JP2612641B2 - 光学的分析方法、そこで使用するための装置、及びアッセイ方法 - Google Patents

光学的分析方法、そこで使用するための装置、及びアッセイ方法

Info

Publication number: JP2612641B2
Authority: JP; Japan
Prior art keywords: refractive index; light; optical; waveguide; optical structure
Prior art date: 1989-06-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2508670A

Other languages

English (en)

Japanese (ja)

Other versions

JPH04501612A (ja

Inventor

ワーシントンアトリッジ，ジョン

Original Assignee

アプライドリサーチシステムズエーアールエスホールディングナームロゼベノートスハップ

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-22

Filing date

1990-06-21

Publication date

1997-05-21

1989-06-22 Priority claimed from GB898914343A external-priority patent/GB8914343D0/en

1990-04-11 Priority claimed from GB909008261A external-priority patent/GB9008261D0/en

1990-06-21 Application filed by アプライドリサーチシステムズエーアールエスホールディングナームロゼベノートスハップ filed Critical アプライドリサーチシステムズエーアールエスホールディングナームロゼベノートスハップ

1992-03-19 Publication of JPH04501612A publication Critical patent/JPH04501612A/ja

1997-05-21 Application granted granted Critical

1997-05-21 Publication of JP2612641B2 publication Critical patent/JP2612641B2/ja

2012-05-21 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

238000003556 assay Methods 0.000 title claims abstract description 11
238000004204 optical analysis method Methods 0.000 title claims description 5
230000003287 optical effect Effects 0.000 claims abstract description 103
238000012360 testing method Methods 0.000 claims abstract description 36
238000000034 method Methods 0.000 claims abstract description 30
238000004458 analytical method Methods 0.000 claims abstract description 25
239000000463 material Substances 0.000 claims description 48
239000007787 solid Substances 0.000 claims description 23
239000007788 liquid Substances 0.000 claims description 20
239000000427 antigen Substances 0.000 claims description 14
108091007433 antigens Proteins 0.000 claims description 14
102000036639 antigens Human genes 0.000 claims description 14
239000000523 sample Substances 0.000 claims description 13
239000011248 coating agent Substances 0.000 claims description 12
238000000576 coating method Methods 0.000 claims description 12
239000012780 transparent material Substances 0.000 claims description 12
230000005855 radiation Effects 0.000 claims description 8
239000003153 chemical reaction reagent Substances 0.000 claims description 7
239000007791 liquid phase Substances 0.000 claims description 6
239000011358 absorbing material Substances 0.000 claims description 4
230000001902 propagating effect Effects 0.000 claims description 4
238000006243 chemical reaction Methods 0.000 claims description 2
239000012530 fluid Substances 0.000 claims 1
239000010410 layer Substances 0.000 description 51
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
102000011022 Chorionic Gonadotropin Human genes 0.000 description 9
108010062540 Chorionic Gonadotropin Proteins 0.000 description 9
229940084986 human chorionic gonadotropin Drugs 0.000 description 9
239000011521 glass Substances 0.000 description 8
239000000377 silicon dioxide Substances 0.000 description 7
241000700605 Viruses Species 0.000 description 4
239000000853 adhesive Substances 0.000 description 4
230000001070 adhesive effect Effects 0.000 description 4
230000027455 binding Effects 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
239000002242 colloidal glass Substances 0.000 description 4
238000001514 detection method Methods 0.000 description 4
238000011049 filling Methods 0.000 description 4
238000003018 immunoassay Methods 0.000 description 4
239000005304 optical glass Substances 0.000 description 4
230000009870 specific binding Effects 0.000 description 4
239000000126 substance Substances 0.000 description 4
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
238000007796 conventional method Methods 0.000 description 3
230000008878 coupling Effects 0.000 description 3
238000010168 coupling process Methods 0.000 description 3
238000005859 coupling reaction Methods 0.000 description 3
230000005284 excitation Effects 0.000 description 3
239000003446 ligand Substances 0.000 description 3
238000005259 measurement Methods 0.000 description 3
239000005365 phosphate glass Substances 0.000 description 3
229920001296 polysiloxane Polymers 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
102000012673 Follicle Stimulating Hormone Human genes 0.000 description 2
108010079345 Follicle Stimulating Hormone Proteins 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
102000009151 Luteinizing Hormone Human genes 0.000 description 2
108010073521 Luteinizing Hormone Proteins 0.000 description 2
AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 2
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
102000013529 alpha-Fetoproteins Human genes 0.000 description 2
108010026331 alpha-Fetoproteins Proteins 0.000 description 2
230000002238 attenuated effect Effects 0.000 description 2
238000013098 chemical test method Methods 0.000 description 2
239000002131 composite material Substances 0.000 description 2
238000010586 diagram Methods 0.000 description 2
239000000835 fiber Substances 0.000 description 2
239000007850 fluorescent dye Substances 0.000 description 2
229940028334 follicle stimulating hormone Drugs 0.000 description 2
229940088597 hormone Drugs 0.000 description 2
