JP2755966B2 - Blood processing equipment - Google Patents
Blood processing equipmentInfo
- Publication number
- JP2755966B2 JP2755966B2 JP63278300A JP27830088A JP2755966B2 JP 2755966 B2 JP2755966 B2 JP 2755966B2 JP 63278300 A JP63278300 A JP 63278300A JP 27830088 A JP27830088 A JP 27830088A JP 2755966 B2 JP2755966 B2 JP 2755966B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- hollow fiber
- plasma
- cylindrical body
- processing apparatus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000004369 blood Anatomy 0.000 title claims description 119
- 239000008280 blood Substances 0.000 title claims description 119
- 239000012510 hollow fiber Substances 0.000 claims description 83
- 239000000463 material Substances 0.000 claims description 24
- 238000004382 potting Methods 0.000 claims description 23
- 210000000601 blood cell Anatomy 0.000 claims description 17
- 238000001914 filtration Methods 0.000 claims description 10
- 239000012528 membrane Substances 0.000 claims description 9
- 210000002381 plasma Anatomy 0.000 description 41
- 230000017531 blood circulation Effects 0.000 description 12
- 238000005534 hematocrit Methods 0.000 description 6
- 238000000926 separation method Methods 0.000 description 5
- 239000011162 core material Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920005749 polyurethane resin Polymers 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229920006268 silicone film Polymers 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Description
【発明の詳細な説明】 「産業上の利用分野」 この発明は、健康なドナーの採血から血漿成分を効率
よく分離採取することができる血液処理装置に関する。Description: TECHNICAL FIELD The present invention relates to a blood processing apparatus capable of efficiently separating and collecting plasma components from blood collected from healthy donors.
「従来の技術」 従来、病人（衰弱者）等に血漿成分を供給するドナー
・フェレーシス・モジュール（ドナー（供血者）から採
血して血液処理しドナーに還流させる装置）が知られて
いる。この装置は、第２図に示すように、健康なドナー
１の静脈から採血してこの血液をポンプ２により血液処
理装置３に送血して、その血液を血液流入孔４より血液
処理装置３の中空糸５内に導入して流下させ、この血液
の流下中に血液中の血球成分から中空糸膜により血漿成
分を濾過分離して中空糸膜外に滲出させ、この血漿成分
を血漿流出孔６から流出させ、血球成分を血液流出孔７
より流出させ、この血球成分を補液（生理食塩水）８と
ともにドナー１の静脈に還流させるものである。2. Description of the Related Art Conventionally, a donor pheresis module (a device that collects blood from a donor (blood donor), processes the blood, and returns the blood to the donor) that supplies a plasma component to a sick person (debilitated person) or the like is known. As shown in FIG. 2, this apparatus collects blood from a vein of a healthy donor 1, sends the blood to a blood processing apparatus 3 by a pump 2, and sends the blood through a blood inlet 4 to the blood processing apparatus 3. Into the hollow fiber 5 and allowed to flow down. During the flow of the blood, the plasma component is separated from the blood cell component in the blood by the hollow fiber membrane and exudes out of the hollow fiber membrane, and the plasma component is removed from the plasma outlet. 6 to allow blood cell components to pass through the blood outlet 7
Then, the blood cell component is returned to the vein of the donor 1 together with the replacement fluid (physiological saline) 8.
健康なドナー１の採血から分離採取した血漿成分は病
人へ輸血同様に供給して用いられる。The plasma component separated and collected from the blood collected from the healthy donor 1 is supplied to the sick person in the same manner as blood transfusion and used.
「発明が解決しようとする課題」 ところで、血液中で血球成分が占められる容量百分
率、即ちヘマトクリット値Htは、健康人ではほぼ45であ
ることが知られている。[Problems to be Solved by the Invention] By the way, it is known that the volume percentage of blood cells occupied by blood cells, that is, the hematocrit value Ht is approximately 45 in healthy people.
ところが、前述の従来の血液処理装置においては、中
空糸５内を流下する血液から血漿成分が分離採取される
ため、中空糸５内で流下する血液が濃縮されてその粘度
が高まる。即ち、中空糸５内を流下する血液のヘマトク
リット値が上がる。このヘマトクリット値は高い方が、
中空糸５外へ採取される血漿成分が多くなり、血漿成分
採取効率は良くなるが、そのヘマトクリット値がある程
度以上高くなると中空糸５内を血液が流通しにくくな
り、圧力損失が大となって血液流量が大幅に減少する。
そこで、中空糸５内を流通する血液に適当な流動性をも
たせる必要があるため、この中空糸５内を流下する血液
にある程度の血漿成分を残さざるを得ないという事情が
ある。なお、血液処理装置の血液流入孔７における血液
の流入圧は50mmHg以上であるとよくないといわれてい
る。However, in the above-described conventional blood processing apparatus, since the blood plasma component is separated and collected from the blood flowing down in the hollow fiber 5, the blood flowing down in the hollow fiber 5 is concentrated and its viscosity increases. That is, the hematocrit value of the blood flowing down in the hollow fiber 5 increases. The higher the hematocrit value,
Although the plasma component collected outside the hollow fiber 5 increases, the plasma component collection efficiency improves, but when the hematocrit value becomes higher than a certain level, blood becomes difficult to circulate in the hollow fiber 5 and the pressure loss increases. Blood flow is greatly reduced.
Therefore, it is necessary to impart appropriate fluidity to the blood flowing through the hollow fiber 5, and there is a situation that some blood plasma component must be left in the blood flowing down the hollow fiber 5. It is said that the blood inflow pressure in the blood inlet 7 of the blood processing apparatus should not be more than 50 mmHg.
以上の事情から前述の従来の血液処理装置において
は、血漿成分採取効率が不十分であり、さらにこの血漿
成分採取効率のよい血液処理装置の出現が望まれてい
た。Under the circumstances described above, the above-described conventional blood processing apparatus has insufficient plasma component collection efficiency, and there has been a demand for a blood processing apparatus having a high plasma component collection efficiency.
また、血漿成分採取効率がよくないことは装置が比較
的大型となり、その分ドナーにかかる負担が大となると
いう問題があった。In addition, poor plasma component collection efficiency has a problem in that the device becomes relatively large and the burden on the donor increases accordingly.
また、中空糸の両端をポッティング材により固める際
に中空糸端内部にポッティング材が入り込み、中空糸内
の血液流路を閉塞してしまうため、この血液流路を開通
させるためにポッティング材凝固後中空糸端を開口させ
るための処置が複雑となる欠点があった。Also, when the both ends of the hollow fiber are solidified by the potting material, the potting material enters into the inside of the hollow fiber end and closes the blood flow path in the hollow fiber. There is a disadvantage that the procedure for opening the end of the hollow fiber is complicated.
本発明は、従来の血液処理装置がもつ以上のような問
題点を解決し、血漿採取効率が大幅に向上し、小型化が
可能となり、安価な血液処理装置を提供することを目的
とする。SUMMARY OF THE INVENTION It is an object of the present invention to provide an inexpensive blood processing apparatus that solves the above-mentioned problems of the conventional blood processing apparatus, greatly improves the efficiency of plasma collection, enables downsizing, and reduces the size.
「課題を解決するための手段」 本発明は、前記目的を達成させるために次のような構
成としている。即ち、側壁の両端に内部に連通する血液
流入管部および血液流出管部が設けられた筒体と、血球
を通過させず血漿を通過させる濾過膜壁からなる中空糸
を交差状に巻回して柱状に形成され前記筒体内に収納さ
れ、かつ前記筒体の両端部においてポッティング材によ
り固定され、すくなくとも前記血液流出管側端において
前記中空糸が開口された中空糸巻回体と、前記筒体の血
液流入管部側端部に嵌着された血液流入側蓋体と、内部
に連通する血漿流出管部が設けられ前記筒体の血液流出
管部側端部に嵌着された血液流出側蓋体とからなる構成
としている。"Means for Solving the Problems" The present invention has the following configuration to achieve the above object. That is, a hollow body including a cylindrical body provided with a blood inflow tube portion and a blood outflow tube portion communicating with the inside at both ends of the side wall, and a hollow fiber formed of a filtration membrane wall that allows plasma to pass without passing through blood cells is wound in a cross shape. A hollow fiber wound body formed in a columnar shape and housed in the cylindrical body, and fixed by a potting material at both ends of the cylindrical body, and at least the hollow fiber opened at the blood outflow tube side end, A blood inflow side lid fitted to the blood inflow tube side end and a blood outflow side lid fitted with a blood outflow tube side end of the cylindrical body provided with a plasma outflow tube communicating with the inside. It consists of a body.
