JP2020085505A - Disposable test piece and analyzer using the test piece - Google Patents

Abstract

To provide a maintenance-free disposable test piece and an analyzer using the test piece with a simple structure at a low manufacturing cost, capable of reducing the effects of air exposure and sedimentation of sample blood cell and the measurement conditions are less susceptible to variations due to human factors.SOLUTION: The disposed disposable test piece is configured to calibrate a measuring unit with a valve closed. After calibrating the measuring unit, the sample liquid is introduced from a sample liquid introducing unit and held in a sample liquid holding unit, and subsequently, the valve is opened and the sample liquid held in the sample liquid holding unit is pushed out toward the measurement unit by sample liquid supply means.SELECTED DRAWING: Figure 1

Description

The present invention relates to a disposable test tool used for measuring and analyzing a gas partial pressure, an electrolyte component, etc. in a blood sample and an analyzer using the test tool.

Correct sample handling is extremely important for measuring blood gas and electrolyte components. The collected blood sample causes a change in gas components and pH upon contact with air. Especially, the oxygen partial pressure tends to change. In addition, hemocyte sedimentation occurs with the passage of time, which affects the measurement of hematocrit and also causes variations in the electrolyte concentration.
Even in a small blood gas measuring device using a disposable test tool, the above-mentioned problems occur without exception.
At present, there are the following three types of methods for measuring blood gas and electrolyte components using a small blood gas measuring device using a disposable test tool that is put to practical use in the market.
In the first method, first, the disposable test tool is set in the blood gas measuring device and the test tool is calibrated. After the calibration is completed, the sample is injected to the measurement unit of the inspection tool using a syringe or the like from which the sample is collected, and measurement is performed (Patent Document 1).
In the second method, the sample is introduced into the test tool before the disposable test tool is set in the blood gas analyzer. Next, the test instrument with the introduced sample is set in the blood gas measuring device to perform calibration and measurement (Patent Document 2).
In the third method, a syringe or the like that has collected blood is directly attached to the disposable inspection tool. Next, the test device with the syringe attached is set in the blood gas analyzer. The blood gas analyzer calibrates the test tool and then sucks the sample directly to the measurement unit from the syringe attached to the test tool to perform the measurement (Patent Document 3).

JP-A-11-83783 JP-A-4-501768 US Pat. No. 8,986,527

The above-mentioned conventional disposable inspection tool has the following problems.

In the first method described in Patent Document 1, after the calibration is completed, the operator injects the sample to the measurement unit of the inspection tool using the syringe that has collected the sample, so the sample is exposed to air until immediately before measurement. It has the advantage that it is not affected and that the effect of blood sedimentation can be minimized, but since the operator injects the sample to the measurement part using a syringe, the pressure and injection amount at the time of injection etc. Depends on the operation of the operator, which causes variation.

In the second method described in Patent Document 2, the sample is put in the test tool in advance, and the sample is automatically moved to the measurement unit after the calibration by the operation of the blood gas measuring device. It has the advantage that the pressure and amount to send the sample to the measurement unit can be kept constant, but since the sample is put in the test tool in advance, the sample is stored in the housing of the test tool during calibration. There is a problem that air exposure and blood cell sedimentation occur due to contact with surrounding materials.

Furthermore, the third method described in Patent Document 3 is to set a syringe from which a sample has been collected on a test tool, mount the syringe on a blood gas measuring device, and after calibrating the test tool, use a pump via a sample suction nozzle to pump the syringe. Since it is configured to aspirate the sample from the sample to the measuring section, it is difficult to be exposed to air, and because the sample is drawn from the syringe to the measuring section by suction using a pump, the pressure to send the sample to the measuring section. It has an advantage that the amount and the like can be kept constant, but since the syringe has to be set in the test tool in advance, blood cell sedimentation may occur during the calibration. And above all, the structure of sucking the sample from the syringe to the measuring section with the pump through the suction nozzle makes the structure of the measuring device very complicated, and the nozzle for sucking the sample is attached to the disposable testing tool. The process is complicated, resulting in higher manufacturing costs.

The present invention solves the above-mentioned conventional problems, does not increase the manufacturing cost by complicating the structure of the measuring device, and does not make maintenance difficult, and the influence of air exposure and blood cell sedimentation of the sample. It is an object of the present invention to provide a disposable inspection tool that is less susceptible to variations in measurement conditions due to human factors and an analyzer that uses the inspection tool.

In order to achieve the above-mentioned object, the disposable testing tool according to the present invention is provided with a sample liquid passage inside a housing, a sample liquid introducing portion is provided at an upstream portion of the sample liquid passage, and a waste liquid collecting portion is provided at a downstream portion. With the provision of a measuring unit capable of measuring at least one component in the sample liquid between the sample liquid introducing unit and the waste liquid reservoir unit in the sample liquid passage, the sample liquid based on the measurement result of the measuring unit. In the disposable testing device for an analyzer configured to be able to analyze at least one component in the analyzer, a valve is provided between the sample liquid introducing part and the measuring part in the sample liquid passage, and the sample Between the sample liquid introduction part and the valve in the liquid passage, a sample liquid holding part for temporarily holding the sample, and a sample liquid supply for pushing the sample held in the sample liquid holding part toward the measuring part. Means is provided, a calibration liquid passage branched from the valve and the measurement unit in the sample liquid passage is provided, and a calibration liquid supply means is provided in the calibration liquid passage, and the valve is closed. In this state, the measurement unit is calibrated, and after the measurement unit is calibrated, a sample liquid is introduced from the sample liquid introduction unit and held in the sample liquid holding unit, and then a valve is opened to open the sample liquid supply unit. With this configuration, the sample liquid held in the sample liquid holding unit can be pushed out toward the measuring unit.

The sample liquid supply means may preferably have an air holding part connected to the sample liquid holding part, and the air held in the air holding part by pressurizing the air holding part, It may be configured to push the sample liquid held in the liquid holding unit to the measuring unit. In this case, preferably, the portion of the housing corresponding to the air holding portion can be configured to be deformable.

Further, a branch passage branching from the specimen liquid holding unit and the valve in the specimen liquid passage is provided, and a specimen liquid detecting unit capable of detecting that the specimen liquid holding unit is filled with the specimen in the branch passage. Can be provided.

Further, an analyzer according to the present invention is an analyzer configured to analyze at least one component in a sample liquid using the above-mentioned disposable test tool, and the test tool capable of mounting the disposable test tool. A mounting part, a measurement signal input part capable of inputting a measurement signal from a measuring part in the disposable test tool, a valve operating device for opening and closing a valve in the disposable test tool, and a sample liquid supply means in the disposable test tool. A sample liquid supply means operating device, a calibration liquid supply means operating device that operates the calibration liquid supply means in the disposable inspection tool, and a control device, and when the disposable inspection tool is attached to the inspection tool attachment portion, After closing the valve, the calibration liquid supply means operating device is operated to supply the calibration liquid to the measurement unit to calibrate the measurement unit, and then the sample liquid holding unit is filled with the sample, Standby until the sample liquid is detected by the detection unit, and when the sample liquid is detected by the sample liquid detection unit, the valve is opened and the sample liquid supply means operating device is operated to hold the sample held in the sample liquid holding unit. The control device is configured to control the operation of each of the devices so as to supply the liquid to the measuring unit and measure at least one component of the sample liquid in the measuring unit.

Disposable inspection tool according to the present invention, a sample liquid passage is provided inside the housing, a sample liquid introducing portion is provided at an upstream portion of the sample liquid passage, and a waste liquid reservoir portion is provided at a downstream portion, and in the sample liquid passage. A measuring unit capable of measuring at least one component in the sample liquid is provided between the sample liquid introducing unit and the waste liquid reservoir, and at least one component in the sample liquid is analyzed based on the measurement result of the measuring unit. In the disposable testing device for an analyzer configured to be able to analyze, a valve is provided between the sample liquid introducing part and the measuring part in the sample liquid passage, and the sample liquid introducing part in the sample liquid passage is provided. Between the valve and the sample liquid holding unit that temporarily holds the sample, and a sample liquid supply unit that pushes out the sample held in the sample liquid holding unit toward the measuring unit, and in the sample liquid passage A calibration liquid passage branched from the valve and the measurement unit is provided, and a calibration liquid supply unit is provided in the calibration liquid passage, and the calibration unit is calibrated with the valve closed. After the calibration of the measuring unit, the sample liquid is introduced from the sample liquid introducing unit and held in the sample liquid holding unit, and then the valve is opened and held in the sample liquid holding unit by the sample liquid supply unit. Since it is configured to push out the existing sample liquid toward the measurement unit, by introducing the sample liquid into the sample liquid passage with the valve closed, the sample liquid passage from the sample collecting tool such as a syringe can be introduced. It is possible to hold the sample liquid introduced into the sample liquid in the sample liquid holding unit once without directly sending it to the measuring unit, and then open the valve to send the sample liquid to the measuring unit by the sample liquid supply means. it can. As a result, when introducing the sample liquid from the sample liquid collecting tool such as a syringe into the measurement unit, the introduction pressure and the introduction amount do not vary. Further, according to the test tool of the present invention, after the calibration is completed, the sample liquid can be introduced into the test tool from the sample collecting tool such as a syringe. It becomes possible to store it in the sample collecting tool such as. Therefore, it is possible to minimize problems such as air exposure of the sample liquid and blood cell sedimentation in the test tool. Further, in addition to the problems of the introduction pressure and the introduction amount, in order to solve the problem of air exposure, it is not necessary to provide a mechanism for aspirating the sample from the sample collecting tool by providing a suction nozzle as in the conventional case. The manufacturing cost can be kept low without complicating the structure.

The sample liquid supply means is provided with an air holding part connected to the sample liquid holding part, and by pressurizing the air holding part, the air held in the air holding part holds the sample liquid holding part in the sample liquid holding part. By configuring so that the sample liquid thus obtained is pushed out to the measurement unit, it becomes possible to easily keep the supply pressure and the supply amount of the sample liquid to the measurement unit by the sample liquid supply means constant. Further, in this case, by configuring the portion of the housing corresponding to the air holding portion to be deformable, it is possible to push out the sample liquid from the sample liquid holding portion by pushing from the outside with a pusher or the like.

Further, a branch passage branching from the specimen liquid holding unit and the valve in the specimen liquid passage is provided, and a specimen liquid detection capable of detecting that the specimen liquid holding unit is filled with the specimen liquid in the branch passage. By providing the portion, the sample liquid can be easily introduced into the sample liquid holding portion.

Further, an analyzer according to the present invention is an analyzer configured to analyze at least one component in a sample liquid using the above-mentioned disposable test tool, and the test tool capable of mounting the disposable test tool. A mounting part, a measurement signal input part capable of inputting a measurement signal from a measuring part in the disposable test tool, a valve operating device for opening and closing a valve in the disposable test tool, and a sample liquid supply means in the disposable test tool. A sample liquid supply means operating device, a calibration liquid supply means operating device that operates the calibration liquid supply means in the disposable inspection tool, and a control device, and when the disposable inspection tool is attached to the inspection tool attachment portion, After closing the valve, the calibration liquid supply means operating device is operated to supply the calibration liquid to the measurement unit to calibrate the measurement unit, and then the sample liquid holding unit is filled with the sample, Wait until the sample liquid is detected by the liquid detection unit, and when the sample liquid is detected by the sample liquid detection unit, open the valve and operate the sample liquid supply means operating device to hold it in the sample liquid holding unit. Since the control device is configured to control the operation of each device so as to supply at least one component of the sample liquid in the measuring part by supplying the sample liquid to the measuring part, the above-mentioned disposable testing tool In combination with the above, variations in the introduction pressure and the introduction amount of the sample liquid are eliminated, and problems such as exposure of the sample liquid to air and blood cell sedimentation do not occur.

It is a schematic top view of the disposable inspection tool which concerns on this invention. It is a schematic perspective view of the analyzer according to the present invention. It is a schematic block diagram which shows the internal structure of an analyzer. It is a figure which shows the flow of the calibration liquid and sample liquid in a disposable inspection tool. It is a figure which shows the flow of the calibration liquid and sample liquid in a disposable inspection tool. It is a figure which shows the flow of the calibration liquid and sample liquid in a disposable inspection tool.

Embodiments of a disposable testing tool and an analyzer according to the present invention will be described below with reference to an embodiment shown in the accompanying drawings.

FIG. 1 is a schematic top view of a disposable inspection tool A according to the present invention.

In this embodiment, a disposable inspection tool A (hereinafter, simply referred to as “inspection tool A”) has a housing 1 made of a suitable material such as a transparent or translucent plastic material.

A sample liquid passage 2 is formed inside the housing 1.

At the upstream end of the sample liquid passage 2 in the housing 1, there is formed a sample liquid introducing section 3 that opens upward (toward the front of the paper in FIG. 1), and the downstream end of the sample liquid passage 2 is connected to a waste liquid reservoir 4. ing. An air hole 4a is formed in the waste liquid reservoir 4.

In the figure, reference numeral 5 indicates a measuring unit. The measuring unit 5 includes a plurality of electrode units 5a formed by applying a conductive ink on an insulating substrate. These electrode parts 5a are arranged so as to be located between the sample liquid introducing part 3 and the waste liquid reservoir part 4 in the sample liquid passage 2, so that the sample liquid supplied to the sample liquid passage 2 is connected to the respective electrode parts 5a. Configured to contact.

For each electrode portion 5a, for example, acidity pH, carbon dioxide partial pressure PCO2, oxygen partial pressure PO2, sodium Na, potassium K, chlorine Cl, ionized calcium Ca, urea nitrogen BUN, glucose Glu, hematocrit Hct, etc. Depending on the component to be measured, a gas permeable membrane through which the gas component to be measured can permeate, and other components to be measured may be appropriately provided with a reagent layer formed by applying a reacting chemical substance or natural substance. .. As a result, when the sample is sent to the position corresponding to the electrode part 5a in the sample liquid passage 2, the component of the sample is measured via each electrode part 5a.
The measuring unit 5 further includes a counter electrode when a current measuring method is used to measure the oxygen partial pressure or glucose concentration in blood as a sample, for example. The measuring unit 5 further includes a reference electrode when a potentiometric measurement method is used to measure the ion concentration of hydrogen, sodium, potassium or the like in the sample. Furthermore, when measuring the electrical conductivity in the sample to measure the hematocrit amount, an alternating voltage can be applied between the electrodes.
Further, the measuring unit 5 includes terminal portions 5b connected to the electrode portion 5a, and these terminal portions 5b are configured to be exposed to the outside of the housing 1, and the inspection tool A is attached to an analyzer described later. Then, it is connected to the terminal of the analyzer.

A valve 7 is provided between the sample liquid introducing section 3 and the measuring section 5 in the sample liquid passage 2 configured as described above. The valve 7 may be of any type as long as it can be opened and closed by the analyzer. For example, a portion of the housing 1 corresponding to the valve 7 is deformed by pressing a piston provided in the analyzer to deform the sample. The liquid passage 2 may be closed by closing the valve, and the portion deformed by pulling up the piston may be restored to its original shape to open the sample liquid passage 2 and open the valve. With this configuration, the valve 7 is in the open state when not in use. The valve 7 is not limited to the above configuration, and may be any appropriate valve, for example, a solenoid valve or a mechanical valve.

A sample liquid holding portion 11 is formed between the valve 7 and the sample liquid introducing portion 3 in the sample liquid passage portion 2, and a branch passage 10 is formed between the sample liquid holding portion 11 and the valve 7. It is provided. A sample liquid detection part 13 having a small diameter is formed in the branch passage 10, a sample liquid reservoir 12 is formed downstream of the sample liquid detection part 13, and further downstream of the sample liquid reservoir 12. An air outlet 19 is provided with a stopper that allows air to pass through, but does not allow a sample to pass through, and the air outlet 19 is provided with an automatic air vent valve. In this embodiment, the automatic air vent valve provided at the air outlet 19 is configured so that it can be closed by the analyzer.

With the above configuration, when the sample liquid is injected from the sample liquid introducing unit 3 with the valve 7 closed, the sample liquid passes through the sample holding unit 11 and enters the branch passage 10, and the sample liquid is detected via the sample liquid detecting unit 13. It flows into the liquid reservoir 12. The sample liquid detection unit 13 detects the state of the sample liquid therein by a sensor provided in an analyzer described later, and, for example, this sensor indicates that "the sample liquid detection unit 13 is filled with the sample liquid". Upon detection, the analyzer may be configured to visually (eg, in text) or audibly (eg, sound a buzzer) inform the operator that the sample fluid reservoir 11 has been filled. The configuration of the sample liquid detection unit 13 is not limited to the present embodiment, and can be detected optically or electrically, for example. Alternatively, it may be configured so that the operator can visually check it from the outside, and the image can be viewed on a monitor with a camera. In this way, by injecting the sample until the sample liquid detection unit 13 is filled with the sample, the sample liquid holding unit 11 is filled with the sample, so that the operator can see the sample liquid detection unit 13 while viewing the sample liquid. It becomes possible to inject the liquid. The sample reservoir 12 functions as a buffer that receives the excess sample when the user overfills the sample, and does not necessarily have to be formed separately from the sample detection unit 13. You may form integrally. In addition, in this embodiment, the sample liquid detection unit 13 is provided in the branch passage 10, but this configuration is not limited to this embodiment, and the sample liquid detection unit 13 includes the sample liquid holding unit 11 as the sample. It can be provided at any position as long as it can detect that it is filled, and for example, it may be arranged between the sample liquid holding unit 10 and the valve 7 instead of the branch passage 10.
Further, the air holding portion 15 constituting the sample liquid supply means according to the present invention is provided in the branch passage 14 formed between the sample liquid holding portion 11 and the sample introducing portion 3. A portion of the upper surface and/or the lower surface of the housing 1 corresponding to the air holding portion 15 has a deformable thickness, and the air holding portion 15 is compressed by being pressed by a pusher provided in an analyzer described later. , So that the air inside can be pushed out. As a result, when the valve 7 is open, the pusher provided in the analyzer presses the portion of the housing 1 corresponding to the air holding portion 15 to compress the air holding portion 15 and push out the air. The sample held in the sample liquid holding unit 2 can be pushed out to the measuring unit 5.

A calibration liquid branch passage 21 is provided between the valve 7 and the measurement unit 5 in the sample liquid passage portion 2, and a calibration liquid container 23 is provided at the downstream end of the calibration liquid branch passage 21. It is provided.

The calibration liquid container 23 is made of a material having no gas permeability or a low gas permeability, and hermetically houses the calibration reagent for each electrode portion 5a therein. A portion of the upper surface and/or the lower surface of the housing 1 corresponding to the calibration liquid container 23 has a deformable thickness, and is deformed or punctured when pressed by a pusher provided in an analyzer described later to calibrate from the calibration liquid container 23. It is configured so that the reagent for use comes out. As a result, when the valve 7 is closed, the calibration solution container 23 is pressed by the pusher provided in the analyzer so that the calibration solution in the calibration solution container 23 is measured via the calibration solution branch passage 21. Extruded to part 5.

Next, the configuration of the analyzer 30 that uses the disposable inspection tool A configured as described above will be briefly described.

2 shows a schematic perspective view of the analyzer 30, and FIG. 3 shows a schematic block diagram of the analyzer 30.

In FIG. 2, reference numeral 31 denotes a test tool mounting portion configured so that the test tool A can be inserted, and reference numeral 32 denotes a monitor that also serves as an input interface.

The analyzer 30 has therein a terminal 35 connectable to the terminal portion 5b of the measuring unit 5 of the inspection tool A, a sensor 37 capable of detecting the presence or absence of the sample liquid in the sample liquid detection unit 13 of the inspection tool A, and a sample liquid. The pusher 39 that presses the air holding unit 15 to push out the sample held in the holding unit 2, the pusher 41 that presses the calibration liquid container 23, the valve operating device 43 that opens and closes the valve 7 of the inspection tool A, and the pusher 39. , 41 and the valve actuator 43, and a controller 47 for calibrating the electrode part 5a and measuring/analyzing the components in the sample liquid based on the input signal from the terminal 35. Signals from various operation buttons displayed on the monitor 32 may also be input to the control device 47.

The process of analyzing the sample liquid using the disposable test tool A and the analyzer 30 configured as described above will be described below.

In the unused state, the valve 7 of the inspection tool A is open.

When the operator sets the inspection tool A in the analyzer 30, the control device 47 confirms that the valve 7 is in the closed state via the valve operating device 43, and if the valve is open, the control device 47 closes the valve. Then, the pusher 41 is operated and the monitor 32 displays that “calibration is in progress”.

As shown in FIG. 4A, when pushed by the pusher 41, the calibration liquid is pushed out from the calibration liquid container 23, and the calibration liquid is sent to the electrode portion 5 a of the measuring unit 5. When the calibration liquid reaches the electrode portions 5a, the controller 47 calibrates each electrode portion 5a.