239000005556 hormone Substances 0.000 description 2
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
238000007689 inspection Methods 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
230000003993 interaction Effects 0.000 description 2
PQXKHYXIUOZZFA-UHFFFAOYSA-M lithium fluoride Chemical compound [Li+].[F-] PQXKHYXIUOZZFA-UHFFFAOYSA-M 0.000 description 2
229940040129 luteinizing hormone Drugs 0.000 description 2
239000000203 mixture Substances 0.000 description 2
239000003973 paint Substances 0.000 description 2
239000000813 peptide hormone Substances 0.000 description 2
239000004033 plastic Substances 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
230000035945 sensitivity Effects 0.000 description 2
229910052710 silicon Inorganic materials 0.000 description 2
239000010703 silicon Substances 0.000 description 2
239000011343 solid material Substances 0.000 description 2
239000000243 solution Substances 0.000 description 2
238000004528 spin coating Methods 0.000 description 2
239000012085 test solution Substances 0.000 description 2
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
235000007173 Abies balsamea Nutrition 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
239000004857 Balsam Substances 0.000 description 1
LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
239000004593 Epoxy Substances 0.000 description 1
239000001293 FEMA 3089 Substances 0.000 description 1
241000725303 Human immunodeficiency virus Species 0.000 description 1
244000018716 Impatiens biflora Species 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
102000004877 Insulin Human genes 0.000 description 1
239000005662 Paraffin oil Substances 0.000 description 1
208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
102000003946 Prolactin Human genes 0.000 description 1
108010057464 Prolactin Proteins 0.000 description 1
229920005654 Sephadex Polymers 0.000 description 1
239000012507 Sephadex™ Substances 0.000 description 1
BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
102000011923 Thyrotropin Human genes 0.000 description 1
108010061174 Thyrotropin Proteins 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
230000004075 alteration Effects 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
230000000711 cancerogenic effect Effects 0.000 description 1
231100000315 carcinogenic Toxicity 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
239000010627 cedar oil Substances 0.000 description 1
239000004568 cement Substances 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
239000005331 crown glasses (windows) Substances 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000000593 degrading effect Effects 0.000 description 1
LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
229960005156 digoxin Drugs 0.000 description 1
LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000009826 distribution Methods 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000000975 dye Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
229920001971 elastomer Polymers 0.000 description 1
239000000806 elastomer Substances 0.000 description 1
229960005309 estradiol Drugs 0.000 description 1
229930182833 estradiol Natural products 0.000 description 1
239000000945 filler Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
208000006454 hepatitis Diseases 0.000 description 1
231100000283 hepatitis Toxicity 0.000 description 1
229960000890 hydrocortisone Drugs 0.000 description 1
238000005286 illumination Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
206010022000 influenza Diseases 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
238000004020 luminiscence type Methods 0.000 description 1
ORUIBWPALBXDOA-UHFFFAOYSA-L magnesium fluoride Chemical compound [F-].[F-].[Mg+2] ORUIBWPALBXDOA-UHFFFAOYSA-L 0.000 description 1
229910001635 magnesium fluoride Inorganic materials 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000011259 mixed solution Substances 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000000186 progesterone Substances 0.000 description 1
229960003387 progesterone Drugs 0.000 description 1
229940097325 prolactin Drugs 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
238000007650 screen-printing Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
229910000077 silane Inorganic materials 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
238000005507 spraying Methods 0.000 description 1
239000012086 standard solution Substances 0.000 description 1
239000003270 steroid hormone Substances 0.000 description 1
239000002344 surface layer Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
239000010409 thin film Substances 0.000 description 1
239000005495 thyroid hormone Substances 0.000 description 1
229940036555 thyroid hormone Drugs 0.000 description 1
229940034208 thyroxine Drugs 0.000 description 1
XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
229940035722 triiodothyronine Drugs 0.000 description 1
241000701161 unidentified adenovirus Species 0.000 description 1
238000001771 vacuum deposition Methods 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
238000005303 weighing Methods 0.000 description 1
229910052724 xenon Inorganic materials 0.000 description 1
FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6465—Angular discrimination

