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JP2006516085A - Mcamインヒビタ - Google Patents

Mcamインヒビタ Download PDF

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Publication number
JP2006516085A
JP2006516085A JP2004520644A JP2004520644A JP2006516085A JP 2006516085 A JP2006516085 A JP 2006516085A JP 2004520644 A JP2004520644 A JP 2004520644A JP 2004520644 A JP2004520644 A JP 2004520644A JP 2006516085 A JP2006516085 A JP 2006516085A
Authority
JP
Japan
Prior art keywords
seq
mcam
cells
antibody
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004520644A
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English (en)
Japanese (ja)
Inventor
ウンガー,クリスチン,マルガレータ
ツェートマイアー,カロリン
トレーラ,クラウディア
ニーヴェーナー,イエンズ
アーレンズ,ビアンカ
ベステ,ゲラルド
Original Assignee
キセリオン ファーマセウティカルズ アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by キセリオン ファーマセウティカルズ アーゲー filed Critical キセリオン ファーマセウティカルズ アーゲー
Publication of JP2006516085A publication Critical patent/JP2006516085A/ja
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1037Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/02Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2004520644A 2002-07-15 2003-07-15 Mcamインヒビタ Pending JP2006516085A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02015591A EP1382615A1 (de) 2002-07-15 2002-07-15 MCAM-Inhibitoren
US41033102P 2002-09-11 2002-09-11
PCT/EP2003/007661 WO2004007550A1 (en) 2002-07-15 2003-07-15 Mcam inhibitors

Publications (1)

Publication Number Publication Date
JP2006516085A true JP2006516085A (ja) 2006-06-22

Family

ID=29762615

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004520644A Pending JP2006516085A (ja) 2002-07-15 2003-07-15 Mcamインヒビタ

Country Status (6)

Country Link
EP (3) EP1382615A1 (de)
JP (1) JP2006516085A (de)
CN (1) CN1675244A (de)
AU (2) AU2003250956A1 (de)
CA (1) CA2492559A1 (de)
WO (2) WO2004007550A1 (de)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012524519A (ja) * 2009-01-30 2012-10-18 ユニヴェルシテ・ドゥ・ラ・メディテラネ ヒト可溶性cd146、その調製および使用
JP2015533795A (ja) * 2012-09-10 2015-11-26 プロセナ バイオサイエンシーズ リミテッド 抗mcam抗体及び関連する使用方法
JP2015232563A (ja) * 2009-10-21 2015-12-24 マイカーティス エヌ.ヴェ.MyCartis NV 体液ホメオスタシスのバイオマーカーとしてのmcam
US9593166B2 (en) 2013-03-14 2017-03-14 Bayer Healthcare Llc Monoclonal antibodies against antithrombin β
JP2017518258A (ja) * 2014-03-12 2017-07-06 プロセナ バイオサイエンシーズ リミテッド 抗mcam抗体及び関連する使用方法
US10654920B2 (en) 2014-03-12 2020-05-19 Prothena Biosciences Limited Anti-laminin4 antibodies specific for LG4-5

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601351B1 (en) 2002-06-26 2009-10-13 Human Genome Sciences, Inc. Antibodies against protective antigen
EP1539235A2 (de) 2002-07-01 2005-06-15 Human Genome Sciences, Inc. Spezifisch an reg iv bindende antikörper
GB0404936D0 (en) * 2004-03-04 2004-04-07 Univ London Screen
US20090053300A1 (en) * 2006-02-23 2009-02-26 Mitsubishi Tanabe Pharma Corporation Monoclonal antibody, gene encoding the antibody, hybridoma, pharmaceutical composition, and diagnostic reagent
TWD116842S1 (zh) * 2006-03-21 2007-05-11 玻璃製造公司
KR20100097716A (ko) 2007-11-27 2010-09-03 아블린쓰 엔.브이. 이종이량체 사이토킨 및/또는 이의 수용체에 대한 아미노산 서열과 이를 포함하는 폴리펩티드
WO2010045469A2 (en) * 2008-10-15 2010-04-22 The Board Of Regents Of The University Of Texas System Muc18 targeting peptides
WO2010117997A2 (en) * 2009-04-07 2010-10-14 University Of Kansas Peptide targeting of inner ear cells
US8293468B2 (en) 2009-06-10 2012-10-23 Centre Hospitalier De L'université De Montréal MCAM modulation and uses thereof
US9220733B2 (en) 2012-03-19 2015-12-29 The Regents Of The University Of California Solubilization of antigen components for removal from tissues
TW201623331A (zh) * 2014-03-12 2016-07-01 普羅帝納生物科學公司 抗黑色素瘤細胞黏著分子(mcam)抗體類及使用彼等之相關方法
CN104710513A (zh) * 2015-04-06 2015-06-17 苏州普罗达生物科技有限公司 黑色素瘤细胞粘附分子拮抗剂多肽及其应用
CN104725483A (zh) * 2015-04-06 2015-06-24 苏州普罗达生物科技有限公司 一种黑色素瘤细胞粘附分子拮抗剂多肽及其应用
CN104725489A (zh) * 2015-04-06 2015-06-24 苏州普罗达生物科技有限公司 关于黑色素瘤细胞粘附分子拮抗剂多肽及其应用
WO2017184562A1 (en) * 2016-04-20 2017-10-26 Merck Sharp & Dohme Corp. Cmv neutralizing antigen binding proteins
US11899020B2 (en) 2017-03-31 2024-02-13 The Regents Of The University Of California Shotgun proteomic antigen identification
WO2018220467A1 (en) 2017-05-30 2018-12-06 Foroogh Nejatollahi Anti-muc18 human immunotoxin and applications thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058501A2 (en) * 1999-03-26 2000-10-05 The Wistar Institute Novel genetic suppressor elements and methods of making the same
US20020052484A1 (en) * 2000-04-10 2002-05-02 English James T. Phage display selection of anti fungal peptides

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012524519A (ja) * 2009-01-30 2012-10-18 ユニヴェルシテ・ドゥ・ラ・メディテラネ ヒト可溶性cd146、その調製および使用
JP2015232563A (ja) * 2009-10-21 2015-12-24 マイカーティス エヌ.ヴェ.MyCartis NV 体液ホメオスタシスのバイオマーカーとしてのmcam
JP2015533795A (ja) * 2012-09-10 2015-11-26 プロセナ バイオサイエンシーズ リミテッド 抗mcam抗体及び関連する使用方法
US10584177B2 (en) 2012-09-10 2020-03-10 Prothena Biosciences Limited Anti-MCAM antibodies and associated methods of use
US9593166B2 (en) 2013-03-14 2017-03-14 Bayer Healthcare Llc Monoclonal antibodies against antithrombin β
US9908942B2 (en) 2013-03-14 2018-03-06 Bayer Healthcare, Llc Monoclonal antibodies against antithrombin β
US10144784B2 (en) 2013-03-14 2018-12-04 Bayer Healthcare Llc Monoclonal antibodies against antithrombin beta
JP2017518258A (ja) * 2014-03-12 2017-07-06 プロセナ バイオサイエンシーズ リミテッド 抗mcam抗体及び関連する使用方法
US10654920B2 (en) 2014-03-12 2020-05-19 Prothena Biosciences Limited Anti-laminin4 antibodies specific for LG4-5
US10889636B2 (en) 2014-03-12 2021-01-12 Prothena Biosciences Limited Anti-Laminin4 antibodies specific for LG4-5

Also Published As

Publication number Publication date
AU2003250065A1 (en) 2004-02-02
EP1382615A1 (de) 2004-01-21
WO2004007717A1 (en) 2004-01-22
WO2004007717A8 (en) 2005-05-12
WO2004007550A1 (en) 2004-01-22
EP1601695A1 (de) 2005-12-07
CN1675244A (zh) 2005-09-28
CA2492559A1 (en) 2004-01-22
AU2003250956A1 (en) 2004-02-02
EP1592792A1 (de) 2005-11-09

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