JP2711630B2 - External preparation for skin - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for the skin, the purpose of which is to provide extremely high safety to the skin and to alleviate the symptoms of skin diseases such as atopic dermatitis, urticaria, acne and pimples, and to suppress exacerbation. Another object of the present invention is to provide a skin external preparation that can be used safely and effectively as cosmetics, cosmeceuticals, and external medicines for the purpose of beautiful skin.

[0002]

2. Description of the Related Art As it has been said from ancient times that "white in color hides seven difficulties", skin whitening and skin smoothing are very important issues for women. However, as the social life improves, more and more people complain of skin allergic symptoms such as atopic dermatitis, and the eczema symptom that occurs especially on the face is the biggest factor that afflicts women of makeup age.

[0003] Atopic dermatitis is one of the allergic diseases with remarkable itching in which bright red spots with a strong tendency to exude are mainly observed. In modern society, factory smoke, automobile exhaust,
There are many factors that induce allergies, such as living space where heating is perfect and a good environment for the growth of mites, westernized dietary habits containing large amounts of proteins and additives, and complicated human relationships. doing. Generally, allergy is defined as a pathological process among the effects of an antigen-antibody reaction on a living body. Specifically, mast cells release chemical mediators such as histamine, bradykinin, and SRS-A in response to an allergen, and these substances are interpreted as a biological reaction caused by damaging surrounding tissues. Therefore, allergic symptoms can be suppressed by suppressing the release of the above-mentioned chemical messenger. SRS-A, which is one of the chemical mediators, is a substance having 5-HETE, which is one of arachidonic acid metabolites, as a precursor. By suppressing the production of 5-HETE, atopic skin It is believed that allergies such as flame and urticaria can be prevented. As a method for treating such atopic dermatitis, a subcutaneous injection using histamine-added immunoglobulin, strong minophagen C, or the like, or an external preparation consisting of adrenocortical hormone has been conventionally used.

[0004] On the other hand, although different from allergic diseases, acne, pimples and the like are also frequently found in adolescent men and women and are one of the skin diseases that hinder the skin from becoming beautiful. Acne is classified as a seborrheic dermatosis, and it occurs in areas where sebaceous lines are widely distributed, such as the face and back of adolescent men and women. Occurrence has been observed.
The cause of acne is exemplified by diet and predisposition, but especially Staphyloco staphylococcus aureus present on the skin surface
It is believed to be closely related to the action of ccus aureus.

[0005] As a method for treating acne, an external preparation containing an antibacterial agent such as hexachlorophen, trichlorocarbanilide or irgasan for the purpose of preventing the growth of Staphylococcus aureus or the like on the skin surface has been mainly used.

[0006]

However, since all of the antihistamines and the like used in the treatment of atopic dermatitis are pharmaceuticals, a doctor must be consulted for prescription and treatment. In particular, subcutaneous injection has a large effect, but has a problem that it is not suitable for treating infants because of pain. In addition, while application of corticosteroids can be expected to be effective, there is a problem that undesired side effects occur, and there is a problem that the use thereof involves risks. In addition, the antibacterial agent used for the treatment or prevention of acne, if its action is strong, may kill even useful microorganisms on the skin surface in addition to the causative bacteria of acne, or on the face For application, there was a problem that there was a problem in safety because these are all drugs. Therefore, the safety in the industry is extremely high, and it can be applied to infants and infants with confidence in the face, etc., and also alleviates the symptoms of skin diseases such as atopic dermatitis, urticaria, acne and pimples. An excellent skin that can be effectively used as a cosmeceutical or a pharmaceutical for the purpose of preventing exacerbation or exacerbation, and that can be suitably used as a cosmetic on healthy skin for the purpose of beautifying the skin in addition to these skin disease symptoms. Creation of an external preparation was desired.

[0007]

Means for Solving the Problems The present invention is characterized in that it comprises, as essential components, a crushed product of Scutellaria baicalensis GEORGI and / or an extract thereof, and a pigment component extracted from crude brown sugar. By providing an external preparation for skin, the conventional problems described above are completely eliminated.

[0008]

The constitution of the external preparation for skin of the present invention will be described below in detail. In the present invention, Scutellaria (Scut
(ellaria baicalensis GEORGI) and / or an extract thereof are used as one of the essential components. Here, Scutellaria baicalensis GEORGI is a perennial plant belonging to the Labiatae family, which is native to eastern Siberia, China. It is about 1 m in height, and purple flowers face the upper part of the stem in summer to form a spike. It is a plant that blooms, and the dried matter at the root is called "Scutellaria Radix" and has been used as a kind of Chinese medicine since ancient times.

[0009] The site of Scutellaria baicalensis GEORGI used in the present invention includes:
Above-ground parts such as leaves, stems and flowers, or underground parts such as roots,
Alternatively, any site such as whole plant can be used. More preferably, a low site of the stem, particularly a yellowish site or a root is preferably used because it contains a large amount of the active ingredient. Scutellaria (Scutellari)
a baicalensis GEORGI), a naturally-occurring non-dried one, or a so-called "Ogon", which is commercially available as one of herbal medicines, and any of them can be suitably used.

[0010] Such Scutellaria baic (Scutellaria baic)
alensis GEORGI) is dried and ground and used as one of the essential components of the present invention. Alternatively, the extract is used as one of the essential components. Scutellaria (Scutella
ria baicalensis GEORGI), if necessary, the dried or ground extract is extracted with an appropriate solvent used for ordinary plant extraction, and is preferably used without particular limitation. can do.

Specifically, the extraction solvent includes water, methanol, ethanol, isopropanol, isobutanol,
alcohols such as n-hexanol, methylamyl alcohol, 2-ethylbutanol, n-octanol, ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene bricol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, Polyhydric alcohols such as triethylene glycol, 1,3-butylene glycol and hexylene glycol or derivatives thereof, acetone, methyl acetone, methyl ethyl ketone,
One or more mixed solvents of polar solvents such as ketones such as methyl isobutyl ketone and methyl-n-propyl ketone, esters such as ethyl acetate and isopropyl acetate, and ethers such as ethyl ether, isopropyl ether and n-butyl ether. Can be preferably used, but there is no particular limitation. Or a kind of non-polar solvent such as petroleum ether, aliphatic hydrocarbons such as n-hexane, n-pentane, n-butane, n-octane, and cyclohexane; carbon tetrachloride, chloroform, dichloromethane, trichloroethylene, benzene, and toluene. Alternatively, a mixed solvent of two or more types can also be suitably used. Further, the above-mentioned mixed solvent of a polar solvent and a non-polar solvent can be suitably used in the present invention without any particular limitation.

Scutellaria baicalensis GE
More specifically, the extract of (ORGI) is described in detail.The low part of the stem, particularly the yellowish part and the root, contain a large number of flavonoid compounds which are one of the active ingredients of the present invention. I have. That is, baicalin represented by the following formula (1), baicalein represented by the following formula (2), chrysin represented by the following formula (3), agonine represented by the following formula (4): Orgonin-7-OD-glucuronide represented by the following formula 5 (formula 5), scalcapflavone represented by the following formula 6 (formula 6), 2 ′, 5,5 represented by the following formula 7 (formula 7) ', 7-tetrahydroxy-6',
8-Dimethoxyflavone, (2S) -2 ′, 5,6 ′, 7-tetrahydroxyflavone represented by the following formula 8 (Chemical formula 8), (2R, 3R) -2 represented by the following formula 9 (Chemical formula 9) ',
Flavonoid compounds such as 3,5,6 ', 7-pentahydroxyflavone are contained in large amounts in the low and root portions of stems. In the present invention, one or more of the above flavonoid compounds are purified, and It can be used separately as one of the essential components.

[0013]

Embedded image

Embedded image

Embedded image

Embedded image

Embedded image

Embedded image

Embedded image

Embedded image

Embedded image

In the present invention, a pigment component extracted from crude brown sugar is used as an essential component together with the ground material of Scutellaria baicalensis GEORGI and / or an extract thereof. Here, the pigment component refers to a black pigment component (for example, Coctoligo (trade name, manufactured by Osaka Pharmaceutical Laboratory Co., Ltd.)) obtained from an unrefined product of sucrose (brown sugar). As a method,
For example, the following method is exemplified. That is, the crude brown sugar as a raw material is dissolved in an appropriate amount of water, and this is brought into contact with an adsorbent to adsorb the dye component, washed with water to sufficiently remove sugar, and the adsorbed dye component is eluted with a solvent. Extraction and separation by Usually, this operation is carried out using a column of an adsorbent and flowing down water and a solvent. In this case, the adsorbent used is a non-polar polystyrene-based adsorption resin, for example, Amberlite XAD-1, Amberlite XAD-2 (trade name, manufactured by Rohm and Haas)
And Selvachrome XAD-2 (trade name, manufactured by Selva) are preferred. In addition, in terms of yield, Selvachrome XAD-
2 is preferred, but not particularly limited. The crude black dye component obtained at this stage can also be suitably used as one of the essential components in the present invention. That is, the effluent is concentrated under reduced pressure, and can be used as a flow extract, a soft extract, and a dry extract.

The amount of the adsorbent used is 8 times the amount of the dye component contained.
0 to 800 times (weight ratio), more preferably 50 to 200 times
It is desirable to make it twice (weight ratio). When eluting the adsorbed dye component, it is preferable to wash with water before elution to sufficiently remove sugars until the washing liquid has no sweetness. The elution of the dye component is preferably performed with a lower alcohol having a concentration of 20% or more, for example, methanol or ethanol. In practice, it is preferable to elute first with 20 to 30% of lower alcohol, and then to elute with 95 to 99% of higher concentration lower alcohol after coloring of the flowing liquid is hardly observed. The reason for this is that elution with only low-concentration lower alcohol reduces the yield of the dye component, which is not preferable. The eluate thus obtained can be evaporated to dryness to obtain a crude brown sugar dye component, which is one of the essential components of the present invention. If the removal of sugar is incomplete and the sweetness remains in the eluate, the evaporation residue is mixed with pure lower alcohol such as pure ethanol, the insoluble sugar is filtered off and removed, and the filtrate is removed from the filtrate. It is preferable to obtain the dye component with high purity by recrystallizing the dye component.

As a method for obtaining a pigment component extracted from crude brown sugar of the present invention, in addition to the above-described method, crude brown sugar is directly cold-immersed or digested in a pure lower alcohol such as methanol or pure ethanol to obtain an insoluble sugar content. May be removed by filtration or the like, and then the remaining liquid is evaporated to dryness to obtain a pigment component.

The pigment component of crude brown sugar extracted and separated by the above method can be used as an essential component of the present invention as it is. Although various components are contained in the pigment component, oligosaccharides such as phenylglucose are mainly contained as main components. As a specific example, for example,
5-dimethoxyphenyl-O-glucose and the following formula 11
2,4,5-trimethoxyphenyl-O-glucose represented by the following formula (12), 3,4-dimethoxyphenyl-OD-glucose represented by the following formula (12), and the following formula (13) 3,4,6-trimethoxyphenyl-OD-glucose or the like represented by the formula (1).

[0018]

Embedded image

Embedded image

Embedded image

Embedded image

The pigment component of crude brown sugar containing oligosaccharide as a main component as described above can be obtained from the raw crude sugar in a yield of about 0.05 to 0.3% by weight, and has a light brown hygroscopicity. It is a powder with a slightly burning odor and a slightly bitter taste.

According to the present invention, the above-mentioned ground material of Scutellaria baicalensis GEORGI and / or an extract thereof and a pigment component extracted from crude brown sugar are essential components. The ratio is 0.01 to 0.1% of the total amount of the external preparation for skin,
More preferably, it is desirably about 0.02 to 0.05%. Also, Scutellaria baicalensi
s GEORGI) and the ratio of the pigment component extracted from crude brown sugar to the pigment component extracted from crude brown sugar are desirably about 3: 7 to 7: 3, more preferably about 5: 5. The reason for this is that if the amount of the pigment component extracted from crude brown sugar is less than 3/10 with respect to the ground material of Scutellaria baicalensis GEORGI and / or its extract, the skin disease targeted by the present invention Is not able to exhibit an extremely good effect on cornflower, while the combination of pigment components extracted from crude brown sugar makes it possible to use Scutellaria baicalensis
GEORGI) and / or its extract
This is because, even if the amount is more than 10, the effect proportional to the compounding example cannot be obtained, and in any case, it is not preferable.

In the present invention, the essential components described above include:
It can be used as it is as a skin external preparation, but more preferably mixed with known excipients and diluents, or any other compounding materials, granules, emulsions, solutions,
It is prepared and used in the form of a suspension or the like. In the present invention, the final form of the skin external preparation may be a cosmetic applied to healthy skin for the purpose of cosmetics, or acne, prevention of deterioration of symptoms such as pimples, improvement of symptoms, and even acne scars. It may be a medicated cosmetic (quasi-drug) for the purpose of beautifying the remaining skin, or a pharmaceutical for the treatment of allergic dermatitis such as atopic dermatitis and urticaria. Either form can be arbitrarily adopted. Moreover, when prepared into these dosage forms, conventionally known sulfur preparations, keratolytic agents such as salicylic acid and resorcin, and antibacterial agents such as hexachlorophene, trichlorocarbanilide, irgasan, chlorhexidine, and the like can be used. Can be used in combination as appropriate within a range that does not impair. Further, hyaluronic acid and hydrolyzed collagen known as skin moisturizing agents, and vitamin C or a derivative thereof known as a whitening agent can be optionally used in combination.

Specific examples of preferred cosmetics include basic cosmetics such as lotions, emulsions, cleansing creams, creams such as massage creams and emollient creams, packs, and makeup cosmetics such as foundations and blushers. Is done. Examples of suitable medicated cosmetics include soaps, facial cleansers, lotions and emulsions for the purpose of improving and preventing acne, packs, body lotions, bath salts, and the like. Further, as pharmaceuticals, ointments, creams, and the like are exemplified as preferred examples. Can be
There is no particular limitation in the present invention.

In such an external preparation for skin, the Scutellaria (Scutellaria) is used at any stage of the manufacturing process.
Any desired amount of the pulverized product of Bacillus baicalensis GEORGI) and / or its extract and the pigment component extracted from crude brown sugar may be blended.

[0024]

EXAMPLES The effects of the external preparation for skin according to the present invention will be described below with reference to examples. However, the present invention is not limited at all by the following examples.

(1) Scutellaria baicalen
Preparation of crushed sis GEORGI sample (A) 50 g of non-dried whole plant of Scutellaria baicalensis GEORGI was cut into small pieces, and the cut pieces were extracted with methanol at 60 ° C. for 1 to 2 hours under heating. After repeating the extraction operation four times, the obtained extract was filtered, and the filtrate was further concentrated under reduced pressure and dried to obtain about 10 g of the extract. Sample (B) After drying and pulverizing the stem and root of Scutellaria baicalensis GEORGI, methanol was added at 60 ° C for 1 hour.
Extraction was performed for 2 hours with heating, and this extraction operation was repeated four times. Then, the obtained extract was filtered, and the filtrate was further concentrated under reduced pressure to dryness. Sample (C) The extract obtained in Sample (C) was separated into four fractions by column chromatography (C-
1, C-2, C-3, C-4). Each fraction was concentrated under reduced pressure to dryness. (When each fraction was identified using high performance liquid chromatography, C-1 was baicalin, C-2 was agonine, C
-3 was identified as agonine 7-O-glucuronide, and C-4 was identified as baicalein. ) Sample (D) The root of Scutellaria baicalensis GEORGI was dried and then pulverized to a pulverized product.

(2) Preparation of Pigment Component Extracted from Crude Brown Sugar (E) 5 kg of brown sugar from Okinawa is dissolved in 25 liters of water, and a polystyrene resin (Amberlite XAD-2, 2500 g) is added to water 1
The mixture was poured into a column having an inner diameter of 8 cm, which was dispersed and packed in liter, and allowed to flow down at a rate of 20 ml / min to adsorb the pigment component of brown sugar. Next, let the water flow down and wash with water until the sweetness has completely disappeared, sufficiently remove the sugar, inject 95% methanol, and add 10 ml
The dye was eluted from the adsorbent by flowing down at a rate of 1 / min. Continue flowing down until the flowing liquid is no longer colored, mix the effluent,
The residue was evaporated to dryness under reduced pressure at 60 ° C. or less, and the residue was evaporated to dryness at 60 ° C. or less to obtain 8 g of a brown powder pigment component having no sweetness. Sample (F) 5 kg of brown sugar produced in Okinawa is dissolved in 25 liters of water, and polystyrene resin (Selvachrome XAD-2, 300 g) is dispersed in 1 liter of water and injected into a column having an inner diameter of 8 cm and filled.
It was allowed to flow down at a rate of 20 ml / min to adsorb the pigment component of brown sugar. Next, let the water flow down and wash with water until the sweetness is completely gone to remove sugar sufficiently.
The dye was eluted from the adsorbent by injecting 20% methanol and flowing down at a rate of 10 ml / min. When little color was observed in the flowing solution, the eluent was replaced with 95% methanol, and the flow was continued until the flowing solution was completely free of color. The eluates were mixed under both flows, and evaporated to dryness under reduced pressure at 60 ° C. or lower to obtain 16 g of a brown residue. This is heated and dissolved in 2 liters of pure ethanol, and after cooling, the precipitated turbid substance is separated by filtration, evaporated to dryness under reduced pressure at 60 ° C or less, and the residue is dried at 60 ° C or less to obtain a completely sweet product. 15 g of a brown powdery pigment component was obtained.

(Examples 1 to 5 and Comparative Examples 1 to 3) (Example 1) Medicinal lotion weight% Scutellaria extract [Sample (B)] 0.02 Crude sugar pigment component [Sample (E)] 0.02 d - camphor 0.02 l-menthol 0.05 1,3-butylene glycol 5.0 ethanol 15.0 perfume qs refining water balance section 100.0 (example 2) medicinal cleansing cream wt% Scutellaria extract [ Sample (A)] 0.02 Crude sugar pigment component [Sample (F)] 0.03 Light liquid paraffin 35.0 Beeswax 8.0 Cetyl palmitate 3.0 Lanolin 1.0 Sorbitan sesquioleate 2.0 Polyoxyethylene (20) sorbit beeswax 4.5 preservative antioxidant qs 70% sorbitol 4.0 perfume qs refining water balance section 100.0

(Example 3) Medicinal pack weight% Cranberry crushed matter 0.04 [1: 1 mixture of baicalein and agonine obtained in sample (C)] Crude sugar pigment component [sample (E)] 0.02 Polyvinyl alcohol 14.0 Vinyl acetate resin emulsion 10.0 Ethyl alcohol 7.0 Kaolin 10.0 Glycerol 1.0 Paraben 0.01 Perfume Appropriate amount Purified water Balance 100.0 (Example 4) Medicinal body shampoo weight% Pulverized Scutellaria 0.06 [1: 1 mixture of baicalein and agonine 7-O-glucuronide obtained in sample (C)] Crude sugar pigment component [sample (F)] 0.05 Sodium lauryl sulfate 10.0 lauryl Sodium sulfosuccinate 20.0 Lauryl diethanolamide 4.0 Hydrolysis collar Down 1.0 Ethylene glycol distearate 1.0 edetate tetrasodium tetrahydrate 0.1 allantoin 0.01 Lysozyme chloride 0.01 Perfume qs Purified water balance section 100.0

(Example 5) Ointment weight% Scutellaria extract [Sample (D)] 0.08 Crude sugar pigment component [Sample (E)] 0.05 Glycerin 10.0 Beeswax 20.0 Olive oil 4.0 Flavor Appropriate amount 100.0

Comparative Example 1 Medicinal lotion weight% Scutellaria extract [sample (B)] 0.02 d-camphor 0.02 1-menthol 0.05 1,3-butylene glycol 5.0 ethanol 15.0 incense charge qs refining water balance section 100.0 (Comparative example 2) medicinal lotion wt% raw sugar dye component sAMPLE (E)] 0.02 d-camphor 0.02 l-menthol 0.05 1,3-butylene glycol 5.0 ethanol 15.0 perfume qs refining water balance section 100.0 (Comparative example 3) medicinal lotion wt% d- camphor 0.02 l-menthol 0.05 1,3-butylene glycol 5.0 ethanol 15.0 perfume qs refining water balance section 100.0

[0031]

Test Examples The effects of the external preparation for skin according to the present invention will be further clarified with reference to test examples.

Test Example 1 Example 1 and Comparative Examples 1 to
The medicated lotion prepared in (3) was administered to (A) 20 male and female children aged 13 to 17 years with severe acne symptoms, and (B) 20 male and female children aged 7 to 12 years with severe atopic dermatitis. Each time, each medicated lotion was continuously applied for 2 weeks to the severely affected area. Two weeks after the application of each medicated lotion, the state of improvement of the symptoms at the application site was visually evaluated. ◎ indicates that the symptom almost disappeared, 〇 indicates improvement of the symptom, and × indicates no change in the symptom. Table 1 shows the results.

[0033]

[Table 1]

(Examples 6 to 10 and Comparative Examples 4 to 7) (Example 6) A methanol extract of whole Scutellaria obtained from the sample (A) and the crude sugar obtained from the sample (E) And an equal amount of the above dye component. (Example 7) The methanol extract of the Scutellaria stalk and root obtained in the sample (B) and the sample (F)
And an equal amount of the pigment component of the crude sugar obtained in the above. (Example 8) Equivalent mixture of baicalein and agonine obtained in sample (C) and sample (E)
The crude sugar obtained in the above was mixed with an equivalent amount of the pigment to obtain a mixture. (Example 9) Equivalent amounts of the baicalein and agonine 7-O-glucuronide obtained in the sample (C) and the pigment component of the crude sugar obtained in the sample (F) were mixed to form a mixture. (Example 10) An equal amount of the ground component of Scutellaria root obtained in the sample (D) and the pigment component of the crude sugar obtained in the sample (E) were mixed to obtain a mixture.

(Comparative Example 4) Only the methanol extract of whole Aspergillus oryzae obtained in the sample (A) was used. (Comparative Example 5) Only the methanol extract of Scutellaria stalk and root obtained in the sample (B) was used. (Comparative Example 6) Only the dried and pulverized material of Scutellaria root obtained in the sample (D) was used. (Comparative Example 7) Only the pigment component of the crude sugar obtained in the sample (E) was used.

(Test Example 2) Antibacterial activity against Staphylococcus aureus Each of the samples of Examples 6 to 10 and Comparative Examples 4 to 7 was dissolved in ethanol to a 10-fold amount, and 0.05 of them was dissolved.
of the sample was impregnated into a filter paper disk having an inner diameter of 8 mm, adhered onto an agar plate (Heart In Fusion Agar Medium, manufactured by Nissui Pharmaceutical Co., Ltd.) inoculated and dispersed with Staphylococcus aureus 269P as a test bacterium, and heated at 35 ° C. Cultured for 24 hours. After completion of the culture, the size of the growth inhibition circle around the filter paper was calculated. Table 2 shows the results.

[0037]

[Table 2]

Test Example 3 The samples obtained in Examples 6 to 10 and Comparative Examples 4 to 7 were tested for 5-HETE production inhibitory activity. Using Wistar male rats, the rat intraperitoneal polynuclear leukocytes were converted to HEPS-saline buffer (pH
The mixture was washed in 7.4), suspended in the same buffer solution and subjected to ultrasonic treatment, and used as an enzyme solution for arachidonic acid metabolism. The samples of the platelet homogenate and the above Examples and Comparative Examples were each adjusted to the concentrations shown in Table 3 and kept at 37 ° C. for 5 minutes. Thereafter, [1 ^-14 C] arachidonic acid (0.05 μCi) was added, and the mixture was incubated for 5 minutes. After completion, the reaction was stopped with formic acid (pH 3), and arachidonic acid metabolite was extracted with ethyl acetate and separated and quantified by silica gel thin-layer chromatography (TLC) (developing solution; petroleum ether: ether: acetic acid = 50: 50). : 1, v /
v, TLC is Merck 5748). The radioactive substance was detected by autoradiography, the spot was cut out, and the radioactive substance was quantified with a liquid scintillation counter.
(It should be noted that those in which the samples of Examples and Comparative Examples were not used were used as control examples.) The results are shown in Table 3. (Note that HHT (1
2-Hydroxyheptadecatrienoic acid) is 5-hydroxyeicosatetraenoic acid (5-HETE) that is metabolized via cyclooxygenase.

[0039]

[Table 3]

As is evident from the results in Table 1, the medicated lotion containing only Scutellaria extract (Comparative Example 1) showed an improvement effect on atopic dermatitis, but an improvement on acne. It turns out that the effect is not sufficiently exhibited. Furthermore, for atopic dermatitis,
Although the improvement effect is recognized, it can be seen that there are very few cases in which the symptoms have almost disappeared. In addition, the medicated lotion containing only the crude sugar extract (Comparative Example 2) showed a slight improvement effect on atopic dermatitis as compared with the medicated lotion shown in Comparative Example 3, but it was not sufficient. I understand. In the medicated lotion of Example 1 in which the extract of Scutellaria and the pigment component of crude sugar were blended,
It can be seen that a remarkable remarkable improvement effect is recognized for both atopic dermatitis and acne. As is evident from the results in Table 2, Staphylococcus aureus was used only in the ground millet of Scutellaria or its extract, or in the pigment component of crude sugar alone.
Although the inhibitory activity against staphylococcus aureus is extremely low (no inhibition circle was formed), a mixture of a millet or extract of Scutellaria and a pigment component of crude sugar (Examples 6-1)
0) shows that the inhibitory activity is extremely high. As is clear from the results in Table 3, it is found that the production inhibitory activity against 5-HETE is not sufficiently expressed only with the pigment component of the crude sugar (Comparative Example 7). In addition, in the case of the mixture of the crushed Scutellaria or the extract thereof and the pigment component of the crude sugar (Examples 6 to 10), the yield is extremely remarkable compared to the case of using only the crushed crude sugar or the crushed Scutellaria or the extract thereof alone. It turns out that the inhibitory activity is recognized.

[0041]

As described in detail above, the present invention relates to a ground product of Scutellaria baicalensis GEORGI and / or
Or an extract thereof, and a skin external preparation characterized by comprising a pigment component extracted from crude brown sugar as an essential component, which is extremely high in safety to the human body, and from the results of the test examples. As is evident, it is extremely effective in improving the symptoms of skin diseases such as atopic dermatitis, acne, pimples and the like. It has an excellent effect that it can be safely applied to the face of infants and the like as a general cosmetic for the purpose of beautiful skin.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code Agency reference number FI Technical display A61K 35/78 ABF A61K 35/78 ABFU ADA ADAQ

Claims (3)

(57) [Claims] 1. Scutellaria baicalensis
An external preparation for skin, comprising as essential components a ground product of GEORGI) and / or an extract thereof, and a pigment component extracted from crude brown sugar. 2. The external preparation for skin according to claim 1, wherein the pigment component is phenyl glucose. 3. The Scutellaria baicalen (Scutellaria baicalen)
3. The crushed product and / or extract of sis GEORGI) comprises a flavonoid compound.
2. The external preparation for skin according to item 1.