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Life Sciences & Earth Sciences (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pathology (AREA)
Chemical Kinetics & Catalysis (AREA)
Optics & Photonics (AREA)
Investigating Or Analysing Materials By Optical Means (AREA)
Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

JP2508670A 1989-06-22 1990-06-21 光学的分析方法、そこで使用するための装置、及びアッセイ方法 Expired - Fee Related JP2612641B2 (ja)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB898914343A GB8914343D0 (en)	1989-06-22	1989-06-22	Optical method of analysis
GB8914343.2		1989-06-22
GB9008261.1		1990-04-11
GB909008261A GB9008261D0 (en)	1990-04-11	1990-04-11	Method of improving assay sensitivity

Publications (2)

Publication Number	Publication Date
JPH04501612A JPH04501612A (ja)	1992-03-19
JP2612641B2 true JP2612641B2 (ja)	1997-05-21

Family

ID=26295521

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2508670A Expired - Fee Related JP2612641B2 (ja)	1989-06-22	1990-06-21	光学的分析方法、そこで使用するための装置、及びアッセイ方法

Country Status (10)

Country	Link
US (1)	US5166515A (es)
EP (1)	EP0429612B1 (es)
JP (1)	JP2612641B2 (es)
AT (1)	ATE98773T1 (es)
AU (1)	AU619120B2 (es)
CA (1)	CA2033168C (es)
DE (1)	DE69005270T2 (es)
DK (1)	DK0429612T3 (es)
ES (1)	ES2047334T3 (es)
WO (1)	WO1990015985A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9008261D0 (en) *	1990-04-11	1990-06-13	Ares Serono Res & Dev Ltd	Method of improving assay sensitivity
WO1992008966A1 (en) *	1990-11-13	1992-05-29	Block Myron J	Fluorescence assay apparatus
US5192510A (en) *	1991-01-30	1993-03-09	E. I. Du Pont De Nemours And Company	Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence
US5677196A (en) *	1993-05-18	1997-10-14	University Of Utah Research Foundation	Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
AU749504B2 (en) *	1993-05-18	2002-06-27	University Of Utah Research Foundation	Apparatus and methods for multianalyte homogeneous fluoroimmunoassays
US5512492A (en)	1993-05-18	1996-04-30	University Of Utah Research Foundation	Waveguide immunosensor with coating chemistry providing enhanced sensitivity
ES2169079T3 (es) *	1993-05-18	2002-07-01	Univ Utah Res Found	Aparato y metodos para fluoroinmunoensayos homogeneos multianalitos.
US5919712A (en)	1993-05-18	1999-07-06	University Of Utah Research Foundation	Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
JPH08116961A (ja) *	1994-10-25	1996-05-14	Hamamatsu Photonics Kk	培養観測用容器及び観測装置
US5814565A (en) *	1995-02-23	1998-09-29	University Of Utah Research Foundation	Integrated optic waveguide immunosensor
US5745231A (en) *	1995-06-12	1998-04-28	American Research Corporation Of Virginia	Method of fluorescence analysis comprising evanescent wave excitation and out-of-plane photodetection
US5832165A (en)	1996-08-28	1998-11-03	University Of Utah Research Foundation	Composite waveguide for solid phase binding assays
