JP2006028051A - Ameliorant for exhausted feeling at time of rising, composition for ameliorating exhausted feeling at time of rising, and food and beverage for ameliorating exhausted feeling at time of rising, containing them - Google Patents
Ameliorant for exhausted feeling at time of rising, composition for ameliorating exhausted feeling at time of rising, and food and beverage for ameliorating exhausted feeling at time of rising, containing them Download PDFInfo
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- JP2006028051A JP2006028051A JP2004206784A JP2004206784A JP2006028051A JP 2006028051 A JP2006028051 A JP 2006028051A JP 2004206784 A JP2004206784 A JP 2004206784A JP 2004206784 A JP2004206784 A JP 2004206784A JP 2006028051 A JP2006028051 A JP 2006028051A
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Images
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
本発明は、睡眠の質を良化し、服用することにより起床時（覚醒時）に疲労感の解消を体感できる起床時疲労感改善剤、起床時疲労感改善用組成物、及びこれらを含む起床時疲労感改善用飲食物に関する。なお、本発明において、飲食物とは、経口的に摂取される一般食品、健康食品、保健機能食品、医薬部外品、及び医薬品などをいう。 The present invention relates to an agent for improving fatigue at wake-up, a composition for improving fatigue at wake-up, and a wake-up comprising the same, which can improve the quality of sleep and allow the user to experience the relief of fatigue when waking up (at awakening). It relates to food and drink for improving fatigue. In the present invention, food and drink refer to general foods, health foods, health functional foods, quasi drugs, and pharmaceuticals that are taken orally.
近年、睡眠障害や不眠など、睡眠に関する問題が多くとりあげられている。
厚生労働省が、１２歳以上の日本人３２，０００人を対象として実施した平成１２年保険福祉動向調査によると、約５人に１人が睡眠に関する問題を抱えていることが明らかになった。このうち、最も多い回答が「朝起きても熟睡感がない（２４．２％）」であり、次いで「朝早く目が覚めてしまう（２２．０％）」、「夜中に何度も目が覚める（１９．５％）」という回答であった。また、平成１４年の日本睡眠学会のシンポジウムでは、アテネ不眠尺度(Soldatos et al.: Journal of Psychosomatic Research 48:555-560, 2000)に基づく回答から、調査した１万４２４人の４９．４％に不眠症の疑いがあることがわかった。
In recent years, many problems related to sleep, such as sleep disorders and insomnia, have been taken up.
According to the 2000 Health and Welfare Trend Survey conducted by the Ministry of Health, Labor and Welfare for 32,000 Japanese people over the age of 12, it was found that about 1 out of 5 people have problems with sleep. Among them, the most common answer is “I don't feel a good sleep when I wake up in the morning (24.2%)”, then “I wake up early in the morning (22.0%)”, “ “Wake up (19.5%)”. In addition, at the symposium of the Japanese Society of Sleep in 2002, 49.4% of 1424 people surveyed based on responses based on the Athens Insomnia Scale (Soldatos et al .: Journal of Psychosomatic Research 48: 555-560, 2000). It was found that there was a suspicion of insomnia.
このような睡眠に関する問題を解決するための商品が多岐にわたって開発・上市されており、その作用機序から大きく二種類に分類することができる。
一つは、音、光、及び香りなどの刺激を体外から与えることにより、入眠や覚醒を補助したり、睡眠改善効果を得ようとする商品群である（特許文献１及び２参照）。しかしながら、刺激に対する応答には個人差があり、また睡眠に関する問題の程度や刺激を受け入れる態勢によっても得られる効果に差が生じるため、必ずしもすべての人々に満足な効果を提供できるものとは言えない。
A variety of products for solving such problems related to sleep have been developed and marketed, and can be roughly classified into two types based on the mechanism of action.
One is a product group that assists falling asleep or awakening or obtains a sleep improvement effect by applying stimuli such as sound, light, and fragrance from outside the body (see
もう一つは、有効成分を含有する飲料（ハーブティ等）、食品（健康食品等）、及び医薬品（睡眠薬等）などを経口摂取（服用）することにより、睡眠改善効果を得ようとする商品群である。例えば、バレリアンエキスを配合した不眠症用組成物（特許文献３参照）、オタネニンジンエキスやイチョウ葉エキス等を含む安眠用健康食品（特許文献４〜６参照）、ステロイドを含む睡眠促進用組成物（特許文献７参照）、テアニンを含む睡眠障害を改善する組成物（特許文献８参照）など、摂取することにより、睡眠障害を誘起するストレスや疲労の改善によって睡眠導入効果や安眠が得られる組成物が提案されている。しかしながら、これらの組成物は、特有の臭気を伴うものが多く、継続的かつ積極的な摂取が妨げられることがある。
The other is a product group that seeks to improve sleep by orally ingesting (taking) drinks (such as herbal tea), foods (such as health foods), and pharmaceuticals (such as sleeping pills) containing active ingredients. It is. For example, a composition for insomnia containing valerian extract (see Patent Document 3), a health food for sleep that includes ginseng extract, ginkgo biloba extract, etc., and a composition for promoting sleep containing steroids (see
一方、睡眠薬などの医薬品については、ＯＴＣ薬もあるものの、一般的に睡眠薬に対する抵抗感が根強い。また、医師の診断及び処方箋が必要となることに加え、服用した場合には副作用の危険性を排除することができないという問題がある。 On the other hand, for drugs such as sleeping pills, although there are OTC drugs, resistance to sleeping pills is generally strong. In addition to the necessity of a doctor's diagnosis and prescription, there is a problem that the risk of side effects cannot be excluded when taken.
ところで、起床時に熟睡感や爽快感が体感でき、心地よく一日の活動を開始できることは非常に重要である。また、真に意味のある睡眠の改善とは、睡眠の質の良化であり、睡眠によって心身の疲労回復が実現することであり、かつ、それが体感できることが不可欠である。 By the way, it is very important to be able to experience a feeling of deep sleep and a refreshing feeling when getting up and to start a day's activities comfortably. In addition, a truly meaningful improvement in sleep is an improvement in sleep quality, that is, the recovery of mental and physical fatigue through sleep, and the ability to experience it.
しかし、従来の提案はいずれも、睡眠の妨げとなる要因を取り除いて入眠を促進する効果を得ることが主な目的となっており、睡眠の質を良化することによって、起床時に疲労感が解消されるという効果については、何ら開示されていない。 However, all of the previous proposals have the main purpose of removing sleep-causing factors and promoting the effects of sleep onset. There is no disclosure of the effect of being eliminated.
よって、経口摂取が容易で、睡眠の質を良化し、服用することにより起床時に爽快感や熟睡感が得られ、特に、疲労感の解消を体感できる起床時疲労感改善剤、起床時疲労感改善組成物、及びこれらを含む起床時疲労感改善用飲食物は、未だ提供されていないのが現状であり、これらの開発が切に望まれている。 Therefore, it is easy to take orally, improves the quality of sleep, and gives a refreshing feeling and a deep sleep feeling when you get up, especially when you get up and get tired when you get up. The present situation is that the improvement composition and the food for improving fatigue feeling at the time of waking up which contain these have not been provided yet, and development of these is earnestly desired.
本発明は、前記従来における問題を解決し、以下の目的を達成することを課題とする。
即ち、本発明は、経口摂取が容易で、睡眠の質を良化し、服用することにより起床時に爽快感や熟睡感が得られ、特に、疲労感の解消を体感できる起床時疲労感改善剤、起床時疲労感改善組成物、及びこれらを含む起床時疲労感改善用飲食物を提供することを目的とする。
An object of the present invention is to solve the conventional problems and achieve the following objects.
That is, the present invention is easy to take orally, improves the quality of sleep, and when taken, a refreshing feeling and a deep sleep feeling can be obtained, and in particular, an agent for improving a feeling of waking up when waking up can be experienced, An object of the present invention is to provide a composition for improving a feeling of getting up at fatigue, and a food and drink for improving the feeling of getting up at fatigue, including these compositions.
前記課題を解決するため、本発明者らが鋭意検討を重ねた結果、ナス科ウィザニア（Ｗｉｔｈａｎｉａ）属植物由来成分が、起床時の疲労感改善に有用であること、及び、心身（特に、脳など）の疲労回復作用を有する動植物由来成分からなる疲労回復剤を組み合わせてなる組成物を摂取することにより、起床時疲労感改善効果が得られるとの新知見を得た。 As a result of intensive studies by the present inventors in order to solve the above-mentioned problems, it has been found that a component derived from a plant belonging to the genus Whitania belongs to the use of a plant belonging to the genus Withania, which is useful for improving the feeling of fatigue when waking up, and the mind and body (particularly the brain Etc.), the inventor has obtained a new finding that the effect of improving fatigue feeling upon waking up can be obtained by ingesting a composition comprising a combination of a fatigue recovery agent comprising an animal and plant-derived component having a fatigue recovery action.
本発明は、本発明者による前記知見に基づくものであり、前記課題を解決するための手段としては、以下の通りである。即ち、
＜１＞ ナス科ウィザニア（Ｗｉｔｈａｎｉａ）属植物由来成分を有効成分として含有することを特徴とする起床時疲労感改善剤である。
＜２＞ ナス科ウィザニア（Ｗｉｔｈａｎｉａ）属植物の根茎部を水系溶媒で抽出して得られる抽出物を有効成分として含有する前記＜１＞に記載の起床時疲労感改善剤である。
＜３＞ ナス科ウィザニア（Ｗｉｔｈａｎｉａ）属植物が、ウィザニアソムニフェラデュナル（Ｗｉｔｈａｎｉａ ｓｏｍｎｉｆｅｒａ Ｄｕｎａｌ）である前記＜１＞から＜２＞のいずれかに記載の起床時疲労感改善剤である。
＜４＞ （Ａ）前記＜１＞から＜３＞のいずれかに記載の起床時疲労感改善剤と、（Ｂ）動植物由来成分を有効成分とする疲労回復剤とを含むことを特徴とする起床時疲労感改善用組成物である。
＜５＞ 動植物由来成分を有効成分とする疲労回復剤（Ｂ）が、羅漢果、茶、ジンジャー、大豆、米、チェリー、牡蠣、乳、及び卵から選ばれる少なくとも１種の素材または抽出物を含む前記＜４＞に記載の起床時疲労感改善用組成物である。
＜６＞ 動植物由来成分を有効成分とする疲労回復剤（Ｂ）が、羅漢果、茶、ジンジャー、大豆、米、チェリー、牡蠣、乳、及び卵から選ばれる少なくとも１種の素材から抽出されたフォスファチジルセリン、γアミノ酪酸、タウリン、トリプトファン、及びテアニンの少なくともいずれかを含む前記＜４＞から＜５＞のいずれかに記載の起床時疲労感改善用組成物である。
＜７＞ アミノ酸、及びビタミン類のいずれかを含む前記＜４＞から＜６＞のいずれかに記載の起床時疲労感改善用組成物である。
＜８＞ 前記＜１＞から＜３＞のいずれかに記載の起床時疲労感改善剤を含むことを特徴とする起床時疲労感改善用飲食物である。
＜９＞ 前記＜４＞から＜７＞のいずれかに記載の起床時疲労感改善用組成物を含むことを特徴とする起床時疲労感改善用飲食物である。
This invention is based on the said knowledge by this inventor, and as a means for solving the said subject, it is as follows. That is,
<1> An agent for improving fatigue at wake-up, comprising a component derived from a plant belonging to the genus Wisania of the solanaceous family as an active ingredient.
<2> The agent for improving fatigue during waking according to <1> above, which contains, as an active ingredient, an extract obtained by extracting a rhizome part of a plant belonging to the genus Withania in an eggplant with an aqueous solvent.
<3> The agent for improving fatigue at wake-up according to any one of <1> to <2>, wherein the plant belonging to the genus Withania is a Wizania somnifera Dunal .
<4> (A) comprising the wake-up fatigue improvement agent according to any one of <1> to <3>, and (B) a fatigue recovery agent comprising an animal or plant-derived component as an active ingredient. It is a composition for improving a feeling of fatigue when waking up.
<5> The fatigue recovery agent (B) comprising an animal or plant-derived ingredient as an active ingredient contains at least one material or extract selected from Rahan fruit, tea, ginger, soybean, rice, cherry, oyster, milk, and egg. The composition for improving a feeling of fatigue when waking up according to the above <4>.
<6> Phosphorus recovery agent (B) comprising an animal or plant-derived ingredient as an active ingredient is extracted from at least one material selected from Rahan fruit, tea, ginger, soybean, rice, cherry, oyster, milk, and egg The composition for improving fatigue feeling upon waking according to any one of <4> to <5>, wherein the composition comprises at least one of fatidylserine, γ-aminobutyric acid, taurine, tryptophan, and theanine.
<7> The composition for improving a feeling of fatigue when waking up according to any one of <4> to <6>, comprising any one of an amino acid and vitamins.
<8> A food / drink for improving fatigue at waking, comprising the agent for improving fatigue at waking up according to any one of <1> to <3>.
<9> A food / drink for improving fatigue at wake-up, comprising the composition for improving fatigue at wake-up according to any one of <4> to <7>.
前記ナス科ウィザニア（Ｗｉｔｈａｎｉａ）属植物、特に、ウィザニアソムニフェラデュナル（Ｗｉｔｈａｎｉａ ｓｏｍｎｉｆｅｒａ Ｄｕｎａｌ）の植物エキスの生理作用、及び薬理作用については、滋養強壮作用、強精作用、抗ストレス作用、及び抗リウマチ作用などについて知られている（例えば、特開２００２−１４５７９４号公報）。しかし、この前記ナス科ウィザニア（Ｗｉｔｈａｎｉａ）属植物由来成分が、睡眠を良化し、服用によって起床時の疲労感改善効果を発揮することについては全く知られておらず、本発明者らの新たな知見である。 With respect to the physiological and pharmacological effects of the plant belonging to the genus Witiania, in particular, the plant extract of Withania somnifera Dunal , nourishing tonic, tonic, anti-stress, and It is known about antirheumatic action and the like (for example, JP-A-2002-145794). However, it has not been known at all that the component derived from the plant belonging to the genus Wisania of the solanaceous family improves sleep and exerts an effect of improving fatigue feeling when waking up by taking it. It is knowledge.
本発明によると、経口摂取が容易で、睡眠の質を良化し、服用することにより起床時に爽快感や熟睡感が得られ、特に、疲労感の解消を体感できる起床時疲労感改善剤、起床時疲労感改善組成物、及びこれらを含む起床時疲労感改善用飲食物を提供することができる。 According to the present invention, it is easy to take orally, improves the quality of sleep, and when taken, a refreshing feeling and a deep sleep feeling can be obtained. It is possible to provide a time fatigue sensation improving composition and a food and drink for improving fatigue sensation when waking up.
（起床時疲労感改善剤）
本発明の起床時疲労感改善剤は、ナス科ウィザニア属植物由来成分を有効成分として含んでなる。該起床時疲労感改善剤は、必要に応じて適宜選択したその他の成分と併用してもよい。
前記ナス科ウィザニア属植物由来成分である起床時疲労感改善効果を示す物質の詳細は不明であるが、前記由来成分としては、例えば、粉砕物、乾燥物、乾燥粉砕物、抽出液、該抽出液の希釈液、該抽出液を乾燥して得られる乾燥物、これらの粗精製物、及び精製物などが挙げられる。
(Wake-up fatigue improvement agent)
The wake-up fatigue sensation-improving agent of the present invention comprises a component derived from a plant belonging to the genus Widonia, as an active ingredient. The wake-up fatigue ameliorating agent may be used in combination with other components appropriately selected as necessary.
The details of the substance that shows the effect of improving fatigue at the time of waking up, which is a component derived from the plant belonging to the genus Wisonia of the solanaceae family, are not known. Examples include a diluted solution of the liquid, a dried product obtained by drying the extract, a roughly purified product, and a purified product.
ナス科ウィザニア属植物としては、ウィザニアソムニフェラデュナルが好ましい。前記ウィザニアソムニフェラデュナルとは、ナス科ウィザニア属植物の常緑低木で、インド西部、パキスタン、スリランカ、及び南アフリカなどの乾燥した亜熱帯地方に自生し、アシュワガンダ（Ａｓｈｗａｇａｎｄｈａ）、ウィンターチェリー（Ｗｉｎｔｅｒ Ｃｈｅｒｒｙ）という名でも呼ばれる植物である。 As the solanaceous wisnia genus plant, wisonia somnifera dunal is preferable. The Wizania somnifera dunal is an evergreen shrub of the plant belonging to the genus Uzaniaaceae, which grows naturally in dry subtropics such as western India, Pakistan, Sri Lanka, and South Africa, and includes Ashwagandha and Winter Cherry. ) Is also called a plant.
本発明で用いるナス科ウィザニア属植物の抽出物としては、根茎部を水系溶媒で抽出して得られる抽出物が好ましい。
前記根茎部を水系溶媒で抽出して得られる抽出物としては、根茎部を乾燥した後、そのまま、または、粗砕機を用い粉砕して水系溶媒に供することにより得られる。
前記根茎部を乾燥する方法としては、特に制限は無く、公知の方法を目的に応じて適宜選択することができる。
なお、前記抽出物を得る方法としては、特に制限は無く、公知の抽出方法を目的に応じて適宜選択することができる。
As the extract of the plant belonging to the genus Widonia, which is used in the present invention, an extract obtained by extracting the rhizome part with an aqueous solvent is preferable.
The extract obtained by extracting the rhizome part with an aqueous solvent can be obtained by drying the rhizome part as it is or by pulverizing it with a crusher and using it in an aqueous solvent.
There is no restriction | limiting in particular as a method of drying the said rhizome part, A well-known method can be suitably selected according to the objective.
In addition, there is no restriction | limiting in particular as a method of obtaining the said extract, A well-known extraction method can be suitably selected according to the objective.
前記水系溶媒としては、水、親水性有機溶媒、およびこれらの混合液を室温乃至溶媒の沸点以下の温度で用いることが好ましい。 As the aqueous solvent, it is preferable to use water, a hydrophilic organic solvent, and a mixture thereof at a temperature from room temperature to the boiling point of the solvent.
前記水としては、純水、水道水、井戸水、鉱泉水、鉱水、温泉水、湧水、淡水等の他、これらに各種処理を施したものが含まれる。水に施す処理としては、例えば、精製、加熱、殺菌、滅菌、ろ過、イオン交換、浸透圧の調整、緩衝化等が含まれる。従って、本発明において抽出溶媒として使用し得る水には、精製水、熱水、イオン交換水、生理食塩水、リン酸緩衝液、リン酸緩衝生理食塩水等も含まれる。 Examples of the water include pure water, tap water, well water, mineral spring water, mineral water, hot spring water, spring water, fresh water, and the like, and those subjected to various treatments. Examples of the treatment applied to water include purification, heating, sterilization, sterilization, filtration, ion exchange, adjustment of osmotic pressure, buffering, and the like. Therefore, the water that can be used as the extraction solvent in the present invention includes purified water, hot water, ion-exchanged water, physiological saline, phosphate buffer, phosphate buffered saline, and the like.
前記親水性有機溶媒としては、例えばメタノール、エタノール、プロピルアルコール、イソプロピルアルコール等の炭素数１〜５の低級アルコール；アセトン、メチルエチルケトン等の低級脂肪族ケトン；１，３−ブチレングリコール、プロピレングリコール、イソプロピレングリコール、グリセリン等の炭素数２〜５の多価アルコールなどが挙げられ、これら親水性有機溶媒と水との混合溶媒などを用いることができる。なお、水と親水性有機溶媒との混合系溶媒を使用する場合には、低級アルコールの場合は水１０質量部に対して１〜９０質量部、低級脂肪族ケトンの場合は水１０質量部に対して１〜４０質量部、多価アルコールの場合は水１０質量部に対して１０〜９０質量部添加することが好ましい。 Examples of the hydrophilic organic solvent include lower alcohols having 1 to 5 carbon atoms such as methanol, ethanol, propyl alcohol, and isopropyl alcohol; lower aliphatic ketones such as acetone and methyl ethyl ketone; 1,3-butylene glycol, propylene glycol, Examples thereof include C2-C5 polyhydric alcohols such as propylene glycol and glycerin, and a mixed solvent of these hydrophilic organic solvents and water can be used. In the case of using a mixed solvent of water and a hydrophilic organic solvent, 1 to 90 parts by mass with respect to 10 parts by mass of water in the case of a lower alcohol, and 10 parts by mass of water in the case of a lower aliphatic ketone. On the other hand, in the case of 1 to 40 parts by mass, in the case of polyhydric alcohol, it is preferable to add 10 to 90 parts by mass with respect to 10 parts by mass of water.
前記抽出液は、該抽出液の希釈液若しくは濃縮液、該抽出液の乾燥物、又はこれらの粗精製物若しくは精製物を得るために、常法に従って希釈、濃縮、乾燥、精製等の処理を施してもよい。 In order to obtain a diluted or concentrated solution of the extracted solution, a dried product of the extracted solution, or a crudely purified product or purified product thereof, the extract is subjected to treatment such as dilution, concentration, drying and purification according to a conventional method. You may give it.
また、起床時疲労感改善効果の低下を招かない範囲で脱色、脱臭等を目的とする精製を行うことも可能であるが、未精製のままでも実用上支障はない。なお、精製は、具体的には活性炭処理、吸着樹脂処理、イオン交換樹脂処理等によって行うことができる。 In addition, it is possible to perform purification for the purpose of decolorization, deodorization, etc. within a range that does not cause a decrease in the fatigue improvement effect at the time of waking up, but there is no practical problem even if it is not purified. Specifically, purification can be performed by activated carbon treatment, adsorption resin treatment, ion exchange resin treatment, or the like.
前記抽出液はそのままでも前記起床時疲労感改善剤として使用することができるが、服用や組成物製造の観点から、濃縮液や乾燥物とするのが好ましい。
前記抽出液の乾燥物を得るにあたっては、吸湿性を改善するためにデキストリン、シクロデキストリン等のキャリアーを添加してもよい。
また、前記抽出液は苦味を有するため、ガラクトマンナン分解物を添加するする方法（特開２００２−２１８９３６号公報参照）摂取時の呈味を改善することができる。また、カプセル化する方法（特開２００３−５５２１９号公報参照）などによって、摂取時の味をマスクするとともに、消化器内で安定に吸収されるようにしてもよい。
The extract can be used as it is as a wake-up fatigue sensation improver as it is, but is preferably a concentrated solution or a dried product from the viewpoint of taking or preparing the composition.
In obtaining a dried product of the extract, a carrier such as dextrin or cyclodextrin may be added to improve hygroscopicity.
Moreover, since the said extract has a bitter taste, the taste at the time of ingesting the method (refer Unexamined-Japanese-Patent No. 2002-218936) which adds a galactomannan degradation product can be improved. In addition, a method of encapsulating (see Japanese Patent Application Laid-Open No. 2003-55219) or the like may mask the taste at the time of ingestion and may be stably absorbed in the digestive organs.
前記起床時疲労感改善組成物を製剤化する方法としては、特に制限はなく、目的に応じて適宜選択することができる。前記起床時疲労感改善剤の剤形としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、固形剤、液剤などが挙げられる。
前記固形剤としては、例えば、錠剤、カプセル剤、顆粒剤、散剤、細粒剤、コーティング法により腸溶性コーティング剤などが挙げられる。前記固形剤としては、経口固形製剤の製造時に用いられる添加剤を、本発明の効果を損なわない範囲で適宜配合することができる。前記添加剤としては、例えば、カリウム塩、酢酸、賦形剤、結合剤、崩壊剤、滑沢剤、矯味矯臭剤、増量剤、被覆剤、酸味料・ｐＨ調整剤、品質改良剤、増粘安定剤、及び保存料などが挙げられる。
前記液剤としては、特に制限はなく、目的に応じて適宜選択することができるが、例えば、前記ナス科ウィザニア属植物由来成分を、乳化剤を用いて水に溶解、及び分散させたもの、エチルアルコール等の可溶性溶媒に溶解させたのちに、水に溶解させたもの、などが挙げられる。
There is no restriction | limiting in particular as a method of formulating the said fatigue-relieving composition at the time of waking, and it can select suitably according to the objective. There is no restriction | limiting in particular as a dosage form of the said wake-up fatigue feeling improvement agent, According to the objective, it can select suitably, For example, a solid agent, a liquid agent, etc. are mentioned.
Examples of the solid agent include tablets, capsules, granules, powders, fine granules, and enteric coating agents by a coating method. As said solid agent, the additive used at the time of manufacture of an oral solid formulation can be mix | blended suitably in the range which does not impair the effect of this invention. Examples of the additive include potassium salt, acetic acid, excipient, binder, disintegrant, lubricant, flavoring agent, extender, coating agent, acidulant / pH adjuster, quality improver, thickener. Stabilizers, preservatives and the like can be mentioned.
The liquid agent is not particularly limited and may be appropriately selected depending on the intended purpose. For example, a solution obtained by dissolving and dispersing the solanaceous wizania plant-derived component in water using an emulsifier, ethyl alcohol And the like dissolved in a water-soluble solvent, and then dissolved in water.
前記起床時疲労感改善剤の使用方法としては、特に制限はなく、目的に応じて適宜選択することができるが、例えば、医薬品、医薬部外品、健康食品などとして使用することができる。また、起床時疲労感改善効果を高める他の成分を配合してなる後述の起床時疲労感改善組成物の成分として使用することができ、さらに一般食品や一般飲料に含有させることにより、後述する起床時疲労感改善用飲食物の成分として好適に使用することができる。 There is no restriction | limiting in particular as a usage method of the said fatigue sensation agent at the time of awakening, Although it can select suitably according to the objective, For example, it can be used as a pharmaceutical, a quasi-drug, health food, etc. In addition, it can be used as a component of a composition for improving a feeling of getting up at the time of waking up, which is formed by blending other components that enhance the effect of improving the feeling of getting up at the time of fatigue, and will be described later by being contained in a general food or a general beverage. It can be suitably used as a component of food and drink for improving the feeling of fatigue when waking up.
前記起床時疲労感改善剤の摂取量としては、睡眠の悩みのレベルに応じて適宜選択することができるが、根茎部抽出物の乾燥物重量として、１〜５０００ｍｇ／日が好ましく、１０〜１０００ｍｇ／日がより好ましい。 The intake amount of the wake-up fatigue sensation-improving agent can be appropriately selected according to the level of sleep troubles. The dry matter weight of the rhizome extract is preferably 1 to 5000 mg / day, and 10 to 1000 mg. / Day is more preferable.
本発明の起床時疲労感改善剤は、日常的に経口摂取することが可能であり、前記ナス科ウィザニア属植物由来成分の働きにより、睡眠の質が良化され、起床時に熟睡感や爽快感が得られ、特に、疲労感の解消が体感できる。 The agent for improving fatigue at wake-up of the present invention can be taken orally on a daily basis, and the quality of sleep is improved by the action of the above-mentioned plant belonging to the plant belonging to the genus Widonia, so that a feeling of deep sleep and a refreshing sensation can be obtained. In particular, the fatigue can be eliminated.
（起床時疲労感改善組成物）
本発明の起床時疲労感改善組成物は、（Ａ）前記起床時疲労感改善剤と、（Ｂ）動植物由来成分を有効成分とする疲労回復剤とを含み、適宜選択したその他の成分を含んでも良い。
(Composition to improve fatigue when getting up)
The composition for improving fatigue at wakeup of the present invention comprises (A) the above-mentioned fatigue amelioration agent at wake-up and (B) a fatigue recovery agent comprising an animal or plant-derived component as an active ingredient, and other components appropriately selected. But it ’s okay.
前記（Ｂ）動植物由来成分を有効成分とする疲労回復剤としては、羅漢果（Momordicae grosvenori Swingle、Siraitia grosvenorii(Swingle)）、ジンジャー（Zingiber属）、大豆（Glycine max(L.) Merrill）、米（Oryza sativa）、チェリー（Prunus属）、茶（茶：Camellia sinensis (L.) O. kuntze、中国種：var. sinensis、アッサム種：var. assamica）、牡蠣（Crassostrea gigas）、乳、及び卵から選ばれる少なくとも１種の素材または抽出物が好ましい。
前記素材の形態としては、粉砕物、乾燥物、及び乾燥粉砕物などが挙げられ、前記抽出物としては、抽出液、該抽出液、該抽出液を乾燥して得られる乾燥物、これらの粗精製物、及び精製物、並びに発酵代謝産物などが挙げられる。
As the fatigue recovery agent comprising the above-mentioned (B) animal and plant-derived ingredients as active ingredients, Rahan fruit ( Momordicae grosvenori Swingle , Siraitia grosvenorii (Swingle) ), ginger (genus Zingiber), soybean ( Glycine max (L.) Merrill ), rice ( Oryza sativa), cherry (Prunus spp.), tea (tea: Camellia sinensis (L.) O. kuntze , China species:. var sinensis, Assam species:. var assamica), oyster (Crassostrea gigas), milk, and eggs from At least one material or extract selected is preferred.
Examples of the form of the material include a pulverized product, a dried product, and a dried pulverized product. Examples of the extract include an extract, an extract, a dried product obtained by drying the extract, and a rough product thereof. Examples include purified products, purified products, and fermentation metabolites.
また、前記（Ｂ）動植物由来成分を有効成分とする疲労回復剤は、羅漢果、茶、ジンジャー、大豆、米、チェリー、牡蠣、乳、及び卵から選ばれる少なくとも１種の素材から抽出されたフォスファチジルセリン、γアミノ酪酸、タウリン、トリプトファン、及びテアニンの少なくともいずれかを含むことが好ましい。なお、これらの物質は、前記素材由来であればよく、発酵代謝産物であってもよい。 In addition, the fatigue recovery agent comprising (B) an animal and plant-derived component as an active ingredient is a phosphine extracted from at least one material selected from Rahan fruit, tea, ginger, soybean, rice, cherry, oyster, milk, and egg. It preferably contains at least one of fatidylserine, γ-aminobutyric acid, taurine, tryptophan, and theanine. These substances may be derived from the above materials and may be fermentation metabolites.
前記素材及び物質の配合量としては、特に制限はなく、目的に応じて適宜選択することができるが、例えば、本発明の起床時疲労感改善組成物の１日の摂取量中に、乾燥物重量として、下記表１に示す量が含まれていることが好ましい。また、前記素材及び物質は、１種または２種以上を配合することができる。 The amount of the material and the substance is not particularly limited and can be appropriately selected depending on the purpose. For example, during the daily intake of the composition for improving fatigue at wakeup of the present invention, It is preferable that the amount shown in Table 1 below is included as the weight. Moreover, the said raw material and substance can mix | blend 1 type (s) or 2 or more types.
さらに、前記起床時疲労感改善組成物中には、起床時疲労感改善効果を高める目的で、その他の成分を配合することができる。
その他の成分としては、例えば、アミノ酸、ビタミン類、ビフィズス菌、オリゴ糖、乳酸菌、ヒアルロン酸、ポリフェノール、ＤＨＡ（ドコサヘキサエン酸）、ＥＰＡ（エイコサペンタン酸）、スクワラン、キトサン、プロポリス、ラクトフェリン、クロレラ原末、スピルリナ原末、セントジョーンスウォートエキス、及び、ミネラル類（亜鉛、カルシウム、マグネシウム等）などが挙げられる。これらの中でも、特に、アミノ酸、及びビタミン類が好ましい。
Furthermore, other components can be blended in the composition for improving a feeling of fatigue when waking up for the purpose of enhancing the effect of improving the feeling of fatigue when waking up.
Other components include, for example, amino acids, vitamins, bifidobacteria, oligosaccharides, lactic acid bacteria, hyaluronic acid, polyphenol, DHA (docosahexaenoic acid), EPA (eicosapentanoic acid), squalane, chitosan, propolis, lactoferrin, chlorella raw material Powder, Spirulina bulk powder, St. John's wort extract, and minerals (zinc, calcium, magnesium, etc.). Among these, amino acids and vitamins are particularly preferable.
前記アミノ酸としては、必須アミノ酸が好ましく、例えば、トリプトファン、メチオニン、リジン、フェニルアラニン、ロイシン、イソロイシン、バリン、スレオニン、及びヒスチジンが挙げられ、これらの中でも、トリプトファンが好ましい。
前記ビタミン類としては、例えば、水溶性ビタミン、脂溶性ビタミン、ビタミン様物質（ビタミンＰ、ビタミンＱ、ビタミンＵ、イノシトール等）、及びプロビタミン類などが挙げられる。これらの中でも、ビタミンＡ類、ビタミンＢ群、ビタミンＣ、ビタミンＥ、及びそれらの組み合わせが好ましい。脂溶性ビタミンは、過剰摂取による弊害が生じない範囲で添加する。
The amino acid is preferably an essential amino acid, and examples include tryptophan, methionine, lysine, phenylalanine, leucine, isoleucine, valine, threonine, and histidine. Among these, tryptophan is preferable.
Examples of the vitamins include water-soluble vitamins, fat-soluble vitamins, vitamin-like substances (vitamin P, vitamin Q, vitamin U, inositol, etc.) and provitamins. Among these, vitamins A, vitamin B group, vitamin C, vitamin E, and combinations thereof are preferable. Add fat-soluble vitamins to the extent that they do not cause harmful effects of excessive intake.
なお、前記（Ａ）前記起床時疲労感改善剤と、（Ｂ）動植物由来成分との配合方法は、特に制限は無く、目的に応じて適宜選択することができる、各成分の抽出物の製造段階で予め配合しておいてもよく、別々に配合してもよい。
前記（Ａ）前記起床時疲労感改善剤と、（Ｂ）動植物由来成分との配合量は、１日あたりの摂取量として、前記（Ａ）が根茎部の乾燥物重量として１〜５０００ｍｇ、前記（Ｂ）の各成分が前記表１の量を満たして含有されている限り、特に制限されない。
In addition, there is no restriction | limiting in particular in the mixing | blending method of the said (A) said tiredness improvement agent at the time of rising, and (B) animal and plant origin component, Manufacturing of the extract of each component which can be suitably selected according to the objective. You may mix | blend beforehand in a step and may mix | blend separately.
The amount of (A) the wake-up fatigue sensation-improving agent and (B) the animal and plant-derived component is the daily intake amount, and (A) is 1 to 5000 mg as the dry matter weight of the rhizome part, As long as each component of (B) is contained so as to satisfy the amount shown in Table 1, it is not particularly limited.
前記起床時疲労感改善組成物の使用方法としては、特に制限はなく、目的に応じて適宜選択することができるが、例えば、医薬品、医薬部外品、サプリメント等の健康食品などとして使用することができる。また、一般食品や一般飲料に含有させることにより、後述する起床時疲労感改善用飲食物の成分として好適に使用することができる。 The method for using the composition for improving fatigue at the time of waking up is not particularly limited and may be appropriately selected depending on the intended purpose. For example, it may be used as a health food such as pharmaceuticals, quasi drugs, and supplements. Can do. Moreover, by making it contain in a general food and a general drink, it can be conveniently used as a component of the food for improving the feeling of fatigue when waking up, which will be described later.
前記起床時疲労感改善組成物を固形剤や液剤などに製剤化する方法としては、特に制限はなく、目的に応じて適宜選択することができる。
前記固形剤としては、例えば、錠剤、カプセル剤、顆粒剤、散剤、細粒剤、コーティング法により腸溶性コーティング剤、などが挙げられる。前記固形剤としては、経口固形製剤の製造時に用いられる添加剤を、本発明の効果を損なわない範囲で適宜配合することができる。前記添加剤としては、例えば、カリウム塩、酢酸、賦形剤、結合剤、崩壊剤、滑沢剤、矯味矯臭剤、増量剤、被覆剤、酸味料・ｐＨ調整剤、品質改良剤、増粘安定剤、及び保存料などが挙げられる。
前記液剤としては、例えば、前記起床時疲労感改善組成物の成分を、乳化剤を用いて水に溶解、及び分散させたもの、エチルアルコール等の可溶性溶媒に溶解させたのちに、水に溶解させたもの、などが挙げられる。
There is no restriction | limiting in particular as a method of formulating the said wake-up fatigue feeling improvement composition in a solid agent, a liquid agent, etc., According to the objective, it can select suitably.
Examples of the solid agent include tablets, capsules, granules, powders, fine granules, enteric coating agents by a coating method, and the like. As said solid agent, the additive used at the time of manufacture of an oral solid formulation can be mix | blended suitably in the range which does not impair the effect of this invention. Examples of the additive include potassium salt, acetic acid, excipient, binder, disintegrant, lubricant, flavoring agent, extender, coating agent, acidulant / pH adjuster, quality improver, thickener. Stabilizers, preservatives and the like can be mentioned.
As the liquid agent, for example, the components of the composition for improving fatigue feeling upon waking up are dissolved and dispersed in water using an emulsifier, dissolved in a soluble solvent such as ethyl alcohol, and then dissolved in water. And so on.
本発明の起床時疲労感改善組成物は、日常的に経口摂取することが可能であり、前記ナス科ウィザニア属植物由来成分の働きと、前記起床時疲労感改善組成物中に含まれる疲労回復成分とにより、睡眠の質が良化され、起床時に熟睡感や爽快感が得られ、特に、疲労感の解消が体感できる。 The composition for improving fatigue at the time of waking up of the present invention can be taken orally on a daily basis, and the function of the component derived from the plant belonging to the genus Widonia belonging to the solanaceous family and the recovery from fatigue contained in the composition for improving the feeling of fatigue at waking up With the ingredients, the quality of sleep is improved, and a deep sleep feeling and a refreshing feeling can be obtained when waking up.
（起床時疲労感改善用飲食物）
本発明の起床時疲労感改善用飲食物は、前記起床時疲労感改善剤、及び、前記起床時疲労感改善組成物のいずれかを含有してなり、必要に応じて適宜選択したその他の成分を含有してなる。
(Food and drink for improving fatigue when waking up)
The food and drink for improving the feeling of waking up of the present invention contains any one of the agent for improving the feeling of waking up when fatigued and the composition for improving the feeling of waking up when waking up, and other components appropriately selected as necessary. It contains.
前記起床時疲労感改善剤、及び前記起床時疲労感改善組成物が適用できる飲食物としては、特に限定されないが、通常の食生活において得られるカロリーに著しく影響を及ぼすことがないものが好ましい。特に、就寝前に摂取される飲食物としては、肥満の原因とならないよう、前記起床時疲労感改善用飲食物１食分のカロリーとしては、０〜１００ｋｃａｌが好ましく、０〜５０ｋｃａｌがより好ましく、０〜１０ｋｃａｌがより好ましい。 The food and drink to which the agent for improving fatigue at wake-up and the composition for improving fatigue at wake-up can be applied are not particularly limited, but those that do not significantly affect the calories obtained in a normal diet are preferred. In particular, as a food / drink taken before going to bed, the calorie content of the above-mentioned food for improving fatigue when waking up is preferably 0-100 kcal, more preferably 0-50 kcal, so as not to cause obesity. 10 kcal is more preferable.
前記起床時疲労感改善用飲食物としては、例えば、清涼飲料、炭酸飲料、栄養飲料、果実飲料、乳酸飲料等の飲料；飴、キャンディー、ガム、チョコレート、錠菓、スナック菓子、ビスケット、ゼリー、ジャム、クリーム、焼き菓子、パン等の菓子類；アイスクリーム、アイスシャーベット、かき氷等の冷菓；ソース、たれ、スパイス等の調味料；加工乳、発酵乳等の乳製品；サラダ油、てんぷら油、マーガリン、マヨネーズ、ショートニング、ホイップクリーム、ドレッシング等の油脂及び油脂加工食品；そば、うどん、はるさめ、ぎょうざの皮、しゅうまいの皮、中華麺、即席麺等の麺類；カニ、サケ、アサリ、マグロ、イワシ、エビ、カツオ、サバ、クジラ、カキ、サンマ、イカ、アカガイ、ホタテ、アワビ、ウニ、イクラ、トコブシ等の水産物；かまぼこ、ハム、ソーセージ等の水産・畜産加工食品；カレー、シチュー、親子丼、お粥、雑炊、中華丼、かつ丼、天丼、うな丼、ハヤシライス、おでん、マーボドーフ、牛丼、ミートソース、玉子スープ、オムライス、餃子、シューマイ、ハンバーグ、ミートボール等のレトルトパウチ食品；種々の形態の健康・栄養補助食品などが挙げられ、これらを製造するに当り通常用いられる補助的な原料や添加物と共に添加することができる。 Examples of the food for improving fatigue when waking up include beverages such as soft drinks, carbonated drinks, nutritive drinks, fruit drinks, and lactic acid drinks; candy, candy, gum, chocolate, tablet confectionery, snack confectionery, biscuits, jelly, jam Confectionery such as ice cream, ice sherbet and shaved ice; seasonings such as sauce, sauce and spices; dairy products such as processed milk and fermented milk; salad oil, tempura oil, margarine, Fats and oils and processed foods such as mayonnaise, shortening, whipped cream, dressing; noodles such as buckwheat, udon, harusame, gyoza skin, cucumber skin, Chinese noodles, instant noodles; crab, salmon, clams, tuna, sardines, shrimp , Bonito, mackerel, whale, oyster, saury, squid, red scallop, scallop, abalone, sea urchin, salmon roe, tocobushi Seafood products such as kamaboko, ham, sausage, processed fishery products such as kamaboko, ham, sausage; curry, stew, oyakodon, rice bowl, miscellaneous food, Chinese rice bowl, and rice bowl, tempura, eel rice, hayashi rice, oden, mabodorf, beef bowl, meat sauce, egg Retort pouch foods such as soup, omelet rice, dumplings, shumai, hamburger, meatballs; various forms of health and nutritional supplements, etc., added with auxiliary ingredients and additives normally used in the production of these can do.
前記その他の成分としては、前記飲食物を製造するに当り通常用いられる補助的原料又は添加物、などが挙げられる。
前記原料又は添加物としては、特に制限はなく、目的に応じて適宜選定することができるが、例えば、ブドウ糖、果糖、ショ糖、マルトース、ソルビトール、ステビオサイド、ルブソサイド、コーンシロップ、乳糖、クエン酸、酒石酸、リンゴ酸、コハク酸、乳酸、Ｌ−アスコルビン酸、ｄｌ−α−トコフェロール、エリソルビン酸ナトリウム、グリセリン、プロピレングリコール、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル、ソルビタン脂肪酸エステル、アラビアガム、カラギーナン、カゼイン、ゼラチン、ペクチン、寒天、ビタミンＢ類、ニコチン酸アミド、パントテン酸カルシウム、アミノ酸類、カルシウム塩類、色素、香料、保存剤、などが挙げられる。
Examples of the other components include auxiliary raw materials or additives that are usually used in producing the food and drink.
The raw material or additive is not particularly limited and may be appropriately selected depending on the intended purpose.For example, glucose, fructose, sucrose, maltose, sorbitol, stevioside, rubusoside, corn syrup, lactose, citric acid, Tartaric acid, malic acid, succinic acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, gum arabic , Carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinamide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances, preservatives, and the like.
前記起床時疲労感改善用飲食物における本発明の前記起床時疲労感改善剤、及び前記起床時疲労感改善組成物の添加量は、対象となる飲食物の種類に応じて異なり一概には規定することができないが、飲食物本来の味を損なわない範囲で添加すれば良く、各種対象飲食物に対し、通常１０ｐｐｍ〜５０％が好ましく、１００ｐｐｍ〜３０％がより好ましい。また、顆粒、錠剤又はカプセル形態の飲食物の場合には、通常０．１〜１００質量％が好ましく、５〜１００質量％がより好ましい。 The amount of addition of the wake-up fatigue sensation-improving agent of the present invention and the wake-up fatigue sensation improving composition in the food for improving wake-up fatigue sensation varies depending on the type of food or drink to be used, and is generally defined. However, it may be added within a range that does not impair the original taste of food and drink, and is usually preferably 10 ppm to 50% and more preferably 100 ppm to 30% with respect to various foods and drinks. Moreover, in the case of foods and drinks in the form of granules, tablets or capsules, usually 0.1 to 100% by mass is preferable, and 5 to 100% by mass is more preferable.
本発明の起床時疲労感改善用飲食物は、日常的に経口摂取することが可能であり、添加した前記起床時疲労感改善剤、及び前記起床時疲労感改善組成物の作用により、睡眠の質が良化され、起床時に熟睡感や爽快感が得られ、特に、疲労感の解消が体感できる。 The wake-up fatigue improvement food and drink of the present invention can be taken orally on a daily basis, and by the action of the added wake-up fatigue amelioration agent and the wake-up fatigue amelioration composition, The quality is improved and a feeling of deep sleep and a refreshing feeling can be obtained when waking up.
以下、本発明の実施例について説明するが、本発明はこの実施例に何ら限定されるものではない。
［製造例１］
−起床時疲労感改善組成物含有カプセル剤−
以下の組成を有する起床時疲労感改善組成物含有カプセル剤を、常法により製造した。なお、カプセルとしては１号ハードゼラチンカプセルを使用した。
＜配合成分とその配合量（カプセル剤４粒中）＞
・ウィザニアソムニフェラデュナル根茎部抽出物の乾燥粉末 ３００．０ｍｇ
・米由来γアミノ酪酸 １００．０ｍｇ
・羅漢果エキス ２０．０ｍｇ
・ビタミンＢ６ １．５ｍｇ
・賦形剤（セルロース） ２００．０ｍｇ
ただし、上記配合量は、１日の摂取量としてカプセル剤４粒中の量を示した。
Hereinafter, although the Example of this invention is described, this invention is not limited to this Example at all.
[Production Example 1]
-Capsule containing composition for improving fatigue at waking-
A capsule containing a composition for improving fatigue at wake-up having the following composition was produced by a conventional method. As the capsule, No. 1 hard gelatin capsule was used.
<Blend ingredients and their amount (in 4 capsules)>
・ Withernia Somnifera dunar rhizome extract dry powder 300.0mg
・ Rice-derived gamma aminobutyric acid 100.0mg
・ Rakan fruit extract 20.0mg
・ Vitamin B6 1.5mg
・ Excipient (cellulose) 200.0mg
However, the said compounding quantity showed the quantity in 4 capsules as a daily intake.
［比較製造例１］
前記製造例１で製造した起床時疲労感改善組成物含有カプセルのプラセボとして、以下の組成を有するカプセル剤を、常法により製造した。なお、カプセルとしては１号ハードゼラチンカプセルを使用した。
＜配合成分とその配合量（カプセル剤４粒中）＞
・ビタミンＢ６ １．５ｍｇ
・賦形剤（セルロース） ６２０．０ｍｇ
ただし、上記配合量は、１日の摂取量としてカプセル剤４粒中の量を示した。製造されたカプセル剤の外観は、前記製造例１のカプセル剤と同様であった。
[Comparative Production Example 1]
As a placebo of the capsule containing the composition for improving fatigue at wake-up produced in Production Example 1, a capsule having the following composition was produced by a conventional method. As the capsule, No. 1 hard gelatin capsule was used.
<Blend ingredients and their amount (in 4 capsules)>
・ Vitamin B6 1.5mg
・ Excipient (cellulose) 620.0mg
However, the said compounding quantity showed the quantity in 4 capsules as a daily intake. The appearance of the produced capsule was the same as that of the capsule of Production Example 1.
（実施例１及び比較例１）
アテネ式不眠尺度の結果、不眠の疑いあり（６点以上）と判定された人、または、睡眠に関する悩みを持っている人で、いずれも医師による診断や投薬を受けていない人３０名を被験者とした。
（１）サンプルの服用
前記被験者３０名を、１５名ずつ２グループに分け、以下のスケジュールで１５日間試験を行った。
・グループ１：サンプル服用５日間、服用なし５日間、プラセボ服用５日間
・グループ２：プラセボ服用５日間、服用なし５日間、サンプル服用５日間
なお、サンプル服用（実施例１）では、前記製造例１のカプセル剤４粒を、プラセボ服用（比較例１）では、前記比較製造例１のカプセル剤４粒を、それぞれ１日１回、就寝する３０〜６０分前に摂取してもらった。
(Example 1 and Comparative Example 1)
As a result of the Athenian insomnia scale, 30 people who were suspected of having insomnia (6 points or more) or who had trouble with sleep and were not diagnosed or administered by a doctor were examined. It was.
(1) Sample taking The 30 subjects were divided into 2 groups of 15 subjects, and the test was conducted for 15 days according to the following schedule.
-Group 1: 5 days of taking a sample, 5 days of non-dosing, 5 days of taking a placebo-Group 2: 5 days of taking a placebo, 5 days of taking no sample, 5 days of taking a sample Note that in the case of taking a sample (Example 1), the above production example For taking 1 capsule of 4 capsules in placebo (Comparative Example 1), 4 capsules of Comparative Production Example 1 were each taken once a day, 30 to 60 minutes before going to bed.
（２）評価方法
−睡眠感に関する評価−
前記被験者に、試験開始前、及び試験中の起床時に、ＯＳＡ睡眠評価票（ＭＡ版）に準拠したアンケートに回答してもらった。
前記アンケートは、１６問の質問で構成された４肢選択回答方式である。前記質問の項目は「（Ｉ）起床時の眠気」、「（II）入眠と睡眠維持（睡眠の質）」、「（III）夢見（悪夢や頻回の夢みによる睡眠の妨害）」、「（IV）疲労回復感（起床時の爽快感）」、及び「（Ｖ）睡眠時間延長感（長く眠っていたという感覚）」の５因子に分類されている。各質問項目は、反応頻度により重み付けられた尺度値（Ｚｃ）を持ち、これに基づいて因子ごとに結果を集計した（脳と精神の医学、１０：４０１−４０９（１９９９））。各因子とも得点が高いと睡眠が良好であると判断される。
試験前の得点と比較して、５点以上の改善がみられた被験者数を表２に示す。
また、試験中におけるサンプル服用時（実施例１）の結果、及び、プラセボ服用時（比較例１）の結果について、得点を表３及び図１に示す。
(2) Evaluation method-Evaluation on feeling of sleep-
The subject was asked to answer a questionnaire based on the OSA sleep evaluation form (MA version) before starting the test and when getting up during the test.
The questionnaire is a four-limb selection answer system composed of 16 questions. The items of the question are “(I) sleepiness when waking up”, “(II) falling asleep and sleep maintenance (sleep quality)”, “(III) dreaming (sleep disturbance due to nightmares and frequent dreams)”, “ (IV) Fatigue recovery feeling (refreshing feeling when waking up) "and" (V) Sleep feeling prolonged feeling (feeling of having slept for a long time) ". Each question item has a scale value (Zc) weighted by the reaction frequency, and based on this, the results are tabulated for each factor (brain and psychiatry, 10: 401-409 (1999)). If each factor has a high score, it is judged that sleep is good.
Table 2 shows the number of subjects who showed improvement of 5 points or more compared with the score before the test.
Moreover, a score is shown in Table 3 and FIG. 1 about the result at the time of sample taking (Example 1) in a test, and the result at the time of taking a placebo (Comparative Example 1).
−起床時の体感に関する評価−
前記被験者には、毎回、起床時の体感を自由回答してもらった。
前記自由回答に対し、（１）試験期間中に何らかの睡眠の良化を示す回答をした被験者数の集計、及び、（２）回答中に指摘された事項を分類し、複数の事項が挙げられた回答は分割し、具体的な睡眠の良化を示す件数の集計を行った。前記（２）については、例えば、「朝までほとんど起きなかったので、よく眠れた」という回答は、「朝までほとんど起きなかった（＝中途覚醒がほとんど無かった）」、「よく眠れた（＝熟睡感が得られた）」という２項目についてそれぞれ良化が認められたものとし、２件として計上した。
その結果、サンプル服用時（実施例１）において、何らかの睡眠の良化を体感したという被験者数は１５名中１０名（６６．７％）であり、「熟睡感が得られた」、「眠りの質が良くなった」、「起床時の疲労感が解消した」などの、具体的な睡眠の良化を示す件数は３８件であった。
一方、プラセボ服用時（比較例１）においては、前記睡眠の良化を体感したという回答をした被験者は、１５名中２名（１３．３％）であり、具体的な睡眠の良化を示す件数は７件であった。
-Evaluation of sensation when getting up-
The subjects were asked to freely answer the sensation of getting up every time.
In response to the above free answers, (1) the total number of subjects who answered that they showed some improvement in sleep during the test period, and (2) the items pointed out in the answers were classified, and multiple items were listed The responses were divided and tabulated for the number of specific sleep improvements. With regard to (2), for example, the answer that “I hardly woke up until morning, so I could sleep well” was “I did not get up until morning (= almost no awakening)”, “I slept well (= It was assumed that the improvement was recognized for each of the two items, “A feeling of deep sleep” was counted.
As a result, at the time of taking the sample (Example 1), the number of subjects who experienced some improvement in sleep was 10 out of 15 (66.7%). The number of cases showing concrete improvement in sleep, such as “Improved quality of sleep” and “Relieved fatigue when waking up” was 38 cases.
On the other hand, at the time of taking a placebo (Comparative Example 1), 2 subjects out of 15 (13.3%) responded that they experienced the improvement of sleep. The number of cases shown was seven.
−起床時の気分に関する評価−
被験者に、サンプル服用５日目及びプラセボ服用５日目に、それぞれ起床時の気分を以下の５段階で評価してもらった。なお、「気分が良い」という評価は、例えば、「爽快感がある」、「疲労感が無い」などの主観的な感覚や気分を示すものであるが、これらには、就寝前に体感していた疲労感の解消などの相対的な評価も含まれるものとして回答を得た。結果を表４に示す。
＜評価＞
５・・・気分が非常によい
４・・・気分がややよい
３・・・どちらともいえない
２・・・気分がやや悪い
１・・・気分が非常に悪い
-Evaluation of mood when getting up-
The subjects were asked to evaluate the mood at the time of waking up on the fifth day after taking the sample and the fifth day after taking the placebo in the following five stages. An evaluation of “feeling good” indicates a subjective feeling or feeling such as “has a refreshing feeling” or “no feeling of fatigue”. Responses were obtained that included relative evaluations such as eliminating fatigue. The results are shown in Table 4.
<Evaluation>
5 ... Feels very good 4 ... Feels slightly good 3 ... Not good 2 ... Feels a little bad 1 ... Feels very bad
（実施例２及び比較例２）
アテネ式不眠尺度の結果、不眠の疑いあり（６点以上）と判定された人、または、睡眠に関する悩みを持っている人で、いずれも医師による診断や投薬を受けていない人１０名を被験者とした。
（１）サンプルの服用
前記被験者１０名を、５名ずつ２グループに分け、以下のスケジュールで１０週間試験を行った。
・グループ１：サンプル服用４週間、服用なし２週間、プラセボ服用４週間
・グループ２：プラセボ服用４週間、服用なし２週間、サンプル服用４週間
なお、サンプル服用（実施例２）では、前記製造例１のカプセル剤４粒を、プラセボ服用（比較例２）では、前記比較製造例１のカプセル剤４粒を、それぞれ１日１回、就寝する３０〜６０分前に摂取してもらった。
(Example 2 and Comparative Example 2)
As a result of the Athenian Insomnia Scale, 10 subjects who were determined to have insomnia (6 points or more) or who had troubles related to sleep and were not diagnosed or administered by a doctor It was.
(1) Sample taking Ten subjects were divided into two groups of five, and the test was conducted for 10 weeks according to the following schedule.
Group 1: 4 weeks of sample taking, 2 weeks of non-dosing, 4 weeks of taking placebo Group 2: 4 weeks of taking placebo, 2 weeks of non-dosing, 4 weeks of taking sample In addition, in the sample taking (Example 2), the above production example In the case of taking 1 capsule of 4 capsules in placebo (Comparative Example 2), 4 capsules of Comparative Production Example 1 were each taken once a day, 30 to 60 minutes before going to bed.
（２）評価方法
−睡眠感に関する評価−
実施例１と同様にして、被験者にＯＳＡ睡眠評価票（ＭＡ版）に準拠したアンケートに回答してもらい、これを集計した。
試験中におけるサンプル服用時（実施例２）の結果、及び、プラセボ服用時（比較例２）の結果について、１週間毎に集計した得点を、表５及び図２〜６に示す。
(2) Evaluation method-Evaluation on feeling of sleep-
In the same manner as in Example 1, the subjects were asked to answer a questionnaire based on the OSA sleep evaluation vote (MA version), and this was totaled.
Table 5 and FIGS. 2 to 6 show the scores obtained every week for the results of taking the sample during the test (Example 2) and the results of taking the placebo (Comparative Example 2).
−起床時の体感に関する評価−
前記被験者には、毎回、起床時の体感を自由回答してもらい、実施例１と同様にして集計を行った。
その結果、サンプル服用時（実施例２）において、何らかの睡眠の良化を体感したという被験者数は１０名中６名（６０％）であり、「熟睡感が得られた」、「爽快な気持ちで目覚めた」、「起床時の疲労感が解消した」などの、具体的な睡眠の良化を示す件数は１４件であった。
一方、プラセボ服用時（比較例２）においては、前記睡眠の良化を体感したという回答をした被験者は、１０名中２名（２０％）であり、具体的な睡眠の良化を示す件数は５件であった。
-Evaluation of sensation when getting up-
The test subjects were asked to freely answer the sensation of getting up each time, and counting was performed in the same manner as in Example 1.
As a result, when taking the sample (Example 2), the number of subjects who experienced some kind of sleep improvement was 6 out of 10 (60%). There were 14 specific cases of sleep improvement, such as “I woke up in the morning” and “I was relieved of my fatigue when waking up”.
On the other hand, at the time of taking a placebo (Comparative Example 2), 2 out of 10 subjects (20%) responded that they experienced the improvement of sleep, and the number of subjects showing a specific improvement of sleep. There were 5 cases.
−起床時の気分に関する評価−
被験者に、サンプル服用４週間後及びプラセボ服用４週間後、起床時の気分を、実施例１と同様にして評価してもらった。結果を表６に示す。
-Evaluation of mood when getting up-
The subjects were evaluated in the same manner as in Example 1 after 4 weeks after taking the sample and 4 weeks after taking the placebo. The results are shown in Table 6.
本発明の起床時疲労感改善組成物は、容易に経口摂取することが可能であり、睡眠の質が良化され、起床時に熟睡感や爽快感が得られ、特に、疲労感の解消が体感できることがわかった。以下、本発明の起床時疲労感改善組成物を含む起床時疲労感改善用飲食物の製造例について説明する。 The composition for improving fatigue at the time of waking up of the present invention can be easily taken orally, the quality of sleep is improved, and a feeling of deep sleep and a refreshing feeling can be obtained at the time of waking up. I knew it was possible. Hereinafter, the manufacture example of the food-drinks for improving the feeling of fatigue at the time of rising containing the composition for improving the feeling of fatigue at the time of rising of the present invention is described.
［製造例２］
−起床時疲労感改善組成物含有カプセル剤−
以下の組成の起床時疲労感改善組成物含有カプセル剤を、常法により製造した。なお、カプセルとしては１号ハードゼラチンカプセルを使用した。
配合成分 配合量
・ウィザニアソムニフェラデュナル根茎部抽出物 ２５質量％
・ＧＡＢＡエキス ５質量％
・ジンジャーエキス １質量％
・トリプトファン ４質量％
・フォスファチジルセリン ８質量％
・羅漢果エキス ２質量％
・アルギニン ２質量％
・リジン ２質量％
・ビタミンＢ６ ０．２質量％
・ビタミンＣ ２０質量％
・賦形剤（セルロース） バランス
製造された前記カプセル剤は、摂取を妨げる臭気や苦味などをほとんど感じることなく、容易に経口摂取することができ、摂取後の睡眠が良化され、起床時の疲労感が改善された。
[Production Example 2]
-Capsule containing composition for improving fatigue at waking-
The capsule composition containing the composition for improving fatigue at wake-up having the following composition was produced by a conventional method. As the capsule, No. 1 hard gelatin capsule was used.
Compounding ingredients Compounding amount
-Withania Somnifera dunar rhizome extract 25% by mass
・ GABA extract 5% by mass
・ Ginger extract 1% by mass
・ Tryptophan 4% by mass
・ Phosphatidylserine 8% by mass
・
・
・
・ Vitamin B6 0.2% by mass
・ Vitamin C 20% by mass
・ Excipient (cellulose) balance
The produced capsules can be easily taken orally with almost no odor or bitterness that impedes intake, improve sleep after intake, and improve the feeling of fatigue when waking up.
［製造例３］
−起床時疲労感改善組成物含有錠剤−
以下の組成の起床時疲労感改善組成物含有錠剤を、常法により製造した。
配合成分 配合量
・ウィザニアソムニフェラデュナルエキス入りカプセル（※１） ３０質量％
・ＧＡＢＡエキス １０質量％
・ジンジャーエキス ２質量％
・フォスファチジルセリン ５質量％
・羅漢果エキス ５質量％
・ビタミンＢ群混合物（※２） １．５質量％
・ナイアシン ５質量％
・β−カロチン ０．３質量％
・コーンスターチ １０質量％
・ヒドロキシプロピルセルロース １０質量％
・乳糖 バランス
※１：前記ウィザニアソムニフェラデュナルエキス入りカプセルは、ウィザニアソムニフェラデュナルエキスを５％配合して常法により調製したサイクロデキストリンカプセルである。
※２：ビタミンＢ１／ビタミンＢ２／ビタミンＢ６／ビタミンＢ１２＝４５０／５００／６７０／１
製造された前記錠剤は、摂取を妨げる臭気や苦味などをほとんど感じることなく、容易に経口摂取することができ、摂取後の睡眠が良化され、起床時の疲労感が改善された。
[Production Example 3]
-Tablets containing composition for improving fatigue at wake-up-
A tablet containing the composition for improving fatigue at wake-up having the following composition was produced by a conventional method.
Compounding ingredients Compounding amount
・ Capsule with wizzania somnifera dunal extract (* 1) 30% by mass
・ GABA extract 10% by mass
・ Ginger extract 2% by mass
・ Phosphatidylserine 5% by mass
・ Arhat extract 5% by mass
・ Vitamin B group mixture (* 2) 1.5% by mass
・ Niacin 5% by mass
・ Β-Carotene 0.3% by mass
・ Corn starch 10% by mass
・ Hydroxypropylcellulose 10% by mass
・ Lactose balance
* 1: The above-mentioned Capsule with Withania Somnifera Dunal Extract is a cyclodextrin capsule prepared by a conventional method containing 5% of Withania Somnifera Dunal Extract.
* 2: Vitamin B1 / Vitamin B2 / Vitamin B6 / Vitamin B12 = 450/500/670/1
The manufactured tablets can be easily taken orally with almost no odor or bitterness that hinders intake, improve sleep after intake, and improve the feeling of fatigue when waking up.
［製造例４］
−起床時疲労感改善組成物含有ゼリー−
以下の組成の起床時疲労感改善組成物含有ゼリーを、常法により製造した。
配合成分 配合量
・ウィザニアソムニフェラデュナルエキス入りカプセル（※） ３質量％
・ＧＡＢＡエキス １質量％
・ジンジャー絞り汁 １質量％
・フォスファチジルセリン １質量％
・羅漢果エキス ２質量％
・ゼラチン １．５質量％
・ノンカロリー甘味料 適量
・香料（ジンジャーフレーバー） 適量
・水 バランス
ただし、前記ウィザニアソムニフェラデュナルエキス入りカプセルは、ウィザニアソムニフェラデュナルエキスを５％配合して常法により調製したサイクロデキストリンカプセルである。
製造された前記ゼリーは、摂取を妨げる臭気や苦味などをほとんど感じることなく、容易に経口摂取することができ、摂取後の睡眠が良化され、起床時の疲労感が改善された。
[Production Example 4]
-A jelly containing a composition for improving fatigue when waking up-
A jelly composition containing a composition for improving fatigue at wake-up having the following composition was produced by a conventional method.
Compounding ingredients Compounding amount
・ Capsule with wizzania somnifera dunal
・ GABA extract 1% by mass
・
・
・
・ Gelatin 1.5% by mass
・ Non-calorie sweetener appropriate amount ・ fragrance (ginger flavor) appropriate amount
・ Water balance
However, the capsule containing the Withania somnifera dunal extract is a cyclodextrin capsule prepared by a conventional method by blending 5% Withania somnifera dunal extract.
The produced jelly can be easily taken orally with almost no odor or bitterness that hinders intake, improves sleep after intake, and improves feeling of fatigue when waking up.
［製造例５］
−起床時疲労感改善組成物含有クッキー−
以下の組成の起床時疲労感改善組成物含有クッキーを、常法により製造した。
配合成分 配合量
・ウィザニアソムニフェラデュナルエキス入りカプセル（※） ３質量％
・羅漢果エキス １０質量％
・牛乳 ６０質量％
・全卵 １０質量％
・砂糖 ５質量％
・コーンスターチ ５質量％
・食塩 ０．５質量％
・フレーバー（バニラエッセンス） 適量
ただし、前記ウィザニアソムニフェラデュナルエキス入りカプセルは、ウィザニアソムニフェラデュナルエキスを５％配合して常法により調製したサイクロデキストリンカプセルである。
製造された前記クッキーは、摂取を妨げる臭気や苦味などをほとんど感じることなく、容易に経口摂取することができ、摂取後の睡眠が良化され、起床時の疲労感が改善された。
[Production Example 5]
-Cookies containing composition to improve fatigue when getting up-
A wake-up fatigue feeling improving composition-containing cookie having the following composition was produced by a conventional method.
Compounding ingredients Compounding amount
・ Capsule with wizzania somnifera dunal
-Rahan fruit extract 10% by mass
・ Milk 60% by mass
・ 10% by mass of whole eggs
・ Sugar 5% by mass
・ Corn starch 5% by mass
・ Salt 0.5% by mass
・ Flavor (vanilla essence)
However, the capsule containing the Withania somnifera dunal extract is a cyclodextrin capsule prepared by a conventional method by blending 5% Withania somnifera dunal extract.
The manufactured cookie can be easily taken orally with almost no odor or bitterness that hinders intake, improves sleep after intake, and improves feeling of fatigue when waking up.
［製造例６］
−起床時疲労感改善組成物含有麺（うどん）−
以下の組成の起床時疲労感改善組成物含有麺（うどん）を、常法により製造した。
配合成分 配合量
・ウィザニアソムニフェラデュナルエキス ０．２質量％
・羅漢果エキス １質量％
・小麦粉 ６５質量％
・食塩 ３質量％
・水 適量
製造された前記麺（うどん）は、摂取を妨げる臭気や苦味などをほとんど感じることなく、容易に経口摂取することができ、摂取後の睡眠が良化され、起床時の疲労感が改善された。
[Production Example 6]
-Noodles (Udon) containing a composition for improving fatigue when waking up-
Noodles (udon) containing the composition for improving fatigue at wake-up having the following composition were produced by a conventional method.
Compounding ingredients Compounding amount
・ Withania Somnifera Dunal Extract 0.2% by mass
-
・ 65% by weight of flour
・
・ Appropriate amount of water
The produced noodles can be easily taken orally with almost no odor or bitterness that hinders intake, improve sleep after intake, and improve the feeling of fatigue when waking up .
本発明の起床時疲労感改善剤及び起床時疲労感改善組成物は、睡眠の質を良化する作用を有し、服用することにより起床時（覚醒時）に疲労感の解消を体感でき、摂取が容易であり、経口的に摂取される一般食品、健康食品、保健機能食品、医薬部外品及び医薬品等の飲食物に幅広く適用できるものである。また、前記起床時疲労感改善剤及び起床時疲労感改善組成物のいずれかを含有する本発明の起床時疲労感改善飲食物は、健康食品として好適に用いることができる。 The wake-up fatigue sensation-improving agent and the wake-up fatigue sensation-improving composition have an effect of improving sleep quality, and can be experienced to eliminate fatigue when waking up (at the time of awakening), It is easy to ingest, and can be widely applied to foods and drinks such as general foods, health foods, health functional foods, quasi drugs and pharmaceuticals that are taken orally. In addition, the wake-up fatigue improvement food or drink of the present invention containing either the wake-up fatigue sensation improving agent or the wake-up fatigue sensation improving composition can be suitably used as a health food.
Claims (9)
A food / drink for improving fatigue feeling when waking up, comprising the composition for improving fatigue feeling when waking up according to any one of claims 4 to 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004206784A JP2006028051A (en) | 2004-07-14 | 2004-07-14 | Ameliorant for exhausted feeling at time of rising, composition for ameliorating exhausted feeling at time of rising, and food and beverage for ameliorating exhausted feeling at time of rising, containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004206784A JP2006028051A (en) | 2004-07-14 | 2004-07-14 | Ameliorant for exhausted feeling at time of rising, composition for ameliorating exhausted feeling at time of rising, and food and beverage for ameliorating exhausted feeling at time of rising, containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2006028051A true JP2006028051A (en) | 2006-02-02 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004206784A Pending JP2006028051A (en) | 2004-07-14 | 2004-07-14 | Ameliorant for exhausted feeling at time of rising, composition for ameliorating exhausted feeling at time of rising, and food and beverage for ameliorating exhausted feeling at time of rising, containing them |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2006028051A (en) |
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| JP2007031309A (en) * | 2005-07-25 | 2007-02-08 | Tokiwa Yakuhin Kogyo Kk | Anti-stress composition |
| WO2013051728A1 (en) | 2011-10-06 | 2013-04-11 | ライオン株式会社 | Agent for improving quality of sleep |
| CN104474388A (en) * | 2014-12-16 | 2015-04-01 | 熊菊莲 | Traditional Chinese medicine for treating insomnia due to fire excess from yin deficiency |
| CN104706925A (en) * | 2015-04-01 | 2015-06-17 | 汪涛 | Traditional Chinese medicine for treating senile insomnia |
| KR20190055258A (en) | 2011-10-06 | 2019-05-22 | 라이온 가부시키가이샤 | Agent for improving quality of sleep |
| WO2019188806A1 (en) | 2018-03-28 | 2019-10-03 | 森永乳業株式会社 | Sleep-promoting composition, and medicinal composition and food and beverage composition using said sleep-promoting composition |
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- 2004-07-14 JP JP2004206784A patent/JP2006028051A/en active Pending
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|---|---|---|---|---|
| JP2007031309A (en) * | 2005-07-25 | 2007-02-08 | Tokiwa Yakuhin Kogyo Kk | Anti-stress composition |
| WO2013051728A1 (en) | 2011-10-06 | 2013-04-11 | ライオン株式会社 | Agent for improving quality of sleep |
| KR20140079389A (en) | 2011-10-06 | 2014-06-26 | 라이온 가부시키가이샤 | Agent for improving quality of sleep |
| KR20190055258A (en) | 2011-10-06 | 2019-05-22 | 라이온 가부시키가이샤 | Agent for improving quality of sleep |
| CN104474388A (en) * | 2014-12-16 | 2015-04-01 | 熊菊莲 | Traditional Chinese medicine for treating insomnia due to fire excess from yin deficiency |
| CN104706925A (en) * | 2015-04-01 | 2015-06-17 | 汪涛 | Traditional Chinese medicine for treating senile insomnia |
| JP7012724B2 (en) | 2016-08-26 | 2022-02-14 | ダブドゥブ，アティフ | Dietary high / micronutrients for patients undergoing renal dialysis |
| JP2019532098A (en) * | 2016-08-26 | 2019-11-07 | ダブドゥブ, アティフDABDOUB, Atif | Dietary macro / micronutrient supplements for patients undergoing renal dialysis |
| US11324784B2 (en) | 2018-03-28 | 2022-05-10 | Morinaga Milk Industry Co., Ltd. | Sleep-promoting composition, and medical composition and food beverage composition using said sleep-promoting composition |
| WO2019188806A1 (en) | 2018-03-28 | 2019-10-03 | 森永乳業株式会社 | Sleep-promoting composition, and medicinal composition and food and beverage composition using said sleep-promoting composition |
| JP2020137462A (en) * | 2019-02-28 | 2020-09-03 | 株式会社ウェルナス | Orally ingesting composition for improving sleep |
| JP7337363B2 (en) | 2019-02-28 | 2023-09-04 | 株式会社ウェルナス | Oral composition for improving sleep |
| JP2023169145A (en) * | 2019-02-28 | 2023-11-29 | 株式会社ウェルナス | Orally ingested composition for improving sleep |
| JP2021180614A (en) * | 2020-05-18 | 2021-11-25 | アサヒグループ食品株式会社 | Nutritive supplement composition and production method thereof, method for suppressing unpleasant odor of nutritive supplement composition, and composition for suppressing unpleasant odor of nutritive supplement composition |
| JP7618939B2 (en) | 2020-05-18 | 2025-01-22 | アサヒグループ食品株式会社 | Nutraceutical Compositions |
| JP2022088794A (en) * | 2020-12-03 | 2022-06-15 | ポーラ化成工業株式会社 | Fatigue state estimation model learning method |
| CN113229430A (en) * | 2021-05-24 | 2021-08-10 | 中国科学院海洋研究所 | Strontium-rich seaweed protein health-care functional beverage and preparation method thereof |
| WO2024090913A1 (en) * | 2022-10-26 | 2024-05-02 | 주식회사 에이치엘사이언스 | Composition for enhancing exercise performance, comprising, as active ingredient, complex of withania somnifera extract and chrysanthemum zawadskii herbich var. latilobum (maxim.) kitamura extract (asc complex) |
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