「作用」 健康人なドナーから採血された血液を血液流入管部よ
り血液処理装置内に圧送して中空糸間に流入させると、
この血液は中空糸間を流下し、この血液が中空糸間を流
下する間に、血液中の血漿成分のみが中空糸の濾過膜壁
を通り中空糸内を流下し、血球成分は中空糸間を流下
し、血液中の血球成分と血漿成分とが分離する。"Action" When blood collected from a healthy donor is pumped from the blood inflow tube into the blood processing apparatus and flows between the hollow fibers,
This blood flows between the hollow fibers, and while this blood flows between the hollow fibers, only the plasma component in the blood flows through the hollow fiber through the filtration membrane wall of the hollow fibers, and the blood cell component flows between the hollow fibers. And the blood cell component and the plasma component in the blood are separated.
血球成分は下部ポッティング材に遮られて血液流出側
蓋体内に流下することができず血液流出管部より血液処
理装置外に流出する。The blood cell component is blocked by the lower potting material and cannot flow down into the blood outflow side lid, but flows out of the blood processing apparatus from the blood outflow tube.
中空糸内を流下した血漿成分は中空糸の下部開口より
血液流出側蓋体内を経て血漿流出管部より血液処理装置
外に流出する。The plasma component that has flowed down the hollow fiber flows out of the blood processing apparatus from the plasma outflow tube through the blood outlet side lid through the lower opening of the hollow fiber.
本血液処理装置によれば、血液を中空糸内に通す場合
よりも中空糸外に通す場合の方が血液の流通抵抗がはる
かに小さいため、血液のヘマトクリット値が上昇しても
その割りに圧力損失が上がらず、血液の高い濃縮度が得
られ、中空糸を交差状に巻回して柱状に形成して筒体内
に収納し、中空糸間で血液を流通させているので、中空
糸内で血液を流通させた場合より血漿濾過面積が増大し
血漿分離採取効率が向上する。According to this blood processing apparatus, the blood flow resistance is much smaller when blood is passed outside the hollow fiber than when it is passed through the hollow fiber. Loss does not increase, high concentration of blood is obtained, hollow fibers are wound in a cross shape, formed into a column shape, housed in a cylinder, and blood is circulated between the hollow fibers. The plasma filtration area increases as compared with the case where blood is circulated, and the efficiency of plasma separation and collection is improved.
また、中空糸が開口しない状態でこの中空糸を筒体の
両端においてポッティング材により固定することができ
るので、中空糸内にポッティング材が浸入せず、ポッテ
ィング材による中空糸の固定が大幅に容易となる。In addition, since the hollow fiber can be fixed by the potting material at both ends of the cylindrical body without opening the hollow fiber, the potting material does not enter the hollow fiber, and the fixing of the hollow fiber by the potting material is greatly facilitated. Becomes
また、血漿分離採取効率が向上するためその分血液処
理装置を小型化することができ、その結果ドナーの負担
を軽くすることができる。In addition, since the efficiency of plasma separation and collection is improved, the blood processing apparatus can be reduced in size accordingly, and as a result, the burden on the donor can be reduced.
また、前記ポッティング材による中空糸の固定容易化
と、血液処理装置を小型化することができることと相俟
って血液処理装置を低コストで製造することができる。In addition, the blood processing apparatus can be manufactured at low cost in combination with easy fixing of the hollow fiber by the potting material and downsizing of the blood processing apparatus.
「実施例」 以下、本発明の一実施例を第１図に基づいて説明す
る。Embodiment An embodiment of the present invention will be described below with reference to FIG.
第１図中10は血液処理装置、11は合成樹脂からなる円
筒体であり、この円筒体11の両端は若干拡径されてい
る。円筒体11の側壁の両端側部には内部に連通する血液
流入管部12および血液流出管部13が設けられている。In FIG. 1, 10 is a blood processing apparatus, 11 is a cylindrical body made of synthetic resin, and both ends of the cylindrical body 11 are slightly enlarged in diameter. A blood inflow tube portion 12 and a blood outflow tube portion 13 communicating with the inside are provided at both ends of the side wall of the cylindrical body 11.
円筒体11内には、血球を通過させず血漿を通過させる
濾過膜壁からなる中空糸14が芯材に交差状に巻回されて
柱状に形成された中空糸巻回体15が収納されている。In the cylindrical body 11, a hollow fiber wound body 15 in which a hollow fiber 14 formed of a filtration membrane wall that allows plasma to pass without passing through blood cells is wound in a cross shape around a core material and formed in a columnar shape is housed. .
中空糸14は、シリコーン膜、ポリカーボネート多孔質
膜、ポリオレフィン多孔質膜、再生セルロース膜、ポリ
サルフォン多孔質膜、ナイロン多孔質膜、ポリエステル
多孔質膜、アクリル多孔質膜、フッ素樹脂多孔質膜等の
生体適合性がよく、血球を通過させず血漿を通過させる
濾過膜壁からなる柔軟な管状かつ糸状のものである。The hollow fiber 14 is formed of a biological material such as a silicone film, a polycarbonate porous film, a polyolefin porous film, a regenerated cellulose film, a polysulfone porous film, a nylon porous film, a polyester porous film, an acrylic porous film, and a fluororesin porous film. It has good compatibility and is a flexible tubular and thread-like material consisting of a filtration membrane wall that allows plasma to pass without passing through blood cells.
中空糸巻回体15は、１〜複数本、例えば５本の中空糸
14…を一束とした中空糸束を、これら中空糸14の両端は
円筒体11の上端または下端に位置するように図示しない
棒状の芯材上にこの芯材の軸線方向（第１図における上
下方向）に対し例えば60゜の角度を持って螺旋状に多数
層巻着し、円筒体11内に収納後に前記芯材を抜き去るこ
とによって構成されたものであり、その両端部はポリウ
レタン樹脂、シリコーン樹脂などのポッティング材16に
より上記円筒体11内に固定されている。The hollow fiber wound body 15 includes one or more, for example, five hollow fibers.
A bundle of hollow fibers is formed on a rod-shaped core (not shown) such that both ends of the hollow fibers 14 are located at the upper end or lower end of the cylindrical body 11 in the axial direction of the core (see FIG. 1). A plurality of layers are spirally wound at an angle of, for example, 60 ° with respect to the vertical direction, and the core material is pulled out after being housed in the cylindrical body 11, and both ends thereof are made of polyurethane resin. Is fixed in the cylindrical body 11 by a potting material 16 such as a silicone resin.
中空糸巻回体15の下端は、前記ポッティング材16によ
り固められた後、円筒体11の軸線方向と直交する方向に
切断され、中空糸14が開口されている。After the lower end of the hollow fiber wound body 15 is solidified by the potting material 16, it is cut in a direction orthogonal to the axial direction of the cylindrical body 11, and the hollow fiber 14 is opened.
中空糸巻回体15の上端は切断しなくてもよく、また下
端同様に切断して中空糸を開口させてもよい。The upper end of the hollow fiber wound body 15 need not be cut, and may be cut like the lower end to open the hollow fiber.
円筒体11には、その両開口部を覆うようにして血液流
入側蓋体17、血液流出側蓋体18が取り付けられている。
これら血液流入側蓋体17、血液流出側蓋体18はキャップ
状に形成されており、血液流入側蓋体17とポッティング
材16との間には空間19が形成され、血液流出側蓋体18と
ポッティング材16との間には空間20が形成されている。
血液流出側蓋体18の中心には血漿流出管部21が形成され
ている。血液流入側蓋体17及び血液流出側蓋体18はそれ
ぞれ円筒体11の端部との間にシール部材（図示せず）を
介在させて円筒体11に溶接されており、円筒体11と血液
流入側蓋体17間及び円筒体11と血液流出側蓋体18間が気
密構造となっている。A blood inflow side lid 17 and a blood outflow side lid 18 are attached to the cylindrical body 11 so as to cover both openings.
The blood inflow side lid 17 and the blood outflow side lid 18 are formed in a cap shape, a space 19 is formed between the blood inflow side lid 17 and the potting material 16, and the blood outflow side lid 18 is formed. A space 20 is formed between and the potting material 16.
At the center of the blood outflow side lid 18, a plasma outflow tube portion 21 is formed. The blood inflow-side lid 17 and the blood-outflow-side lid 18 are welded to the cylinder 11 with a sealing member (not shown) interposed between the end of the cylinder 11 and the cylinder 11, respectively. The space between the inflow-side lid 17 and the space between the cylindrical body 11 and the blood-outflow-side lid 18 have an airtight structure.
次に、前記のように構成された血液処理装置の作用に
ついて説明する。Next, the operation of the blood processing apparatus configured as described above will be described.
健康なドナーから採血された血液を血液流入管部12よ
り血液処理装置10内に圧送して中空糸14間に流入させる
と、この血液は中空糸14間を流下し、この血液が中空糸
14間を流下する間に、血液中の血漿成分のみが中空糸14
の濾過膜壁を通り中空糸14内を流下し、血球成分は中空
糸14間を流下し、血液中の血球成分と血漿成分とが分離
する。When blood collected from a healthy donor is pressure-fed into the blood processing apparatus 10 from the blood inflow tube section 12 and flows between the hollow fibers 14, the blood flows down between the hollow fibers 14, and the blood flows through the hollow fibers 14.
While flowing down the space between 14, only the plasma components in the blood are hollow fibers 14
The blood cell component flows down through the hollow fiber 14 through the filtration membrane wall, and the blood cell component flows down between the hollow fibers 14 to separate the blood cell component and the plasma component in the blood.
前記血球成分は下部ポッティング材16に遮られて血液
流出側蓋体18内に流下することができず血液流出管部13
より血液処理装置10外に流出する。The blood cell component is blocked by the lower potting material 16 and cannot flow down into the blood outflow side lid 18, so that the blood outflow tube 13
It then flows out of the blood processing apparatus 10.
中空糸14内を流下した血漿成分は中空糸14の下部開口
より血液流出側蓋体18内を経て血漿流出管部21より血液
処理装置10外に流出する。従って、第１図に示すよう
に、この血漿成分22を容器23に貯えることによりこの血
漿成分を病弱者に輸血同様に提供することができる。The plasma component that has flowed down in the hollow fiber 14 flows out of the blood processing apparatus 10 through the plasma outflow tube 21 through the blood outflow-side lid 18 through the lower opening of the hollow fiber 14. Therefore, as shown in FIG. 1, by storing the plasma component 22 in the container 23, the plasma component can be provided to the sick as well as blood transfusion.
本実施例の血液処理装置10によれば、血液を中空糸14
内に通す場合（血流量100ml/分で圧力損失ΔＰ＝30mmH
g）よりも中空糸14外に通す場合の方（血流量100ml/分
で圧力損失ΔＰ＝10mmHg）が血液の流通抵抗がはるかに
小さい（中空糸14外を流通する血液の流通抵抗は中空糸
14内を流通する血液の流通抵抗の約1/3である）ため、
血液のヘマトクリット値が上昇してもその割りに圧力損
失が上がらず、血液の高い濃縮度が得られる。According to the blood processing apparatus 10 of the present embodiment, the blood
When passing through (pressure drop ΔP = 30mmH at blood flow rate 100ml / min)
g), the blood flow resistance is much smaller when passing outside the hollow fiber 14 (pressure drop ΔP = 10 mmHg at a blood flow rate of 100 ml / min) (the flow resistance of blood flowing outside the hollow fiber 14 is lower than that of the hollow fiber 14).
14 is about 1/3 of the resistance of blood flowing through)
Even if the hematocrit value of the blood increases, the pressure loss does not increase so much, and a high blood concentration can be obtained.
また、中空糸14を交差状に巻回して柱状に形成して円
筒体11内に収納し、中空糸14間で血液を流通させている
ので、中空糸14内で血液を流通させた場合より血漿濾過
面積が増大し血漿分離採取効率が向上する。Further, since the hollow fibers 14 are wound in a cross shape and formed into a columnar shape and housed in the cylindrical body 11 and blood is circulated between the hollow fibers 14, the blood is circulated within the hollow fibers 14 as compared with the case where blood is circulated within the hollow fibers 14. The plasma filtration area is increased, and the efficiency of plasma separation and collection is improved.
また、中空糸14が開口しない状態でこの中空糸14を円
筒体11の両端においてポッティング材16により固定する
ことができるので、中空糸14内にポッティング材16が浸
入せず、ポッティング材16による中空糸14の固定が大幅
に容易となる。Further, since the hollow fiber 14 can be fixed at both ends of the cylindrical body 11 by the potting material 16 in a state where the hollow fiber 14 is not opened, the potting material 16 does not enter the hollow fiber 14 and the hollow fiber 16 The fixing of the thread 14 is greatly facilitated.
また、上述のように血漿分離採取効率が向上するため
その分血液処理装置10を小型化することができ、その結
果ドナーの負担を軽くすることができる。Further, since the efficiency of separating and collecting plasma is improved as described above, the blood processing apparatus 10 can be downsized accordingly, and as a result, the burden on the donor can be reduced.
また、前記ポッティング材16による中空糸14の固定容
易化と、血液処理装置10を小型化することができること
と相俟って血液処理装置10を低コストで製造することが
できる。Further, the blood processing apparatus 10 can be manufactured at low cost in combination with the ease with which the hollow fiber 14 is fixed by the potting material 16 and the downsizing of the blood processing apparatus 10.
「発明の効果」 本発明によれば、側壁の両端に内部に連通する血液流
入管部および血液流出管部が設けられた筒体と、血球を
通過させず血漿を通過させる濾過膜壁からなる中空糸を
交差状に巻回して柱状に形成され前記筒体内に収納さ
れ、かつ前記筒体の両端部においてポッティング材によ
り固定され、すくなくとも前記血液流出管部側端におい
て前記中空糸が開口された中空糸巻回体と、前記筒体の
血液流入管部側端部に嵌着された血液流入側蓋体と、内
部に連通する血漿流出管部が設けられ前記筒体の血液流
出管部側端部に嵌着された血液流出側蓋体とからなる構
成としたので、血液を中空糸内に通す場合よりも中空糸
外に通す場合の方が血液の流通抵抗がはるかに小さいこ
とにより、血液のヘマトクリット値が上昇してもその割
りに圧力損失が上がらず、血液の高い濃縮度が得られ、
中空糸を交差状に巻回して柱状に形成して筒体内に収納
し、中空糸間で血液流通させているので、中空糸内で血
液を流通させた場合より血漿濾過面積が増大し血漿分離
採取効率が向上する。[Effects of the Invention] According to the present invention, a cylindrical body provided with a blood inflow tube portion and a blood outflow tube portion communicating with the inside at both ends of the side wall, and a filtration membrane wall that allows plasma to pass without passing through blood cells The hollow fiber was wound in a cross shape and formed into a columnar shape, housed in the cylinder, and fixed at both ends of the cylinder with a potting material, and at least the hollow fiber was opened at the end of the blood outlet tube side. A hollow fiber wound body, a blood inflow side lid fitted to the blood inflow side end of the cylindrical body, and a plasma outflow side communicating with the inside, and a blood outflow side end of the cylindrical body And the blood outflow side lid fitted to the part, the blood flow resistance is much smaller when blood is passed outside the hollow fiber than when it is passed through the hollow fiber. Even if the hematocrit value of Power loss does not increase, high concentration of blood is obtained,
Since the hollow fibers are wound in a cross shape and formed into a columnar shape and housed in a cylindrical body, and blood is circulated between the hollow fibers, the plasma filtration area is increased as compared with the case where blood is circulated in the hollow fibers, resulting in plasma separation. The collection efficiency is improved.
また、中空糸が開口しない状態でこの中空糸を筒体の
両端においてポッティング材により固定することができ
るので、中空糸内にポッティング材が浸入せず、ポッテ
ィング材による中空糸の固定が大幅に容易となる。In addition, since the hollow fiber can be fixed by the potting material at both ends of the cylindrical body without opening the hollow fiber, the potting material does not enter the hollow fiber, and the fixing of the hollow fiber by the potting material is greatly facilitated. Becomes
また、血漿分離採取効率が向上するためその分血液処
理装置を小型化することができ、その結果ドナーの負担
を軽くすることができる。In addition, since the efficiency of plasma separation and collection is improved, the blood processing apparatus can be reduced in size accordingly, and as a result, the burden on the donor can be reduced.
また、前記ポッティング材による中空糸の固定容易化
と、血液処理装置を小型化することができることと相俟
って血液処理装置を低コストで製造することができる。In addition, the blood processing apparatus can be manufactured at low cost in combination with easy fixing of the hollow fiber by the potting material and downsizing of the blood processing apparatus.
