JP2005013124A - Food composition having cosmetic effect - Google Patents
Food composition having cosmetic effect Download PDFInfo
- Publication number
- JP2005013124A JP2005013124A JP2003183723A JP2003183723A JP2005013124A JP 2005013124 A JP2005013124 A JP 2005013124A JP 2003183723 A JP2003183723 A JP 2003183723A JP 2003183723 A JP2003183723 A JP 2003183723A JP 2005013124 A JP2005013124 A JP 2005013124A
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- Prior art keywords
- food composition
- component
- effect
- msm
- skin
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Abstract
Description
【０００１】
【発明の属する技術分野】
本発明は、美容効果を有する食品組成物に関する。
【０００２】
【従来の技術】
従来から、美白、シワの防止、皮膚のハリやツヤの改善などの美容を目的とした種々の化粧品が用いられている。しかし、化粧品の使用は局所的または対処的なものにすぎないため、不十分である場合が多い。
【０００３】
美容の目的のために、種々の美容食品、例えば、コラーゲン粉末と杜仲茶エキスとを含有する食品などが報告されている（例えば、特許文献１）。さらに、皮膚の色素沈着を防止するために、アスコルビン酸とＬ−システインとを配合した健康食品などが市販されている。しかし、これらの食品の美容効果は十分とはいえない。
【０００４】
美白効果、シワの防止および低減効果、ならびに皮膚のハリやツヤを改善する効果を有し、手軽に利用可能な食品組成物が求められている。
【０００５】
近年、メチルスルフォニルメタン（ＭＳＭ）を皮膚に塗布することによって、皮膚が柔軟になることが報告されている。ＭＳＭは、その他、アレルギーの改善効果および抗炎症効果を有することが知られているが（例えば、特許文献２〜４）、それ以外の効果については明らかになっていない。
【０００６】
【特許文献１】
特開平８−２０５８３５号公報
【特許文献２】
特開昭５６−３６４１２号公報
【特許文献３】
特開平２−２７３２１号公報
【特許文献４】
特公平５−１６４０６号公報
【０００７】
【発明が解決しようとする課題】
本発明の目的は、美白効果、シワの防止および低減効果、皮膚のハリやツヤを改善する効果などの美容効果が十分に得られ、かつ手軽に利用可能な食品組成物を提供することにある。
【０００８】
【課題を解決するための手段】
本発明者らは、美容効果が得られる食品について、鋭意検討を行った結果、ＭＳＭを摂取することによって、美白効果、シワの防止および低減効果、肌のハリやツヤを改善する効果などの美容効果が得られることを見出して、本発明に至った。
【０００９】
本発明の美容効果を有する食品組成物は、メチルスルホニルメタンを含有する。
【００１０】
好ましい実施態様においては、上記食品組成物は、さらに抗酸化作用、ヒアルロニダーゼ阻害作用、コラゲナーゼ阻害作用、およびエラスターゼ阻害作用からなる群より選択される少なくとも一種の作用を有する成分を含有する。
【００１１】
好ましい実施態様においては、上記食品組成物は、さらにムコ多糖類、アミノ糖、コラーゲン、エラスチン、アミノ酸、およびセラミド類からなる群より選択される少なくとも一種を含有する。
【００１２】
【発明の実施の形態】
以下、本発明の美容効果を有する食品組成物について説明する。なお、以下に説明する構成は、本発明を限定するものでなく、本発明の趣旨の範囲内で種々改変することができることは当業者に明らかである。
【００１３】
本発明の美容効果を有する食品組成物は、メチルスルホニルメタン（以下、Ａ成分という場合がある）を含有する。この食品組成物は、好ましくは、抗酸化作用、ヒアルロニダーゼ阻害作用、コラゲナーゼ阻害作用、およびエラスターゼ阻害作用からなる群より選択される少なくとも一種の作用を有する成分（以下、Ｂ成分という場合がある）、ならびにムコ多糖類、アミノ糖、コラーゲン、エラスチン、アミノ酸、およびセラミド類からなる群より選択される少なくとも一種（以下、Ｃ成分という場合がある）の少なくとも一方を含有し、必要に応じて、添加剤などを含有する。。
【００１４】
（１）Ａ成分：メチルスルホニルメタン（ＭＳＭ）
ＭＳＭは、自然界に存在する硫黄化合物であり、以下の式で示される化合物である。この化合物は、ほとんどの動植物に吸収され、体内の硫黄源として利用され、主に結合組織や骨を構成する成分の１つとなっている。
【００１５】
【化１】
メチルスルホニルメタン（ＭＳＭ）は、食品としては、加工されていない新鮮な牛乳に最も多く含有され、コーヒー、茶（例えば、茶葉）、松（例えば、松の葉）、トマト、リンゴ、緑黄色野菜（例えば、キャベツ）などの植物にも、ごく微量ではあるが含有されている。
【００１７】
本発明の食品組成物に含有されるＭＳＭは、天然物由来であっても、合成品であってもよい。天然物由来のＭＳＭは、例えば、上記の牛乳あるいは植物から抽出することによって得られる。例えば、松からリグニンを単離し、このリグニンと硫黄とを混合することにより硫黄を酸化して得られる。得られたＭＳＭは、その後、蒸留などの精製によって純度を高めることが好ましい。合成品の場合、例えば、以下の反応式に示されるジメチルスルホキシドの酸化などによって得ることができる。ＭＳＭは、その純度が９０重量％以上のものが好ましく用いられる：
（ＣＨ３）２ＳＯ＋Ｈ２Ｏ２ → （ＣＨ３）２ＳＯ２＋Ｈ２Ｏ
【００１８】
ＭＳＭは、上述のように、結合組織や骨を構成する成分の１つであり、加齢とともに減少し、例えば肌にシワが生じるなどの現象が現れる。しかし、本発明のＭＳＭを含有する食品組成物を摂取することにより、このような肌のシワ、シミを回避し、さらに肌のハリやツヤを改善するなどの美容効果が得られることが見出された。
【００１９】
（２）Ｂ成分：抗酸化作用、ヒアルロニダーゼ阻害作用、コラゲナーゼ阻害作用、およびエラスターゼ阻害作用からなる群より選択される少なくとも一種の作用を有する成分
本発明の食品組成物に含有され得るこれらの成分は、ＭＳＭの有する美容効果をさらに増強し得る。
【００２０】
以下に上記Ｂ成分についての説明を行う。これらの中には、複数の上記作用を有する物質もある。この場合、単一の作用に限定して使用してもよく、複数の作用を意図して使用してもよい。これらの成分は、単独で使用してもよく、あるいは組み合わせて使用してもよい。
【００２１】
抗酸化作用を有する成分としては、ヘスペリジン、ケルセチンなどのフラボノール；プロアントシアニジン、エピガロカテキンなどのフラバノール；ビタミンＡ、ビタミンＣ、ビタミンＥなどの抗酸化作用を有するビタミン類；ユビキノン（ＣｏＱ１０）；シスチン、システイン、およびシステイン含有ペプチド（グルタチオンなど）；セサミン、セサモリンなどのリグナン類；クルクミンおよびその誘導体；上記いずれか１つ以上の成分を含有する植物抽出物などが挙げられる。これらの成分の中でも、プロアントシアニジン、ビタミンＣ（コラーゲン合成のために経口摂取が必要な成分である）、ビタミンＥ、ユビキノン、およびシステイン含有ペプチドが好ましく、プロアントシアニジンがより好ましい。抗酸化作用を有する成分は、特に、活性酸素によるコラーゲンなどの結合組織が崩壊するのを防止する効果、チロシナーゼ阻害効果、メラニンの還元作用などにより、ＭＳＭと相乗的に作用して、美容効果を増強し得る。
【００２２】
ヒアルロニダーゼ阻害作用を有する成分としては、大黄、茶葉、ハマメリス、シソ、タイム、海藻、およびこれらの抽出物、プロアントシアニジンなどが挙げられる。好ましくは、大黄、茶葉、およびプロアントシアニジンである。
【００２３】
コラゲナーゼ阻害作用を有する成分としては、ハマメリス、グアバ、大豆、茶、山査子などの植物およびこれらの植物抽出物、コーヒー酸、フラボノール、ラクトフェリン、プロアントシアニジンなどが挙げられる。好ましくは、プロアントシアニジンである。
【００２４】
エラスターゼ阻害作用を有する成分としては、ユキノシタ、グァバ、ガラナ、ローズマリー、ソウハクヒ、ホップなどの植物、およびこれらの抽出物、プロアントシアニジンなどが挙げられる。好ましくは、グァバおよびその抽出物、ならびにプロアントシアニジンである。
【００２５】
上記成分の中でも、プロアントシアニジンが特に好ましい。プロアントシアニジンは、高い活性酸素除去能を有し、ヒアルロニダーゼ阻害作用、コラゲナーゼ阻害作用、およびエラスターゼ阻害作用を発揮する。さらに、コラーゲンの合成促進作用などを有するため、ＭＳＭとともに相乗的な美容効果を発揮し得る。
【００２６】
（３）Ｃ成分：ムコ多糖類、アミノ糖、コラーゲン、エラスチン、アミノ酸、およびセラミド類からなる群より選択される少なくとも一種
本発明の食品組成物に含有され得るこれらの物質は、肌質の改善効果を促進する作用を有するため、ＭＳＭの有する美容効果をさらに増強し得る。
【００２７】
ムコ多糖類としては、ヒアルロン酸、コンドロイチン、デルマタン、ヘパラン、ヘパリン、ケタラン、およびこれらの塩（例えば、硫酸塩や塩酸塩）が挙げられる。これらを豊富に含有する食品素材、例えば、鮫や牛の軟骨の抽出物、鶏冠、鶏皮、ツバメの巣、納豆、およびオクラなどの食品素材を使用してもよい。これらの成分の中で、ヒアルロン酸塩、コンドロイチン塩、および鮫や牛の軟骨の抽出物が好ましい。
【００２８】
ムコ多糖類、特に、ヒアルロン酸およびコンドロイチン硫酸は、皮膚の真皮層の細胞間物質を構成する成分である。ムコ多糖類は、加齢と共に減少するため、真皮層の細胞間物質が減少する。この細胞間物質の減少により、皮膚の保水性および弾力性が失われ、肌荒れや小皺が生じる。したがって、本発明の食品組成物にムコ多糖類が含有されると、肌荒れの防止効果およびシワの発生の防止効果がさらに増強され得る。
【００２９】
アミノ糖としては、グルコサミン、アセチルグルコサミン、ガラクトサミン、アセチルガラクトサミン、ノイラミン酸、アセチルノイラミン酸、ヘキソサミン、これらの塩（例えば、リン酸塩）などが挙げられる。これらを豊富に含む食品素材、例えば、鮫や牛の軟骨の抽出物を使用してもよい。好ましくはグルコサミンおよび鮫や牛の軟骨の抽出物である。
【００３０】
ムコ多糖類およびアミノ糖は、組み合わせて使用することが好ましい。例えば、ムコ多糖類およびアミノ糖をいずれも豊富に含有する鮫や牛の軟骨の抽出物が、特に好適である。
【００３１】
コラーゲンは、動物の皮膚（真皮組織）、骨、腱、血管の壁などに多く含まれている繊維状のタンパク質である。コラーゲンを摂取することによって、皮膚の水になじむ能力を高め、保水効果を強める；皮膚の温度放散を抑える；皮膚の表面をなめらかにする；および脂性の皮膚では皮膚表面の脂分を減少させる一方、乾燥性の皮膚では皮膚表面の脂分を増加させてバランスをとる等の効果を有することが知られている。コラーゲンは、ＭＳＭの有する美容効果をさらに高めるために、好適に使用され得る。
【００３２】
アミノ酸としては、コラーゲン、エラスチンなどを構成する主要なアミノ酸が好ましく、例えば、プロリン、システイン及びその誘導体、アラニン、アルギニン、およびグリシンが挙げられる。これらのアミノ酸は、真皮を構成するタンパク質の合成を促進し、肌の老化を防止するため、ＭＳＭの有する美容効果を増強し得る。
【００３３】
セラミド類としては、例えば、セラミド、グルコシルセラミド、およびガラクトシルセラミドが挙げられる。好ましくは、グルコシルセラミドである。さらに、これらを含有する医薬品原料；牛等の動物の脳からの抽出物などの動物由来の抽出物；小麦、米、大豆、黍、ホウレンソウ、コンニャクなどの植物由来の抽出物；酵母などの微生物由来の抽出物などの市販品を用いることもできる。セラミド類は、人間の皮膚の構成成分の１つで、食品として皮膚の保湿および保護作用、ならびに肌荒れの防止および改善効果を有する。したがって、ＭＳＭの有する美容効果をさらに高めることができる。
【００３４】
（４）その他の成分
本発明の食品組成物は、さらに必要に応じて、賦形剤、増量剤、結合剤、増粘剤、乳化剤、着色料、香料、機能性成分、調味料などの添加剤を含有する。これらのうち、機能性成分としては、例えば、ローヤルゼリー、ビタミン、プロテイン、アミノ酸、カルシウム含有材料（例えば、卵殻カルシウム）、キトサン、レシチンなどが挙げられる。調味料としては、例えば、ステビア末、抹茶パウダー、レモンパウダー、はちみつ、ソルビドール、還元麦芽糖、乳糖、糖液などが挙げられる。
【００３５】
（５）美容効果を有する食品組成物
本発明の美容効果を有する食品組成物は、メチルスルホニルメタン（Ａ成分）を含有し、好ましくは抗酸化作用、ヒアルロニダーゼ阻害作用、コラゲナーゼ阻害作用、およびエラスターゼ阻害作用からなる群より選択される少なくとも一種の作用を有する成分（Ｂ成分）、ならびにムコ多糖類、アミノ糖、コラーゲン、エラスチン、アミノ酸、およびセラミド類からなる群より選択される少なくとも一種（Ｃ成分）のうちの少なくとも一方を含有する。
【００３６】
本発明の食品組成物中のＭＳＭ（Ａ成分）の含有量に特に制限はない。ＭＳＭの摂取量が、成人一日当たり、好ましくは１００ｍｇ〜３０００ｍｇ、より好ましくは３００ｍｇ〜２０００ｍｇ、さらに好ましくは５００ｍｇ〜１０００ｍｇとなるように食品組成物中に含有させることが好ましい。
【００３７】
本発明の食品組成物中の抗酸化作用、ヒアルロニダーゼ阻害作用、コラゲナーゼ阻害作用、およびエラスターゼ阻害作用からなる群より選択される少なくとも一種の作用を有する成分（Ｂ成分）の含有量に特に制限はないが、その摂取量が、成人一日当たり、好ましくは０．００１ｍｇ〜２０００ｍｇ、より好ましくは０．００５ｍｇ〜１０００ｍｇとなるように食品組成物中に含有されることが好ましい。
【００３８】
本発明の食品組成物中のムコ多糖類、アミノ糖、コラーゲン、エラスチン、アミノ酸、およびセラミド類からなる群より選択される少なくとも一種（Ｃ成分）の含有量に特に制限はないが、その摂取量が、一日当たり、好ましくは１０ｍｇ〜５０００ｍｇ、より好ましくは２０ｍｇ〜３０００ｍｇとなるように食品組成物中に含有されることが好ましい。
【００３９】
本発明の食品組成物が、Ｂ成分を含有する場合、Ａ成分１００重量部に対して、Ｂ成分を、好ましくは０．００１〜１０００重量部、より好ましくは０．０１〜５００重量部となるように含有されることが好ましい。Ｃ成分を含有する場合、Ａ成分１００重量部に対して、Ｃ成分を、好ましくは０．０１〜１０００重量部、より好ましくは０．１〜５００重量部となるように含有されることが好ましい。このような割合で含有する食品組成物は、美容効果が相乗的に発揮される。
【００４０】
本発明の食品組成物は、種々の形態であり得、この形態に特に制限はない。例えば、ハードカプセル、ソフトカプセルなどのカプセル剤、錠剤、丸剤などの形態、あるいは粉末状、顆粒状、茶状、ティーバッグ状、飴状、液体（飲料）、ペースト状などの形態であり得る。これらは、形状または好みに応じて、そのまま飲食してもよく、あるいは水、湯などに溶いて飲んでも良い。
【００４１】
本発明の食品組成物は、ＭＳＭを含有するため、美白効果、シワの防止および低減効果、肌のハリやツヤを改善する効果などの優れた美容効果を発揮する。本発明の食品組成物は、長期的に摂取すること、例えば、１ヶ月以上摂取することが好ましい。
【００４２】
【実施例】
以下、本発明をさらに具体的に説明するが、本発明がこの実施例に限定されないことはいうまでもない。
【００４３】
（実施例１）
ＭＳＭ（協和ハイフーズ株式会社）と低ビタミンＣ飼料（ＣＧ−７：日本クレア（株）、ビタミンＣ含有量０．０１重量％）とを表１に記載の割合にて混合して飼料１を調製した。この飼料１を用いて、肌のハリやツヤを改善する効果を以下のようにして評価した。
【００４４】
まず、平均体重２６９ｇの雄性モルモット（日本エスエルシー（株））５０匹に一週間基本飼料（ＣＧ−７：日本クレア（株）、ビタミンＣ含有量０．１７重量％）を与えて馴化させた。これらのモルモットを総無作為化法により一群５匹の１０群にわけた。次いで、１群のモルモットに上記飼料１を４週間自由摂取させた。摂取期間終了後、モルモットから皮膚を摘出し、１０倍希釈ホルマリン溶液に１２時間浸漬させた後、精製水で洗浄した。さらに、５０容量％メタノール水溶液に２時間、７０容量％メタノール水溶液に２時間、および８０容量％メタノール水溶液に２４時間浸漬した。その後、無水メタノールに２．５時間浸漬する操作を４回繰り返して脱水処理を行った。得られた処理物をさらに、キシレンに１時間浸漬する操作を３回繰り返した後、溶媒をパラフィンに置換して、１時間浸漬する操作を２回繰り返して包埋した。包埋後、ミクロトーム（ヤマト科学株式会社）を用いて厚さ１μｍの病理切片を作製し、病理切片からパラフィンを除去した後に、アザン−マロリー法により染色して基底板と筋膜との間の距離（すなわち、真皮に相当する部分の厚み）を顕微鏡で測定し、真皮の厚さの平均値を算出した。結果を表２に示す。なお、真皮に相当する部分の厚さが大きいほど、肌のハリやツヤが改善されたことを示す。
【００４５】
（実施例２〜９）
実施例１と同様に、表１に記載の組成の各成分を混合して飼料を調製した（各々飼料２〜９とする）。これらの飼料を用いて実施例１と同様に、肌のハリやツヤを改善する効果を評価した。結果を表２に併せて示す。
【００４６】
（比較例１）
実施例１と同様に、表１に記載の組成の各成分を混合して飼料１０を調製した。この飼料１０を用いて実施例１と同様に、肌のハリやツヤを改善する効果を評価した。結果を表２に併せて示す。
【００４７】
【表１】
【表２】
表２の結果から、実施例１〜９のＭＳＭ（Ａ成分）を含有する飼料を摂取した群は、比較例１のＭＳＭを含有しない飼料を摂取した群に比べて、真皮の厚さが増加していることが分かる。このことは、ＭＳＭを含有する飼料が、優れた肌のハリやツヤを改善する効果を有することを示す。特に、実施例２〜９のＭＳＭ（Ａ成分）と、Ｂ成分およびＣ成分のいずれか一方の成分とを含有する飼料を摂取した群は、真皮の厚さが大きく増加した。
【００５０】
（実施例１０）
ＭＳＭ（協和ハイフーズ株式会社製）および賦形剤（結晶セルロース、還元麦芽糖、ショ糖エステル、および二酸化ケイ素の等量混合物）を、表３に記載の割合にて混合して１錠が３００ｍｇの重量の錠剤１を製造した。
【００５１】
５人の女性ボランティア（４５歳以上）に、錠剤１を１日あたり１２錠、４週間摂取させた。摂取期間終了後、摂取前に比べて、肌の状態に関する表４に記載の項目をアンケート調査し、美容効果を評価した。アンケート調査は、「はい」または「いいえ」で自己評価してもらい、「はい」と答えた人数を集計した。結果を表４に示す。
【００５２】
（実施例１１〜１５）
実施例１０と同様にして、表３に記載の成分を混合して錠剤２〜６をそれぞれ製造した（１錠あたり３００ｍｇ）。錠剤１の代わりに、錠剤２〜６をそれぞれ、各５人の女性ボランティア（４５歳以上）に摂取させたこと以外は、実施例１０と同様に実施した。結果を表４に併せて示す。
【００５３】
（比較例２）
実施例１０と同様にして、表３に記載の成分を混合して錠剤７を製造した（１錠あたり３００ｍｇ）。錠剤１の代わりに、この錠剤７を、５人の女性ボランティア（４５歳以上）に摂取させたこと以外は、実施例１０と同様に実施した。結果を表４に併せて示す。
【００５４】
【表３】
【表４】
表４の結果から、実施例１０〜１５のＭＳＭ（Ａ成分）を含有する錠剤は、比較例２のＭＳＭを含有しない錠剤に比べて、優れた美容効果を有することがわかる。特に、実施例１１〜１５のＭＳＭ（Ａ成分）と、Ｂ成分およびＣ成分の少なくとも一方の成分とを含有する錠剤が、高い美容効果を有することがわかる。
【００５７】
【発明の効果】
本発明によれば、このように、メチルスルホニルメタンを含有し、美容効果を有する食品組成物が提供される。この食品組成物を摂取することによって、美白効果、シワの防止および低減効果、肌のハリやツヤを改善する効果などの優れた美容効果が得られる。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a food composition having a cosmetic effect.
