JP2014069027A - Suction type implantation device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a device capable of inserting a sensor chip at a fixed angle into the skin surface for implantation because, according to the conventional dynamic skin elevation methods, an elevation of skin is not uniform depending on a person for implantation and an implantation part, and the depth of an implanted sensor chip and its inclination to the skin are not fixed in every implantation.SOLUTION: According to an implantation method provided in this invention, the skin surface for implantation is sucked to be elevated in an arbitrary shape, and a sensor chip is implanted in the epidermis or the dermis in the elevated skin through a surface parallel to a contact surface with the apex part of the skin surface, in order to highly efficiently attain the optical signal strength which can be obtained utilizing the surface of the sensor chip implanted in an organism such as reflected light, surface intensifying Raman light and fluorescence with respect to the light entering from the vertical direction to the contact surface.

Description

  The present invention relates to an apparatus for a sensor chip embedding method in a living body. In particular, the present invention relates to an apparatus for embedding in a dermis parallel to the skin surface, metal fine particles in which localized surface plasmon resonance occurs or fluorescent fine particles whose fluorescence characteristics change by reacting with a test substance.

  Conventionally, various apparatuses have been proposed for measuring the concentration of a test substance such as glucose by irradiating light of a specific wavelength from outside the living body, detecting the intensity of generated light such as fluorescence or Raman scattered light.

  Among the test substance concentration measuring devices, there has been conventionally proposed a device that embeds a sensor chip in a living body and detects the test substance using a phenomenon that occurs on the surface of the embedded sensor chip.

  For example, microparticles containing a reagent that changes its fluorescence characteristics by reacting with glucose are embedded in the upper layer of the skin as a sensor chip, and the microparticles are irradiated with light from outside the body, and the fluorescence generated in the microparticles is detected transcutaneously. Thus, an apparatus for measuring glucose concentration is disclosed. (Patent Document 1).

  The above-mentioned conventional technology embeds the sensor chip completely in the living body, and only irradiates light of a certain wavelength from the outside only when it is desired to measure the glucose concentration. Means that it can be measured.

  On the other hand, as a device for embedding a sensor chip itself in a living body, a device has been proposed in which the skin is dynamically raised and can puncture a specific site in the living body in a plane parallel to the contact surface with the skin apex.

  For example, it is disclosed that the puncture needle is moved by moving a puncture needle moving means so as to puncture the skin raised from the opening (see Patent Document 2).

  The above technique means that the skin can be punctured at a desired position and site under the skin by mechanically pushing up and raising the skin at the desired position.

JP-T-2002-519164 Special table 2008-136271 gazette

  However, when the above-described conventional mechanical skin bulging method is used, the skin of the desired position cannot be uniformly bulged depending on the person to be implanted, the location of implantation, and the degree of implantation, so the depth of the embedded sensor chip The inclination with respect to the skin does not become constant every time it is embedded. Therefore, the conventional method has a problem that it is difficult to obtain an optical signal intensity such as fluorescence intensity or surface-enhanced Raman intensity with high efficiency because the sensor chip is inserted while being inclined with respect to the embedded skin. .

  Therefore, in order to solve the above-described conventional problems, the present invention raises the skin surface into a uniform shape by sucking a desired embedded skin surface, and is parallel to the tangential surface with respect to the apex of the raised skin surface. A device that embeds the sensor chip is adopted. An object of the present invention is to reduce the embedding angle of the sensor chip embedded in the living body with respect to the contact surface to the apex of the desired skin surface by using the sensor chip embedding device, compared with the conventional device. Optical light intensity such as fluorescence intensity and surface-enhanced Raman signal intensity, which are responses from the surface of the sensor chip when light is incident from a direction perpendicular to the contact surface of the apex portion of the surface, can be obtained with high efficiency.

  In order to solve the above-described conventional problems, a sensor chip embedding device according to the present invention includes a skin aspirator and an embedding machine, and the skin aspirator includes a bulge-shaped support body having a gap portion, and an inside of the gap portion. An adhesive part that can be sealed from the outside, a suction part that can bulge the skin in the sealed gap part depending on the shape of the gap part, and an exhaust path as a path to the air suction part in the gap part, The gap includes a sensor for confirming whether the raised skin is raised to such an extent that the sensor chip can be embedded, and a suction port capable of sucking air in the gap sealed by the suction part. The implanting device has a syringe that allows the sensor chip to be inserted, and a support base that enables the syringe to be embedded in a direction parallel to the skin. Nji with parallel and stably retainable insertion needle outer tube, said sensor is configured with a controller that can process and determines hump can detect, the detection signal of the desired skin.

  The sensor can confirm that the skin is raised with a desired depth so as to be in close contact with the gap shape. For example, a pressure sensor, an optical sensor, or a conductivity sensor is preferable.

  After the controller determines whether the skin is raised to such an extent that the sensor chip can be embedded along the gap shape through the sensor, the controller can maintain the raised skin shape as it is. Has a feedback circuit capable of automatically controlling.

  The support base needs to be longer than the length of the syringe so that it can be stably installed on the skin.

  According to the suction type embedding device of the present invention, after the skin is raised to a shape that can be embedded in the sensor chip, the skin shape is maintained in the shape by automatically adjusting the suction force, and the surface that contacts the apex of the raised skin Fluorescence that can be obtained through the sensor chip surface of light incident on the apex of the raised skin from a direction perpendicular to the contact surface by embedding the sensor chip in a desired position in the living skin with a plane parallel to This is effective because optical signal intensity such as intensity and surface enhanced Raman signal intensity can be obtained with high efficiency.

Schematic sectional view showing the configuration of the suction type embedding device 100 according to the first embodiment of the present invention. Sectional drawing which shows the detail of the suction type | mold embedding apparatus 100 in Embodiment 1 of this invention. Sectional drawing which showed the structure of the syringe which can be inserted in the suction type | mold embedding apparatus 100 in Embodiment 1 of this invention. Detailed sectional view showing the entire configuration of suction-type embedding device 100 according to Embodiment 1 of the present invention Detailed plan view showing the entire structure of the suction type embedding device 100 of the present invention Sectional drawing of the suction type embedding apparatus 100 when the optical sensor in Embodiment 1 of this invention is used. Sectional view of suction-type embedding device 100 when the conductivity sensor according to Embodiment 1 of the present invention is used. Sectional drawing explaining the implementation method of the suction type embedding apparatus 100 of this invention

  Hereinafter, embodiments of the present invention will be described with reference to FIGS.

  FIG. 1 is a diagram showing a configuration of a suction type embedding device 100 according to an embodiment of the present invention.

  In FIG. 1, the suction-type embedding device 100 includes a skin suction device 200 and an embedding device 300.

  As shown in FIG. 2, the skin suction machine 200 includes a suction part 210 that can raise a desired skin, a gap part 220 that can hold and restrict the raised skin in a certain shape, and an interior of the gap part 220. It was read by the adhesive part 260 that can be hermetically shut off, the exhaust passage 230 that leads from the gap part 220 to the suction part 210, the suction port 240 installed in the gap part, and the sensor 250 and the sensor 250 that can detect changes in the shape of the skin. It comprises a controller 600 that processes information and determines whether the skin has been raised to a shape sufficient to embed the sensor chip 410.

  On the other hand, as shown in FIG. 2, the implanter 300 also has a grasping portion 310 that can correctly hold the implanter 300 when the sensor chip 410 or the syringe 400 is inserted into the desired skin 500 by embedding the sensor chip 410. And an insertion needle outer cylinder 320, a guide hole 320 for connecting the skin suction device 200 and the syringe 400, and a support base 340 that can stably hold the implanter 300 against the surface of the skin 500.

  As shown in FIG. 3, the syringe 400 includes a sensor chip 410 that enables measurement of a subcutaneous biological component, a plunger 440 that can be embedded in the skin 500 by mechanically pushing the sensor chip 410, and a path of the plunger 440. The insertion needle inner cylinder 430 and the insertion needle 420 that can be punctured into the skin 500 are configured.

  As shown in FIG. 4, skin 500 is mainly composed of epidermal tissue 510, dermal tissue 520, and subcutaneous tissue 530.

  The epidermal tissue 510 is on the surface of the living body and has a thickness of about 0.2 to 0.5 mm.

  The dermis tissue 520 has a thickness of about 0.5 to 2 mm.

  The sensor chip 410 is embedded in the dermal tissue 520 and is immersed in a body fluid between tissue cells, that is, a cell interstitial fluid. Since many capillaries exist in the dermis tissue 520, it is well known that components in the capillaries penetrate into the interstitial fluid.

  In particular, since glucose has high permeability, it has been confirmed that the glucose concentration of the interstitial fluid has a high correlation with the blood glucose level. The subcutaneous tissue 530 is mainly composed of fat cells.

  The gap 220 must limit, determine and maintain the shape of the skin 500 sucked by the suction part 210.

  Here, the requirement of the shape and size of the gap 220 is defined as that the sensor chip 410 can be embedded in the skin 500 if the skin 500 raised by the suction part 210 is in close contact with the gap 220. To do.

  An example of the shape of the gap 220 is a hemisphere.

  In addition, a structure such as an elliptical sphere, a rectangular parallelepiped, a cube, or a part of a cylinder may be used.

  However, the structure of the gap 220 is not limited to these structures.

  Further, in order to allow the skin 500 to rise using the suction part 210, the gap part 220 includes a suction port 240.

  However, the shape and number of the suction ports 240 should not be uniquely limited as long as the skin is in close contact with the gap 220 and can be raised to the extent that the shape can be maintained as it is.

  The suction part 210 must have at least a suction force that fills the bulges so that the skin 220 can be kept in contact with the gap part 220.

  Examples of the suction unit 210 include a vacuum pump such as a diaphragm vacuum pump and a dry pump.

  However, the suction unit 210 is not limited to these pumps.

  The sensor 250 must have the ability to check whether the raised skin 500 is tight enough to maintain contact with the gap 220.

  The signals detected by the various sensors are transmitted to the controller 600 and processed, and the controller 600 determines whether the skin 500 is deformed in close contact with the gap 220.

  Examples of sensor 250 may include sensors such as pressure sensors, light sensors, and conductivity sensors.

  In the case of the pressure sensor, as shown in FIG. 5, at least one or more places are installed in the gap 220, the pressure sensor detects the magnitude and direction of the pressure from the raised skin, and the controller 600 transmits the pressure signal. To communicate. When the magnitude of the pressure exceeds a certain threshold value and the direction thereof is a stress direction with respect to the gap 220, the controller 600 indicates that the raised skin 500 is sufficiently in close contact with the inner wall of the gap 220 and the sensor chip 410 can be embedded. to decide.

  On the other hand, in the case of the optical sensor, as shown in FIG. 6, at least one pair of a combination of the laser 251 and the light receiving unit 252 is installed in the gap 220. The transmitted light amount of the light emitted from the laser 251 is detected by the light receiving unit 252 and transferred to the controller 600 as a signal. When the ratio of the light amount in the light receiving unit 252 to the irradiation light amount of the laser 251 is equal to or less than a certain threshold value, the controller 600 determines that the raised skin 500 is in close contact with the gap 220 and is raised.

  Finally, in the case of the conductivity sensor, as shown in FIG. 7, at least one pair of electrode parts, that is, the first electrode part 253 and the second electrode part 254 are installed in the gap part 220. When the raised skin 500 touches the first electrode part 253 and the second electrode part 254 at the same time, a voltage difference is transmitted from the power source 255 to the first electrode part 253 and the raised skin 500 to the second electrode part 254. This is the mechanism that occurs. Information about the voltage difference that has flowed is transmitted to the controller 600. When the voltage described above exceeds a certain threshold, the controller 600 determines that the desired skin 500 to be implanted is in close contact with the gap 220 and is raised.

  However, the type of the sensor 250 should not be limited to only the three sensors described above, and other sensors can be used as long as they have similar capabilities.

  When the controller 600 determines that the gaps 220 of the skin 500 raised by the suction unit 210 are sufficiently close, the suction of the suction unit 210 is temporarily stopped to raise the raised skin 500. Is controlled so as to be held in close contact with the gap 220.

  However, if the raised shape of the skin 500 is significantly impaired, the controller 600 can restart the suction by the suction unit 210 again.

  The exhaust path 230 is installed so as to cover part or all of the gap 220 through the suction port 240.

  The exhaust path 230 is used as a path for air in the gap 220 to be exhausted by the suction part 210.

  Although the shape and cross section of the exhaust passage 230 depend on the shapes of the gap 220 and the suction port 240, they do not have to be exactly the same shape or size.

  The bonding part 260 should have a structure and a shape that are hermetically sealed from outside air so that the air in the gap part 220 can be exhausted by the suction part 210.

  Examples of the material of the bonding portion 260 include rubbers such as natural rubber and artificial rubber, plastics such as polystyrene, acrylic resin, and polyamide, and metals such as aluminum and iron.

  However, the material of the adsorption | suction part 260 is not necessarily limited only to these materials, if the said requirements are satisfy | filled.

  As shown in FIG. 3, the syringe 400 preferably has an inner diameter of about 0.1 to 2.0 mm so that the syringe 400 can be embedded in the dermis 520 although it depends on the size or shape of the sensor chip 410.

  However, it is more preferable to be transparent so that the process in which the sensor chip 410 is embedded is visible.

  A commercially available syringe can also be used as long as it can puncture the skin 500 and embed the sensor chip 410 at a desired position on the skin 500.

  The insertion needle outer cylinder 330 may have any shape and size that holds the syringe 400 and can be stably installed on the support base 340.

  Examples of the shape of the insertion needle outer cylinder 330 include a rectangular parallelepiped and a cylinder.

  However, the insertion needle outer cylinder 330 should not be limited to these shapes.

  In addition, it is more preferable that the insertion needle outer cylinder is substantially transparent in order to ensure internal visibility.

  The insertion needle 420 can also be used as a commercially available insertion needle as long as it can puncture the epidermis 510 and dermis 520 and the passage of the sensor chip 410 is secured and can be embedded.

  Further, the insertion needle 420 is manufactured by plastic processing, for example.

  The support base 340 is sufficiently larger than the length of the syringe 400 so that the suction-type embedding device 100 closely contacts the skin so that the surface of the skin 500 is not detached from or displaced from the desired position when the sensor chip 410 is embedded. Should have length and area.

  Examples of the material of the support base 340 may include soft polymers such as soft polyurethane, rubber elastic elastomers, other synthetic resins, rubbers, and the like.

  However, the material of the support base 340 should not be limited only to these materials.

  The grasping part 310 embeds the syringe 400 or the sensor chip 410 more stably by operating the insertion needle 420 or the plunger 440 by putting part or all of the finger of the user of the suction type embedding device 100. It has possible functions.

  The guide hole 320 is a hole provided to let the syringe 400 pass through the skin suction device 200 and has the same shape as the cross section provided in the insertion needle outer cylinder 330.

  Note that the shape of the opening is not limited to the shape of the present embodiment.

  Next, the operation of the suction-type embedding device 100 in the present embodiment when embedding a glucose detection sensor chip using the surface-enhanced Raman principle will be described with reference to FIG.

  First, in FIG. 8.A, the desired skin 500 location of the sensor chip 410 is selected, and the suction-type embedding device 100 is installed.

  At this time, the suction type embedding device 100 should be stably installed on the surface of the skin 510 through the support base 340 so that the inside of the gap portion 220 is sufficiently sealed by the adhesive portion 260.

  The suction of the skin 500 in the gap 220 is started through the suction part 210.

  At this time, the air in the gap 220 is exhausted through the exhaust path 230 and the suction port 240.

  As shown in FIG. 8B, the controller 600 determines whether the desired skin 500 is deformed to have a shape necessary for embedding the sensor chip 410, that is, whether the desired skin 500 is raised in close contact with the shape of the gap 220. Judged by 250.

  After confirming whether the skin 500 is deformed and closely adhered to the gap portion 220 of the skin 500 according to the suction condition, the controller 600 automatically controls the suction force of the suction portion 210 so as to maintain the skin bulge shape.

