JP2015206608A - Blood coagulation time measurement device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prevent such a situation, that, a coagulation promoter 76 which is coated to and disposed on a measurement channel 40 is peeled or cut, due to movement of a sphere 78 which is disposed as to be movable back and forth in a longitudinal direction in the measurement channel 40, during midway of transport.SOLUTION: A groove 62 in a longitudinal direction is provided on a bottom part of a measurement channel 40, and width of the groove 62 is set so that, a sphere 78 which may be reciprocatingly moved in the longitudinal direction in the measurement channel 40 does not contact the groove bottom part. A blood coagulation promoter 76 is coated to and disposed on the groove 62. Because the sphere 78 does not contact the coagulation promoter 76, even when the sphere 76 moves, the coagulation promoter 76 is not peeled or cut.

Description

  In the present invention, in order to measure the time until blood coagulates, the coagulation promoter applied and disposed in the measurement channel is peeled off or scraped by the moving body disposed in the measurement channel. The present invention relates to a blood coagulation time measurement apparatus that is not to be used.

In dialysis and circulatory system surgery, etc., blood is taken out of the body and returned to the body. The blood taken out of the body will coagulate over time and become inappropriate for return to the body. An anticoagulant is administered to prevent this blood from clotting, but the effect of such an anticoagulant is gradually reduced by the action of the human body. Need to be administered. Thus, the anticoagulant can be administered again at an appropriate time if the time during which the blood will clot before the blood spontaneously clots can be predicted. Here, when the blood taken out of the body is stirred and a coagulation promoter is mixed with the blood, coagulation of the blood is promoted. If this phenomenon is used to promote blood coagulation and measure the time to coagulate, it is possible to predict the blood coagulation time without mixing the coagulation promoter from the measurement time, and the blood is not stirred. It is possible to predict the blood coagulation time. For this purpose, various techniques for measuring the clotting time of blood taken out of the body have been proposed. As an example, the technique disclosed in Japanese Translation of PCT International Publication No. 2008-525784 (Patent Document 1) is as follows. A magnet is arranged in a measurement channel that is long relative to the cross-sectional area so that the magnet can reciprocate in the length direction, and the magnetic field applied from the outside is periodically and alternately switched to the measurement channel using an electromagnetic coil or the like. Is measured, and the time until the moving distance of the magnet is shortened to a predetermined value or less is measured. A coagulation accelerator is applied and disposed on the inner wall surface of the measurement channel. From the time measured in this way, it is possible to predict the time when the measured blood naturally starts coagulation. Further, in Japanese Patent Application Laid-Open No. 2011-196843 (Patent Document 2) previously proposed by the applicant of the present invention, a magnet is disposed in a measurement channel that is long with respect to the cross-sectional area so as to be capable of reciprocating in the length direction. By using an electromagnetic coil as a magnetic field generator in the measurement flow path, by switching the current direction to be energized, the magnetic field direction applied from the outside is switched alternately to move the magnet back and forth. The time until the deviation between the position where the magnet should exist and the position where the magnet actually exists is measured according to the magnetic field direction of the electromagnetic coil. Alternatively, a ferromagnetic material can be reciprocated in the length direction in the measurement channel, and the ferromagnetic material can be reciprocated by alternately exciting electromagnetic coils as magnetic field generators provided at both ends of the measurement channel. The time until the position where the ferromagnetic body should exist and the position where the ferromagnetic body actually exists is measured by the excitation of the electromagnetic coil due to the coagulation of the measurement blood is measured. Even in the technique described in Patent Document 2, a coagulation accelerator is applied and disposed on the inner wall surface of the measurement channel. From the time measured in this way, it is possible to predict the time when the measured blood naturally starts coagulation.
Special table 2008-525784 gazette JP 2011-196843 A

  In any of the techniques described in Patent Documents 1 and 2 described above, since a solidification accelerator is applied and disposed on the inner wall surface of the measurement channel, when a strong impact or the like is applied during transportation, There is a possibility that a magnet or a ferromagnetic material disposed in the measurement channel moves in the length direction in the measurement channel and peels off or removes the solidification accelerator on the inner wall surface. If the coagulation accelerator is peeled off or shaved in this way, the mixing state with the measurement blood administered into the measurement channel in the state where it has not been peeled off or shaved is different, and the measurement accuracy is increased. The trouble of having a bad influence arises. Therefore, careful attention was required for transportation and the like so as not to cause a difference in the mixed state of the coagulation promoter and the measured blood.

  The present invention has been made in view of the circumstances of the prior art, and the coagulation accelerator is appropriate for the measurement blood administered to the measurement channel so that the coagulation accelerator is not peeled off or scraped off during transportation. It is an object of the present invention to provide a blood coagulation time measuring device which can be mixed with the blood.

  In order to achieve such an object, the blood coagulation time measurement apparatus of the present invention includes a measurement cartridge provided with a measurement channel that is long with respect to a cross-sectional area, and the measurement blood in the measurement channel that contains the measurement cartridge. In the blood coagulation time measuring device comprising a measuring device main body for measuring the coagulation time, a movable body that can reciprocate in the length direction is disposed in the measurement channel, and the movable body is reciprocated to move the measurement flow. The measurement blood injected into the channel is agitated, a groove in the length direction is provided at the bottom of the measurement channel, the width of the groove is set so that the movable body does not contact the groove bottom, and the groove A coagulation accelerator is applied and disposed inside.

  The moving body is a sphere, and the measuring apparatus body swings so that the end of the length direction moves up and down and tilts in an oblique state through the measurement cartridge in the horizontal direction in the length direction of the measurement flow path. The sphere may be configured to reciprocate within the measurement flow path.

  Further, the moving body is composed of a magnet, and the magnetic field generator provided in the measurement apparatus main body is configured to reciprocate the magnet in the measurement flow path by alternately switching the direction of the magnetic field applied to the measurement flow path. It can also be configured.

  In addition, the moving body is made of a ferromagnetic material, and the magnetic field generating device provided in the measuring device main body facing the both ends of the measuring channel, and the generation position of the magnetic field applied to the measuring channel is measured. The ferromagnetic material can be reciprocated in the measurement flow path by alternately switching one end and the other end of the flow path.

  In the blood coagulation time measuring apparatus according to claim 1, a lengthwise groove is provided at the bottom of the measurement channel, a coagulation accelerator is applied and disposed in the groove, and the width of the groove is determined by the measurement channel. Since the moving body that reciprocates in the length direction does not come into contact with the bottom of the groove, the solidification accelerator is not peeled off or scraped by the movement of the moving body. Therefore, the coagulation accelerator is not peeled off or scraped off by the movement of the moving body during the transportation of the measurement cartridge. Accordingly, the coagulation promoter is melted and mixed with the stirring of the measurement blood, and the reproducibility of the mixed state of the coagulation promoter and the measurement blood is excellent, and the measurement accuracy of the coagulation time is unlikely to vary.

  In any one of the blood coagulation time measuring devices according to claims 1 to 3, the structure for moving the moving body in the measurement channel is different, but the coagulation applied and disposed in the groove by the movement of the moving body. The accelerator is not peeled off or scraped off.

  Hereinafter, a first embodiment of the blood coagulation time measuring apparatus of the present invention will be described with reference to FIGS. FIG. 1 is an external perspective view of a first embodiment of a blood coagulation time measuring apparatus according to the present invention, which includes a measuring apparatus main body and a measuring cartridge, and shows a state before the measuring cartridge is inserted into the measuring apparatus main body. FIG. 2 shows a state in which the measurement cartridge is inserted into the measurement apparatus main body from the state of FIG. FIG. 3 is a partially cutaway view showing the inside of the measuring apparatus main body in the state of FIG. 2, (a) is a partially cutaway front view, and (b) is a partially cutaway side view. FIG. 4 is a longitudinal sectional view of a cartridge housing member provided in the measuring apparatus main body and a view showing a swing mechanism. FIGS. 5A and 5B are diagrams showing the movement of the cartridge housing member in the measuring apparatus main body. FIG. 5A shows a state in which the tip end is swung obliquely upward, and FIG. 5B shows a state in which the tip end is swung obliquely downward. It is in a state of being moved. 6A and 6B are diagrams showing the structure of the measurement cartridge, wherein FIG. 6A is a partially cutaway plan view, FIG. 6B is a left side view, and FIG. 6C is an AA cross-sectional arrow of FIG. It is a view and (d) is a BB cross-sectional arrow view of (a). 7A and 7B show the structure of the measurement flow path provided in the measurement cartridge, where FIG. 7A is a plan view, FIG. 7B is a cross-sectional view taken along the line A-A in FIG. It is a BB cross-section arrow enlarged view of a). FIG. 8 is a diagram illustrating that the piston of the cylinder mechanism provided in the measurement cartridge is pressed by the rod of the cylinder driving mechanism. FIG. 9 shows the state of the measurement blood and the sphere in the measurement channel when the measurement cartridge is swung in the cartridge housing portion, and (a) shows the state in which the tip side is raised most obliquely upward. (B) is the state where the tip side is lowered most diagonally downward.

  In the first embodiment, the blood coagulation time measuring device of the present invention is constituted by a measuring device main body 10 and a measuring cartridge 12, as shown in FIG. The measuring apparatus main body 10 is provided with a power switch 14 as an operating means, a start switch 16 and a display means 18 for displaying the coagulation time. Further, the measuring cartridge 12 can be inserted and accommodated in the measuring apparatus main body 10. Thus, an opening 20 is provided. As shown in FIG. 2, the measurement cartridge 12 is inserted into the measurement apparatus main body 10 in the length direction, and in this inserted state, the insertion rear end of the measurement cartridge 12 is located outside the measurement apparatus main body 10, and blood injection to be described later is performed. Measurement blood can be injected into the inlet 22. As shown in FIGS. 3 and 4, the cartridge housing member 26 provided with the cartridge insertion hole 24 in which the measurement cartridge 12 is inserted and can accommodate the measurement cartridge 12 in the measurement apparatus main body 10 measures the opening of the cartridge insertion hole 24. A swinging shaft 28 is provided so as to be swingable so as to face the opening 20 of the apparatus main body 10. A guide pin 30 is provided on the cartridge housing member 26, and a cam 34 of a swing mechanism 32 provided on the measurement apparatus main body 10 is in contact therewith. The cam 34 is rotationally driven by a motor 36, the rotational state thereof is detected by a photo interrupter 38, and switching control of the rotational direction is performed. Therefore, the cartridge housing member 26 is swung by the rotation of the cam 34. Furthermore, the cartridge housing member 26 has a light emitting device 42 and a light receiving device 44 so as to face the central portion of the measurement cartridge 12 in the inserted and housed state and to face a measurement flow path 40 to be described later so as to be sandwiched vertically. Arranged. These light emitting device 42 and light receiving device 44 constitute a light receiving detection means. In addition, a limit switch 46 for detecting that the measurement cartridge 12 is properly inserted into the cartridge insertion hole 24 is disposed at a position behind the cartridge insertion hole 24. Further, a heater 48 and a temperature sensor 50 are provided to maintain the measurement cartridge 12 at a predetermined temperature. The cartridge housing member 26 is provided with a rod slide mechanism 56 as a cylinder driving mechanism for pressing and moving a piston 54 of a cylinder mechanism 52 (described later) provided in the measurement cartridge 12. As shown in FIG. 5, the rotation of the cam 34 of the swing mechanism 32 causes the cartridge housing member 26 to be tilted upward as shown in FIG. 5A, and as shown in FIG. It is swung between the state lowered downward. The state in which the tip portion is raised most obliquely upward and the state in which the tip portion is lowered obliquely downward are determined by the position of the cam 34 detected by the photo interrupter 38 and appropriately controlled by a microcomputer or the like. The direction of movement is switched.

  As shown in FIGS. 6 and 7, the measuring cartridge 12 has a flat shape made entirely of a transparent member such as a resin, and upper and lower surfaces are covered with thin sealing materials 58 and 58, respectively. As an example, the length is about 80 mm, the width is about 25 mm, and the thickness is about 8 mm. Then, the measurement channel 40 that is long in the length direction is provided in the central member 60 by cutting from above, and a groove 62 that is narrow in the length direction is provided at the bottom. A coagulation accelerator 76 is applied and disposed in the groove 62. It is desirable that the groove 62 is not provided at the position of the central portion of the measurement channel 40 through which the optical axis of the light receiving detection means passes. As an example, the measurement channel 40 has a length of about 25 mm, a width of about 5 mm, and a depth of about 7 mm. In addition, the blood injection port 22 is cut and provided on the rear end side of the central member 60 from above. Further, a hole that becomes the cylinder wall 64 of the cylinder mechanism 52 is deeply drilled from the insertion tip surface of the central member 60. This hole is formed with a large diameter on the opening side and a step in the middle. Further, an air vent hole 66 communicating with the outside of the central member 60 is formed at the drilling tip portion of the hole. A groove having a narrow width and a shallow depth is cut and provided in the central member 60 as a communication path 68 that communicates the bottom of the blood inlet 22 and the bottom of one end of the measurement channel 40 from below. Further, the second communication passage 70 having a narrow width and a small depth communicates with the central member 60 from below the bottom of the other end of the measurement flow path 40 and the pressure chamber whose internal volume increases as the piston 54 of the cylinder mechanism 52 moves. Shallow grooves are cut and provided. The measurement channel 40 is covered with a sealing material 58 provided on the upper surface, and the communication path 68 and the second communication path 70 are covered with a sealing member 58 provided on the lower surface. A piston 54 provided with a gasket 72 that slides in close contact with the cylinder wall 64 having a small diameter on the tip side is inserted into the hole that becomes the cylinder wall 64 of the cylinder mechanism 52. In addition, a bush 74 through which the piston 54 penetrates is provided at a step portion having a large diameter hole. The pressure chamber between the gasket 72 and the bush 74 constitutes a cylinder mechanism 52 whose internal volume is increased by the movement of the piston 54.

  When the cartridge housing member 26 is swung by driving the swing mechanism 32, the sphere 78 is inserted into the insertion tip side in the state where the insertion tip side of the measurement cartridge 12 is lifted up obliquely as shown in FIG. It is in the state which is on the other end side opposite to, and the measurement blood has also accumulated on the other end side. In this state, the amount of light that passes through the thickness of the measurement blood adhering to the bottom of the central portion of the measurement channel 40 through which the optical axis of the light receiving detection means passes is detected. 9B, when the insertion tip side of the measurement cartridge 12 is lowered downward most obliquely as shown in FIG. 9B, the sphere 78 is on the insertion tip side, and the measurement blood is also on the tip side. It is a state that has accumulated. In this state, the amount of light that passes through the thickness of the measurement blood adhering to the bottom of the central portion of the measurement channel 40 through which the optical axis of the light receiving detection means passes is detected. When such shaking is repeated and the coagulation of the measurement blood proceeds, the thickness of the measurement blood adhering to the central portion of the measurement channel 40 gradually increases. As the measurement blood layer adhering to the bottom becomes thicker, the amount of transmitted light decreases and the signal value corresponding to the amount of received light decreases. The light receiving detection means uses infrared light. Therefore, a signal corresponding to the amount of received light as an initial value in a state where a predetermined amount of measurement blood is sucked into the measurement channel 40 and is swung several times, and the inner wall of the measurement channel 40 is wet with the measurement blood. The value is detected and stored. Further, the signal value is detected for each swing operation, the signal value changes with respect to the initial value, the change rate is calculated by the discriminating means, and it is determined whether or not it has changed to a predetermined rate or more. The swinging operation and the time measurement are continued until the ratio changes to a predetermined ratio or more. When the change in the signal value increases and changes to a predetermined ratio or more, the swing operation is stopped and the time measurement is stopped, and the measured time is displayed as the coagulation time by the display means 18. . Note that the detection control and determination operation of these signal values are performed by a microcomputer (not shown).

  As shown in FIGS. 9A and 9B, the measurement cartridge 12 is swung and the sphere 78 reciprocates in the measurement flow path 40, whereby the measurement blood in the measurement flow path 40 is agitated. Then, the coagulation promoter 76 applied and disposed in the groove 62 is melted and mixed with the measurement blood to be stirred, and the coagulation promoter 76 is evenly mixed with the measurement blood by stirring. The concentration of the coagulation promoter 76 in the measurement blood is excellent in reproducibility, and the accuracy of measuring the time until the measurement blood is coagulated is excellent. In addition, in the state where the coagulation promoter is peeled off or scraped before measuring the coagulation time of the measurement blood, the degree of mixing of the coagulation promoter to the measurement blood is not constant, and the measurement results are likely to vary. .

  Next, a measurement cartridge used in the second embodiment of the blood coagulation time measuring apparatus of the present invention will be described with reference to FIGS. 10A and 10B are diagrams showing the structure of the measurement cartridge used in the second embodiment, where FIG. 10A is a plan view, FIG. 10B is a cross-sectional view taken along the line A-A in FIG. These are BB cross-sectional arrow views of (a). FIG. 11 is a diagram showing a method of using the measurement cartridge shown in FIG. 10, (a) is a diagram in which measurement blood is injected into the measurement channel with a dispenser, and (b) is dispensed into the measurement channel. FIG. 8C is a diagram showing a state in which measurement blood is injected by a vessel, and FIG. 10C is a diagram illustrating measurement blood by reciprocating a sphere by swinging a measurement cartridge in which measurement blood is injected into a measurement flow channel at an end in a length direction. It is a figure of the state which wetted the inner wall of the measurement flow path.

  As shown in FIG. 10, the structure of the measurement cartridge 112 used in the second embodiment is a flat shape made of a transparent member as a whole, and a measurement channel 40 that is long in the longitudinal direction is cut from the center at the center of the center member 114 from above. The upper surface is covered with a thin sealing material 116. A groove 62 having a narrow width in the length direction is provided at the bottom of the measurement channel 40, and a coagulation accelerator 76 is applied and disposed in the groove 62. A spherical body 78 is disposed in the measurement channel 40 so as to be capable of reciprocating in the length direction. The width of the groove 62 is set so that the sphere 78 does not contact the bottom of the groove 62 as in the first embodiment. As an example, the overall dimensions of the measurement cartridge 112 of the second embodiment are about 80 mm in length, about 13 mm in width, and about 8 mm in thickness. As shown in FIG. 11, first, a predetermined amount of measurement blood is collected by the dispenser 120, and the measurement blood is injected into the measurement channel 40 from the injection hole 118 as shown in (a). In a state where the measurement blood is injected into the measurement channel 40 by the dispenser 120, the measurement blood does not flow in the measurement channel 40 due to the surface tension as shown in (b). Therefore, if the measurement cartridge 112 is swung so that the end in the length direction of the measurement channel 40 moves up and down and the sphere 78 is reciprocated in the measurement channel 40, the inner wall of the measurement channel 40 is measured. It becomes a state like (c) wetted with blood. As in the first embodiment, the coagulation time can be measured in the same manner as in the first embodiment by inserting it into the measurement cartridge insertion port 24 of the measurement apparatus main body 10.

  In the description of the above-described embodiment, the sphere 78 as the moving body is not limited to a spherical shape, and may be a disc shape as long as the sphere 78 as a moving body can reciprocate in the length direction as the moving body 40 swings. It may be. With this disk shape, the contact area between the side surface of the disk and the inner wall of the measurement flow path 40 increases, which may act as a resistance against movement. The contact resistance may be reduced by providing a protruding protrusion in the length direction in contact or by providing a protrusion at the center of the side surface of the disk. Further, the side surface of the disk may be a curved surface having a convex outer side, and the shape viewed from the side surface may be a circular shape but may be an ellipse having a vertically long vertical cross-sectional shape. Moreover, the spherical body 40 should just be a thing whose specific gravity is heavier than measurement blood, and is not restricted to iron, The product made from glass etc. may be sufficient.

  Further, in the description of the above-described embodiment, the measurement cartridge 12 is swung to reciprocate the sphere 78 in the measurement flow path 40 to be agitated by the sphere 78 and to coagulate the measurement blood by the coagulation accelerator 76. Although the time until solidification is accelerated is measured, the measurement of the coagulation time may be performed by another method. For example, as in the technique described in Patent Document 1, a magnet as a moving body is movably disposed in the length direction in the measurement channel, and the magnetic field direction applied to the measurement channel is alternately switched at a constant period, The magnet may be reciprocated in accordance with the switching of the magnetic field direction, and the coagulation time may be measured from the change in the distance that the magnet can move during a certain period due to the increase in viscosity due to the progress of coagulation of the measured blood. . Even in such a measurement method, a groove is provided at the bottom of the measurement flow channel and a coagulation accelerator is applied and disposed, and the width of the groove may be set to be narrow so that the magnet does not contact the bottom. Further, as in the technique described in Patent Document 2, a magnet or a ferromagnetic body as a moving body is movably disposed in the length direction in the measurement channel, and from the reciprocating movement of the magnet or the ferromagnetic body, Even in the technique for measuring the clotting time of the blood to be measured, a groove is provided at the bottom of the measurement channel and a coagulation accelerator is applied and disposed, and the width of the groove is narrow so that the magnet or the ferromagnetic material does not contact the bottom. Set it to something. As described above, any technique for measuring the clotting time of blood to be measured by arranging a moving body in the measurement channel so as to be able to reciprocate is provided with a groove at the bottom of the measurement channel of the present invention to promote clotting. It will be readily understood that a technique can be applied in which an agent is applied and disposed, and the width of the groove is set to be narrow so that the moving body does not contact the bottom. Further, as in the above-described embodiment, in the technique using the light receiving detection means in which the optical axis passes through the central portion of the measurement channel for the measurement of the coagulation time, the coagulation accelerator 76 is arranged at the position where the optical axis passes. Since it is desirable that the provided groove 62 is not provided, the groove 62 is divided and provided in the middle of the length direction. However, as in the techniques described in Patent Document 1 and Patent Document 2, in the case where the optical axis does not pass through the central portion of the measurement channel, it is needless to say that the groove 62 does not need to be divided in the middle. .

It is an external appearance perspective view of 1st Example of the blood coagulation time measuring apparatus of this invention, consists of a measuring device main body and a measuring cartridge, and shows the state before inserting a measuring cartridge in a measuring device main body. It is a figure which shows the state which inserted the measurement cartridge into the measuring apparatus main body from the state of FIG. FIG. 3 is a partially cutaway view showing the inside of the measurement apparatus main body in the state of FIG. 2, (a) is a partially cutaway front view, and (b) is a partially cutout at A-A in (a). It is a side view. It is a figure which shows the longitudinal cross-sectional view and swing mechanism of the cartridge accommodating member provided in the measuring apparatus main body. It is a figure which shows a motion of the cartridge accommodating member in a measuring device main body, (a) is the state which rock | fluctuated the front-end | tip part diagonally upward, (b) is the state which rock | fluctuated the front-end | tip part diagonally downward It is. It is a figure which shows the structure of a measurement cartridge, (a) is a partially cutaway plan view, (b) is a side view, (c) is an AA cross-sectional arrow view of (a), (D) is a BB cross-sectional arrow view of (a). The structure of the measurement flow path provided in the measurement cartridge is shown, (a) is a plan view, (b) is an AA cross-sectional arrow view of (a), and (c) is B of (a). It is -B cross-section arrow enlarged view. It is a figure which shows pressing the piston of the cylinder mechanism provided in the measurement cartridge with the rod of a cylinder drive mechanism. The state of the measurement blood and the sphere in the measurement channel when the measurement cartridge is swung in the cartridge housing portion is shown, (a) is the state where the tip side is raised upward obliquely upward ( b) is a state where the tip side is lowered most obliquely downward. It is a figure which shows the structure of the measurement cartridge used in 2nd Example, (a) is a top view, (b) is an AA cross-sectional arrow view of (a), (c) is (a). It is a BB cross-sectional arrow view of It is a figure which shows the usage method of the measurement cartridge shown in FIG. 10, (a) is a figure which inject | pours measurement blood into a measurement flow path with a dispenser, (b) is measurement blood with a dispenser into a measurement flow path. (C) is a diagram showing a state where the measurement cartridge in which the measurement blood is injected into the measurement channel is swung at the end in the length direction, and the measurement channel is measured with the measurement blood by reciprocating the sphere. It is a figure of the state which got wet the inner wall.

DESCRIPTION OF SYMBOLS 10 Measuring apparatus main body 12 Measurement cartridge 14 Power switch 16 Start switch 18 Display means 20 Opening part 22 Blood injection port 24 Cartridge insertion hole 26 Cartridge accommodating member 28 Oscillation shaft 30 Guide pin 32 Oscillation mechanism 34 Cam 36 Motor 36 Photo interrupter 40 Measurement channel 42 Light emitting device 44 Light receiving device 46 Limit switch 48 Heater 50 Temperature sensor 52 Cylinder mechanism 54 Piston 56 Rod slide mechanism 58 Sealing material 60 Center member 62 Groove 64 Cylinder wall 66 Air vent hole 68 Communication channel 70 Second communication channel 72 Gasket 74 Bush 76 Coagulation accelerator 78 Sphere 80 Rod 112 Measurement cartridge 114 Center member 116 Sealing material 118 Injection hole 120 Dispenser

Claims (4)

In a blood coagulation time measuring device comprising a measurement cartridge having a long measurement channel with respect to a cross-sectional area, and a measurement device main body for storing the measurement cartridge and measuring the coagulation time of the measurement blood in the measurement channel, A movable body capable of reciprocating in the length direction is provided in the measurement channel, and the movable body is reciprocated to agitate the measurement blood injected into the measurement channel. A lengthwise groove is provided at the bottom of the path, the width of the groove is set so that the movable body does not contact the groove bottom, and a coagulation accelerator is applied and disposed in the groove. Blood clotting time measurement device. 2. The blood coagulation time measuring device according to claim 1, wherein the moving body is a sphere, and the measuring device main body moves the measuring cartridge vertically in the length direction of the measuring flow path through a horizontal state. Then, the blood coagulation time measuring device is configured to reciprocate in the measurement flow path by swinging so as to be inclined in an oblique state. 2. The blood coagulation time measurement apparatus according to claim 1, wherein the moving body is a magnet, and a magnetic field generator provided in the measurement apparatus main body alternately switches the direction of the magnetic field applied to the measurement flow path. A blood coagulation time measuring device configured to reciprocate in the measurement channel. 2. The blood coagulation time measuring apparatus according to claim 1, wherein the moving body is made of a ferromagnetic material and is provided in the measuring apparatus main body so as to face both ends of the measuring flow path. The blood coagulation time measurement is characterized in that the generation position of the magnetic field to be applied is alternately switched between one end and the other end of the measurement flow path to reciprocate the ferromagnetic material in the measurement flow path. apparatus.