JP2007119431A - Activator of peroxisome proliferator-activated receptor (ppar) - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To discover a new activator of a PPAR to provide an external preparation for the skin, effective for prevention/amelioration of rough skin, skin inflammation and reduction of skin barrier function. <P>SOLUTION: The activator of the PPAR comprises one or more kinds of compounds selected from N-acetylcysteine, seneciphylline, sulfuretin, chalcone, resveratrol, ceramide, oleuropein, magnolol, silybin and phloretin as an active ingredient. The external composition for the skin contains the compounds as active ingredients. The activator of the PPAR has excellent PPAR β/δ activating activity, and the external composition for the skin containing the activator as the active ingredient is effective for prevention/amelioration of the rough skin, the skin inflammation and the reduction of the skin barrier function. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a novel Peroxisome Proliferator Activated Receptor (PPAR) activator, and a skin external preparation composition containing the same and effective for preventing and improving rough skin, skin inflammation, and skin barrier function deterioration. About.

Peroxisome proliferators-activated receptors (hereinafter referred to as PPARs) are transcription factors belonging to the nuclear receptor superfamily, as are steroid hormones, thyroid hormones, vitamin D3 and retinoic acid. Three subtypes (α, γ, β / δ) have been identified so far, and PPARα is distributed in tissues with high levels of fatty acid catabolic brain such as the liver. It regulates gene expression related to sex fat metabolism. PPARγ is manifested in white adipocytes and brown adipocytes, and plays a central role in inducing differentiation of the cells and promotes fat storage in mature adipocytes. In contrast, PPARβ / δ is universally expressed in each tissue including skeletal muscle, but its function is unknown (see Non-Patent Documents 1 to 3).
Pharmacological Journal of Japan, 117, 319-327, 2001 Protein Nucleic Acid Enzyme, 40 (13), 50-55,1995 Pharmaceutical Journal, 124 (11), 803-813,2004

Recent studies have shown that activation of PPARγ and PPARβ / δ induces keratinocyte differentiation (see Non-Patent Documents 4 and 5), which may play an important role in wound healing in the skin. It is considered (see Non-Patent Document 6).
J. Invest. Dermatol., 123, 305-312, 2004 J. Invest. Dermatol., 122, 971-983, 2004 Inflammation / Regeneration, 23 (2), 74-83, 2003

On the other hand, in recent years, various natural product-derived components have been found as PPAR activators, but their application fields are activation of lipid metabolism and prevention / improvement of obesity, diabetes, hyperglycemia, hyperlipidemia, and insulin resistance. (Refer to patent documents 1 to 3).
JP 2002-80362 A JP2003-34636 JP 2002-8036

  Accordingly, an object of the present invention is to find a novel PPAR activator. Another object of the present invention is to provide an external preparation for skin that is effective in preventing and improving rough skin, skin inflammation, and skin barrier function deterioration.

  As a result of earnest research on the component having PPAR activation activity, the present inventor has found that N-acetylcysteine, senecifylline, sulfretin, chalcone, resveratrol, ceramide, ololopain, magnolol, silybin, and phloretin have the above-mentioned activity. The headline and the present invention were completed.

  In addition, the present invention was completed by providing a skin external preparation composition comprising the PPAR activator as an active ingredient.

  One or more compounds selected from N-acetylcysteine, senefiphilin, sulfetin, chalcone, resveratrol, ceramide, ololopain, magnolol, silybin, and phloretin, which are active ingredients of the present invention, have an excellent PPAR activation effect. It was confirmed to have. Moreover, it became possible to provide a composition effective for preventing and improving rough skin, skin inflammation, and skin barrier function deterioration by blending this into an external preparation composition as an active ingredient.

  In the present invention, one or two or more compounds selected from N-acetylcysteine, senecifylline, sulfretin, chalcone, resveratrol, ceramide, ololopain, magnolol, silybin, and phloretin can be used, and these aglycones and glycosides can be used. And those having a hydroxyl group, a methoxy group, a methyl group or the like added thereto can also be used. Regarding ceramide, in addition to free ceramide having a structure in which a fatty acid is bonded to sphingosine, a sugar ceramide bonded with a sugar or a ceramide phospholipid bonded with a phosphate group can be used.

  Although the said compound can also be manufactured by a well-known chemical synthesis method, what is generally marketed can also be used.

  The PPAR activator used in the present invention and the composition containing the PPAR activator may be in any form such as liquid, solid, powder, paste, gel, etc. An optimum shape can be arbitrarily selected. Depending on the dosage form, these can be administered or ingested to humans by any route such as oral, enteral, injection, transmucosal, transdermal, etc., but by external routes such as transmucosal and transdermal. It is preferable to use it.

  The dosage form of the PPAR activator and the external preparation for skin composition containing the PPAR activator is arbitrary, and includes ampoules, capsules, powders, granules, pills, tablets, solids, liquids, gels, and bubbles. , Emulsions, creams, ointments, sheets, mousses, powder dispersions, multilayers, aerosols, and other cosmetic compositions, pharmaceuticals, quasi-drugs or foods and beverages. .

  The field of use can be used in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, pills, tablets, powders, granules, solids, liquids, gels 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (for example, lotion, milky lotion) , Basic cosmetics such as cream, ointment, lotion, oil, pack, facial cleanser and skin cleanser, massage agent, cleansing agent, hair remover, hair remover, shaving treatment, after shave lotion, pre-show lotion, Makeup cosmetics such as shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail preparation, nail enamel, nail enamel Leavening agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoos, rinses, hairs) Treatment agents, pre-hair treatment agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair growth and hair nourishing agents, poultices, plaster agents, tape agents, sheet agents, patch agents, aerosol agents, etc.), 5) bath water 6) In addition, anti-smell and deodorant, deodorant, antiperspirant, hygiene products, sanitary cotton, wet tissue, toothpaste, mouth freshener, gargle, etc. .

  Furthermore, as foods and drinks, oral compositions (gum, candy, etc.), processed fishery products such as kamaboko and chikuwa, livestock products such as sausages and ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles, buckwheat etc. Seasonings such as noodles, sauce, soy sauce, sauce, sugar, honey, powdered candy, syrup, etc., spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, red vegetables, sprinkles, or Processed vegetables and fruits such as canned and bottled vegetables, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey drink, soft drink, alcoholic beverages, etc. It can be used for general foods and drinks such as health foods.

  The content of the compound which is the active ingredient of the present invention varies slightly depending on the type, quality, and expected level of action of the PPAR activator and the external preparation for skin, and is not particularly limited. When converted to about 0.0001 to 20% by mass, preferably about 0.01 to 10%, usability and good effects can be obtained.

  In addition to the above essential components, the PPAR activator of the present invention and a skin external preparation composition containing the same include components and additives exemplified below within a range that does not impair the effects of the present invention. It can be selected and used in combination. The content in the preparation is not particularly limited, but is usually preferably 0.0001 to 50%.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber oil, safflower oil , Shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, palm Oil, beef tallow, pork tallow, squalene, squalane, pristane or hydrogenated products of these oils (hardened oil, etc.).

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax and the like.

(3) Mineral oils Liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax, etc.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid Synthetic fatty acids such as natural fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) Alcohols: natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol .

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate, Diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) gum, sugar or water-soluble polymer compound gum arabic, benzoin rubber, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or ester thereof, Trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan to which alkylene (C2-C4) oxide such as ethylene oxide is added, low molecular chitin Or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethylcellulose, methylcellulose Polycarboxylate such as carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene oxide Alkylene oxide or its crosslinked polymer, carboxyvinyl polymer, polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt), amphoteric Surfactant: Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant ( Ether type nonionic surfactant, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants ( Natural surfactants, protein hydrolyzate derivatives, polymer surfactants, surfactants containing titanium and silicon, fluorocarbons System surfactant) and the like.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), Riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: Ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or derivatives thereof, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), me Dione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), vitamin U and the like.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine , Arginine, ornithine, histidine and the like, and their amino acid derivatives such as sulfate, phosphate, nitrate, citrate or pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, fermentation, purification) , Compression, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc., arbitrarily selected and combined), arbitrarily selected from various materials You can use it.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol , Lower alcohols such as isobutanol or hydrous lower alcohols, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyhydric alcohol such as polyethylene glycol (molecular weight 100 to 100,000) or water-containing polyhydric alcohol, acetone, ethyl acetate, Diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xy , Benzene, chloroform, carbon tetrachloride, various organic solvents such as phenol, toluene, etc., and acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, water, etc.) prepared as appropriate. It is desirable to use one or a mixture of two or more selected from potassium oxide, calcium hydroxide, ammonia and the like. However, if it is not preferable to contain an organic solvent depending on the purpose of use, use only water or perform extraction using a highly volatile solvent that can be easily removed after extraction, and use purified water after removing the solvent. It is also possible to use a method such as dissolving in a solution.

  In addition, when using additives derived from plant or animal-based ingredients for systemic or topical external preparations and cosmetics, it protects skin and hair, moisturizes, improves touch and texture, imparts flexibility, and stimulates Relaxation, stress relief by fragrance, cell activation (cell aging prevention), suppression of inflammation, improvement of skin and hair quality, prevention of rough skin and its improvement, hair growth, hair growth, hair loss prevention, imparting gloss, cleansing effect, In addition to cosmetic effects such as fatigue relief, blood flow promotion, and warm bath effects, effects such as flavoring, deodorization, thickening, antiseptic, and buffering can also be expected.

  In addition, in food and drink, nutritional supplementation, fatigue recovery, tonicity, cell activation (cell aging prevention) and other healthy and cosmetic effects, as well as improved taste, color tone, aroma, gloss, stabilization, thickening, It can be used for antiseptic purposes. In addition to this, various cosmetic and pharmaceutical effects of each of the known raw materials are expected, and by combining these, the intended effect can be promoted or multifunctional. It is also possible to make the product expected to be effective.

Specific plants (herbal medicines) as raw materials include, for example, almonds (toen), ai (indigo leaves), aokazura (Keifu Fuji), Aoki (Aoki), Aogiri or Kenashia Ogiri (Ao Tung), Aotsu Samurai (wooden candy) , Aotenma, acacia, red ginseng, red spruce `` fruit '', red clover, red grapes, red ginseng (logwood), red wrinkles (red buds), red crested or red crested or reddish (root), red crested or reddish (ground yellow), Agi (Aki), Aki larch, Akinire (crusted skin), Aguay Guassou, Aguahe (Omiten coconut palm), Akebi (Kitsu), Asa (Asakojin), Maruba morning glory or morning glory (Chicken), Hydrangea (hydrangea), Ashitaba (Tomorrow), Azuki (Red Azuki), Asunaro, Acerola, Asenyaku (Asenyaku), Athira (Shokuyokanna), Anise, Abiyu, A Biurana, oilseed rape, Abemaki `` fruit '', avocado, ama, achacha (Amacha), Achacharu, Amadokoro (Jade bamboo), Amana (a light-hearted), amaranth (Hyuyu, Hagatetou, Himogeito, Senninkoku, Sugimorigateto, Hosoaogeito, Hasoagoito Aozulan, Amaranthus hypochondriacus), Amigasayuri or Baimo (shellfish mother), Aristolomeria (Yurizuisen), Arcana (Alcanna), Algarrobo (Cabe), Altea, Arnica, Alpinia or Katsumadai (Suzukuku), Aloe (蘆薈), Aloe vera, angelica, apricot or honanzu (Anzujin), Ansokkou (benzoic incense), yellow support, igakozolina (geo-biliary head), licorice or gecko licorice (indian oyster), rush (light heart grass), itadori (tiger cane root), yew (one Place), Strawberry, fig (no flower `` fruit, leaf ''), Ichihatsu (first), Ichibi (winter lion), Ichiyakusou (one medicinal herb), ginkgo (Ginkgo `` seed, leaves ''), Japanese yellow peas (distant), carob, Japanese beetle ( Taillexi), Inubiyu (Honagainubiyu), Rice `` Seeds, Seed coat '', Inondo `` Seeds '', Ibuki-so-sou, Nettle, Ylang-ylang, Iwa-tobacco (Iwabuchi), Iwahiba or Iwamatsu (rolling mushroom), kidney beans, oolong tea, fennel (mustard) , Wheat (Chibusanoki), Ukiyara (Sanryo), Uguisukagura `` Fruit '', Himewikyo, Turmeric (Urban), Duckweed, Usubasaishin or Keirinsaishin or Oshusaishin (spicy), Usvenia Oy, Usbeni Hollyhock, phalaenopsis, weevil (summer hay), udo or shishiudo (gung, alone, tangy), unyadegato (unkari) A, Cat's Claw), Uba tea, Ume (Japanese apricot `` seed, pulp ''), Japanese white beetle, Uwaurushi (Kusako-kemomo), Unshuumika (Chen), Unboku, Estragon, Ezoukogi (Tomogoka), Ezo-suzuran, Echinashi (Hosobamurasaki Barengiku) , Enishida, Enokitake (榎 茸), Ebisugusa or Cassia Tora (Keiko), El Campre, Elderberry “fruit”, Elemi, Elingi or Pre-Lotus Elinji, Enju (Safflower, Camellia rice), Pea, Ogi or Kibanaogi (Yellow Twilight), Naruko Yuri or Kagura-mabanaru Koyuri (Yellow), Ohisasa Yuki or Sasano Yuki, Ouren (Yo Ren), Ogata Houken, Okarasuri (Karokon), Oguruma (Civil Works Incense), Otsu Samurai (Prevention), Psyllium , Car forage), toucan thistle (Zhengzhou leakage, bald eagle), toucan Mi (coconut palm), toucan cactus, Ovana okera or okera (white moth), Osana squirrel (Banaba), Ooyabaya shabushi "fruit", Ohitake, Tosushi (cereal essence), Omia catechu, Oha hawthorn or Hawthorn Barley (barley), Oka, Okazeri (snake bed), Okra `` fruit '', Oguruma (overturned), Oguri higotai (Zhengzhou leakage, indigo head), Panax ginseng or Tochibaninjin (carrot), Hypericum pertussis Hypericum pertussis (brother cut grass), Odrichospodium (continuous), Onamomi (amberjack), Onigurumi, Onidokoro or Tokoro or Nagadokoro (hikai), Onyogara (Tempa), Onyuri or Sasayuri or Hakatayuri (lily), Onoelan, Ononis (Kibaba), Ominae (defeated soy sauce), Yuuko, Dutch mustard (Lesson), Dutch jellies, Dutch ville, Dutch honey bees, olives `` fruits, seeds, leaves '', oregano, orange `` fruits, pericarps '', silkworms (ripening yellow), cacao `` fruits, pericarps, seeds '', oysters (柿蒂 `` `` Leaf ''), Kagikazura (Katsufuji 鈎), Kakidooshi or Kantori (Lotus herb), oysters, Gaku hydrangea, Cassia, casino oyster (fruit `` fruit ''), gadget (莪 朮), oak (kaki tree, 槲 葉), Cascarilla, Cascaraca grada, Gypsophila, Kasensou, Crab (Kinshato), Kaniwa, Carnation, Cyprus (Valentine Root), Hippopotamus, Hippopotamus, Birch or Fern birch (Bird), Gerbera, Pumpkin, Kapokoki (Seeds), Kahoku salamander蜀椒), cattail (yellow-yellow), chamomile or Roman chamomile, chamomile (weed), cam cam (camo duck), carraguwa or yamagwa (mulberry moth), camo Rara, Carax salmon man, Crows cricket or Cinnamon cucumber (Wang 瓜), Crow Bishaku (Half summer), Oats, Guarana `` seed '', Calahoo (Koh-Pak), Karaya, Garyu, Karin (Kiso), Garcinia, Kawamidori, Kawara psycho ), Kawadisha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawara Nadeshiko (Soba, buckwheat), Kawaraninjin (blue strawberry), Kawara mugwort (茵? 蒿), Kansui (Akansai), Kanzo (licorice), Kantarasa , Candelilla, canto, canna, kanran, raspberry (Ezo strawberry, Dutch strawberry, shrimp strawberry, nava white strawberry, maple strawberry, European raspberry), kiwi `` fruit, leaf '', kikarasuri (guro-root), kyo-kyo (kikyo, bellflower root), chrysanthemum (Chrysanthemum flower, Shimakangiku, Kyakusengiku), Kikutanikugi, Kisage (Kurumi), Gishigishi (Yotei) Root), pheasant (fruit), kizuta, yellow aloe vera, yellowfin mint, quina, linden (shinkona, red linden), quinoa (quinoa), yellowfin (yellow tuna), yellow bean, kimnema sylvestre, kimenakaku, cabbage, cabbage `` unripe fruit '', character Way, cucumber, gyory (Nishikawa willow, deer willow), Kiraja saponaria, Kiraya, Kiransou (golden grass), kumquat `` fruit '', kinkiju, ginsekai, kimbusen, betel, kinzhiki (Sentsukakusa), quinlan, ginlan, kinryohen , Guapeba vermela, guava `` fruit '', guayule, quellus infectria (galling), kukui nuts, kugenumaran, wolfberry (bamboo shoots, coconut leaves, cocoon leaves, husks), kusasugikazura (tenmon winter), kudzu (kudzu), Camphor, gooseberry “fruit”, carrot, yellow flower Titi River, Gardenia (Mountain Reed), Kunugi (Mountain Sow), Kupuas, Kubeba, Kumazasa, Kumatsutsura (Horse Citrus), Clara (Bitter), Cranberry "Fruit", Chestnut "Seeds, Fruits, Astringent Skin", Curkurigo Latifolia "Fruits '', Grapefruit `` fruit / leaves '', buckthorn, black beetle (rescue necessity), tortoise brackish or black beetle or tocotic (prolonged herb), clove (clove, clove), gumbai tuna (sekimei, budgerigar), keigai , Celosia (chicken crown flower, hen crown), gekkavidin, bay bay (laurel wreath), Kenashi Sartorii rose (Tsumago, mountain return), gentiana, ganoderma (old lady grass), kemponashi (kigushi), kokisekoku, kushimikan (kouji, tachibana, Giant mandarin orange, fukumi mandarin, sagamikoji, ponkan, santara (tachibana )), Koshinbara (monthly flower), Kousuihakka, Kozo `` fruit '', Kocha (tea), Kohone (river bone), Kohon (Kakimoto, Karamoto), Koryang, Koryokyo (Koryo), Koendoro `` fruit '' , Kourien (Huo Ren), Koganebana (Yellow Gon), Cowberry (Etsutachibana), Coco `` Fruits '', Goshuyu (Kureo), Gosho Strawberry (Golden Bonsai), Pepper (Pepper), Cosmos, Copaiba Balsam, Coffee `` Seeds, Leaves '', Kofukisarokoshikake (plum infestation), Kobushi or magnolia (hot pepper), burdock (beef bowl, beef eggplant), kobotanru, sesame (sesame seeds), sesame seeds (genus ginseng), trash beetle (gumiko), sakanekazura or binankazura or pine bush, wheat ( Wheat), rice or rice bran “red cocoon, white birch”, rice oil, cola acminata “seed”, cola vera “seed”, coleus forskori, colony llya, koroha “fruit” `` Fruit '', colombo, konzurango, kombu, konjac, comfrey (candid grass), sisal (sisal asa), rhinoceros, sakaneran (ezosakaneran), saxima button eel or cinnabar bud or cinnamon ginseng (weikensen), sakura (oshima cherry, yamazakura, Oyama cherry, Edhigashi, Bean cherry, Miyaza cherry, Yoshino cherry, Takane cherry, Kasumi cherry, Kohigan, Sato cherry, Kanzakura `` Leaf, flowers, fruit, bark (cherry bark) ''), cherry, pomegranate, Sasa, Sasabaginran, Sasanka, Sasiomodaka , Sweet potato, sugar cane, sugar beet, sunflower jujube (acidic vine), saffron (banban flower, west red flower), sapodilla, sapotea mariyo, pomelo `` fruit '', bonito, salmon berry `` fruit '', salamander ginger, salamander Indigo head), Salvia (sage), Sagaki (mountain curd), Sawagurumi (mountain walnut), Sangaku cactus, Sangre de Grado (croton), Sangakuyosou, Sansinjinjin (Thirty-seven ginseng), Sanshuyu Salamander, Sanzukon (Mamezu), Shia (Kalite), Cyanoki (fruit), Shiitake mushroom, Shion (Shigetsu), Shikakumame, Dikitaris, Sikunshi (Amiko), Perilla or Blue-tailed or Chimmento or Catamendizo (Shiyo leaves, Shisoko), Rosewood, Shinanoki, Shinohonoki, Sinarenkyo (ream), Shimeji (Hinshimeji, Shakashimeji, Hatake-Shimeji, Oshiroi-Shimeji, Buna-shimeji, Honjimeshi, Shirotamogitake), Shimokuren (Shigeki), Shimo-gakuso Glaze), Shajin (Shasan), Jasmine (Matsurika), Janohige (Bakumon Winter), Ju Horseradish, Shukukonkamiso, Shukushamitsu (sand seeds, shredded sand), Juzudama, Shuro `` fruit '', Shunran, Jiaoshui, ginger (ginger), Zhoushan hydrangea (Tsuneyama), shobu (bamboo shoot, root), shozu `` fruit '', Shirakashi `` Seeds '', Silane (Bikkyu), White Rooster butterfly `` Seeds '', White clover (Clover), White clover (chicken bone grass), White squirrels (Nioiris), Shirobanatsuta `` Flowers '', Shirobanarupin, Shirominanten (Southern fruit), Cinchona Sacylbra, Ginkgo biloba (Mizuka, Mika, Shencho), Cinnamon, Cinnamomum cassia (Cinnamon), Watermelon (Sairan), Honeysuckle (Gin silver flower, Shinobi), Sorrel (Acid), Swimberry "fruit", Star apple , Stevia, Strawberry `` fruit '', Suzu-Psycho (Xucho), Sugina (question), Subhihiyu ( Toothpaste, Horse Teeth), Plum `` fruit '', Sulgaran (Oran), Japanese red pine `` Conifer '', Japanese larch, Japanese cypress, Japanese walnut, Japanese hawthorn, Japanese cypress, Japanese dandelion, Japanese horse chestnut (Maroni) Pear `` Fruit '', Eurythus, Elder, Prunus (Juniper, Juniper), Achillea millefol (milfoil), Rose, Pteropus, Mistletoe, Atlantic mint or Papilio, Horseradish, Sekisho (Ishizone), Sekkoku (Sakura Sekkoku, Koki Sekkoku, Obanase Sekkoku, Okinawa Sekkoku, Honsekoku, Kocho Sekkoku, Shika Sekkokuk, Kibanano Sekkoku) (Dendrobium, Shiso), Cedron ), Mallow, Senegal, seri, celery, nematode (river cucumber), senshinren (centripetal ream), sendan, sennin cactus, senna `` fruit, leaf '', sennin (Otsuka), senburi (this drug), senboku , Sowka (grass), Elephant burrow, Sobain baibai, buckwheat `` seed '', Somer potato, broad bean, Daio (daihuang), Japanese radish, soybean, Daidai (orange peel, fruit), Takasagorihigotai (Southeast indigo sashimi), Takasaburo (旱) Lotus), Takatodai (Otsuka), Takarabi (Kashiwaji), dark sweet cherry `` fruit '', hollyhock, hollyhock (thyme, Hyakuka), tachidokoro (hikai), tachiyanagi, tamarind `` seed '', onion, ramshiba (hot pepper) ), Taranoki `` fruit, leaves, root bark '', tarayo (large leaf winter blue, one leaf tea, bitter tea, bitter tea), dahlia (tenji button), tarwi, Nikirimame, tanshichiwa, tanjin (dansang), dandelion (Sanko) or Shirobana dandelion or mouko dandelion, danmaru, cherry `` fruit '', chigaya `` fruit, root, bud '', chikutsuninjin (bamboo ginseng), chicory, chancapiedra (kidachi) (Komikansou), tulip, chokonostay, dungeon thistle (artichoke), ginkgo biloba (large yellow), ginseng (蕪 夷), ginseng (leaf), choreimaitake (bamboo), chorogi, tsukimisakane, tsukushikananeran, tsukuritake ( Mushrooms), camellia, camellia, camellia, clover (lacquered weed), camellia (duck weed), cranberries (red azuki beans), periwinkle, crested duck (what neck rice cake), tuna (apricot apricot), clove carrot (four leaf ginseng), cirrus, Tsuwabuki, Deiko, Teuchigurumi, Duberry "fruit", Tengusa, Tencha (bamboo tea), Tendai-yaku (glaze), Toga (winter lion), Toka moth, pepper, (Toban), Toki (Tokai), Tokinsenka (marigold), Toukachichi, Tounabena (river cut), corn Or corn hair (south cocoon hair), horned potato (Sadako), Torindo or Kyakusen Gindou (dragon gall), Tokusa (wood band), dokudami (ten medicines), Tokon (gush roots), toshi or bean pods `` Bark, leaves, roots ''), ash (crust), tomato, tragacanth, triacanthus `` seed '', truffles (carp), eustoma, tormentilla, dronoki, trorooi, tongamame, nigerian berry `` fruit '', Chinese yam or Yamanoimo (Yakuyaku), Nagiikada (Butcher Bloom), Naginata Koju, Nazuna, Rapeseed, Na Beans or vertical blades (sword beans), Natsumikan, jujube (Otsuchi), Naniwaibara (Golden Sakurako), Nabena (continuous), Nameko, peanuts (peanuts), Nanten (Southern fruit), Nanban ramie (Sanma), Niois violet, Nigaki (bitter tree), sagebrush (bitter melon), nutmeg, Kay or Nikkei or Ceylon Nikkei or Yab Nikkei (Kinshie) or Keishi (Katsura branch), nymph plover, leek (lion), elderberry (bone, `` fruit, flower, stem ``, Leaves ''), garlic (large coral), nurde (penta), leek, nemno or nebu or nebi or nemlinoki or digokubana (community), noamis (large cormorant), neubara (fruit), nousenkazura (Lyoen flower), nogateto, yarrow, Nodake (frontal cucumber), wild rose, peach, pineapple `` fruit '', hibiscus (bushroom, furinbusuuge, roselle), hailindou, hauchiwa, pau do , Hakama Labosi (bone crushing), Hakukayumatou, Hakusanchidori, Hakusen (white ring skin), Hakulberry `` fruit '', Hakobe (breeding), hazel (coconut), Hashiridokoro (roth root), basil, lotus (lotus, lotus meat, (Renko), parsley (Netherlands jellies), hadakamugi, batata, wasp or madake (bamboo shoots), patchouli, mint (thin load, thin load leaf), pepper bean, pearl barley (yokuinin), hanasuge (knowing mother), banana, hanahakka, hanabishi ( (Shitsuri, Shitsutsuri), Vanilla Bins, Papaya, Hakogakusa, Pahalobobo, Hub `` Whole Grass, Stem, Leaves '', Paprika, Hamakakiran, Hamago or Mitsubahamago (Vulgaris), Hamasuge (Incense Binder), Hamabishi ( Situation), Hermanus (Maika), Hamabou Fu (beach wind), Hamelis, Palm, Rose (Rose), Balata, Balata rubber tree, Haratake (Harata) , White-faced agaric, Ukimori no Kasa), Haran, Pariurus (Haricus japonicus), Parietalia, Harkanran, Balsamina (Tsurureishi, Nigauri), Haruni (Skin, Shirakaba, Saba), Barbasco, Harindou, Handaikai ), Breadfruit, giant eagle (dried), chickweed carrot (participant), pecan nuts, ganbanana (stone wall, vine rosacea), hygurumadaria, higotai, shinki (rhizomi), pistachio, beet, human camellia (stone wall), Hitosumenida, Daisies (Daisy), Hinata Taikozuchi (Cow Knee), Japanese Plover, Hinoki, Hiba, Castor, Sunflower, Pepper, Himeuzu (Tempo), Himematsu (Kaori), Himematsutake (Kawariharatake, Hiromatsutake), Himetakeran "Fruits", peanuts, beakkyu, hyu "fruits", chickpeas, hira Meow, Bellows oyster, Hirohaokinagusa (bald eagle), loquat "fruits, leaves, stems", betel nuts (large clothes, coconut), Pu'er tea (Fuyu tea), Futsukazura (south rattan), fuki, squirrel dandelion , Fuji Fubakama (Orchid), Fuji Bean (Tanzu), Fujimodoki (Chojizakura, Spike), Grapes `` Fruits, Pericarp, Seeds, Leaves '', Beech, Fuyushinatsusatake (Chinese Cordyceps), Brazilian Licorice, Brazilian Carrot, Brazil palm, Brazilian elephant palm, black currant `` fruit '', blackberry, brunnen, plum `` fruit '', fullceraria, blueberry (Prunus japonica), prune, floral blanka, blond psyllium, bundo (mung bean), hazelnut, loofah , Hetsukaran, safflower (Safflower), Henken, Belladonna, Berry "fruit", Percea, Pell Amberg, Pereschia grandifolia, red beetle or duckweed (scenic sky), boysenberry `` fruit '', broom or elder or nendo or hahagigi kokia (silk), horsiran, larva (daffodil, acute pupa, peony) Powteria sapota, Powteria rukuma, spinach, spinach, physalis (Torune), honoki (Japanese folk magnolia, pak), bokeh (wooden moss), hosoba aragiku (bitter moth), hosobaoguruma, hosobanaokera (蒼朮), Kageten 37), Hosobabarengiku, Bodaiju (bamboo tree), buttons (peony `` flowers, leaves, stems, bark ''), button pi (peony skin), hops, jojoba, borage (Lulichisha), Bordeaux, white berry `` fruit ”, Hononiku (meat jugo, Daige), Honsecek (iron skin stone, sparrow mountain stone 斛), Mizul Tennan Show (Tennan star), Maitake (Maiko), Maou (mao), Maca, Macadamia nuts, Margaret (Mokushungiku), Macri (Marine grass), Magwa (mulberry bark `` bark, leaf ''), Magnolia sprenger, Masalan saba, Masaransuba de Seara, Masheira de Boi, Mashua (Tamanozen Hallen, Kyukonkinrenka), Matatabi (Tenten-don), Matsukasa, Pine “Leaf, Bark, Root”, Matta Oryo, Matsutake (matsutake), Matsuhodo (茯苓) , Matico (Cordon Schijo), Mayoram (Hanahakka), Malvano Jazine (Bitter), Mulberry `` Fruit '', Quince, Malene (Bilaud Muzuka), Mango, Mangosteen, Manzanya (Andesca Mitsule), Manshugurumi, Mandarin `` Fruit '', Mannentake (Ganoderma lucidum), pheasant (fruit berries), Mishima Saiko (Shibako), Mizuoboba or Japanese morning glory (long-tailed grass), Mizokakushi (half-sided lotus), Misohagi (Chinese rape), Japanese willow or elderflower (Henpotsu), Japanese oak, Japanese honeybee, Midorisapote, Green mint, Mimosa, Myoga, Miracle fruit "fruit", Myrrh, Milobaran , Wheat straw, mugweed, mugwort, mugwort (prolonged skin), munya, murasaki (purple root), murasakiki kibu or omura sakikibu (purple pearl), murasaki corn, murasaki kinafuji (Kunming chicken blood wisteria), megakansa opuntica, mesima cob (Mulberry yellow), Mejijiki (beneficial mother grass), Mebougi, Japanese primrose (Evening primrose), Melaleuca, Melissa, Merirot, Melon `` Fruit '', Moukomugigi, Mosouchiku, Mokukirin, Mogi (Pepper), Mochinoki, Mokko (wooden incense), Momijiba Daio, peach (peach "leaves, seeds, flowers, fruit"), coconut, more Cherry `` fruit '', Morohaya (burlap), Yakawa Murasaki potato, Yakuchi (masashi), Yakuyo garage, cornflower (cornflower), cornflower mint, yacon, yaba santa, yashabushi or himeyamashabushi or oyabaya sabushi '', Willow willow, starfish (octagonal gold plate), mistletoe (willow parasitism), willow (kawa willow, holly willow, weeping willow, red willow, cat willow, incolyana, kinu willow, koryanagi, unryu willow, palm, willow, willow (Village willow, Dronoki), Willow tree `` leaves, stems '', Yaba Santa, Yabugarashi, Yabukouji (purple gold beef), Yabu tobacco (Tsuruga, Tenmeisei), pokeweed (commercial land), Yamadoritake (Bortini, Cep, Steinpilz), Yamahan Japanese yam, Japanese yam, Japanese mugwort, Eucalyptus, Yukinoshita (tiger ear grass), Yucca or flevifolia, Yuzu `` fruit '', Lily, Yoroigusa, Mugwort (lily leaf), Ligan (Thunder circle), Lime (fruit) `` Rye, Lacanca `` Fruit '', Raspberry `` Leaf, Fruit '', Latania (Clamelia), Lackey or Shallot (Purple), Lavender, Longan (Dagan), Agave (Aonogave agave, Fuchrin agave), Ryokucha (green tea), Apple `` Fruits, seeds, leaves, roots '', gentian, lubas or suabishimusu (Suzuro), rulitama thisami (urajiro higotai, shinjiai sashimi), litchi (toothpick, toothpick core), lettuce (tissue), red currant `` fruit ”, Red Pitaya, Lemon“ Fruit ”, Lemongrass, Forsythia or Chinese Forsythia (Region), Forsythia, Wintersweet ( (Waume), wax palm, locon (yoshi, sone), Logan berry `` fruit '', rosemary (mannenrou), rose hip (novara), wasabi, stag beetle (mongjang flower), walmocow (earthen) etc. .

  As seaweeds, seaweed [Green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usba aonori, Sugiaonori, Hiraaoori, Boaonori, Hosoeda Aonori), Anaaosa (Aosa)] (Macombu, Resilibu, Hosocome, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis Integrifolia, Neocitus Ruetkeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Umiuchiwa, Akaba Umiuchiwa, Konami Uchiwa, Okinawa Uchiwa, Usuki Uchiwa, Etsumi Uchiwa], seaweed [Red algae: Hijirimen, Maca (Tengusa), Hiraksa, Syria, Oaxa Caterpillar, Yatabegusa, Yuukiri, Shimatengusa, Tosakanori, Togekirinsai, Amakusakirinsai, Giraffe, Juniper ginkgo rhinoceros, Tsunomata, Totsuka (Yahazutsu notamata), Ezotsunotamata, Togetu no Takita , Yaleus banori, Kagius banori, Susius banori, Haius banori, Akamo mizunori] and the like.

  In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kuwanomimo: Kuwanomimo, Volbox: Ohigegawa, Volbox, Palmera, Yotsumeo, Aomido: Chrysanthemum, Aoumidro, Tirguimidro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa Magama genus: Magamata, Iwagata: Fusaikawa, Surichogata, Heraiwata, Kurokita, Hanemo, Genus: Mill, Chromel, Sakibutimil, Nagamil, Hira Lemon, Casanori genus: Casanori, Jusmo genus: Jujusmo, Tamajusmo, Mizojuzumo, Mika ヅ kimo, Korekaete, Tsutsumimo genus: Kyukougusa, Hitogususa genus: Humanegusa, Hirohatohigususa, Umushihimoe, Sakikimoe Sumiremo: Sumiremo, Hoshimamidro, Fushinashimidoro etc.).

  Cyanobacteria (Suizenjinori: Suizinori, Aoko, Nenju: Kawatake, Ishijelly, Hassai, Yuremo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Iaciasio), etc.

  Brown alga Sanadagusa: Sanadagusa, Fukurimamiji, Commongusa: Commongusa, Yahazugusa: Ezoyahaz, Yahazugusa, Uraboshiyahaz, Jigamusa: Jigmygusa, Umichiwagusa, Umamisakugakua, Hakusou : Navarimo, Chasomen genus: Motsuki Chasomen, Matsumo genus: Matsumo, Nagamatsumo genus: Nagamatsumo, Okinawa mozuku: Okinawa mozuku, fake Tomozuku: Niseft Mozuku, Futomozuku: Futomozuku, Ishimozuku: Ishimozuku, Kuromo: Kuromo, Nisemozuku: Nisemozuku, Mozuku: Mozuku, Ishige: Ishige, Iroro, Ichimosa: Ichimegasa Umibosu, Urushigusu: Urushigusa, Keurushigusa, Tobaccogusa, Composita: Composita, Haberodomo: Haberodoki, Havanori: Habanori, Habanori: Habanori, Commonbukuro, Ezobukuro, Ezobukuro Chishima fukuronori genus: Chishima fukuronori, Kagomenori genus: Kagomenori, Muraridori genus: Murachidori, shark genus: shark zusa, genus genus: lobster, genus genus: yokojimamanori, Ganoderma genus: cynomolgus, fennel spider: fennel spider, vine genus: turmo, turtle genus: sea turtle, scorpion genus: sujime, misji kumbu genus: misji kumbu, atsuba misji kumbu, kumbu genus: tsutsugara kumbu, oyster kumbu, onikombu, gakonbubu Barracuda, Trollocombu: Trollocombu, Antokume: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikombu: Kikuishicombu, Nejikcombu: Nejicombu, Kuroshiome: Kuroshiome, Nekoshikonbu, Aramei Genus: Ainuwakame, Chigaiso, Oniwakame Ezoi Shige: Ezoi Shige, Yabane Moku: Yabane Moku, Rappa Moku: Rappa Moku, Joromoku: Ugano Moku, Jo Lomoku, Hiemoku, Honda Walla: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yatsumata Moku, Umitora no Moku, Fushishimoku, Mohmokumoku, Hahamokumoku , Ukimo: Ouokimo, Burukimo: Burukimo, Kayamonori: Kayamonori, etc.).

  Red algae Genus: Sea urchins, Tsukumonori, Anemone crickets, Astragalus, Amaranthus, Amaranthus, Agaricata Genus: Tamaitadaki, Kaikekenori Genus: Kaginori, Kaikekenori, Tengusa: Himetengususa, Hytengususa, Oobusa, Nambugu , Kohira, Yohira, Kinukusa, Hibirodo: Hibirodo, Himebiro, Isomumedo: Isommedo, Aedes: Rhizome, Ryumons: Ryumon, Ranunculaceae, Nisekare Naminohana: Hosobanaminohana, Naminohana, Sangomodoki: Ragaramomodoki, Shiogusagoromo: Shiogusagoromo, Iwanokawa: Etsukiiwanawa, Kinokawa: Kinokawa, Kanonote, Sangori Kyono Shiro, Sakuranori, Nikumukade, Tambanori, Tsurutsuru, Fudarak, Marubahdarak, Isonohana: Nurakusa, Ronulaksa, Oomkadenori, Hirakintoki: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Rice, Tokamatsu, Hitomatsu, Fushikintoki, Tsunomude, Nagakinito, Crayfish Nagaobane: Naganobane, Funori genus: Hanafonori, Fukurofunori, Mafunori, Karekigusa: Karekigusa, Tosakamodoki: Hosobanatosakamodoki, Hironotosakamodoki, Yatsudegatatosakamodoki, Kurotosakamodokisane, Zotosofomoza Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hana Tacarimenia, Hoonoo: Honoo, Hikagenoit: Hikagenoit, Usuginu, Nikuhounoo: Nikuhounoo, Venus nago, Venus nago, Susca veni: Suscabeni, Okarugusa: Yamadagusa, Mirin: Mirin, Hosokamiso , Isomocca genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagibaranori, Kojinoo: Kizino-o, Isodantsu: Isodantsu, Atsubanori: Atsubanori, Ogonori, Ogonori, Ogori Mizo-okonori, birch, beniogonori, fukureshinori, purple birch, shinkaibanori, spruce birch, kataogonori, ryukyuogono Li, Atlantic scorpion, Ivy genus, Yumigataonori, Kubireogonori, Mosagogonori, Kinubanori, Amanita genus: Hachijotensamodoki, Fushikenori genus: Fushikenori, Namiiwatake, Nymphalanthus Itagususa, Saimi, Hari, Lotus Jigusa: Lotus Jigusa, Sugi nori: Ikanoashi, Hosoibonori, Nobonori, Black Haginansou Genus: gourd, cherries, octopus: octopus, sedge, genus: genus, genus: goat, dals : Dulse, Scorpionus, Anadalus, Weibusa: Uebusca, Benifronori: Benifuronori, Fusunagi: Futsutsunagi, Himefusunagi, Hirohafushitsugi, Otsunagisou, Hirawatagigi, Usuwasugi , Egonori: Egonori, Futogigi, Saeda: Saeda, Chirimomiji: Chirimomiji, Konohori family: Habutaenori, Konohori, Suzuronori, Usubeni: Genus: Kagios banori, Yareus banori, Susius banori, Heius banori, Usubanorimodoki: Usubanorimodoki, Ayanishiki genus: Ayani Genus: Aeginu, Dadia: Enasidadia, Shimadadia: Isohagi, Shimadadia, Dajimodoki: Dajimodoki, Euglena: Morayogusa, Fuyugusa, Makuri: Makri, Yanaginogi, Yuna, Yukinagina , Sasabayanaginori, Sozo genus: Kurosozo, Kobsozo, Hanesozo, Sozonohana, Hanegusa genus: Hananegusa, Hananegusa, Kozanemo genus: Kozanemo, Isomurasaki, Hosozozanemo, Himegoshigusu, Giant genus Isomagusa, Suginasugusa: Suginasusa, Isobasho: Isobasho, Fujimatsumo: Fujimatsumo, Sawweed: Haezaki Sawflower, Kawamoku : Kawamoke, Aokawa Mozuku, Himekawa Mozuku, Ideyugogome: Ideyugogome, Okichimozuku: Okichizu, Otosa, Chinomo: Chinomo, Chisujinori, Chisujinori, etc.).

  Axial algae (Shajikumo, Shiratamamo, Hoshitsurimo: Hoshitsurimo, Rikunotumusu, Flaskmo: Himebumo, Chaboflasmo, Tripera, etc.), yellow algae (Hikarimo: Hikarimo, etc.), etc.

  In addition, the materials derived from animal materials include chicken crown extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposition product thereof, cow or pig brain tissue Extracts, cattle / pigs / fish collagen hydrolyzate (acid, alkali, enzyme etc.) degradation products, water-soluble collagen or collagen derivatives such as acylated collagen, cattle / pigs / fish elastin or elastin hydrolyzate (acid, Alkali, enzyme, etc.) or water-soluble elastin derivative, wool or feather keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or cow blood cell protein degradation product (globin peptide), cow Or porcine hemoglobin degradation product (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its degradation products or derivatives thereof, skim milk powder and its Hydrolyzate or a derivative thereof, lactoferrin or a degradation product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.

  In addition, as a material derived from a plant or animal material, any site, cell, tissue, organ, metabolite, etc. derived from a gene recombinant or a cell fusion can be used. Furthermore, for example, an undifferentiated cell group, a cell group in the middle of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can also be used.

(14) Marine components Seawater such as deep seawater, for example, sea salt, dried seawater, inorganic salt (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (from the Dead Sea or Atlantic Ocean) Fango), for example, Italian mud, German fungo, Eifelfango, Freiburg fungo, etc. Sea mud or mud from various locations (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, Magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, black meteorite, etc.

(15) Microbial culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermentation extract , Fermented rice bran (red rice bran, white birch) extract, Euglena extract or decomposition product thereof or water-soluble derivative thereof, trehalose or derivative thereof, lactic acid fermentation product of raw milk or skim milk powder, fermented lactic acid bacteria of legumes, coconut plant Lactic acid bacteria fermented products.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, Bengala, black iron oxide, gunjo, chromium oxide, chromium hydroxide, carbon black, calamine, etc.

(18) UV absorber / blocker benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxy Dimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, Octyl paradimethylaminobenzoate), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxycinnamic acid cinnamate) Til, sodium paramethoxycinnamate, potassium paramethoxycinnamate, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, Methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives , Camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative Body, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin etc.

(19) Whitening agent Paraaminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative, Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, Shikonin, baicalin, baicalein, berberine, placenta extract, ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, vitamin E or a derivative thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camille, mulberry, gardenia, pearl oyster, clam, clam, mugwort, honeysuckle) , Kihada, dokudami, matsuhod, pearl barley, nettle, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankaishi, hamamelis, karagua or yamagwa, life-prolonging grass, bellflower, toshishi, zetsugo, gyu, mao, sen Oxalic, Dokkatsu, Psycho, storm, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.

(21) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether).

(22) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, ganoderma extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe, Ogon, Japanese horsetail, Gentian, Burdock, Shikon, Carrot, Camelis, Hop, Yokuinin, Odori, Semburi, Japanese cypress, Japanese red snapper, Achacha, Hypericum, Cucumber, Necklace, Mannenrou, Parsley).

(23) Astringents Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds) and the like.

(24) Active oxygen scavenger
SOD, catalase, glutathione peroxidase and the like.

(25) Antioxidants Vitamin C or salts thereof, stearic acid ester, vitamin E or derivatives thereof, nordihydrogua cetelenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole , Propyl gallate, sesamol, sesamorin, gossypol, propolis, etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame culture cell, hamcha, hypericum, hamamelis, clove, melissa, birch, birch, salvia, mannenro, minamitenji, agetsu, ginkgo, green tea).

(27) Anti-inflammatory agents Allantoin, azulene, guaiazulene, camazulene, ictamol, indomethacin, ε-aminocaproic acid, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, malein Acid chlorpheniramine, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract, propolis, etc.

(28) Antibacterial / bactericidal / disinfectant Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, Sarashi flour, iodine compound, iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, resorcin, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, 2 , 2,4-Trichloro-2-hydroxyphenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halo Carban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (Polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (brominated Cetyltrimethylammonium, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, briria Togreen, Malachite Green, Crystal Violet, Jamal, Photosensitive Element 101, Photosensitive Element 201, Photosensitive Element 401, N-Long Chain Acyl Basic Amino Acid Derivatives and Acid Additive Salts, Zinc Oxide, Hinokitiol, Kudin, Propolis, etc. .

(29) Moisturizer Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprycapric acid, glycolic acid (α-hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or Derivatives or chitosan derivatives, pyrrolidone carboxylic acid or salts thereof, sodium lactate, urea, sorbitol, amino acids or derivatives thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine , Cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine and their sulfates Phosphate, nitrate, citrate, or pyrrolidone carboxylic acid), oils and fats “Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil , Cucumber oil, beef tallow fatty acid, quince seed oil, cucumber seed oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil , Peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, molasses, coconut oil, eucalyptus oil, beef tallow, squalene, squalane, pristane or hydrogenated products of these oils and fats ( Hardened oil) ”, waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lath Norin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax), natto bacteria metabolites, natto extract, silk fiber extract, plant extract (Akamatsu sap, aloe, kudzu, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, birch or birch sap, assembly, mulberry white skin, birch leaf, loofah, peony skin, persimmon) and the like.

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (eg, gongoid, hypericum, clara, mulberry leaves, keihi, genokosho, comfrey, salvia, elderberry, bodaiju, button pie), seaweed extract and the like.

(31) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castari tincture, pepper tincture, pepper tincture, quinine hydrochloride, strong ammonia water, potassium bromate, sodium bromate, thio Glycolic acid and the like.

(32) Antiandrogens Follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, etc.

(33) Peripheral vascular blood flow promoter Vitamin E or derivatives thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitive element 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.

(36) Antiseborrheic agent Pyridoxine or its derivatives, sulfur, salicylic acid, resorcin, vitamin B6, benzalkonium chloride, benzethonium chloride, halocarban, 2,4,4-trichloro-2-hydroxyphenol, and the like.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea and the like.

(38) Oxidizing agent Hydrogen peroxide water, formic acid, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrophosphate peroxide Sodium phosphate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(39) Hair remover Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate) Strontium thioglycolate) and the like.

(40) Hair swelling agents such as ethanolamine, urea and guanidine.

(41) Dye agent
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, para Nitroorthophenylenediamine, paraphenylenediamine, paramethylamino Phenol, picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N -Phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diamino sulfate Diphenylamine, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, parasulfate sulfate Methylaminophenol, metaaminosulfate Diol, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfone Sodium acid, hematein, etc.

(42) Fragrance Natural animal fragrance such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, Cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, Otsuka perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, trout balsam essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, persimmon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot Spirit , Peru balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary (mannenrou) essential oil, Japanese mint mint essential oil Other synthetic fragrances.

(43) Dye and Colorant Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Amber Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye, Onion Dye , Tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin etc.

(44) Sweeteners Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract and the like.

(45) Nutritional enhancer Shell-calcined calcium, cyanocolabamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.

(46) Dairy products Milk, cheese, fresh cream, butter, margarine, powdered milk, whey, condensed milk, etc.

(44) Others Hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antibacterial agents, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animal and vegetable polysaccharides And its degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound treatment agents, foam increasing agents, thickeners, enzymes, purified water (electronic Water, small clustering, etc.), oral preparations, deodorizing / deodorizing agents, bittering agents, seasonings, etc., and in combination with these, additive or synergistic effects of the present invention or other cosmetic effects Improvement can be expected.

[Test 1] PPAR activation effect test The test was performed using the PPARβ / δ activation measurement method by luciferase activity.
(Method)
HeLa cells (derived from human / cervical cancer) are seeded in a 24-well plate and incubated at 37 ° C. After 24 hours, a reporter vector incorporating a PPARβ / δ binding base sequence, a firefly luciferase reporter vector, and a Renilla luciferase reporter vector as an internal standard were introduced into HeLa cells by lipofection.
After 3 hours, a compound as an active ingredient of the product of the present invention adjusted to a final concentration of 50, 100 μM was added. After 24 hours, the cell contents were extracted, and the luciferase activity of the cell extract was measured. The value obtained by dividing the measured value of firefly luciferase by the measured value of Renilla luciferase was defined as the expression level of PPARβ / δ per cell. The activation fold was calculated from <Formula 1> when the control solvent addition group (control) was 1, and was designated as PPARβ / δ activation effect. The results are shown in <Table 1>.

<Equation 1> Activation multiple (fold) = (expression amount of test solution / expression amount of control)

<Table 1>

(Test results)
As shown in Table 1, an excellent PPARβ / δ activating effect was observed for N-acetylcysteine, senecifylline, sulfretin, chalcone, resveratrol, ceramide, ololopain, magnolol, silybin, and phloretin of the present invention. Therefore, it is considered that the product of the present invention is useful as a PPAR activation agent.

[Test 2] Skin barrier function improving effect test The amount of water transpiration and keratin water retention ability were measured and the keratin state was observed, and the skin barrier function improving action of the product of the present invention was evaluated.
(Method)
Hairless mice (♀, 5week) were acclimatized for 1 week. Food and water were freely consumed. It was divided into 3 groups: a) control, b) blank, c) test substance administration, and n = 3. Prior to the test, the amount of water transpiration and keratin water retention capacity of the test animals were measured and the keratinous state was observed (day 0).
100% DMSO 0.1 mL was applied once a day from the back neck of the animal other than the blank to the buttocks (3 × 5 cm ² ). After several days of DMSO application, the formation of scales and desquamation, an increase in transepidermal water transpiration, and a decrease in the ability to retain keratinous water were observed.
Application of the compound, which is an active ingredient of the product of the present invention, adjusted to 50 μM was started from the next day after confirming the “rough skin condition”. It was applied once a day. Two weeks after confirming the “rough skin condition”, transepidermal water transpiration (TEWL), keratin water retention ability (impedance) were measured, and keratin condition was observed (day 14). The stratum corneum was observed visually according to the following criteria, and the average value was calculated. The results are shown in Table 2.

(Evaluation criteria for stratum corneum)
Score Score criteria
-------------------------------------------------- --------------
1 Skin groove, disappearance of skin hills, and widening of the stratum corneum are observed.
2 The skin groove and skin are unclear and the stratum corneum is turned up.
3 Skin grooves and hills are observed, but flat.
4 Clear skins and skins 5 Clear skins and skins.

<Table 2>

(Test results)
As shown in Table 2, by applying N-acetylcysteine, senecifylline, sulfetin, chalcone, resveratrol, ceramide, ololopain, magnolol, silybin, and phloretin of the present invention, the transepidermal water transpiration amount is reduced, and the keratin water retention ability is reduced. It was found to show recovery. Furthermore, improvement in the keratinous state was also observed, and it was confirmed that the product of the present invention has an action of improving the skin barrier function.

(Manufacturing example) Manufacture of various skin external preparation compositions According to the above evaluation results, the following formulation examples are shown. It was. The present invention is not limited to these.

(Formulation Example 1) Milk Mass%
1.Squalane 5.0
2.Olive oil 5.0
3. Jojoba oil 5.0
4.Cetyl alcohol 1.5
5. Glycerin monostearate 2.0
6.Polyoxyethylene (20) cetyl ether 3.0
7. Polyoxyethylene (20) soorbitan monooleate 2.0
8.1,3-Butylene glycol 1.0
9.Glycerin 2.0
10. A: N-acetylcysteine B: Senecifylline C: Sulfretin D: Chalcone E: Resveratrol F: C6 ceramide G: C16 ceramide H: C16 ceramide-O-glucoside I: Magnolol J: Silybin K: Phloretin * A ~ Any one compound of K 0.1
11. Preservative (paraoxybenzoic acid ester) appropriate amount
12.Perfume appropriate amount
13. Residue with 100 purified water

(Formulation Example 2) Milk Mass%
1. Squalane 8.0
2. Jojoba oil 7.0
3.Glyceryl paraaminobenzoate 1.0
4.ethyl urocanate 1.0
5. Vitamin C phosphate magnesium salt 1.0
6.Cetyl alcohol 1.5
7. Glycerin monostearate 2.0
8.Polyoxyethylene (20) cetyl ether 3.0
9.Polyoxyethylene (20) soorbitan monooleate 2.0
10.1,3-Butylene glycol 1.0
11.Glycerin 2.0
12.1,2-Pentanediol 3.0
13.C16 Ceramide 1.0
14.Magnolol 0.5
15. Murasaki root 50% propylene glycol extract 1.0
16. Silk Protein Enzyme Decomposition Solution 1.0
17. Pig placenta water extract 1.0
18. Antibacterial and antiseptic (paraoxybenzoic acid ester) appropriate amount
19.Residue with 100 purified water

(Formulation Example 3) Cosmetic Oil Mass%
1.liquid paraffin 30.0
2.Squalane 20.0
3.Olive oil 20.0
4.Isopropyl palmitate 10.0
5. Chalcone 0.3
6. Grapefruit fruit or leaf hot water extract 1.0
7. Tochu Nakaba Hot Water Extract 1.0
8. Soybean seed hot water extract 1.0
9.Olive oil 1.0
10. Shea fat 1.0
11.Butylhydroxyanisole 0.1
12. Vitamin E derivative 0.1
13. Antibacterial and antiseptic (benzalkonium chloride) appropriate amount
14. Fragrance (rose water) appropriate amount
15. Residue with 100 purified water

(Formulation example 4) Flexible lotion mass%
1.Glycerin 5.0
2.1,3-Butylene glycol 5.0
3.Polyoxyethylene sorbitan monolaurate (20E.O) 1.0
4.Ethanol 15.0
5. C6 Ceramide 0.5
6. Bodhi tree flower or fruit 50% 1,3-butylene glycol extract 1.0
7. Eggplant 30% ethanol extract 1.0
8.Yamakatsu peel or fruit 30% 1,2-pentanediol extract 1.0
9. Kiwi fruit 50% ethanol extract 1.0
10. Antibacterial (Lactoferrin solution) appropriate amount
11. Antibacterial / preservative (paraoxybenzoic acid ester) appropriate amount
12. Fragrance (Western light water) appropriate amount
13. Residue with 100 purified water

(Formulation Example 5) Astringent lotion
1.Sorbit 2.0
2.POE (20) oleyl alcohol 1.0
3.Ethanol 15.0
4.1,2-Pentanediol 3.0
5.Silybin 0.2
6. Gentian whole plant 50% ethanol extract 2.0
7. Clam leaf or bark 50% 1,3-butylene glycol extract 1.0
8. Japanese yam peel or fruit 30% ethanol extract 1.0
9. Cucumber fruit 50% propylene glycol extract 1.0
10. Yeast 50% 1,3-butylene glycol extract 1.0
11.Allantoin 0.2
12. Astringent (Zinc Sulfocolate) 0.2
13. Antibacterial and antiseptic (thiamin lauryl sulfate) appropriate amount
14. Fragrance (lavender water) appropriate amount
15. Residue with 100 purified water

(Prescription Example 6) Two-layer lotion (liquid to liquid type)
1. Squalane 8.0
2.POE sorbitan tetraoleate 0.3
3. Sorbitol 1.0
4.Ethanol 15.0
5.C16 Ceramide-O-Glucoside 1.0
6. Acacia rhizome or root bark 50% propylene glycol extract 2.0
7. Green tea leaf or stem 50% 1,3-butylene glycol extract 2.0
8. Sage whole plant 50% ethanol extract 1.0
9. Western bodhi tree flower or fruit 30% ethanol extract 1.0
10.Ascorbic acid glucoside 0.2
11. Astringent (calamine) 0.1
12. Antibacterial / preservative (phenoxyethanol)
13. Perfume (apple water) appropriate amount
14. Residue with 100 purified water

(Formulation example 7) Carmine lotion (liquid to solid type)
1.Glycerin 3.0
2.1,3-Butylene glycol 5.0
3.Ethanol 15.0
4. Iron oxide (Bengara) 0.2
5.Zinc oxide 0.5
6.Kaolin 2.0
7.Magnolol 0.5
8. Shark root 50% propylene glycol extract 2.0
9. Usvenia mallow flower or leaf 50% propylene glycol extract 2.0
10. Chamomile flower 50% propylene glycol extract 2.0
11. Comfrey leaves and stems 50% ethanol extract 1.0
12. Fuquitan poppo flower or leaf 50% 1,3-butylene glycol extract 1.0
13. Porcine placenta enzymatic degradation solution 1.0
14. Silk protein alkaline solution 2.0
15.Camphor 0.2
16.Phenol 0.03
17. Antibacterial / preservative (photosensitive element 201 & 401)
18. Fragrance (Bodhi Tree Water) Appropriate amount
19.Residue with 100 purified water

(Formulation example 8) Pack mass%
1.Polyvinyl alcohol 15.0
2.Carboxymethylcellulose sodium 5.0
3.Propylene glycol 3.0
4.Ethanol 10.0
5. A: N-acetylcysteine B: Senesiphyllin C: Sulfretin D: Chalcone E: Resveratrol F: C6 Ceramide G: C16 Ceramide H: C16 Ceramide-O-Glucoside I: Magnolol J: Silybin K: Phloretin * A ~ Any one compound of K 0.5
6. Ginseng root 30% ethanol extract 1.0
7. Stem or leaf 30% ethanol extract 1.0
8. Wenzhou tangerine peel 50% 1,3-butylene glycol extract 1.0
9.Green tea leaf hot water extract 1.0
10.Peach leaf hot water extract 1.0
11. Yeast 50% 1,3-butylene glycol extract 1.0
12. Pig placenta hot water extract 1.0
13. Antibacterial and antiseptic (paraoxybenzoic acid ester) appropriate amount
14. Fragrance (rose water) appropriate amount
15. Residue with 100 purified water

(Formulation example 9) Peel-off pack mass%
1.Glycerin 5.0
2.Propylene glycol 4.0
3.Polyvinyl alcohol 15.0
4.Ethanol 8.0
5.Polyoxyethylene glycol 1.0
6. Pantothenyl ethyl ether 1.0
7.Sulfletin 0.1
8. Dutch jelly (parsley) leaves or stems 50% ethanol extract 1.0
9. Eucalyptus leaf or stem 30% ethanol extract 1.0
10. Royal jelly 50% ethanol extract 1.0
11. Trehalose solution 1.0
12. Antibacterial and antiseptic (paraoxybenzoic acid ester) appropriate amount
13. Perfume (camomile water) appropriate amount
14. Residue with 100 purified water

(Prescription Example 10) Cold cream mass%
1. Sarah Beeswax 11.0
2.liquid paraffin 22.0
3.Lanoline 10.0
4.Olive oil 5.0
5. Chamomile oil 5.0
6. Palm oil 5.0
7.borax 0.5
8. Resveratrol 0.2
9. Soybean seed water extract 1.0
10. Yeast 50% 1,3-butylene glycol extract 2.0
11.Liquid shea fat 1.0
12.Dipotassium glycyrrhizinate 0.1
13. Antibacterial and antiseptic (Acrinol) 0.1
14. Perfume (ylang ylang water) appropriate amount
15. Residue with 100 purified water

(Formulation example 11) Emollient cream mass%
1.Stearic acid 2.0
2. Stearyl alcohol 7.0
3.Reduced lanolin 2.0
4.Squalane 5.0
5. Octyldodecanol 6.0
6. Polyoxyethylene cetyl ether (25E.O.) 3.0
7. Lipophilic glyceryl monostearate 2.0
8.Propylene glycol 2.0
9.1,2-Pentanediol 2.0
10.C16 Ceramide 0.2
11. Murasaki (purple) root 50% propylene glycol extract 2.0
12. Soybean seed natto fermentation liquid 1.0
13.Glycyrrhetinic acid 0.1
14. Swine Placenta Enzymatic Decomposition Solution 1.0
15. Antibacterial (Lactoferrin solution) 0.5
16. Antibacterial and antiseptic (zinc pyridione) appropriate amount
17. Fragrance (mugwort water) appropriate amount
18.Residual water 100

(Formulation example 12) Facial cleansing cream mass%
1.Myristic acid 25.0
2.Stearic acid 5.0
3. Tallow fatty acid 5.0
4.Propylene glycol 10.0
5.Potassium hydroxide 6.0
6. Palm oil fatty acid diethanolamide 6.0
7.N-acetylcysteine 0.2
8.C16 Ceramide 2.0
9. Apple fruit 20% 1,3-butylene glycol extract 1.0
10. Rosehip fruit 30% ethanol extract 1.0
11.Kakkon hot water extract 1.0
12. Burdock root 50% 1,3-butylene glycol extract 1.0
13.Glycyrrhizic acid 1.0
14.Apricot kernel 0.1
15 Walnut shell grain 0.1
16. Antibacterial and antiseptic (2-phenoxyethanol) 0.1
17. Perfume (today water) appropriate amount
18.Residual water 100

(Prescription Example 13) Facial cleansing cream mass%
1.Stearic acid 10.0
2.palmitic acid 10.0
3.Myristic acid 12.0
4.Lauric acid 4.0
5.Glycerin 18.0
6. dl-Pyrrolidonecarboxylate sodium solution 1.0
7.Dioctyl adipate1.0
8.Cetostearyl alcohol 3.0
9.Triethanolamine 3.0
10.Ergocalcifer 1
11.Oleyl alcohol 1.5
12. Lanolin derivative (EO adduct) 1.0
13.Potassium hydroxide 6.0
14. A: N-acetylcysteine B: Senesiphyllin C: Sulfretin D: Chalcone E: Resveratrol F: C6 ceramide G: C16 ceramide H: C16 ceramide-O-glucoside I: Magnolol J: Silybin K: Phloretin * A ~ Any one compound of K 0.3
15. Royal Jelly Extract 1.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
16. Oil-soluble chamomile flower or leaf extract 1.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
17. Oil soluble licorice root or rhizome extract 1.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
18. Edetate 1.0
19.Glycyrrhizic acid 1.0
20.Corn cob grain 0.1
21. Teut Walnut Shell Grain 0.1
22. Antibacterial and antiseptic (photosensitive element 401) 0.1
23. Fragrance (mugwort water) appropriate amount
24. The balance of 100 purified water

(Prescription Example 14) Body soap mass%
1.Potassium laurate 15.0
2.Potassium myristate 5.0
3.Propylene glycol 5.0
4.Alkanediol 1.0
5.Senesiphyllin 0.4
6. Fennel fruit 70% 1,3-butylene glycol extract 0.5
7. Achacha leaf or stem 70% 1,3-butylene glycol extract 0.5
8. Soybean seed natto fermentation liquid 0.5
9. Persimmon leaf 50% dipropylene glycol extract 0.5
10. Crape myrtle leaf 20% 2,3-butylene glycol extract 0.5
11. Aloe Flour Powder 1.0
12.Polyethylene powder 0.5
13.Hydroxypropyl chitosan solution 0.5
14. Amino acids (Arginine, Glycine, Glutamine, etc.) 0.5
15 Monoammonium glycyrrhizinate 0.1
16. Antibacterial / preservative (undecylenic acid, phenol)
17.pH adjuster
18. Perfume (lavender water) appropriate amount
19.Residue with 100 purified water

(Formulation Example 15) Sunscreen cosmetics (O / W type)
1.Oxybenzone 2.0
2.Octyl paramethoxycinnamate 5.0
3.Dihydroxymethoxybenzophenone 0.2
4.Squalane 10.0
5.Vaseline 5.0
6. Stearyl alcohol 3.0
7.Stearic acid 3.0
8. Glyceryl monostearate 2.0
9.Ethyl polyacrylate 1.0
10.1,3-Butylene glycol 6.0
11. Edetate disodium 0.1
12.Triethanolamine 1.0
13.Titanium dioxide 5.0
14.Calcon 0.3
15. 50% ethanol extract of oat root 1.0
16. Birch bark 70% dipropylene glycol extract 1.0
17. Cornflower leaf 50% propylene glycol extract 0.5
18. Kakkon 50% propylene glycol extract 0.5
19. Palm fruit 50% dipropylene glycol extract 0.5
20. Antibacterial and antiseptic (benzyl paraoxybenzoate) appropriate amount
21. Fragrance (jasmine water) appropriate amount
22.Residue with 100 purified water

(Prescription Example 16) Sunscreen cosmetics (oil type)
1.liquid paraffin 70.0
2.Tetrahydroxybenzophenone 1.0
3.Cetyl octanoate 19.8
4.Silybin 0.5
5. Chamomile flower 10% 1,3-butylene glycol extract 1.0
6. Horse chestnut seed 30% 1,3-butylene glycol extract 0.5
7. Mallow flower or leaf 50% propyl alcohol extract 0.5
8. Whole barley 50% 1,3-butylene glycol extract 0.5
9. Merirot flower or leaf 70% 1,3-butylene glycol extract 0.5
10.Ethyl paraaminobenzoate 0.2
11. Antioxidant (butylhydroxytoluene) appropriate amount
12. Perfume (amber perfume) appropriate amount

(Prescription example 17) Cream foundation (O / W type)
1. Stearic acid 4.0
2.Glycerol monostearate3.0
3.Cetanol 1.5
4.Isopropyl myristate 7.0
5. Liquid paraffin 10.0
6. Sarah Beeswax 3.0
7.Triethanolamine 1.5
8.Glycerin 3.0
9. Bentonite 1.0
10.Titanium oxide 8.0
11.2,4-Dihydroxybenzophenone 8.0
12.Kaolin 3.0
13. Talc 3.0
14. Colored pigment (yellow iron oxide) 1.0
15.Ploretin 0.1
16.Dokudami leaf hot water extract dry powder 0.3
17.Yukinoshita whole plant hot water extract dry powder 0.3
18. Persimmon rhizome or root bark 50% ethanol extract 0.3
19. Antibacterial and antiseptic (phenoxyethanol) 0.1
20. Fragrance (rose water) appropriate amount
21. The balance of 100 purified water

(Prescription Example 18) Shampoo Mass%
1.Lauryl sulfate triethanolamine 5.0
2. Sodium polyoxyethylene lauryl ether sulfate 12.0
3.1,3-Butylene glycol 4.0
4.Lauric acid diethanolamide 2.0
5. Edetate disodium 0.1
6. Resveratrol 0.3
7. Large-scaled crape myrtle 20% 2,3-butylene glycol extract 2.0
8.Hyperum root bark or rhizome hot water extract 2.0
9. Spike or rhizome 30% 1,4-butylene glycol extract 2.0
10. Toki 30% 1,4-butylene glycol extract 2.0
11. Tomato fruit hot water extract 1.0
12.Hydroxypropyl chitosan solution 1.0
13. Hyaluronic acid solution 1.0
14.Dipotassium glycyrrhizinate 0.1
15. Antibacterial and antiseptic (photosensitive element 101) appropriate amount
16.pH adjusting agent
17. Perfume (white sand water) appropriate amount
18.Residual water 100

(Formulation example 19) Rinse mass%
1. Stearyl trimethyl ammonium chloride 3.0
2.Cetostearyl alcohol 3.0
3.Polyoxyethylene lanolin ether 3.0
4.Propylene glycol 5.0
5.1,2-Pentanediol 2.0
6. C6 Ceramide 1.0
7. Tokachinka flower 50% 1,3-butylene glycol extract 1.0
8. Perfumed fruit 30% 1,2-butylene glycol extract 1.0
9. Yellow rhizome 50% 1,3-butylene glycol extract 1.0
10. Comfrey leaf or stem 50% 1,3-butylene glycol extract 1.0
11. Soybean seed natto fermentation liquid 0.5
12.Hydroxyethyl chitosan solution 0.5
13. Fish (carp or carp) derived collagen solution 0.5
14. Trehalose solution 0.5
15.Hydrolyzed silk solution 0.5
16. Antibacterial / preservative (benzalkonium chloride) appropriate amount
17. Perfume (flooded water) appropriate amount
18.Residual water 100

(Formulation example 20) Rinse mass%
1. Stearyltrimethylammonium chloride 2.0
2.Cetostearyl alcohol 2.0
3.Polyoxyethylene lanolin ether 3.0
4.Propylene glycol 5.0
5.Ethylene glycol 3.0
6. A: N-acetylcysteine B: Senesiphyllin C: Sulfretin D: Chalcone E: Resveratrol F: C6 Ceramide G: C16 Ceramide H: C16 Ceramide-O-Glucoside I: Magnolol J: Silybin K: Phloretin * A ~ Any one compound of K 0.1
7. Soybean leaves 50% 1,3-butylene glycol extract 1.0
8. Western bodhi tree flower or fruit 50% 1,4-butylene glycol extract 1.0
9. Olive leaf 50% 1,2-butylene glycol extract 1.0
10. Muggei fruit or flower 50% 1,3-butylene glycol extract 1.0
11. Sweet tea whole plant 50% glycerin extract 1.0
12.Bifidobacterium fermentation broth 1.0
13.Sodium alginate 1.0
14. Trehalose solution 1.0
15. Hydrolyzed keratin solution 1.0
16. Antibacterial / preservative (benzalkonium chloride) appropriate amount
17. Fragrance (camomile water) appropriate amount
18.Residual water 100

(Formulation Example 21) Hair Liquid Mass%
1.Ethanol 29.0
2.Polyoxypropylene butyl ether phosphate 10.0
3.Polyoxypropylene monobutyl ether 5.0
4.Triethanolamine 1.0
5.Magnolol 0.3
6. Apricot fruit 50% glycerin extract 1.0
7. Hop female flower ear 50% ethanol extract 1.0
8. Melissa whole plant 50% ethanol extract 1.0
9. Usbasaicin rhizome 30% ethanol extract 1.0
10 Birch sap 1.0
11.Carpronium chloride 0.3
12. Hinokitiol 0.5
13.Keratin degradation solution 0.5
14. Stearyl glycyrrhetinate 0.1
15. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount
16. Fragrance (Rosehip water)
17.Residue with 100 purified water

(Prescription Example 22) Hair artnic mass%
1.Ethanol 40.0
2.Ethyl oleate 1.0
3.Polyoxyethylene (40) hydrogenated castor oil 2.0
4.N-acetylcysteine 0.3
5. Enju flower 30% ethanol extract 1.0
6. Antibacterial and preservative (propyl paraoxybenzoate) 0.2
7. Residue with 100 purified water

(Prescription example 23) Hair artnic mass%
1. l-Menthol 0.2
2.Ethanol 32.5
3.Polyoxyethylene hydrogenated castor oil 0.5
4.Propylene glycol 5.0
5.Diphenhydramine hydrochloride 0.3
6. A: N-acetylcysteine B: Senesiphyllin C: Sulfretin D: Chalcone E: Resveratrol F: C6 Ceramide G: C16 Ceramide H: C16 Ceramide-O-Glucoside I: Magnolol J: Silybin K: Phloretin * A ~ Any one compound of K 0.1
7. Hypericum fruit or pericarp hot water extract 1.0
8. Western bodhi tree flower or leaf 50% propylene glycol extract 1.0
9. Lavender flower or flower ear hot water extract 1.0
10. Belode oyster rhizome or root bark 50% ethanol extract 1.0
11. Ogon rhizome or root bark 50% ethanol extract 1.0
12. Soybean seed hot water extract 1.0
13.Carboxymethylchitin solution 1.0
14 Chicken crown extract solution 0.2
15.Pantethine aqueous solution 0.2
16. Antibacterial / preservative (phenoxyethanol)
17. Perfume (rose water) appropriate amount
18.Residual water 100

(Prescription Example 24) Hair growth / hair growth agent
1.Ethanol 60.0
2.Sulfletin 0.5
3. Sanshuyu fruit 50% propylene glycol extract 2.0
4. Vitamin E derivative 0.5
5.Pepper tincture 0.5
6.Resorcin 0.5
7.Dipotassium glycyrrhizinate 0.5
8.Carboxymethylchitin solution 0.5
9. Collagen protein enzyme solution 1.0
10.Pig hematin solution 0.5
11. Porcine mucin solution 0.5
12. Amino acids (Arginine, Glycine, Glutamine, etc.) 0.5
13. Antibacterial and antiseptic (paraben) 0.1
14. Fragrance (rosemary water)
15. Residue with 100 purified water

(Formulation Example 25) Granule bath agent
1.Sodium bicarbonate 58.0
2.Anhydrous sodium sulfate 30.0
3. Borax 5.0
4. A: N-acetylcysteine B: Senecifylline C: Sulfretin D: Chalcone E: Resveratrol F: C6 ceramide G: C16 ceramide H: C16 ceramide-O-glucoside I: Magnolol J: Silybin K: Phloretin * A ~ Any one compound of K 1.0
5. Sorbitol 1.0
6. Peach leaf 70% ethanol extract dry powder 1.0
7. Black tea leaf 30% ethanol extract dry powder 1.0
8. Pigment (Gungjo Green) appropriate amount

(Formulation Example 26) Granule bath agent
1.Sodium bicarbonate 58.0
2.Anhydrous sodium sulfate 30.0
3. Borax 3.0
4. Hyaluronic acid powder 3.0
5.C16 Ceramide-O-Glucoside 1.0
6. Ginseng root 50% hot water extract dry powder 1.0
7. Tougan seed hot water extract dry powder 1.0
8. Apple fruit juice powder 1.0
9. Dye (Gunjou, chromium hydroxide) appropriate amount
10. Fragrance (Water)

(Formulation example 27) Coating protective agent A gauze or liniment cloth is impregnated with a prescription solution in which an appropriate amount of C16 ceramide, antibiotics, anti-inflammatory agent or the like is mixed, and attached to the wound. Alternatively, C16 ceramide may be directly applied locally and coated with gauze or the like.

Claims (2)

Peroxisome proliferator-responsive receptor comprising one or more compounds selected from N-acetylcysteine, senecifylline, sulfretin, chalcone, resveratrol, ceramide, ololopain, magnolol, silybin, and phloretin as active ingredients Body activator. An external preparation composition for skin, comprising the peroxisome proliferator-responsive receptor activator according to claim 1 as an active ingredient.