第１図は本発明の一実施例を示す縦断面図、第２図は従
来の血液処理装置の一例を示す縦断面図である。 10……血液処理装置、11……円筒体、12……血液流入管
部、13……血液流出管部、14……中空糸、15……中空糸
巻回体、16……ポッティング材、17……血液流入側蓋
体、18……血液流出側蓋体、21……血漿流出管部。FIG. 1 is a longitudinal sectional view showing an embodiment of the present invention, and FIG. 2 is a longitudinal sectional view showing an example of a conventional blood processing apparatus. 10 blood treatment apparatus, 11 cylindrical body, 12 blood inflow pipe section, 13 blood outflow pipe section, 14 hollow fiber, 15 hollow fiber wound body, 16 potting material, 17 ... blood inflow side lid, 18 ... blood outflow side lid, 21 ... plasma outflow tube.
Claims (1)
および血液流出管部が設けられた筒体と、血球を通過さ
せず血漿を通過させる濾過膜壁からなる中空糸を交差状
に巻回して柱状に形成され前記筒体内に収納され、かつ
前記筒体の両端部においてポッティング材により固定さ
れ、すくなくとも前記血液流出管部側端において前記中
空糸が開口された中空糸巻回体と、前記筒体の血液流入
管部側端部に嵌着された血液流入側蓋体と、内部に連通
する血漿流出管部が設けられ前記筒体の血液流出管部側
端部に嵌着された血液流出側蓋体とからなることを特徴
とする血液処理装置。1. A hollow body comprising a cylindrical body provided with a blood inflow tube and a blood outflow tube communicating with the inside at both ends of a side wall, and a hollow fiber comprising a filtration membrane wall which allows plasma to pass through without passing through blood cells. A hollow fiber wound body wound and formed in a columnar shape and housed in the cylindrical body, and fixed by a potting material at both ends of the cylindrical body, and at least the hollow fiber is opened at the blood outflow tube side end, A blood inflow side lid fitted to the blood inflow tube side end of the cylinder, and a plasma outflow tube communicating with the inside are provided, and fitted to the blood outflow tube side end of the cylinder. A blood processing apparatus comprising a blood outlet side lid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63278300A JP2755966B2 (en) | 1988-11-02 | 1988-11-02 | Blood processing equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63278300A JP2755966B2 (en) | 1988-11-02 | 1988-11-02 | Blood processing equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02124169A JPH02124169A (en) | 1990-05-11 |
| JP2755966B2 true JP2755966B2 (en) | 1998-05-25 |
Family
ID=17595429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63278300A Expired - Fee Related JP2755966B2 (en) | 1988-11-02 | 1988-11-02 | Blood processing equipment |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2755966B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0874683A1 (en) * | 1995-10-23 | 1998-11-04 | Hemasure, Inc. | Extra-lumenal crossflow plasmapheresis devices |
-
1988
- 1988-11-02 JP JP63278300A patent/JP2755966B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02124169A (en) | 1990-05-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0128556B1 (en) | Apparatus for removing bubbles from a liquid | |
| US5849186A (en) | Integrated cardiotomy and venous blood reservoir | |
| US6719907B2 (en) | Dual-stage filtration cartridge | |
| US3508662A (en) | Disposable,low-prime,spirally wound,artificial kidney | |
| US11931499B2 (en) | Pressure detector | |
| JP3284028B2 (en) | Dialysis machine | |
| US20030057147A1 (en) | Filtration device and system for biological fluids | |
| JP2755966B2 (en) | Blood processing equipment | |
| JPH1147269A (en) | Medical heat-exchanger | |
| JPS63226364A (en) | Blood component sampling set | |
| JP2003111837A (en) | Hollow fiber membrane type artificial lung | |
| JP5390578B2 (en) | Air trap chamber | |
| US20190224398A1 (en) | Portable Dialysis System | |
| EP3407932B1 (en) | Filter for purifying blood | |
| JPS6335763Y2 (en) | ||
| JP4084869B2 (en) | In-body purification device | |
| JP2000042100A (en) | Hollow fiber membrane type liquid treatment apparatus | |
| US11260156B2 (en) | Pressure relief mechanism for sorbent canisters | |
| EP3789060B1 (en) | Air trap chamber and extracorporeal circulation circuit | |
| JP3257998B2 (en) | Hollow fiber membrane dialyzer | |
| JPH0613737Y2 (en) | Hemodialyzer | |
| JPH0984873A (en) | Hollow yarn membrane type dialysis filter | |
| JPH0410827B2 (en) | ||
| JPS61113463A (en) | Circuit and method for serum operation system | |
| JPH0548704B2 (en) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |