fragrance components and the like.

The emulsified cosmetic of the present invention can be in a form suitable for various uses, such as a vanishing cream, a milky lotion, a cold cream, a cleansing cream, a foundation cream, a hand cream, an external ointment, and the like.

[Examples] Next, examples will be described, but the present invention is not limited to these examples.

Example 1 Cold Cream A Oily Component Vaseline 3 Beeswax 2 Cetanol 2.5 Lanolin 5 Squalane 20 Liquid Paraffin 10 B Fragrance 0.5 C Preservatives Appropriate D Antioxidant Appropriate E Emulsifier Hydroxypropylated β-CD 3.9 F Water Phase Purified Water Residue Propylene Glycol Heat and dissolve E in 5 F at 70 ° C to make the aqueous phase, and then add A, B, C, D
Is heated to 70 ° C. and mixed and dissolved to form an oil phase. While stirring the aqueous phase, the oil phase is gradually added, dispersed and emulsified. The emulsion is cooled using a heat exchanger to obtain a cold cream.

Comparative Example 1 Cold Cream A Oily Component Vaseline 3 Beeswax 2 Cetanol 2.5 Lanolin 5 Squalane 20 Liquid Paraffin 10 B Flavor 0.5 C Preservatives Appropriate D Antioxidant Appropriate E Emulsifier / Emulsifier Sorbitan Monostearate (HLB4.7) 2.2 Polyoxyethylene (20 mol) sorbitan monostearate (HLB14.9) 1.2 Methylated β-CD 0.5 F aqueous phase Purified water Residue Propylene glycol 5 A cold cream is obtained in the same manner as in Example 1.

Comparative Example 2 Cold Cream A Oily Component Vaseline 3 Beeswax 2 Cetanol 2.5 Lanolin 5 Squalane 20 Liquid Paraffin 10 B Flavor 0.5 C Preservatives Appropriate D Antioxidant Appropriate E Emulsifier β-CD 3.9 F Water Phase Purified Water Residue Propylene Glycol 5 Example A cold cream is obtained in the same manner as in 1.

The emulsion stability and skin irritation of Example 1 and Comparative Examples 1 and 2 were evaluated according to the following criteria, and the results are shown in Table 1.

Emulsion stability The cold creams of Example 1 and Comparative Examples 1 and 2 were heated at 50 ° C.
After standing in a constant temperature bath for 1 week, the state was observed.

○: no change in state △: slight separation of oil phase and aqueous phase ×: considerable separation of oil phase and aqueous phase Skin irritation Example 1 and Comparative Example 1 , 2 cold creams were applied to the upper arm of each of 50 panels, the appearance of the skin 24 hours later was observed, and the number of panels with reddishness on the skin was examined.

Example 2 Vanishing Cream A Stearate 10 Stearyl Alcohol 4 Butyl Stearate 8 B Fragrance 0.1 C Preservatives Adequate D Antioxidant Adequate E Hydroxypropylated β-CD 5 F Propylene Glycol 3 Glycerin 4 Purified Water Residue Same as Example 1 To get a burnishing cream.

Example 3 Cleansing Cream A Liquid Paraffin 40 Vaseline 10 Beeswax 6 Paraffin 2 B Fragrance 0.1 C Preservative Appropriate amount E Hydroxyethylated β-CD 7 F Purified Water Residue A cleansing cream is obtained in the same manner as in Example 1.

Example 4 Emulsion A Liquid paraffin 7 Lanolin 3 Oleic acid 3 B fragrance 0.1 C Preservative Appropriate amount E Hydroxypropylated β-CD 3 F Vegum 1 Glycerin 3 Purified water Residue The same procedure as in Example 1 is used to obtain an emulsion.

Example 5 Ointment for external use A Liquid paraffin 10 Squalane 15 Lanolin 5 Antiphlogistic agent 3 C Preservative proper amount D Antioxidant proper amount E Hydroxypropylated β-CD3 α, β, γ-CD mixture 7 F glycerin 3 oligosaccharide 3 Purified water Residual An ointment for external use is obtained in the same manner as in Example 1.

Example 6 Foundation cream A Stearic acid 2.5 Cetostearyl alcohol 2 Liquid lanolin 2 Liquid paraffin 3 Jojoba oil 2 Isopropyl myristate 8 B Antioxidant proper amount C preservative proper amount D flavor 0.2 E titanium oxide 8 talc 4 Color pigment proper amount F carboxymethylcellulose Sodium 0.2 Bentonite 0.5 Propylene glycol 5 Purified water Residual B, C, D are dissolved in G hydroxypropyl α-CD 10 A by heating, and E is mixed and dispersed to form an oil phase. G is dissolved in F to form an aqueous phase. 70 ° oil phase
C. The mixture is heated and stirred, and the aqueous phase is gradually added to disperse and emulsify. Cool using a heat exchanger to obtain a foundation.

As described above, each of the above embodiments has no fear of irritation to the skin,
It has good storage stability.

[Effects of the Invention] The emulsified cosmetic of the present invention can obtain good stability without using a conventional surfactant, and has no fear of skin irritation.
It has high moisturizing properties.

──────────────────────────────────────────────────続 き Continued on front page (58) Field surveyed (Int.Cl. ⁶ , DB name) A61K 7/00

Claims (1)

(57) [Claims] 1. A composition containing a hydroxyalkylated cyclodextrin, water and an oil, containing neither a cyclodextrin polymer nor lecithin, and blending an oil in an equal amount (weight ratio) with respect to the hydroxyalkylated cyclodextrin. An emulsified cosmetic, characterized in that: