JP2009234933A - Skin external preparation - Google Patents
Skin external preparation Download PDFInfo
- Publication number
- JP2009234933A JP2009234933A JP2008079603A JP2008079603A JP2009234933A JP 2009234933 A JP2009234933 A JP 2009234933A JP 2008079603 A JP2008079603 A JP 2008079603A JP 2008079603 A JP2008079603 A JP 2008079603A JP 2009234933 A JP2009234933 A JP 2009234933A
- Authority
- JP
- Japan
- Prior art keywords
- oil
- weight
- skin external
- external preparation
- silicone oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000003921 oil Substances 0.000 claims abstract description 25
- 235000019198 oils Nutrition 0.000 claims abstract description 23
- 229920002545 silicone oil Polymers 0.000 claims abstract description 21
- -1 fatty acid ester Chemical class 0.000 claims abstract description 19
- 239000000843 powder Substances 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 16
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 15
- 239000000194 fatty acid Substances 0.000 claims abstract description 15
- 229930195729 fatty acid Natural products 0.000 claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 11
- 239000010696 ester oil Substances 0.000 claims abstract description 5
- 239000007762 w/o emulsion Substances 0.000 claims abstract description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 150000004665 fatty acids Chemical class 0.000 claims description 8
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000002736 nonionic surfactant Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims description 4
- 235000019486 Sunflower oil Nutrition 0.000 claims description 3
- 229940119170 jojoba wax Drugs 0.000 claims description 3
- 229940057995 liquid paraffin Drugs 0.000 claims description 3
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 3
- 239000004006 olive oil Substances 0.000 claims description 3
- 235000008390 olive oil Nutrition 0.000 claims description 3
- 238000006116 polymerization reaction Methods 0.000 claims description 3
- 229940032094 squalane Drugs 0.000 claims description 3
- 239000002600 sunflower oil Substances 0.000 claims description 3
- 230000037072 sun protection Effects 0.000 claims description 2
- 238000000149 argon plasma sintering Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 230000000475 sunscreen effect Effects 0.000 abstract description 7
- 239000000516 sunscreening agent Substances 0.000 abstract description 5
- 239000010775 animal oil Substances 0.000 abstract description 4
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract description 4
- 239000008158 vegetable oil Substances 0.000 abstract description 4
- 230000007613 environmental effect Effects 0.000 abstract description 3
- 238000005406 washing Methods 0.000 abstract description 3
- 239000004094 surface-active agent Substances 0.000 abstract description 2
- 229920001296 polysiloxane Polymers 0.000 description 9
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 7
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 7
- WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000004677 Nylon Substances 0.000 description 6
- 239000000839 emulsion Substances 0.000 description 6
- 229920001778 nylon Polymers 0.000 description 6
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 5
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 4
- JNAYPSWVMNJOPQ-UHFFFAOYSA-N 2,3-bis(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C JNAYPSWVMNJOPQ-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 230000001771 impaired effect Effects 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 4
- 239000011787 zinc oxide Substances 0.000 description 4
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 3
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000006096 absorbing agent Substances 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 229940106189 ceramide Drugs 0.000 description 3
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 235000013980 iron oxide Nutrition 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 3
- 239000000344 soap Substances 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 2
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 2
- OUCGJMIVSYHBEC-UHFFFAOYSA-N 2-ethylhexyl 2-ethylhexanoate Chemical compound CCCCC(CC)COC(=O)C(CC)CCCC OUCGJMIVSYHBEC-UHFFFAOYSA-N 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 2
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 235000014653 Carica parviflora Nutrition 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 2
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- 241001072282 Limnanthes Species 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 2
- 240000000912 Macadamia tetraphylla Species 0.000 description 2
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 235000019482 Palm oil Nutrition 0.000 description 2
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 2
- 235000019485 Safflower oil Nutrition 0.000 description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- OEWBEINAQKIQLZ-CMRBMDBWSA-N [(2s)-2-[(2r)-3,4-bis(2-hexyldecanoyloxy)-5-oxo-2h-furan-2-yl]-2-(2-hexyldecanoyloxy)ethyl] 2-hexyldecanoate Chemical compound CCCCCCCCC(CCCCCC)C(=O)OC[C@H](OC(=O)C(CCCCCC)CCCCCCCC)[C@H]1OC(=O)C(OC(=O)C(CCCCCC)CCCCCCCC)=C1OC(=O)C(CCCCCC)CCCCCCCC OEWBEINAQKIQLZ-CMRBMDBWSA-N 0.000 description 2
- GLLSGHWYBGERSE-UHFFFAOYSA-N [2-(hydroxymethoxy)phenyl]-phenylmethanone;sodium Chemical compound [Na].OCOC1=CC=CC=C1C(=O)C1=CC=CC=C1 GLLSGHWYBGERSE-UHFFFAOYSA-N 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000001336 alkenes Chemical class 0.000 description 2
- 229960000458 allantoin Drugs 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 2
- 239000012965 benzophenone Substances 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- DHAZIUXMHRHVMP-UHFFFAOYSA-N butyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCCCC DHAZIUXMHRHVMP-UHFFFAOYSA-N 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 229930016911 cinnamic acid Natural products 0.000 description 2
- 235000013985 cinnamic acid Nutrition 0.000 description 2
- 239000012459 cleaning agent Substances 0.000 description 2
- 229940086555 cyclomethicone Drugs 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- PGRHXDWITVMQBC-UHFFFAOYSA-N dehydroacetic acid Chemical compound CC(=O)C1C(=O)OC(C)=CC1=O PGRHXDWITVMQBC-UHFFFAOYSA-N 0.000 description 2
- 239000002612 dispersion medium Substances 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 229960003720 enoxolone Drugs 0.000 description 2
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 239000010466 nut oil Substances 0.000 description 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 2
- 239000002540 palm oil Substances 0.000 description 2
- 239000011049 pearl Substances 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 229950001574 riboflavin phosphate Drugs 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 239000003813 safflower oil Substances 0.000 description 2
- 235000005713 safflower oil Nutrition 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 229940010747 sodium hyaluronate Drugs 0.000 description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229920003169 water-soluble polymer Polymers 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- DEQUKPCANKRTPZ-UHFFFAOYSA-N (2,3-dihydroxyphenyl)-phenylmethanone Chemical compound OC1=CC=CC(C(=O)C=2C=CC=CC=2)=C1O DEQUKPCANKRTPZ-UHFFFAOYSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- FBZQBGYPONNWCG-UHFFFAOYSA-N (4,5-dihydroxy-2,3-dimethoxyphenyl)-phenylmethanone Chemical compound COC1=C(O)C(O)=CC(C(=O)C=2C=CC=CC=2)=C1OC FBZQBGYPONNWCG-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 229940043375 1,5-pentanediol Drugs 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- WAYINTBTZWQNSN-UHFFFAOYSA-N 11-methyldodecyl 3,5,5-trimethylhexanoate Chemical compound CC(C)CCCCCCCCCCOC(=O)CC(C)CC(C)(C)C WAYINTBTZWQNSN-UHFFFAOYSA-N 0.000 description 1
- SAMYFBLRCRWESN-UHFFFAOYSA-N 16-methylheptadecyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC(C)C SAMYFBLRCRWESN-UHFFFAOYSA-N 0.000 description 1
- RKJGFHYCZPZJPE-UHFFFAOYSA-N 2,2-bis(16-methylheptadecanoyloxymethyl)butyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C RKJGFHYCZPZJPE-UHFFFAOYSA-N 0.000 description 1
- RRZWKUGIZRDCPB-UHFFFAOYSA-N 2,3-dihydroxypropyl hexanoate Chemical compound CCCCCC(=O)OCC(O)CO RRZWKUGIZRDCPB-UHFFFAOYSA-N 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N 2-Ethylhexanoic acid Chemical compound CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 1
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 description 1
- BGRXBNZMPMGLQI-UHFFFAOYSA-N 2-octyldodecyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC BGRXBNZMPMGLQI-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 241000242757 Anthozoa Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- SGPMPZKXUXPIBJ-UHFFFAOYSA-N C(C)C(CCCCC(=O)OCC(O)CO)(CC)CC Chemical compound C(C)C(CCCCC(=O)OCC(O)CO)(CC)CC SGPMPZKXUXPIBJ-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 241000243321 Cnidaria Species 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 239000004287 Dehydroacetic acid Substances 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- KIENGQUGHPTFGC-JLAZNSOCSA-N L-ascorbic acid 6-phosphate Chemical compound OP(=O)(O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O KIENGQUGHPTFGC-JLAZNSOCSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 229940093740 amino acid and derivative Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- VQWFNAGFNGABOH-UHFFFAOYSA-K chromium(iii) hydroxide Chemical compound [OH-].[OH-].[OH-].[Cr+3] VQWFNAGFNGABOH-UHFFFAOYSA-K 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 229940061632 dehydroacetic acid Drugs 0.000 description 1
- 235000019258 dehydroacetic acid Nutrition 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940100554 isononyl isononanoate Drugs 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940113915 isostearyl palmitate Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229960000448 lactic acid Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
- 229960002261 magnesium phosphate Drugs 0.000 description 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 1
- 235000010994 magnesium phosphates Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229940099690 malic acid Drugs 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 229940073665 octyldodecyl myristate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 229960003330 pentetic acid Drugs 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 1
- 229960003656 ricinoleic acid Drugs 0.000 description 1
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229930003802 tocotrienol Natural products 0.000 description 1
- 239000011731 tocotrienol Substances 0.000 description 1
- 235000019148 tocotrienols Nutrition 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940118594 trimethylolpropane triisostearate Drugs 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Description
本発明は、日焼け防止効果を有する化粧品、医薬部外品等の皮膚に塗布する製剤に関するものである。 The present invention relates to a preparation to be applied to the skin of cosmetics, quasi-drugs and the like having an effect of preventing sunburn.
日常生活においても太陽の紫外線は、肌の老化に影響していて、紫外線対策は美容には必須になってきている。 Even in daily life, the sun's ultraviolet rays affect skin aging, and measures against ultraviolet rays are becoming essential for beauty.
市場には多くの紫外線対策の製品が見られ、その効果をＳＰＦで著されている。ＳＰＦ表示ができる製品はその働きを有する成分として紫外線吸収剤及びまたは紫外線散乱剤を配合している。 There are many UV-resistant products on the market, and their effects have been written by SPF. A product capable of displaying SPF contains an ultraviolet absorber and / or an ultraviolet scattering agent as a component having the function.
ＮＩＫＫＥＩ−ＮＥＴの２００８．２．１６の記事において「日焼け止めでサンゴが白化――伊大学、実験で確認」の見出しで、日焼け止めの「パラベン、桂皮酸、ベンゾフェノン、カンファー抽出物という４種類の物質に、使用時に海に溶け出すのと同程度の量で、サンゴを白化させる作用があることが分かった。」と記載された。桂皮酸、ベンゾフェノンは紫外線吸収剤の構成成分である。さらに紫外線吸収剤は高配合すると皮膚への安全性の問題もあるため、パラメトキシケイ皮酸2―エチルヘキシル、ヒドロキシメトキシベンゾフェノンスルホン酸ナトリウムなど厚生労働省告示第３３１号で使用上限が決められている。 In the article of NIKKEI-NET's 2008.2.16, “corals are whitened by sunscreen—I University, confirmed by experiment”, the sunscreen “paraben, cinnamic acid, benzophenone, camphor extract” The substance was found to have the effect of whitening coral in an amount comparable to that which would dissolve into the sea when in use. " Cinnamic acid and benzophenone are constituents of UV absorbers. Furthermore, since there is a problem of safety to the skin when a high amount of the UV absorber is blended, the upper limit of use is determined in Ministry of Health, Labor and Welfare Notification No. 331 such as 2-ethylhexyl paramethoxycinnamate and sodium hydroxymethoxybenzophenone sulfonate.
また、通常、紫外線量が多くなる夏に使用される事が多いため、さっぱりとしたシリコーン油が好まれ、殆どの日焼け止めに用いられている。特に紫外線散乱剤は酸化チタンや酸化亜鉛が主であり、汗で流れないように表面を疎水化処理して、分散媒にシリコーン油を使われる場合がほとんどであった。反面、シリコーン油は生分解性に乏しく、使用後も長く存在し、環境面の懸念も考えられる。 Also, since it is often used in the summer when the amount of ultraviolet rays increases, a refreshing silicone oil is preferred and is used for most sunscreens. In particular, the ultraviolet scattering agent is mainly titanium oxide or zinc oxide, and in most cases, silicone oil is used as a dispersion medium by hydrophobizing the surface so that it does not flow with sweat. On the other hand, silicone oil is poor in biodegradability, it exists for a long time after use, and environmental concerns are also considered.
シリコーン油の代わりにさっぱりしたエステル油や鉱物油などもあるが、皮膚への安全性が問題になり、実用的ではなかった。 There are refreshing ester oils and mineral oils in place of silicone oils, but safety to the skin has become a problem and is not practical.
紫外線散乱剤を配合し、シリコーン油を分散媒の主体に使用せず、水に容易に流れ落ちない油中水型乳化組成物からなる日焼け止め効果を有する製品の発明が望まれていた。 There has been a demand for an invention of a product having a sunscreen effect comprising a water-in-oil emulsion composition which contains an ultraviolet scattering agent and does not use silicone oil as the main component of the dispersion medium and does not easily flow into water.
化学的、生物的に安定なシリコーン油は分解しないため、使用後の環境面の懸念があった。そのシリコーン油を含まないか含んでも僅かに抑えられ、紫外線散乱剤を用いた日焼け止めで皮膚に対する安全性が高い皮膚外用剤が課題である。 Since chemically and biologically stable silicone oil does not decompose, there was an environmental concern after use. The topic is a topical skin preparation that is slightly suppressed even if it does not contain the silicone oil, and is highly safe to the skin by sunscreen using an ultraviolet scattering agent.
上記の目的を達成する為に、本発明による製剤は、紫外線散乱剤を常温で液体の油であるエステル油、動物油、植物油、鉱物油に分散し、シリコーン油を含まないか含んでも１％以下に抑え、常温で液状の非イオン性界面活性剤を６重量％以下、水を１０重量％以上、紫外線散乱剤以外に吸油性がある粉体を１重量％以上含有し、ＳＰＦ５以上の油中水型乳化物であることを特徴としている。水分量は１０重量％以上であれは特に限定しない。１０重量％未満であれば、油感が強く使用の感覚が好ましくない。 In order to achieve the above object, the preparation according to the present invention is prepared by dispersing an ultraviolet scattering agent in ester oil, animal oil, vegetable oil, mineral oil which is liquid oil at room temperature, and containing 1% or less of silicone oil. In an oil of SPF5 or higher, containing 6% by weight or less of a nonionic surfactant that is liquid at room temperature, 10% by weight or more of water, and 1% by weight or more of an oil-absorbing powder other than an ultraviolet scattering agent It is characterized by being a water-type emulsion. The amount of water is not particularly limited as long as it is 10% by weight or more. If it is less than 10% by weight, the oily feeling is strong and the feeling of use is not preferred.
常温で液体の油としては、サフラワー油、ヤシ油、パーシック油、メドウフォーム油、オリーブ油、コメ胚芽油、ホホバ油、ヒマワリ油、スクワラン、マカデミアナッツ油等の動植物油、トリ(カプリル・カプリン酸)グリセリル、トリイソステアリン酸グリセリル、トリエチルヘキサン酸グリセリル等のトリグリセライド、パルミチン酸オクチルドデシル、パルミチン酸エチルヘキシル、トリ(カプリル・カプリン酸)グリセリル、トリイソステアリン酸トリメチロールプロパン、トリイソステアリン酸グリセリル等のエスイル油、その他、流動パラフィン、オレフィンオリゴマー等であり、これらの油の一種以上を含有し、この油の合計を１５〜７０重量％配合する。微量で安全性など本発明の特徴が損なわれない範囲であれば炭酸ジカプリル、エチルヘキサン酸エチルヘキシル、ミリスチン酸イソプロピル、ミリスチン酸ブチル、イソノナン酸イソノニルなど分子量２９０以下の比較的低分子量の油を配合する事も可能である。 Liquid oils at room temperature include safflower oil, palm oil, persic oil, meadow foam oil, olive oil, rice germ oil, jojoba oil, sunflower oil, squalane, macadamia nut oil and other animal and vegetable oils, and tri (capryl and capric acid) Triglycerides such as glyceryl, glyceryl triisostearate, glyceryl triethylhexanoate, octyldodecyl palmitate, ethylhexyl palmitate, glyceryl tri (caprylic / capric) glyceryl, trimethylolpropane triisostearate, glyceryl triisostearate, etc. , Liquid paraffin, olefin oligomer, and the like, containing one or more of these oils, and a total of 15 to 70% by weight of this oil is blended. As long as the characteristics of the present invention such as safety are not impaired, a relatively low molecular weight oil having a molecular weight of 290 or less such as dicapryl carbonate, ethylhexyl ethylhexanoate, isopropyl myristate, butyl myristate, and isononanoyl isononanoate is blended. Things are also possible.
非イオン性界面活性剤がポリグリセリル脂肪酸エステルまたはグリセリル脂肪酸エステルで、グリセリンの重合度が１〜１０で、脂肪酸はイソステアリン酸、オレイン酸、リノール酸、縮合リシノレイン酸、カプリル酸などであり、ＨＬＢが７以下であり、１〜６重量％配合とする。陽イオン性界面活性剤、陰イオン性界面活性剤、両性界面活性剤などその他の界面活性剤の配合も安全性など本発明の特徴が損なわれない範囲での配合は可能である。 The nonionic surfactant is polyglyceryl fatty acid ester or glyceryl fatty acid ester, the polymerization degree of glycerin is 1 to 10, the fatty acid is isostearic acid, oleic acid, linoleic acid, condensed ricinoleic acid, caprylic acid, etc., and HLB is 7 It is the following, and is 1 to 6% by weight. Other surfactants such as cationic surfactants, anionic surfactants, and amphoteric surfactants can be blended within the range where the features of the present invention such as safety are not impaired.
吸油性がある粉体としては無水ケイ酸、酸化鉄、水酸化アルミニウム、タルク、カオリン、雲母、マイカ、水酸化クロム、ベントナイト、ケイ酸アルミニウム、モンモリロナイト、ナイロン末、ポリメタクリル酸メチル、セルロース末、ポリエチレン末等や無水ケイ酸、デンプン、ベントナイト、セルロース等に疎水基を化合させた誘導体であり、１〜３０重量％配合とする。１重量％未満であれば、油のべたつきが問題になり、使用の感覚が好ましくない。３０重量％以上では粉の感覚が強く、肌に厚く残り使用の感覚が好ましくない。 Oil-absorbing powders include silicic anhydride, iron oxide, aluminum hydroxide, talc, kaolin, mica, mica, chromium hydroxide, bentonite, aluminum silicate, montmorillonite, nylon powder, polymethyl methacrylate, cellulose powder, It is a derivative in which a hydrophobic group is combined with polyethylene powder or the like, silicic anhydride, starch, bentonite, cellulose or the like, and is incorporated at 1 to 30% by weight. If it is less than 1% by weight, stickiness of the oil becomes a problem, and the feeling of use is not preferable. If it is 30% by weight or more, the powdery sensation is strong, thick on the skin, and the remaining sensation is not preferred.
紫外線散乱剤は酸化チタン、酸化亜鉛等の無機粉体であり、脂肪酸や脂肪酸の金属石鹸、シリコーン等により表面処理したそれらを含み、１〜２５重量％配合する。１重量％未満では日焼け防止効果が弱く、２５重量％を超えると使用時に白さが増し、使用性が悪くなる。 The ultraviolet scattering agent is an inorganic powder such as titanium oxide or zinc oxide, and includes those that have been surface-treated with a fatty acid, a metal soap of a fatty acid, silicone, or the like, and is blended in an amount of 1 to 25% by weight. If it is less than 1% by weight, the sun protection effect is weak, and if it exceeds 25% by weight, the whiteness increases during use and the usability deteriorates.
シリコーン油はデカメチルシクロペンタシロキサンなどのシクロメチコン、メチルポリシロキサン、メチルフェニルポリシロキサンなどの液状の油で、これらを含有しないか、含有しても１重量％以下である。 Silicone oils are liquid oils such as cyclomethicone such as decamethylcyclopentasiloxane, methylpolysiloxane, and methylphenylpolysiloxane. These oils do not contain these or are contained in an amount of 1% by weight or less.
ＳＰＦは５未満でも本発明の皮膚外用剤の調製は可能であるが、市場において日焼け止めの効果を有す製品はより高いＳＰＦ値を表記しているため、ＳＰＦは５以上の油中水型乳化物である皮膚外用剤とした。ジヒドロキシジメトキシベンゾフェノン、ジヒドロキシベンゾフェノン、ヒドロキシメトキシベンゾフェノンスルホン酸ナトリウム、４−ｔｅｒｔ−ブチル−４’−メトキシジベンゾイルメタン、パラメトキシケイ皮酸２−エチルヘキシル、ジパラメトキシケイ皮酸モノ−２−エチルヘキサン酸グリセリルなど紫外線吸収剤を配合することも可能であり、紫外線散乱剤との併用によりより高いＳＰＦが期待できる。 Although the skin external preparation of the present invention can be prepared even if the SPF is less than 5, since the product having sunscreen effect has a higher SPF value in the market, the SPF is a water-in-oil type of 5 or more. It was set as the skin external preparation which is an emulsion. Dihydroxydimethoxybenzophenone, dihydroxybenzophenone, sodium hydroxymethoxybenzophenone sulfonate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2-ethylhexyl paramethoxycinnamate, mono-2-ethylhexanoic acid diparamethoxycinnamate An ultraviolet absorber such as glyceryl can also be blended, and a higher SPF can be expected when used in combination with an ultraviolet scattering agent.
本発明の効果が損なわれない範囲で、通常、皮膚外用剤に使用されるエタノール、グリセリン、ソルビトール、ブチレングリコール、ペンチレングリコール、ブドウ糖、ジプロピレングリコール、異性化糖などのアルコール類、リン酸リボフラビンナトリウム、アスコルビン酸、リン酸Ｌ−アスコルビルマグネシウム、テトラ２−ヘキシルデカン酸アスコルビル、トコフェロールなどのビタミンおよびその誘導体、アスパラギン酸、カチオニン、メチオニン、リジン、トリメチルグリシンなどのアミノ酸およびその誘導体、ポリクオタニウム−５１、キトサン、カルボキシメチルセルロースナトリウム、カルボキシビニルポリマー、コラーゲン、エラスチン、メチルセルロースやヒアルロン酸ナトリウムなどの水溶性高分子、グリチルリチン酸およびその誘導体、グリチルレチン酸およびその誘導体、アラントインおよびその誘導体などの抗炎症剤、リゾレシチン、レシチン、セラミド、水素添加大豆リン脂質、水酸化大豆リン脂質、水素添加リゾレシチンなどのリン脂質、グコール酸、アルギン酸、サリチル酸、グルタミン酸、エデト酸、ジエチレントリアミン五酢酸、クエン酸、乳酸、リンゴ酸、デヒドロ酢酸やその塩、水酸化ナトリウム、トリエタノールアミン、２−アミノ−２−メチル−１，３−プロパンジオール、アルギニンなどｐＨ調節剤、ナイロン末や架橋型シリコーン・網状型シリコーンブロック共重合体、酸化鉄などの粉体、タール系色素などの色素、シコンエキス、ソウハクヒエキスなどの植物エキス、香料、パール剤、防腐剤や殺菌剤、菌代謝液、還元剤、γ−オリザノール、セラミド、トコトリエノール、ユビキノンなどの配合も可能である。 As long as the effect of the present invention is not impaired, alcohols such as ethanol, glycerin, sorbitol, butylene glycol, pentylene glycol, glucose, dipropylene glycol, and isomerized sugar, which are usually used for external preparations for skin, and riboflavin phosphate Vitamin and derivatives thereof such as sodium, ascorbic acid, magnesium L-ascorbyl phosphate, ascorbyl tetra-2-hexyldecanoate, tocopherol, amino acids and derivatives thereof such as aspartic acid, cationionine, methionine, lysine, trimethylglycine, polyquaternium-51, chitosan , Sodium carboxymethylcellulose, carboxyvinyl polymer, collagen, elastin, water-soluble polymers such as methylcellulose and sodium hyaluronate, glycyrrhizin And its derivatives, glycyrrhetinic acid and its derivatives, anti-inflammatory agents such as allantoin and its derivatives, lysolecithin, lecithin, ceramide, hydrogenated soybean phospholipid, hydroxylated soybean phospholipid, hydrogenated lysolecithin and other phospholipids, gucholic acid, alginic acid , Salicylic acid, glutamic acid, edetic acid, diethylenetriaminepentaacetic acid, citric acid, lactic acid, malic acid, dehydroacetic acid and its salts, sodium hydroxide, triethanolamine, 2-amino-2-methyl-1,3-propanediol, arginine PH regulators, nylon powder, cross-linked silicone / network-type silicone block copolymers, powders such as iron oxides, pigments such as tar pigments, plant extracts such as sicon extract, Sakuhakuhi extract, flavorings, pearls, preservatives And bactericides, bacterial metabolites, reducing agents, γ -Oryzanol, ceramide, tocotrienol, ubiquinone, etc. can be blended.
クリーム、乳液、化粧水、エアゾール、ファンデーションなど剤型は限定しない。 The dosage form is not limited, such as cream, emulsion, lotion, aerosol, foundation.
生分解性が悪いとされるシリコーンを配合しないか、少量の配合でも安全でＳＰＦ効果を有する油中水型乳化物である皮膚外用剤が得られる。 A skin external preparation that is a water-in-oil emulsion that is safe and has an SPF effect can be obtained even when a silicone, which is considered to have poor biodegradability, is not blended or even in a small amount.
常温で液状の非イオン性界面活性剤は親水基、親油基ともに植物又は動物由来で作ることができるポリグリセリル脂肪酸エステルまたはグリセリル脂肪酸エステルが適している。天然界に存在する物質からなり、環境に優しい。グリセリンの重合度が１〜１０で、脂肪酸はイソステアリン酸でＨＬＢが７以下に相当数のモル数エステル化した活性剤で、１〜６重量％を配合する。好ましくは１〜３重量％を配合する。 As the nonionic surfactant that is liquid at room temperature, a polyglyceryl fatty acid ester or a glyceryl fatty acid ester that can be produced from plants or animals with both hydrophilic groups and lipophilic groups is suitable. Made of natural substances, it is environmentally friendly. The degree of polymerization of glycerin is 1 to 10, and the fatty acid is an activator obtained by esterifying a considerable number of moles of isoleic acid with HLB of 7 or less, and 1 to 6% by weight is blended. Preferably 1-3 weight% is mix | blended.
ＳＰＦ効果を有する油中水型乳化物である皮膚外用剤の多くはシリコーン油を配合してさっぱりとしてべたつかなく、使用性が良好である。シリコーン油を常温で液体の油に代替すると、油感が強く、使用性が悪くなる。分子量２９０以下の比較的低分子量の油で代替すると比較的近い使用感が得られるが、皮膚に対して刺激を与え易くなる。サフラワー油、ヤシ油、パーシック油、メドウフォーム油、オリーブ油、コメ胚芽油、ホホバ油、ヒマワリ油、スクワラン、マカデミアナッツ油等の動植物油、トリ(カプリル・カプリン酸)グリセリル、トリイソステアリン酸グリセリル、トリエチルヘキサン酸グリセリル等のトリグリセライドとパルミチン酸オクチルドデシル、パルミチン酸エチルヘキシル、トリ(カプリル・カプリン酸)グリセリル、トリイソステアリン酸トリメチロールプロパン、トリイソステアリン酸グリセリル等のエスイル油や流動パラフィン、オレフィンオリゴマー等の組み合わせ、又は炭酸ジカプリル、エチルヘキサン酸エチルヘキシル、ミリスチン酸イソプロピル、ミリスチン酸ブチル、イソノナン酸イソノニルなどエステル油のみ又は主体として配合する。特にミリスチン酸オクチルドデシル、イソノナン酸イソトリデシルは使用性、安全性ともに良好であり、この一方又は両者の合計が２５〜５０重量％、他の油は１０重量％以下の配合が最も好ましい。 Many of the external preparations for skin which are water-in-oil emulsions having an SPF effect are blended with silicone oil and are not sticky and have good usability. If silicone oil is replaced with liquid oil at room temperature, the oily feeling is strong and the usability deteriorates. Replacing with a relatively low molecular weight oil having a molecular weight of 290 or less provides a relatively close feeling of use, but it tends to irritate the skin. Animal and vegetable oils such as safflower oil, palm oil, persic oil, meadow foam oil, olive oil, rice germ oil, jojoba oil, sunflower oil, squalane, macadamia nut oil, tri (caprylic / capric) glyceryl, glyceryl triisostearate, triethyl Combinations of triglycerides such as glyceryl hexanoate and octyldodecyl palmitate, ethylhexyl palmitate, glyceryl tri (capryl / capric) glyceryl, triisostearate trimethylolpropane, glyceryl triisostearate, liquid paraffin, olefin oligomer, etc. Alternatively, it is blended solely or mainly as an ester oil such as dicapryl carbonate, ethylhexyl ethylhexanoate, isopropyl myristate, butyl myristate, isononyl isononanoate. In particular, octyldodecyl myristate and isotridecyl isononanoate have good usability and safety, and the combination of one or both is 25 to 50% by weight, and the other oil is most preferably 10% by weight or less.
シリコーン油(デカメチルシクロペンタシロキサンなどのシクロメチコン、メチルポリシロキサン、メチルフェニルポリシロキサンなどポリシロキサン鎖を有する液状の油)を含有しない。紫外線散乱剤の微粒子酸化亜鉛や微粒子酸化チタンの表面処理にもメチコンやジメチコンなどシリコーン処理をしていない方が望ましい。たとえば、微粒子酸化亜鉛や微粒子酸化チタンなどをステアリン酸、ラウリン酸などの脂肪酸の鉄、マグネシウム、カルシウム、鉄などの金属塩で表面処理して表面を疎水化した紫外線散乱剤が好ましい。 Silicone oil (liquid oil having a polysiloxane chain such as cyclomethicone such as decamethylcyclopentasiloxane, methylpolysiloxane, and methylphenylpolysiloxane) is not contained. It is desirable that the surface treatment of the fine particle zinc oxide and fine particle titanium oxide of the ultraviolet scattering agent is not subjected to silicone treatment such as methicone or dimethicone. For example, an ultraviolet scattering agent obtained by surface-treating fine zinc oxide or fine titanium oxide with a metal salt of a fatty acid such as stearic acid or lauric acid, such as iron, magnesium, calcium, or iron to make the surface hydrophobic is preferable.
ＳＰＦは高い方が好ましいが、紫外線散乱剤の量が増えると透明度が低下して使用感が悪くなる。有機化合物の紫外線吸収剤の併用も可能である。紫外線吸収剤を含まない場合、ＳＰＦ１５以上は可能であり、紫外線吸収剤を含む場合、ＳＰＦ２５以上が可能となる。 Higher SPF is preferable, but when the amount of the ultraviolet scattering agent is increased, the transparency is lowered and the usability is deteriorated. An organic compound UV absorber may be used in combination. When the ultraviolet absorber is not included, SPF 15 or higher is possible, and when the ultraviolet absorber is included, SPF 25 or higher is possible.
シリコーンは化学的にも生物的にも不活性で安定であるため、シリコーン油を用いた油中水型乳化物である皮膚外用剤の場合、洗い流す場合、専用の洗浄剤を用いなければ肌に残ることもしばしばであった。シリコーンやテフロン（登録商標）など化学合成により、化学的にも生物的にも不活性で安定である油を配合しないと特別な洗浄剤を使用しなくても容易に洗い流すことが出来きる。 Silicone is chemically and biologically inert and stable, so in the case of a skin external preparation that is a water-in-oil emulsion using silicone oil, if it is washed away, a special cleansing agent will not be used on the skin. Often left. By chemical synthesis, such as silicone and Teflon (registered trademark), oil that is chemically and biologically inert and stable can be easily washed out without using a special cleaning agent.
紫外線散乱剤以外に吸油性がある粉体は無水ケイ酸、タルク、カオリン、ナイロン末が良好で、この一種以上で、その合計３〜１５重量％が望ましい。ただ、平均粒子径が１μｍ以下の粉体は１〜３重量％で良好である。これらの形状は板状、球状、不定形等、特に限定はしないが、無水ケイ酸、ナイロン末は球状が望ましい。 Oil-absorbing powders other than ultraviolet scattering agents are preferably silicic anhydride, talc, kaolin and nylon powder, and one or more of these powders are desirably 3 to 15% by weight in total. However, powder having an average particle diameter of 1 μm or less is good at 1 to 3% by weight. These shapes are not particularly limited, such as a plate shape, a spherical shape, and an indeterminate shape. Silica anhydride and nylon powder are preferably spherical.
水分量は１０重量％以上であれは特に限定しない。１０重量％未満であれば、油感が強く使用の感覚が好ましくない。 The amount of water is not particularly limited as long as it is 10% by weight or more. If it is less than 10% by weight, the oily feeling is strong and the feeling of use is not preferred.
前記記載の組成物には、本発明の効果が損なわれない範囲で、エタノール、グリセリン、ソルビトール、ブドウ糖、異性化糖などのアルコール類、リン酸リボフラビンナトリウム、アスコルビン酸、リン酸Ｌ−アスコルビルマグネシウム、テトラ２−ヘキシルデカン酸アスコルビルなどのビタミンおよびその誘導体、アスパラギン酸、カチオニン、メチオニン、リジン、トリメチルグリシンなどのアミノ酸およびその誘導体、ポリクオタニウム−５１、キトサン、カルボキシメチルセルロースナトリウム、カルボキシビニルポリマー、メチルセルロースやヒアルロン酸ナトリウムなどの水溶性高分子、グリチルリチン酸およびその誘導体、グリチルレチン酸およびその誘導体、アラントインおよびその誘導体などの抗炎症剤、ナイロン末や架橋型シリコーン・網状型シリコーンブロック共重合体、タルク、酸化鉄などの粉体、タール系色素などの色素、シコンエキス、ソウハクヒエキスなどの植物エキス、香料、パール剤、防腐剤や殺菌剤、菌代謝液、還元剤、γ−オリザノール、セラミド、ピロリドンカルボン酸ナトリウムなどの配合も可能である。 In the composition described above, alcohols such as ethanol, glycerin, sorbitol, glucose, isomerized sugar, riboflavin sodium phosphate, ascorbic acid, L-ascorbyl magnesium phosphate, as long as the effects of the present invention are not impaired. Vitamins such as ascorbyl tetra-2-hexyldecanoate and derivatives thereof, amino acids such as aspartic acid, cationion, methionine, lysine, trimethylglycine and derivatives thereof, polyquaternium-51, chitosan, sodium carboxymethylcellulose, carboxyvinyl polymer, methylcellulose and sodium hyaluronate Water-soluble polymers such as glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, allantoin and its derivatives, anti-inflammatory agents, nylon powder and bridges Type silicone / reticulated type silicone block copolymer, powders such as talc and iron oxide, pigments such as tar pigments, plant extracts such as sicon extract and suhakuhi extract, fragrances, pearls, antiseptics and fungicides, bacterial metabolite , A reducing agent, γ-oryzanol, ceramide, sodium pyrrolidonecarboxylate and the like are also possible.