[0002]
[Prior art]
Conventionally, various cosmetics for the purpose of beauty such as whitening, prevention of wrinkles, improvement of skin firmness and gloss have been used. However, cosmetic use is often insufficient because it is only topical or coping.
[0003]
For the purpose of beauty, various beauty foods such as foods containing collagen powder and Tochu tea extract have been reported (for example, Patent Document 1). In addition, health foods containing ascorbic acid and L-cysteine are commercially available to prevent skin pigmentation. However, the beauty effects of these foods are not sufficient.
[0004]
There is a need for a food composition that has a whitening effect, an effect of preventing and reducing wrinkles, and an effect of improving the firmness and gloss of the skin, and can be easily used.
[0005]
Recently, it has been reported that the skin becomes soft by applying methylsulfonylmethane (MSM) to the skin. In addition, MSM is known to have an allergy ameliorating effect and an anti-inflammatory effect (for example, Patent Documents 2 to 4), but other effects are not clear.
[0006]
[Patent Document 1]
JP-A-8-205835 [Patent Document 2]
JP 56-36412 A [Patent Document 3]
Japanese Patent Laid-Open No. 2-27321 [Patent Document 4]
Japanese Examined Patent Publication No. 5-16406 [0007]
[Problems to be solved by the invention]
An object of the present invention is to provide a food composition that can sufficiently provide cosmetic effects such as a whitening effect, an effect of preventing and reducing wrinkles, and an effect of improving skin firmness and gloss, and can be easily used. .
[0008]
[Means for Solving the Problems]
As a result of intensive studies on foods that have a beauty effect, the present inventors have taken beauty care such as whitening effect, wrinkle prevention and reduction effect, skin firmness and glossiness by taking MSM. The inventors have found that an effect can be obtained and have reached the present invention.
[0009]
The food composition having a cosmetic effect of the present invention contains methylsulfonylmethane.
[0010]
In a preferred embodiment, the food composition further contains a component having at least one action selected from the group consisting of an antioxidant action, a hyaluronidase inhibitory action, a collagenase inhibitory action, and an elastase inhibitory action.
[0011]
In a preferred embodiment, the food composition further contains at least one selected from the group consisting of mucopolysaccharides, amino sugars, collagen, elastin, amino acids, and ceramides.
[0012]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the food composition having a cosmetic effect of the present invention will be described. The configurations described below are not intended to limit the present invention, and it will be apparent to those skilled in the art that various modifications can be made within the scope of the present invention.
[0013]
The food composition having a cosmetic effect of the present invention contains methylsulfonylmethane (hereinafter sometimes referred to as component A). This food composition is preferably an ingredient having at least one action selected from the group consisting of an antioxidant action, a hyaluronidase inhibitory action, a collagenase inhibitory action, and an elastase inhibitory action (hereinafter sometimes referred to as B ingredient), And at least one selected from the group consisting of mucopolysaccharides, amino sugars, collagen, elastin, amino acids, and ceramides (hereinafter sometimes referred to as “C component”), and if necessary, additives Etc. .
[0014]
(1) Component A: methylsulfonylmethane (MSM)
MSM is a sulfur compound existing in nature and is a compound represented by the following formula. This compound is absorbed by most animals and plants, is used as a sulfur source in the body, and is mainly one of the components constituting connective tissue and bone.
[0015]
[Chemical 1]
As a food, methylsulfonylmethane (MSM) is the most abundant in fresh milk that has not been processed. Coffee, tea (for example, tea leaves), pine (for example, pine leaves), tomatoes, apples, green-yellow vegetables ( For example, plants such as cabbage) contain a very small amount.
[0017]
The MSM contained in the food composition of the present invention may be a natural product or a synthetic product. MSM derived from natural products can be obtained, for example, by extracting from the above milk or plant. For example, it can be obtained by isolating lignin from pine and oxidizing sulfur by mixing this lignin and sulfur. The resulting MSM is then preferably purified by purification such as distillation. In the case of a synthetic product, it can be obtained, for example, by oxidation of dimethyl sulfoxide shown in the following reaction formula. MSM having a purity of 90% by weight or more is preferably used:
(CH 3 ) 2 SO + H 2 O 2 → (CH 3 ) 2 SO 2 + H 2 O
[0018]
As described above, MSM is one of the components constituting connective tissue and bone, and decreases with age, for example, a phenomenon such as wrinkles on the skin appears. However, by ingesting the food composition containing the MSM of the present invention, it has been found that such skin wrinkles and spots can be avoided, and further cosmetic effects such as improving skin firmness and gloss can be obtained. It was done.
[0019]
(2) Component B: a component having at least one action selected from the group consisting of an antioxidant action, a hyaluronidase inhibitory action, a collagenase inhibitory action, and an elastase inhibitory action. These ingredients that can be contained in the food composition of the present invention include: The cosmetic effect of MSM can be further enhanced.
[0020]
The B component will be described below. Some of these substances have a plurality of the above-mentioned actions. In this case, it may be limited to a single action, or may be used intentionally. These components may be used alone or in combination.
[0021]
Ingredients having antioxidant activity include flavonols such as hesperidin and quercetin; flavanols such as proanthocyanidins and epigallocatechin; vitamins having antioxidant activity such as vitamin A, vitamin C and vitamin E; ubiquinone (CoQ10); cystine , Cysteine, and cysteine-containing peptides (such as glutathione); lignans such as sesamin and sesamolin; curcumin and derivatives thereof; and plant extracts containing any one or more of the above components. Among these components, proanthocyanidins, vitamin C (components that need to be taken orally for collagen synthesis), vitamin E, ubiquinone, and cysteine-containing peptides are preferable, and proanthocyanidins are more preferable. Ingredients that have an anti-oxidant action synergistically with MSM due to the effect of preventing the breakdown of connective tissues such as collagen due to active oxygen, the effect of inhibiting tyrosinase, the action of reducing melanin, etc. Can be enhanced.
[0022]
Examples of the component having a hyaluronidase inhibitory action include large yellow, tea leaves, hamamelis, perilla, thyme, seaweed, and extracts thereof, proanthocyanidins and the like. Of these, large yellow, tea leaves, and proanthocyanidins are preferable.
[0023]
Examples of the component having a collagenase inhibitory action include plants such as hamamelis, guava, soybean, tea, and yamako, and plant extracts thereof, caffeic acid, flavonol, lactoferrin, proanthocyanidins and the like. Proanthocyanidins are preferable.
[0024]
Examples of the component having an elastase inhibitory action include plants such as Yukinoshita, guava, guarana, rosemary, Sakuhakuhi, hop, and extracts thereof, proanthocyanidins and the like. Preferably, guava and its extract, and proanthocyanidins.
[0025]
Among the above components, proanthocyanidins are particularly preferable. Proanthocyanidins have a high ability to remove active oxygen and exert hyaluronidase inhibitory action, collagenase inhibitory action, and elastase inhibitory action. Furthermore, since it has an action of promoting the synthesis of collagen, it can exert a synergistic beauty effect together with MSM.
[0026]
(3) Component C: At least one selected from the group consisting of mucopolysaccharides, amino sugars, collagen, elastin, amino acids, and ceramides, these substances that can be contained in the food composition of the present invention improve skin quality Since it has an effect of promoting the effect, the cosmetic effect of MSM can be further enhanced.
[0027]
Examples of mucopolysaccharides include hyaluronic acid, chondroitin, dermatan, heparan, heparin, ketalan, and salts thereof (for example, sulfate and hydrochloride). Food materials containing abundant of these may be used, for example, food materials such as salmon and bovine cartilage extract, chicken crown, chicken skin, swallow's nest, natto, and okra. Among these components, hyaluronate, chondroitin salt, and salmon and bovine cartilage extracts are preferred.
[0028]
Mucopolysaccharides, particularly hyaluronic acid and chondroitin sulfate, are components that constitute intercellular substances in the dermal layer of the skin. Since mucopolysaccharides decrease with aging, intercellular substances in the dermis layer decrease. This reduction in intercellular substances loses the water retention and elasticity of the skin, resulting in rough skin and wrinkles. Therefore, when mucopolysaccharide is contained in the food composition of the present invention, the effect of preventing rough skin and the effect of preventing the generation of wrinkles can be further enhanced.
[0029]
Examples of amino sugars include glucosamine, acetylglucosamine, galactosamine, acetylgalactosamine, neuraminic acid, acetylneuraminic acid, hexosamine, and salts thereof (for example, phosphate). You may use the food material which contains these abundantly, for example, the extract of a salmon or cow cartilage. Glucosamine and salmon and bovine cartilage extracts are preferred.
[0030]
The mucopolysaccharide and amino sugar are preferably used in combination. For example, a salmon or bovine cartilage extract that is rich in both mucopolysaccharides and amino sugars is particularly suitable.
[0031]
Collagen is a fibrous protein that is abundant in animal skin (dermis tissue), bones, tendons, blood vessel walls, and the like. Ingesting collagen enhances the ability of skin to adapt to water and enhances water retention effect; suppresses skin temperature dissipation; smoothes skin surface; and oily skin reduces skin surface fat It is known that dry skin has effects such as increasing the fat content on the skin surface to achieve balance. Collagen can be preferably used to further enhance the cosmetic effect of MSM.
[0032]
As the amino acid, main amino acids constituting collagen, elastin and the like are preferable, and examples thereof include proline, cysteine and derivatives thereof, alanine, arginine and glycine. Since these amino acids promote the synthesis of proteins constituting the dermis and prevent skin aging, the cosmetic effects of MSM can be enhanced.
[0033]
Examples of ceramides include ceramide, glucosylceramide, and galactosylceramide. Preferably, it is glucosylceramide. Furthermore, medicinal raw materials containing them; animal-derived extracts such as extracts from the brain of animals such as cattle; plant-derived extracts such as wheat, rice, soybeans, straw, spinach, konjac; microorganisms such as yeast Commercial products such as an extract derived from the origin can also be used. Ceramides are one of the components of human skin, and have a moisturizing and protecting action on the skin as a food, and an effect of preventing and improving rough skin. Therefore, the cosmetic effect of MSM can be further enhanced.