US6395558B1 (en) *	1996-08-29	2002-05-28	Zeptosens Ag	Optical chemical/biochemical sensor
US6222619B1 (en)	1997-09-18	2001-04-24	University Of Utah Research Foundation	Diagnostic device and method
DE59915078D1 (es) *	1998-02-05	2009-10-22	Novartis Ag
US6300638B1 (en)	1998-11-12	2001-10-09	Calspan Srl Corporation	Modular probe for total internal reflection fluorescence spectroscopy
WO2001025759A1 (de) *	1999-10-01	2001-04-12	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Verfahren und einrichtung zur bestimmung von substanzen, wie z.b. dna-sequenzen, in einer probe
CA2397943A1 (en) *	2000-01-20	2001-07-26	Ikonisys, Inc.	Device and method for detecting and localizing cells by means of photosensitive waveguides
EP1311824A4 (en)	2000-06-25	2010-12-08	Affymetrix Inc	OPTICALLY ACTIVE SUBSTRATES
WO2002016990A1 (en) *	2000-08-18	2002-02-28	Koninklijke Philips Electronics N.V.	Optical component and method of manufacturing same
US6947651B2 (en) *	2001-05-10	2005-09-20	Georgia Tech Research Corporation	Optical waveguides formed from nano air-gap inter-layer dielectric materials and methods of fabrication thereof
US6890619B2 (en) *	2001-11-13	2005-05-10	Agilent Technologies, Inc.	Optical systems and refractive index-matching compositions
US7029631B2 (en) *	2002-04-19	2006-04-18	Agilent Technologies, Inc.	Apparatus for improved light collection
US7154598B2 (en) *	2002-07-12	2006-12-26	Decision Biomarkers, Inc.	Excitation and imaging of fluorescent arrays
US7196788B2 (en) *	2002-07-22	2007-03-27	Ikonisys, Inc.	Device and method for detecting and localizing cells by means of photosensitive waveguides
US20060127946A1 (en) *	2002-08-16	2006-06-15	Montagu Jean I	Reading of fluorescent arrays
US7384742B2 (en) *	2002-08-16	2008-06-10	Decision Biomarkers, Inc.	Substrates for isolating reacting and microscopically analyzing materials
US20070196863A1 (en) *	2006-02-17	2007-08-23	Hanson Technologies, Inc.	Prion protein detection
US20080026373A1 (en) *	2006-07-26	2008-01-31	Rodionova Natalia A	Assays Based On Light Emission From Analyte Complexes Within A Cassette
US9212995B2 (en)	2009-03-02	2015-12-15	Mbio Diagnostics, Inc.	System and method for detecting multiple molecules in one assay
US9658222B2 (en)	2009-03-02	2017-05-23	Mbio Diagnostics, Inc.	Planar waveguide based cartridges and associated methods for detecting target analyte
US8331751B2 (en) *	2009-03-02	2012-12-11	mBio Diagnositcs, Inc.	Planar optical waveguide with core of low-index-of-refraction interrogation medium
US8300993B2 (en) *	2009-03-02	2012-10-30	Mbio Diagnostics, Inc.	Waveguide with integrated lens
JP5351815B2 (ja) *	2010-03-31	2013-11-27	富士フイルム株式会社	光学部材および表面プラズモン共鳴測定装置
US9453791B2 (en) *	2014-07-01	2016-09-27	Octrolix Bv	Flow cytometry system and method