When the calibration is completed, the control device 47 displays on the monitor 32 that the calibration is completed, and also displays an instruction to inject the sample liquid from the sample liquid introducing unit 3 by the sample collecting tool such as a syringe.

When the operator injects the sample liquid with a syringe or the like, since the valve 7 is closed, the sample liquid is sent toward the sample liquid reservoir 12 via the branch passage 10. When the sample detection unit 13 is filled with the sample liquid, the sample liquid then enters the sample liquid reservoir 12 (FIG. 4B).

When the sensor 37 detects that the sample liquid detection unit 13 is filled with the sample liquid, the control device 47 displays on the monitor 32 an instruction to finish the injection of the sample liquid. It is needless to say that this is not limited to visual display via the monitor 32, and may be configured to be aurally displayed using, for example, a buzzer or the like.

When the injection of the sample liquid is completed, the control device 47 opens the valve 7, closes the air outlet 19, moves the pusher 39, and presses the air holding portion 15. As a result, the air in the air holding unit 15 is pushed out to the upstream side of the sample liquid holding unit 11, and the sample liquid pushed out of the sample liquid holding unit 11 is swept toward the measurement unit 5 side because the valve 7 is opened, and the measurement is performed. The electrode portion 5a of the portion 5 is reached. At this time, the calibration liquid remains in the electrode portion 5a, but the remaining calibration liquid is pushed out to the waste liquid reservoir 4 by the sample liquid (FIG. 4(c)). Since the operator injects the sample, the sample is not always injected until the sample reservoir 12 is full. However, as described above, the air outlet 19 is closed by the analyzer to retain the air. When the part 15 is deformed to move the sample to the measuring part 5, air does not leak from the air outlet 19 and the sample does not go to the measuring part 5 and enters the branch passage 10 side. In this state, the control device 47 measures and analyzes the components of the sample liquid, and the measurement and analysis results are displayed on the monitor 32. The measurement and analysis results may be configured such that a printer (not shown) is provided in the analysis device 30 so that the measurement and analysis results can be printed out, or can be stored in a memory (not shown).

As described above, in the disposable testing tool according to the present embodiment, by providing the sample liquid holding part 2 with the valve 7, the sample liquid injected from the sample liquid collecting tool such as a syringe is once stored in the sample liquid holding part 11. Since it is configured to be sent out to the measurement unit 5 by air pressure after being stored, there is no variation in injection pressure or injection amount when the sample liquid is injected from a syringe or the like. Further, since the sample liquid can be injected from the sample liquid collecting tool such as a syringe after the calibration is completed, the sample liquid is stored in the sample liquid collecting tool until immediately before the measurement. It is also possible to stir immediately before setting the syringe in the sample liquid introducing section 3 of the disposable inspection tool. Therefore, problems such as exposure of the sample liquid to the air and blood cell sedimentation can be minimized.

In the embodiment described above, a sensor for detecting that the sample liquid detection unit 13 is filled with the sample is provided on the analyzer side, and when the sample liquid detection unit 13 is filled with the sample, the valve 7 is automatically opened. Then, the pusher 39 is operated to push the air holding unit 15 to push out the sample liquid to the measuring unit 5. However, this configuration is not limited to this embodiment, and for example, the operator may It may be configured so that it can be viewed from the inside, and the operator injects the sample liquid while viewing it on the monitor with the camera and looking at the sample liquid detection unit 13. When the sample liquid detection unit 13 is filled with the sample liquid, It may be configured to stop. When automatically detected by the control device 47, the control device 47 may be configured to open the valve 7 and operate the pusher 39. When the operator injects the sample by visual observation, the monitor 32 is provided with a measurement start button, and when the operator presses the measurement start button after injecting the sample liquid, the control device 47 opens the valve 7. , Pusher 39 may be configured to operate. Alternatively, the above two methods may be combined.

Further, in the present embodiment, as the sample liquid supply means, an air holding part is provided, and the sample liquid is sent to the measuring part by pressing the air holding part with a pusher. The configuration is not limited to this example, and for example, a pump is provided in the analyzer, a connection part that can be connected to the pump is provided in the inspection tool, and the sample liquid is supplied from the sample liquid holding part by the air supplied from the pump. You may comprise so that it may supply to a measuring part.

Various configurations can be considered for the configuration of the housing 1. For example, as disclosed in Japanese Patent Laid-Open No. 11-37883, two housing pieces are superposed with a partition plate interposed therebetween. It can be configured by combining.