[0034]
(4) Other components The food composition of the present invention may be further added with excipients, extenders, binders, thickeners, emulsifiers, colorants, fragrances, functional ingredients, seasonings and the like as necessary. Contains agents. Among these, examples of the functional component include royal jelly, vitamins, proteins, amino acids, calcium-containing materials (for example, eggshell calcium), chitosan, and lecithin. Examples of the seasoning include stevia powder, matcha powder, lemon powder, honey, sorbidol, reduced maltose, lactose, sugar solution, and the like.
[0035]
(5) Food composition having a cosmetic effect The food composition having a cosmetic effect of the present invention contains methylsulfonylmethane (component A), and preferably has an antioxidant action, a hyaluronidase inhibitory action, a collagenase inhibitory action, and an elastase inhibitor. A component having at least one action selected from the group consisting of actions (component B), and at least one selected from the group consisting of mucopolysaccharides, amino sugars, collagen, elastin, amino acids, and ceramides (component C) Of at least one of them.
[0036]
There is no restriction | limiting in particular in content of MSM (A component) in the food composition of this invention. It is preferable to contain the MSM in the food composition so that the daily intake of MSM is preferably 100 mg to 3000 mg, more preferably 300 mg to 2000 mg, and even more preferably 500 mg to 1000 mg.
[0037]
The content of the component (B component) having at least one action selected from the group consisting of the antioxidant action, hyaluronidase inhibitory action, collagenase inhibitory action, and elastase inhibitory action in the food composition of the present invention is not particularly limited. However, it is preferable to be contained in the food composition so that the intake amount thereof is preferably 0.001 mg to 2000 mg, more preferably 0.005 mg to 1000 mg per adult day.
[0038]
The content of at least one (C component) selected from the group consisting of mucopolysaccharides, amino sugars, collagen, elastin, amino acids, and ceramides in the food composition of the present invention is not particularly limited. However, it is preferably contained in the food composition so as to be preferably 10 mg to 5000 mg, more preferably 20 mg to 3000 mg per day.
[0039]
When the food composition of the present invention contains the B component, the B component is preferably 0.001 to 1000 parts by weight, more preferably 0.01 to 500 parts by weight with respect to 100 parts by weight of the A component. It is preferable to contain. When the component C is contained, the component C is preferably contained in an amount of 0.01 to 1000 parts by weight, more preferably 0.1 to 500 parts by weight, with respect to 100 parts by weight of the component A. . The food composition contained at such a ratio synergistically exhibits a cosmetic effect.
[0040]
The food composition of the present invention can be in various forms, and this form is not particularly limited. For example, it may be in the form of capsules such as hard capsules and soft capsules, tablets and pills, or in the form of powder, granules, tea, tea bags, bowls, liquids (beverages), pastes, and the like. Depending on the shape or preference, these may be eaten or consumed as they are, or may be dissolved in water, hot water or the like.
[0041]
Since the food composition of the present invention contains MSM, it exhibits excellent cosmetic effects such as a whitening effect, an effect of preventing and reducing wrinkles, and an effect of improving skin firmness and gloss. The food composition of the present invention is preferably taken for a long time, for example, for one month or longer.
[0042]
【Example】
Hereinafter, the present invention will be described more specifically, but it is needless to say that the present invention is not limited to these examples.
[0043]
(Example 1)
MSM (Kyowa High Foods Co., Ltd.) and low vitamin C feed (CG-7: Nippon Claire Co., Ltd., vitamin C content 0.01% by weight) were mixed at the ratio shown in Table 1 to prepare feed 1. did. Using this feed 1, the effect of improving skin firmness and gloss was evaluated as follows.
[0044]
First, 50 male guinea pigs (Japan SLC Co., Ltd.) with an average body weight of 269 g were fed with a basic feed (CG-7: Nippon Claire Co., Ltd., vitamin C content 0.17% by weight) for one week to acclimatize. . These guinea pigs were divided into 10 groups of 5 per group by the total randomization method. Next, a group of guinea pigs were allowed to freely take the above feed 1 for 4 weeks. After the intake period, the skin was removed from the guinea pig, immersed in a 10-fold diluted formalin solution for 12 hours, and then washed with purified water. Furthermore, it was immersed in a 50 volume% methanol aqueous solution for 2 hours, a 70 volume% methanol aqueous solution for 2 hours, and an 80 volume% methanol aqueous solution for 24 hours. Thereafter, the operation of immersing in anhydrous methanol for 2.5 hours was repeated four times for dehydration treatment. The operation of immersing the obtained processed product in xylene for 1 hour was further repeated 3 times, and then the solvent was replaced with paraffin and the operation of immersing for 1 hour was repeated twice for embedding. After embedding, a microtome (Yamato Scientific Co., Ltd.) was used to prepare a pathological section having a thickness of 1 μm, and after removing paraffin from the pathological section, staining was performed by the Azan-Mallory method, and between the basement plate and fascia. The distance (that is, the thickness of the portion corresponding to the dermis) was measured with a microscope, and the average value of the thickness of the dermis was calculated. The results are shown in Table 2. In addition, it shows that the firmness and gloss of the skin were improved, so that the thickness of the part corresponded to dermis was large.