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3990779A (en) *	1975-07-24	1976-11-09	International Telephone And Telegraph Corporation	Single optical fiber connector
US4575181A (en) *	1983-04-26	1986-03-11	Tokyo Shibaura Denki Kabushiki Kaisha	Optical fiber assembly with cladding light scattering means
WO1986000138A1 (en) *	1984-06-13	1986-01-03	Unilever Plc	Devices for use in chemical test procedures
AT383684B (de) *	1984-09-17	1987-08-10	Avl Verbrennungskraft Messtech	Anordnung zur fluoreszenzoptischen messung von stoffkonzentrationen in einer probe
US4668636A (en) *	1984-11-06	1987-05-26	Battelle Memorial Institute	Analytical assembly usable in apparatuses for optically determining species in solution
US4844869A (en) *	1985-09-09	1989-07-04	Ord, Inc.	Immunoassay apparatus
AU604364B2 (en) *	1987-08-13	1990-12-13	Dow Chemical Company, The	Sulfur dioxide removal from gas streams using hydroxyalkyl substituted piperazinones

1990
- 1990-06-21 DE DE69005270T patent/DE69005270T2/de not_active Expired - Fee Related
- 1990-06-21 CA CA002033168A patent/CA2033168C/en not_active Expired - Lifetime
- 1990-06-21 EP EP90909063A patent/EP0429612B1/en not_active Expired - Lifetime
- 1990-06-21 US US07/623,817 patent/US5166515A/en not_active Expired - Lifetime
- 1990-06-21 JP JP2508670A patent/JP2612641B2/ja not_active Expired - Fee Related
- 1990-06-21 ES ES90909063T patent/ES2047334T3/es not_active Expired - Lifetime
- 1990-06-21 AT AT90909063T patent/ATE98773T1/de not_active IP Right Cessation
- 1990-06-21 AU AU58277/90A patent/AU619120B2/en not_active Ceased
- 1990-06-21 WO PCT/GB1990/000953 patent/WO1990015985A1/en active IP Right Grant
- 1990-06-21 DK DK90909063.1T patent/DK0429612T3/da active

Also Published As

Publication number	Publication date
EP0429612A1 (en)	1991-06-05
AU5827790A (en)	1991-01-08
DE69005270T2 (de)	1994-07-07
ATE98773T1 (de)	1994-01-15
JPH04501612A (ja)	1992-03-19
US5166515A (en)	1992-11-24
EP0429612B1 (en)	1993-12-15
ES2047334T3 (es)	1994-02-16
DK0429612T3 (da)	1994-03-07
CA2033168C (en)	1998-08-18
DE69005270D1 (de)	1994-01-27
CA2033168A1 (en)	1990-12-23
WO1990015985A1 (en)	1990-12-27
AU619120B2 (en)	1992-01-16

Publication	Publication Date	Title
JP2612641B2 (ja)	1997-05-21	光学的分析方法、そこで使用するための装置、及びアッセイ方法
EP0426817B1 (en)	1993-10-20	Devices for use in chemical test procedures
JP3018006B2 (ja)	2000-03-13	光学的分析用センサ
US5478755A (en)	1995-12-26	Long range surface plasma resonance immunoassay
US4582809A (en)	1986-04-15	Apparatus including optical fiber for fluorescence immunoassay
US5830766A (en)	1998-11-03	Enhanced signal-to-noise ratio and sensitivity optical immunoassay
EP0359807B1 (en)	1994-11-17	Method of assay
US4368047A (en)	1983-01-11	Process for conducting fluorescence immunoassays without added labels and employing attenuated internal reflection
JP3474880B2 (ja)	2003-12-08	免疫分析を行うための光学装置
JP2969177B2 (ja)	1999-11-02	分析方法
JP2003502660A (ja)	2003-01-21	統合マルチ導波管センサー
JPS61502418A (ja)	1986-10-23	光学分析方法及び装置
JP3283065B2 (ja)	2002-05-20	癌の免疫検査法とそれに使用される検査用内視鏡
Lackie et al.	1991	Instrumentation for cylindrical waveguide evanescent fluorosensors

Legal Events

Date	Code	Title	Description
2005-02-08	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2006-02-07	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2007-02-06	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2008-01-31	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20080227 Year of fee payment: 11
2008-02-05	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20090227 Year of fee payment: 12
2009-02-27	LAPS	Cancellation because of no payment of annual fees