A inspection tool 1 housing 2 sample liquid passage 3 sample liquid introduction part 4 waste liquid storage part 4a air hole 5 measurement part 5a electrode part 5b terminal part 7 valve 10 branch passage 11 sample liquid holding part 12 sample liquid storage part 14 sample liquid detection part 14 Branch passage 15 Air holding part 19 Air outlet

21 Branch Flow Path for Calibration Solution 23 Calibration Solution Container

30 Analytical device 31 Inspection tool mounting section 32 Monitor 35 terminal (measurement signal input section)
37 sensor 39 pusher (sample liquid supply means operation device)
41 Pusher (calibration liquid supply means operating device)
43 valve actuation device 47 control device

Claims (5)

The sample liquid passage (2) is provided inside the housing (1),
A sample liquid introduction part (3) is provided in the upstream part of the sample liquid passage (2), and a waste liquid reservoir part (4) is provided in the downstream part,
A measuring unit (5) capable of measuring at least one component in the sample liquid is provided between the sample liquid introducing unit (3) and the waste liquid reservoir (4) in the sample liquid passage (2),
A disposable inspection tool for an analyzer, which is configured to analyze at least one component in a sample liquid on the basis of the measurement result of the measuring unit (5),
A valve (7) is provided between the sample liquid introduction part (3) and the measurement part (5) in the sample liquid passage (2),
A sample liquid holding part (11) for temporarily holding a sample between the sample liquid introducing part (3) and the valve (7) in the sample liquid passage (2), and a sample liquid holding part (11). A sample liquid supply means for pushing the sample held in the direction toward the measuring section (5),
A calibration liquid passage branched from the valve (7) and the measurement unit (5) in the sample liquid passage (2) is provided, and a calibration liquid supply means is provided in the calibration liquid passage.
The measurement unit (5) is calibrated with the valve (7) closed, and a sample liquid is introduced from the sample liquid introduction unit (3) after the measurement unit (5) is calibrated to retain the sample liquid. It is configured such that the sample liquid held in the part (11) and then the valve (7) is opened to push the sample liquid held in the sample liquid holding part (11) toward the measuring part (5). Disposable inspection tool characterized by: The sample liquid supply means comprises an air holding part (15) connected to the sample liquid holding part (11),
By pressurizing the air holding part (15), the sample liquid held in the sample liquid holding part (11) is measured by the air held in the air holding part (15) up to the measuring part (5). The disposable testing tool according to claim 1, wherein the disposable testing tool is configured to be pushed out. The disposable inspection tool according to claim 2, wherein a portion of the housing (1) corresponding to the air holding portion (15) is configured to be deformable. A branch passage (10) branching from the sample liquid holding portion (11) and the valve (7) in the sample liquid passage (2) is provided, and the sample liquid holding portion (11) is provided in the branch passage (10). 4. The disposable testing tool according to claim 3, further comprising a sample liquid detection section (13) capable of detecting that the sample liquid is filled with the sample liquid. An analysis device configured to analyze at least one component in a sample liquid using the disposable testing tool according to any one of claims 1 to 4,
An inspection tool attachment part (31) to which the disposable inspection tool can be attached,
A measurement signal input unit (35) capable of inputting a measurement signal from the measurement unit (5) of the disposable inspection tool;
A valve actuating device (43) for opening and closing the valve (7) of the disposable inspection tool,
A sample liquid supply means operating device (39) for operating the sample liquid supply means in the disposable inspection tool,
A calibration liquid supply means operating device (41) for operating the calibration liquid supply means in the disposable inspection tool;
And a control device (47),
When the disposable inspection tool is attached to the inspection tool attachment section (31), the valve (7) is closed, and then the calibration solution supply means operating device (41) is operated to transfer the calibration solution to the measurement section (5). Supply and calibrate the measurement unit (5), then wait until the sample liquid holding unit (11) is filled with the sample liquid and the sample liquid detection unit (13) detects the sample liquid. When the sample liquid is detected by the part (13), the valve (7) is opened, the sample liquid supply means operating device (39) is operated, and the sample liquid held in the sample liquid holding part (11) is measured. The control device (47) is configured to control the operation of each device so as to supply at least one component of the sample liquid in the measurement unit (5) by supplying the device to the unit (5). Disposable inspection device analyzer.

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