  As shown in FIG. 8.C, the user of the suction-type embedding device 100 puts the syringe 400 having the sensor chip 410 in the insertion needle inner cylinder 430 and puts a part or all of the finger on the grasping portion 310, and 510 and the dermis 520 are punctured, and the insertion needle 420 is moved to a desired subcutaneous position.

  Finally, as shown in FIG. 8D, the user of the suction-type implanter 100 pushes the plunger 440 to insert the sensor chip 410 into the epidermis 510 and leave it at the desired skin position.

  After the sensor chip 410 is embedded, the syringe 400 is pulled out in the order of the raised skin 500, the guide hole 320, and the insertion needle outer cylinder 330. The user of the suction type embedding device 100 removes the suction by the suction unit 210 and then removes the suction type embedding device 100 from the surface of the skin 500 in which the sensor chip 410 is embedded. This is the end of the embedding operation.

  The suction-type embedding device 100 according to the present embodiment has the shape and size necessary for embedding the sensor chip 410 so that it is in close contact with the gap 220 and is automatically sucked and deformed, so that the raised shape of the skin becomes constant. Later, the sensor chip 410 is placed in parallel to the surface of the skin 500 without being dependent on the person, body location, or each time by driving into a surface parallel to the contact surface with respect to the apex of the raised skin 500. Can be made.

  The suction-type embedding device 100 embeds a sensor chip on a surface parallel to the surface that contacts the apex of the raised skin surface, so that the surface of the sensor chip 410 with respect to light incident from a direction perpendicular to the contact surface can be obtained. Optical signal intensity such as fluorescence intensity and surface-enhanced Raman signal intensity that can be obtained through the detection can be detected with high efficiency.

  Using the present invention, a sensor chip is embedded in the skin.

DESCRIPTION OF SYMBOLS 100 Suction type embedding device 200 Skin suction device 210 Suction part 220 Gap part 230 Exhaust path 240 Suction port 250 Sensor 251 Laser 252 Light receiving part 253 First electrode part 254 Second electrode part 255 Power supply 260 Adhesion part 300 Implanter 310 Grasping part 320 Guide hole 330 Insert needle outer cylinder 340 Support base 400 Syringe 410 Sensor chip 420 Insert needle 430 Insert needle inner cylinder 440 Plunger 500 Skin 510 Epidermis 520 Dermis 530 Subcutaneous tissue 600 Controller

Claims (8)

  The skin suction machine is composed of a skin suction machine, an implanter, and a controller. The implanting machine comprises a support base that can be placed stably and in parallel on the skin surface, and an insertion needle outside that is a part that can hold the syringe on a surface parallel to the contact surface with respect to the top surface of the skin surface. A suction-type embedding device comprising a tube and a guide hole through which the syringe can pass through the skin suction device.   The suction-type embedding device according to claim 1, wherein the bonding portion includes a regulating member that blocks the inside of the gap portion from outside air.   The suction-type embedding device according to claim 1, wherein the suction-type embedding device is installed on a desired skin through the support base and the adhesive portion, and the skin can be raised by degassing the air in the gap portion by the suction portion. 4. The suction-type embedding device according to claim 1, wherein the gap is made of a member and a shape that can regulate the shape of the raised skin in close contact with the shape of the gap.   The gap includes a suction port through which the suction part can exhaust air inside the gap, and a sensor capable of detecting whether the skin is in close contact with the shape of the gap according to claim 4. The suction-type embedding device according to claim 1, wherein the suction-type embedding device is provided.   The suction-type implant according to claim 1, wherein the controller is provided with a feedback circuit that automatically controls suction of the suction part after confirming whether the skin is raised in the shape according to claim 4 through the sensor. apparatus.   The suction-type embedding device according to claim 1, wherein the sensor chip can measure a glucose concentration through a surface-enhanced Raman phenomenon using a surface structure and a fluorescence phenomenon.   2. The suction-type embedding device according to claim 1, wherein the suction portion has a suction capability sufficient to make the suction portion protrude in close contact with the gap portion shape according to claim 4.

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