[処方例]
実施例として、ＳＰＦ１０美容液、ＳＰＦ２５クリーム、ＳＰＦ２５クリーム、ＳＰＦ３５クリーム、ＳＰＦ２５振って使用する乳液の５点につき下記に例示する。
As examples, SPF10 serum, SPF25 cream, SPF25 cream, SPF35 cream, and SPF25 are shown below with respect to five points of emulsion used.
本発明のＳＰＦ２５乳液の実施例１、実施例２と比較例１、比較例２、比較例３の処方を表５に示した。パネラー１５名での通常のサンスクリーン製品と同様に肌に塗布して調べた使用感評価とパッチテストの結果を表６に示した。使用感評価の塗布時の油感は、油感が無いが１、適度が３、油感が強いが５として１〜５の５段階評価を行い、その平均値を記した。使用３時間後の保湿感は同様に、しっとり感が強いが１、適度が３、乾燥が強いが５とした。使用３時間後の脂肪酸石鹸での洗浄性は洗浄しなくても落ちているが１、適度が３、洗浄しても残るが５とした。実施例１のパルミチン酸イソステアリルは分子量５０８．９、実施例２のエチルヘキサン酸セチルは分子量３６８．９、比較例１のミリスチン酸イソプロピルの分子量は２７０．５である。比較例１の使用性は大差は無いが、パッチテストの結果が悪い。比較例２はシリコーン油を用いた例で、パッチテストは良好であり、塗布時の感触はさっぱりして良好であるが、３時間後は乾燥し、一般的な洗浄剤である脂肪酸石鹸では落ち難い。比較例３は酸化チタン以外の吸油性がある粉体であるナイロン末、カオリンを抜いた処方であるが、パッチテストの結果が悪く、刺激がある。
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008079603A JP2009234933A (en) | 2008-03-26 | 2008-03-26 | Skin external preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008079603A JP2009234933A (en) | 2008-03-26 | 2008-03-26 | Skin external preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2009234933A true JP2009234933A (en) | 2009-10-15 |
Family
ID=41249356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008079603A Pending JP2009234933A (en) | 2008-03-26 | 2008-03-26 | Skin external preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2009234933A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2574337A4 (en) * | 2010-05-18 | 2015-11-04 | Fujifilm Corp | Carotenoid-containing composition and production method therefor |
| KR20180082874A (en) | 2017-01-11 | 2018-07-19 | (주)아모레퍼시픽 | Cosmetics composition comprising wax having low melting point |
| CN109276482A (en) * | 2018-12-10 | 2019-01-29 | 深圳市欧科力科技有限公司 | Without silicone oil suncream and preparation method thereof |
-
2008
- 2008-03-26 JP JP2008079603A patent/JP2009234933A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2574337A4 (en) * | 2010-05-18 | 2015-11-04 | Fujifilm Corp | Carotenoid-containing composition and production method therefor |
| KR20180082874A (en) | 2017-01-11 | 2018-07-19 | (주)아모레퍼시픽 | Cosmetics composition comprising wax having low melting point |
| CN109276482A (en) * | 2018-12-10 | 2019-01-29 | 深圳市欧科力科技有限公司 | Without silicone oil suncream and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5728388B2 (en) | Oil-in-water emulsified cosmetic | |
| KR101809628B1 (en) | Topical skin formulation | |
| US9119785B2 (en) | Cosmetic basic composition and its use | |
| JPWO2010110020A1 (en) | Sunscreen cosmetics | |
| JP2015526465A (en) | Branched polymer type emulsifier | |
| JP2002275020A (en) | Oils and cosmetics and external preparations containing the same | |
| CA2483301A1 (en) | Sunscreen compositions and containing azolium compounds | |
| JP2018108994A (en) | Oil-in-water emulsion composition | |
| JP2018008910A (en) | Sunscreen cosmetics | |
| JP5540243B2 (en) | Sunscreen cosmetics | |
| JP2003277223A (en) | Matrix metalloprotease inhibitor and skin elasticity- retaining cosmetic | |
| WO2012017733A1 (en) | Skin cosmetic | |
| JP2015168635A (en) | Water-in-oil type emulsion cosmetic and method for manufacturing the same | |
| JP2006282632A (en) | Solid state water-in-oil type emulsion cosmetic | |
| JP6865522B2 (en) | Underwater oil type UV protection cosmetics | |
| JP2017137300A (en) | Oil-in-water type emulsion cosmetic | |
| JP2004175750A (en) | Dermopathy inhibitor and dermopathy improving agent, and skin care preparation for external use containing them | |
| JP4996408B2 (en) | Sunscreen cosmetics | |
| JP2009234933A (en) | Skin external preparation | |
| JP6929333B2 (en) | Water-in-oil emulsified cosmetic | |
| JP2005126329A5 (en) | ||
| JP6945810B2 (en) | Emulsified cosmetics | |
| EA024856B1 (en) | Photostable sunscreen composition | |
| JP2003277261A (en) | Skin care preparation | |
| JP2010510187A (en) | Cosmetic composition |