[0045]
(Examples 2-9)
As in Example 1, feeds were prepared by mixing the components having the composition described in Table 1 (each feed 2-9). Using these feeds, the effect of improving skin firmness and gloss was evaluated in the same manner as in Example 1. The results are also shown in Table 2.
[0046]
(Comparative Example 1)
As in Example 1, feed 10 was prepared by mixing the components having the composition shown in Table 1. Using this feed 10, the effect of improving skin firmness and gloss was evaluated in the same manner as in Example 1. The results are also shown in Table 2.
[0047]
[Table 1]
[Table 2]
From the results of Table 2, the group that ingested the feed containing the MSM (component A) of Examples 1 to 9 increased the thickness of the dermis compared to the group that ingested the feed that did not contain the MSM of Comparative Example 1. You can see that This shows that the feed containing MSM has an effect of improving excellent skin firmness and gloss. In particular, in the group that ingested the feed containing the MSM (A component) of Examples 2 to 9 and any one of the B component and the C component, the thickness of the dermis was greatly increased.
[0050]
(Example 10)
MSM (manufactured by Kyowa High Foods Co., Ltd.) and excipients (equivalent mixture of crystalline cellulose, reduced maltose, sucrose ester, and silicon dioxide) were mixed in the proportions shown in Table 3, and each tablet had a weight of 300 mg. Tablet 1 was produced.
[0051]
Five female volunteers (over 45 years old) were given 12 tablets per day for 4 weeks. After the intake period, compared with before intake, the items listed in Table 4 regarding the skin condition were surveyed to evaluate the beauty effect. In the questionnaire survey, the number of people who answered "Yes" was counted by having them evaluate themselves with "Yes" or "No". The results are shown in Table 4.
[0052]
(Examples 11 to 15)
In the same manner as in Example 10, the ingredients listed in Table 3 were mixed to produce tablets 2 to 6 (300 mg per tablet). Instead of tablet 1, tablets 2 to 6 were each carried out in the same manner as in Example 10 except that 5 female volunteers (45 years old or older) were ingested. The results are also shown in Table 4.
[0053]
(Comparative Example 2)
In the same manner as in Example 10, the ingredients listed in Table 3 were mixed to produce tablet 7 (300 mg per tablet). Instead of tablet 1, this tablet 7 was carried out in the same manner as in Example 10 except that 5 female volunteers (45 years old or older) were ingested. The results are also shown in Table 4.
[0054]
[Table 3]
[Table 4]
From the results in Table 4, it can be seen that the tablets containing MSM (component A) of Examples 10 to 15 have an excellent cosmetic effect as compared with the tablet not containing MSM of Comparative Example 2. It turns out that especially the tablet containing MSM (A component) of Examples 11-15 and at least one component of B component and C component has a high cosmetic effect.
[0057]
【The invention's effect】
According to the present invention, there is thus provided a food composition containing methylsulfonylmethane and having a cosmetic effect. By taking this food composition, excellent cosmetic effects such as a whitening effect, an effect of preventing and reducing wrinkles, and an effect of improving skin firmness and gloss can be obtained.
Claims (3)
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| Application Number | Priority Date | Filing Date | Title |
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| JP2003183723A JP2005013124A (en) | 2003-06-27 | 2003-06-27 | Food composition having cosmetic effect |
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| JP2003183723A JP2005013124A (en) | 2003-06-27 | 2003-06-27 | Food composition having cosmetic effect |
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| JP2005013124A true JP2005013124A (en) | 2005-01-20 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009240285A (en) * | 2008-03-31 | 2009-10-22 | Kobayashi Pharmaceut Co Ltd | Food composition comprising processed material of peanut seed coat as active ingredient |
| US7851441B2 (en) | 2004-10-29 | 2010-12-14 | Kyushu Institute Of Technology | Water-soluble elastin, process for producing same, and food and medicine containing same |
| JP2012065605A (en) * | 2010-09-24 | 2012-04-05 | Toyo Shinyaku Co Ltd | Food composition |
| JP2015512439A (en) * | 2012-04-02 | 2015-04-27 | イーグルファーマ ピーティーワイ エルティーディＥａｇｌｅｐｈａｒｍａ Ｐｔｙ Ｌｔｄ | Compositions for the treatment of inflammatory and immune diseases |
| CN111956790A (en) * | 2020-08-17 | 2020-11-20 | 张会方 | Preparation method of medicine for increasing human collagen and reticular fiber |
-
2003
- 2003-06-27 JP JP2003183723A patent/JP2005013124A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7851441B2 (en) | 2004-10-29 | 2010-12-14 | Kyushu Institute Of Technology | Water-soluble elastin, process for producing same, and food and medicine containing same |
| JP2009240285A (en) * | 2008-03-31 | 2009-10-22 | Kobayashi Pharmaceut Co Ltd | Food composition comprising processed material of peanut seed coat as active ingredient |
| JP2012065605A (en) * | 2010-09-24 | 2012-04-05 | Toyo Shinyaku Co Ltd | Food composition |
| JP2015512439A (en) * | 2012-04-02 | 2015-04-27 | イーグルファーマ ピーティーワイ エルティーディＥａｇｌｅｐｈａｒｍａ Ｐｔｙ Ｌｔｄ | Compositions for the treatment of inflammatory and immune diseases |
| CN111956790A (en) * | 2020-08-17 | 2020-11-20 | 张会方 | Preparation method of medicine for increasing human collagen and reticular fiber |
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