JP2008000202A - Dispensing content deciding apparatus and dispensing content deciding method for radioactive chemical - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dispensing content deciding apparatus capable of precisely dispensing a radioactive chemical of the desired amount of radioactivity, and to provide a dispensing content deciding method. <P>SOLUTION: The dispensing content deciding apparatus 70 decides the dispensing content of the radioactive chemical from a container for administration set to a dispensing and administering apparatus. The apparatus 70 comprises: a first information acquisition means 72 for acquiring the storage time at which the radioactive chemical is stored in the container for the administration and the information of the chemical inside the container for the administration at the storage time; a second information acquisition means 74 for acquiring the dispensing time at which the radioactive chemical is to be dispensed from the container for the administration; a third information acquisition means 72 for acquiring the amount of the radioactivity to be dispensed from the container for the administration; and a content deciding means 78 for deciding the content of the radioactive chemical to be dispensed from the container for the administration on the basis of the acquired information and the attenuation characteristics of the radioactive chemical obtained beforehand. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a dispensing volume determination device and a dispensing volume determination method for a radioactive drug solution.

A nuclear medicine diagnostic method for diagnosing diseases and the like by administering a radiopharmaceutical solution containing a compound labeled with a radionuclide (RI) into the body and imaging the state in which the labeled compound is collected at a specific location in the body with a dedicated device. Has been developed. In this diagnostic method, a relatively short-lived radionuclides (e.g., as a positron-emitting nuclide, ¹⁵ O 2 minutes, ¹¹ C is 20 minutes, ¹⁸ F has a half-life of 110 minutes) labeled with, ¹⁵ O -Water, ¹¹ C-methionine, ¹⁸ F-FDG (fluorodeoxyglucose) or the like is used as the radioactive chemical solution.

As a dispensing administration device that dispenses this radioactive drug solution and administers it to a subject, for example, there is one disclosed in Patent Document 1. In this dispensing administration device, a predetermined amount of a radioactive drug solution is drawn from a vial using a syringe, and is pushed out and dispensed into a tube connected to a subject. Then, the dispensed radioactive liquid is sent out together with physiological saline and administered to the subject. In this dispensing and administration device, the radioactivity concentration sensor provided on the side of the tube drawn from the vial is used to measure the radioactivity concentration of the drug solution in the tube, and based on this, the necessary radioactivity is obtained. The dispensing volume is calculated, and the calculated dispensing volume of the radioactive drug solution is dispensed.
JP 2002-306609 A

  However, in the above-described conventional technology, the radioactivity concentration is measured by the radioactivity concentration sensor provided on the side of the tube. Therefore, it is not always possible to calculate an accurate radioactivity concentration due to variations in the tube or mixing of bubbles. It was difficult and there was a possibility that high-precision dispensing could not be performed.

  The present invention has been made in view of the above-described circumstances, and provides a dispensing volume determination device and a dispensing volume determination method capable of accurately dispensing a radioactive drug solution having a desired radioactivity amount. Objective.

  A dispensing volume determination device according to the present invention is a dispensing volume determination device that determines a dispensing volume of a radioactive drug solution from an administration container set in a dispensing administration device. This device dispenses the radioactive chemical solution from the administration container, the first information acquisition means for acquiring the storage time when the radioactive chemical solution is stored in the administration container, and the chemical solution information in the administration container at the storage time. Second information acquisition means for acquiring the dispensing time, third information acquisition means for acquiring the amount of radioactivity to be dispensed from the administration container, the acquired information, and the attenuation characteristics of the radiopharmaceutical solution obtained in advance And a volume determining means for determining the volume of the radioactive drug solution dispensed from the administration container.

  The dispensing volume determination method according to the present invention is a dispensing volume determination method for determining a dispensing volume of a radioactive drug solution from an administration container set in a dispensing apparatus. This method acquires the time at which the radiopharmaceutical solution was stored in the administration container and the information on the drug solution in the administration container at the time of storage, and the dispensing time at which the radiochemical solution was dispensed from the administration container. Furthermore, the amount of radioactivity to be dispensed from the administration container is acquired, and the volume of the radiopharmaceutical solution to be dispensed from the administration container is determined based on the acquired information and the attenuation characteristics of the radiopharmaceutical solution obtained in advance. It is characterized by.

  According to this apparatus and method, information that is easy to acquire, such as the time of storage in the administration container, information on the liquid medicine at the time of storage, the time of dispensing, and the amount of radioactivity to be dispensed, and the attenuation characteristics of the radioactive liquid medicine are used. Since the volume of the radiopharmaceutical solution dispensed for administration can be determined, it is not necessary to measure the radioactivity concentration with the radioactivity concentration sensor provided on the side of the tube to determine the dispense volume Thus, even when the tube has variations or the like, it is possible to accurately dispense a radioactive drug solution having a desired amount of radioactivity.

  The administration container has storage means capable of storing the storage time and the drug solution information, and the first information acquisition means has a reading device that reads the storage time and drug solution information from the storage means of the administration container. May be a feature. In this way, at the stage of storing the radiopharmaceutical solution in the administration container, the storage time and the medicinal solution information are stored in the storage means, and these information are read by the reading device when set in the dispensing administration device. Information can be acquired. At this time, since the storage time and the drug solution information correspond to the administration container, it is possible to reduce the possibility of acquiring information on different administration containers by mistake.

  The first information acquisition means may receive the accommodation time and the drug solution information wirelessly. In this way, complication of wiring and the like can be avoided.

  According to the dispensing volume determination device and the dispensing volume determination method of the present invention, it is possible to accurately dispense a radioactive drug solution having a desired radioactivity.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. In the following description, the same reference numerals are used for the same elements, and duplicate descriptions are omitted.

  FIG. 1 is a diagram showing a configuration of a radioactive liquid dispensing system 1 according to the present embodiment. As shown in FIG. 1, the dispensing administration system 1 includes a dispensing administration device 10 and a control device 70. The dispensing administration device 10 has an accommodating part 14 for accommodating an administration container 16 for storing a radioactive drug solution. The administration container 16 has a vial 12 contained in a radiation shielding box made of a material such as lead or tungsten. An IC tag (storage means) 13 is provided at the bottom of the radiation shielding box. The administration container 16 is accommodated and supported from the upper opening while being inclined in the accommodating portion 14. A reading device 15 that reads information from the IC tag 13 of the administration container 16 in a non-contact manner is provided in the container 14.

  In addition, the dispensing apparatus 10 has a holding unit 20 that holds a syringe (chemical liquid suction / discharge device) 18 for dispensing a radioactive chemical liquid. The holding unit 20 is, for example, a cylindrical container that holds the syringe 18 inserted from the lower end, and is entirely formed of a material such as lead or tungsten that shields radiation.

  The syringe 18 includes a cylinder 22 and a piston 24 that slides in the cylinder 22. A packing made of an elastic body such as rubber is provided at the tip of the piston 24. A driving device 25 that pushes and pulls the piston 24 such as a stepping motor is connected to the piston 24. Therefore, by pushing and pulling the piston 24 within the cylinder 22 by the driving device 25, the radioactive chemical liquid can be sucked or discharged from the tip end port.

  A quantitative sensor 26 for measuring radioactivity is provided around the syringe 18. With this quantitative sensor 26, the amount of radioactivity of the radiopharmaceutical contained in the syringe 18 can be measured.

  The vial 12 and the syringe 18 described above are communicated with each other via a chemical solution carry-out line L1. A cattellan needle 29 is provided at one end of the chemical solution carry-out line L 1, and the catalan needle 29 is inserted into the vial 12. The other end of the chemical solution carry-out line L1 extends to a connection point between the chemical solution administration line L2 and a saline feed introduction line L3 for introducing physiological saline. The chemical solution carry-out line L1 branches in the middle, and is connected to the syringe 18 at the branch point.

  A pair of counter-support valves 28 are provided so as to sandwich this branch point on the chemical solution carry-out line L1. The pair of reverse support valves 28 regulates the flow direction of the radioactive chemical liquid in one direction.

  Moreover, the dispensing administration device 10 includes a saline feed line L3 for introducing physiological saline from the physiological saline pack 30 into the drug solution administration line L2, and a syringe 32 for sucking and discharging the physiological saline. One end of the raw food introduction line L3 is connected to the physiological saline pack 30. The other end of the raw food introduction line L3 extends to a connection point between the chemical solution administration line L2 and the chemical solution introduction line L1. The raw food introduction line L3 branches in the middle, and is connected to a syringe (raw food suction / discharge device) 32 at this branch point. The syringe 32 is driven by a drive device 33.

  A pair of reverse support valves 34 are provided so as to sandwich this branch point on the raw food introduction line L3. The pair of reverse support valves 34 regulates the flow direction of the physiological saline in one direction.

  Moreover, the dispensing administration apparatus 10 is provided with the chemical | medical solution administration line L2 which conveys a radioactive chemical | medical solution toward administration to a test subject. One end of the chemical liquid administration line L2 extends to a connection point between the chemical liquid introduction line L1 and the saline eating introduction line L3. A three-way pipe 36 is provided at this connection point, and a chemical solution administration line L2, a chemical solution introduction line L1, and a saline intake line L3 are connected to the three openings, respectively.

  The other end of the chemical liquid administration line L2 extends to the air vent filter 38. The air vent filter 38 blocks air. A reverse support valve 40 is provided in the front stage of the air vent filter 38 to restrict the back flow of the chemical solution. Note that the reverse valve 40 may be omitted. The medicinal solution administration line L2 is branched in the middle, and a drainage vial 42 for storing drainage is connected to the end of the branch line L4. A pinch valve 44 is provided on the branch line L4.

  A pinch valve 48 is provided in the middle of the drug solution administration line L2 and after the branch point of the branch line L4, and a radiation passage sensor 46 that detects the passage of the radioactive drug solution is provided in the subsequent stage of the pinch valve 48. Is provided.

  In addition, the dispensing administration device 10 includes a final administration line L5. One end of the final administration line L5 is connected to the air vent filter 38. On the other hand, the other end of the final administration line L5 is connected to the winged needle 50. The dispensing apparatus 10 further includes a drainage introduction line L6 that extends from the outside of the outer radiation shielding box 62 to the drainage vial 42 in the inner radiation shielding box 60. A sealing plug 52 made of rubber or the like is provided at the outer end of the drainage introduction line L6. The sealing plug 52 can accommodate unnecessary drainage discharged from the winged needle 50 into the drainage vial 42 through the drainage introduction line L6 by piercing the winged needle 50.

  The above-described members are accommodated in the outer radiation shielding box 60 in a state where a part of the final administration line L5 to which the winged needle 50 is connected is exposed. In particular, the vial 12 accommodated in the box 16, the syringe 18, the chemical solution introduction line L <b> 1 connecting them, and the first drainage vial 42 are accommodated in the inner radiation shielding box 62. These inner and outer radiation shielding boxes 60 and 62 are made of a material such as lead or tungsten that shields radiation. The radiation shielding ability of the inner radiation shielding box 62 is configured to be greater than the radiation shielding ability of the outer radiation shielding box 60. For example, the inner radiation shielding box 62 is made of lead with a thickness of 30 mm to 50 mm, while the outer radiation shielding box 60 is made of lead with a thickness of 5 mm to 10 mm. Comparing the shielding ability per unit area, the radiation shielding ability of the inner radiation shielding box 62 is configured to be about 22 to 1064 times larger than the radiation shielding ability of the outer radiation shielding box 60.

  The final administration line L5 from the physiological saline pack 30 and the air vent filter 38 is configured to be able to be taken in and out from the outer radiation shielding box 60.

  The pair of reverse support valves 28 and the reverse support valve 34 are preferably provided integrally with each other, and the integrated reverse support valve 28, the reverse support valve 34, and the three-way pipe 36 are preferably connected in series. In this way, connection work becomes easy.

  The control device 70 is electrically connected to the reading device 15, the driving devices 25 and 33, the radiation passage sensor 46, and the pinch valves 44 and 48, and controls the dispensing device 10 and serves as a dispensing volume determination device. Function. As shown in FIG. 2, the control device 70 includes a data receiving unit 72, a clock unit 74, a memory 76, and a calculation control unit 78.

  The data receiving unit 72 receives the storage time of the radioactive chemical solution in the administration container 16 read by the reading device 15 and the chemical solution information, and functions as a first information acquisition unit. The data accepting unit 72 accepts the amount of radioactivity to be dispensed input by the operator from the outside, and functions as a third information acquisition unit. The data receiving unit 72 is connected to the calculation control unit 78 and transmits the acquired information to the calculation control unit 78.

  Based on the request from the calculation control unit 78, the clock unit 74 transmits the dispensing time when the dispensing is attempted to the calculation control unit 78, and functions as a second information acquisition unit.

  The memory 76 stores a calculation program that takes into account the attenuation characteristics of the radioactive drug solution to be dispensed. The calculation control unit 78 uses the calculation program read from the memory 72 based on the storage time, the drug solution information, and the dispensing radioactivity amount sent from the data receiving unit 72 and the dispensing time sent from the clock unit 74. The volume of the radiopharmaceutical solution dispensed from the administration container 16 is calculated and functions as a volume determination means. That is, the radioactivity attenuation characteristic is determined by the radioisotope, and if the initial time and the radioactivity concentration (or radioactivity amount) at that time are known as the initial value, the radioactivity concentration (or radioactivity concentration) at the time after a predetermined time has passed (or Radioactivity). And the capacity | capacitance which needs to be dispensed can be calculated | required by the radioactivity density | concentration (or radioactivity amount) calculated | required in this way and the radioactivity amount to dispense. Accordingly, the memory 76 stores a program for this calculation. And the calculation control part 78 controls the drive device 25 of the syringe 18 so that the radioactive chemical | medical solution of the determined capacity | capacitance may be extracted.

  FIG. 3 is a diagram showing a configuration of a synthetic dispensing system 100 that is provided on the upstream side of the dispensing administration system 1 and that dispenses and stores the radioactive drug solution from the synthesizer 112 to the administration container 16.

  As shown in FIG. 3, the synthetic dispensing system 100 includes a synthetic dispensing device 110 and a control device 150. The combined component injection device 110 includes a synthesis device 112 and a dispensing device 114.

The synthesizer 112 synthesizes a radiopharmaceutical solution labeled with a radioisotope. Examples of the radioactive chemical liquid include ¹⁵ O-water, ¹¹ C-methionine, and ¹⁸ F-FDG (fluorodeoxyglucose) labeled with a positron radionuclide having a relatively short life.

  The dispensing device 114 dispenses the radiochemical solution synthesized by the synthesizer 112. The dispensing device 114 is connected to the synthesis device 112 by a pipe 122. The dispensing device 114 includes a stock solution storage unit 124 that stores a stock solution of a radioactive chemical solution sent from the synthesis device 112 through a pipe 122.

  The stock solution storage unit 124 includes a storage unit 128 that stores the stock solution vial 126. In the vicinity of the storage unit 128, a radioactivity measuring device 130 that measures the amount of radioactivity of the whole radiopharmaceutical stock solution contained in the stock solution vial 128, and a fluid amount sensor 133 that measures the amount of radioactive liquid in the stock solution vial 128. Is provided.

  In addition, the dispensing device 114 has a dispensing storage unit 134 that dispenses and stores a stock solution of a radiochemical solution. The dispensing storage unit 134 includes a storage unit 138 that stores the administration container 16. The storage unit 138 is provided with a writing device 139 that writes information to the IC tag 13 of the administration container 16 in a non-contact manner.

  The dispensing device 114 has a syringe 138 used for dispensing the radioactive drug solution from the stock solution vial 126 to the administration container 16, and a diluent supply unit 140 for supplying a diluent for diluting the radioactive drug solution. . The syringe 138 is driven by the driving device 141. Examples of the diluent include distilled water and physiological saline. The dispensing device 114 also has a purge gas supply unit 142 that supplies a purge gas (for example, He gas) for purging the liquid in the pipe line.

  The stock solution vial 126 of the stock solution storage unit 124, the administration container 16 of the dispensing storage unit 134, the syringe 138, the diluent supply unit 140, and the purge gas supply unit 142 are connected to each other by a flow path switching device 144. The flow path switching device 144 has four first to fourth three-way valves, and the most downstream three-way valve is connected to a quality verification device (not shown) via a pipe 146.

  The synthesis device 112 and the dispensing device 114 described above are accommodated in the hot cell 118.

  The control device 150 is electrically connected to the radioactivity measuring instrument 130, the liquid amount sensor 133, the writing device 139, the driving device 141, and the flow path switching device 144, and controls the synthetic dispensing device 110. The control device 150 controls the flow path switching device 144 and the driving device 141 based on the dispensing command value input from the outside by the operator, and the radioactive liquid of the necessary radioactivity amount from the stock solution vial 126 to the administration container 16. Dispense into.

  The control device 150 incorporates a clock unit (not shown), and writes the storage time when the radioactive drug solution is stored in the administration container 16 and the drug solution information in the vial 12 to the IC tag 13 via the writing device 139. . The chemical solution information includes the amount (ml) of the contained radioactive chemical solution, the radioactivity amount (MBq), and at least one of the radioactivity concentration (MBq / ml).

  Next, a method for dispensing and administering a radioactive drug solution by the dispensing system 1 according to the present embodiment will be described.

First, as shown in FIG. 3, in the synthetic dispensing system 100, a radiopharmaceutical solution having a desired radioactivity is dispensed and stored in the administration container 16. As the radioactive chemical solution, for example, ¹⁸ F-FDG (fluorodeoxyglucose), ¹⁵ O-water, or ¹¹ C-methionine can be used. Then, the storage time when the radioactive drug solution is stored in the administration container 16 and the drug solution information in the vial 12 at this time are written into the IC tag 13 of the administration container 16 via the writing device 139. The chemical solution information includes at least one of the amount (ml), the radioactivity amount (MBq), and the radioactivity concentration (MBq / ml) of the contained radiochemical solution.

  Next, the administration container 16 containing the radiopharmaceutical solution is taken out from the synthetic dispensing apparatus 110, carried to the dispensing administration apparatus 10 shown in FIG. Then, the cattellan needle 29 is inserted into the vial 12.

  Next, a certain amount of the physiological saline contained in the physiological saline pack 30 is drawn into the syringe 32 via the saline intake line L3. Next, the piston of the syringe 32 is pushed back by a predetermined amount, and physiological saline is introduced into the drug solution administration line L2. At this time, the pinch valves 44 and 48 are opened, and the drug solution administration line L2, the branch line L4, and the final administration line L5 are filled with physiological saline. Then, the pinch valve 48 is closed.

  Next, a certain amount of the radioactive chemical liquid contained in the vial 12 is drawn into the syringe 18 via the chemical liquid carry-out line L1. Next, the piston 24 of the syringe 18 is pushed back by a predetermined amount, and a part of the radioactive drug solution is carried out to the drug solution administration line L2. Then, the piston of the syringe 32 is pushed back by a predetermined amount, and physiological saline is introduced into the drug solution administration line L2. At this time, since the pinch valve 44 is opened, excess radioactive chemical solution carried on the chemical solution administration line L2 is discharged from the branch line L4 to the drainage vial 42 together with physiological saline.

  At this ready stage, the volume of radiopharmaceutical solution required for administration to the subject is determined. First, as shown in FIG. 1 and FIG. 2, the data receiving unit 72 receives the storage time of the radioactive drug solution in the administration container 16 read by the reading device 15 and the drug solution information. Moreover, the data reception part 72 receives the amount of radioactivity dispensed by the operator input from the outside. Then, the data receiving unit 72 transmits the acquired information to the calculation control unit 78.

  Next, the calculation control unit 78 acquires the dispensing time when attempting to dispense from the clock unit 74. Then, the calculation control unit 78 calculates the calculation read from the memory 72 based on the storage time, the drug solution information, and the dispensing radioactivity amount sent from the data receiving unit 72 and the dispensing time sent from the clock unit 74. The volume of the radioactive drug solution dispensed from the administration container 16 is calculated and determined by the program. And the calculation control part 78 calculates the drive amount of the syringe 18 by the drive device 25 for extracting the radioactive chemical | medical solution of the determined capacity | capacitance.

  The drive device 25 pushes back the piston of the syringe 18 with the calculated drive amount, and carries out a radioactive chemical solution in a volume necessary for administration to the subject to the chemical solution administration line L2. At this time, since the quantitative sensor 26 is provided around the syringe 18, the dispensed radioactivity amount can be confirmed by measuring the radioactivity amount of the radioactive drug solution in the syringe 18. When a necessary amount of the radioactive drug solution is carried out to the drug solution administration line L2, the physiological saline is sent from the branch line L4 to the drainage vial 42 by the amount of the radioactive liquid dispensed. Then, the pinch valve 44 is closed.

  After preparing for administration in this way, the pinch valve 48 is opened, the piston of the syringe 32 is pushed back, physiological saline is introduced into the drug solution administration line L2, and the necessary amount carried out to the drug solution administration line L2 is reached. The radiopharmaceutical solution is swept away and administered to the subject through the final administration line L5.

  It should be noted that the radiopharmaceutical solution was dispensed to the medicinal solution administration line L2. However, when the time has elapsed and the radiopharmaceutical solution has become unusable, or when an unnecessary amount of the radiopharmaceutical solution has been dispensed, When it is not suitable, the physiological saline is introduced into the drug solution administration line L2 by the syringe 32 with the pinch valve 48 closed and the pinch valve 44 opened, thereby sending unnecessary waste liquid to the drainage vial 42 through the branch line L4.

  As described above, in the dispensing administration system 1 according to the present embodiment as described in detail, information such as the storage time in the administration container 16, the drug solution information at the storage time, the dispensing time, and the amount of radioactivity to be dispensed is easily acquired. And the decay characteristics of the radiopharmaceutical solution can be used to determine the volume of radiopharmaceutical solution to be dispensed for administration, so the radioactivity provided on the side of the tube to determine the dispense volume Even if there is no need to measure the radioactivity concentration by the concentration sensor and the tube of the chemical solution carry-out line L1 is uneven, it is possible to accurately dispense the radioactive chemical solution having a desired radioactivity amount. .

  Further, at the stage of storing the radiopharmaceutical solution in the administration container 16, the IC tag 16 stores the storage time and the drug solution information, and these information are read by the reading device 15 when set in the dispensing administration device 10, Information can be acquired. At this time, since the storage time and the drug solution information correspond to the administration container 16, it is possible to reduce the possibility of acquiring information on different administration containers 16 in error.

  Further, in the dispensing apparatus 10 according to the present embodiment, a portion where the radiation is released is surrounded by the inner radiation shielding box 62, and a portion where the radiation is less emitted is surrounded by the outer radiation shielding box 60 having a lower shielding ability. Therefore, it is not necessary to enclose the whole with a shielding box having a high shielding ability, and it is possible to reduce the weight while maintaining a high radiation shielding ability.

  In addition, the dispensing administration device 10 includes a branch line L4 branched from the drug solution administration line L2, a pinch valve 44 provided in the branch line L4, and a drainage vial 42 for storing drainage discharged through the branch line L4. Therefore, when the desired radiopharmaceutical solution is not dispensed, it can be discharged to the drainage vial 42 through the branch line L4.

  And since this drainage vial 42 is also accommodated in the inner radiation shielding box 62, the amount of radioactivity leaking from the dispensing apparatus 10 can be further reduced.

  Further, since the reverse support valve 28 is provided so as to sandwich the suction / discharge point by the syringe 18 and the reverse support valve 34 is provided so as to sandwich the suction / discharge point by the syringe 32, the flow path switching like a three-way stopcock is performed. Means are no longer required, the possibility of electrical and mechanical problems being reduced, and reliability is improved. Moreover, attachment becomes easy.

  The present invention is not limited to the above-described embodiment, and various modifications can be made. For example, the reading device 15 of the dispensing device 10, the writing device 139 of the synthetic dispensing device 110, and the IC tag 13 of the administration container 16 are omitted, and the data receiving unit 72 of the control device 70 is wireless or wired. The accommodation time and the chemical information may be received directly from the control device 150. In this way, complication of wiring and the like can be avoided.

  Moreover, if it is not necessary to confirm the radioactivity amount of the radioactive chemical solution to be dispensed, the quantitative sensor 26 around the syringe 18 may be omitted.

It is a figure which shows typically the structure of the dispensing administration system of the radiopharmaceutical solution which concerns on this embodiment. It is a block diagram which shows the structure of the control apparatus of the dispensing administration system of FIG. It is a figure which shows typically the structure of the synthetic | combination dispensing system of the radioactive chemical | medical solution which concerns on this embodiment.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1 ... Dispensing administration system, 10 ... Dispensing administration apparatus, 16 ... Dosing container, 18, 32 ... Syringe, 25, 33 ... Drive apparatus, 28, 34 ... Check valve, 42 ... Drainage vial, 44, 48 DESCRIPTION OF SYMBOLS ... Pinch valve, 60 ... Outer radiation shielding box, 62 ... Inner radiation shielding box, 70 ... Control device, 72 ... Data receiving part, 74 ... Clock part, 76 ... Memory, 78 ... Calculation control part, 100 ... Synthetic dispensing system , 110 ... Synthetic dispensing apparatus, 112 ... Synthetic apparatus, 114 ... Dispensing apparatus, 139 ... Writing apparatus, 150 ... Control apparatus, L1 ... Chemical solution carry-out line, L2 ... Chemical solution administration line, L3 ... Saline feed introduction line, L4 ... Branch line, L5 ... Final dosing line.

Claims (4)

A dispensing volume determination device for determining a dispensing volume of a radiopharmaceutical solution from an administration container set in a dispensing administration device,
First information acquisition means for acquiring the storage time when the radioactive liquid medicine is stored in the administration container, and the chemical liquid information in the administration container at the storage time;
A second information acquisition means for acquiring a dispensing time for dispensing the radioactive drug solution from the administration container;
Third information acquisition means for acquiring the amount of radioactivity to be dispensed from the administration container;
Volume determination means for determining the volume of the radioactive drug solution to be dispensed from the administration container, based on the acquired information and the attenuation characteristics of the radioactive drug solution obtained in advance,
A dispensing volume determination device comprising: The administration container has storage means capable of storing the storage time and the drug solution information,
2. The dispensing volume determination device according to claim 1, wherein the first information acquisition unit includes a reading device that reads the storage time and the drug solution information from the storage unit of the administration container.   2. The dispensing volume determination device according to claim 1, wherein the first information acquisition unit wirelessly receives the storage time and the drug solution information. A dispensing volume determination method for determining a dispensing volume of a radiopharmaceutical solution from an administration container set in a dispensing apparatus,
Acquiring the storage time when the radioactive drug solution was stored in the administration container, and the drug solution information in the administration container at the storage time,
Obtain a dispensing time for dispensing the radiopharmaceutical solution from the administration container,
Furthermore, obtain the amount of radioactivity to be dispensed from the administration container,
Based on these acquired information and the attenuation characteristics of the radiopharmaceutical liquid obtained in advance, determine the volume of the radiopharmaceutical liquid dispensed from the administration container,
Dispensing volume determination method characterized by the above.

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