JP2004527578A5 - - Google Patents
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- Publication number
- JP2004527578A5 JP2004527578A5 JP2002592087A JP2002592087A JP2004527578A5 JP 2004527578 A5 JP2004527578 A5 JP 2004527578A5 JP 2002592087 A JP2002592087 A JP 2002592087A JP 2002592087 A JP2002592087 A JP 2002592087A JP 2004527578 A5 JP2004527578 A5 JP 2004527578A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- eye
- composition according
- inhibitor
- dry eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 3
- 206010013774 Dry eye Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 238000009736 wetting Methods 0.000 claims 2
- FAWLNURBQMTKEB-URDPEVQOSA-N 213546-53-3 Chemical compound N([C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N1[C@@H](CCC1)C(O)=O)C(C)C)C(C)C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(C)C FAWLNURBQMTKEB-URDPEVQOSA-N 0.000 claims 1
- FXRYWOJYVGJZLE-UHFFFAOYSA-N 4,4-dimethyl-2,3-dihydro-1,2-benzoselenazine Chemical compound C1=CC=C2C(C)(C)CN[Se]C2=C1 FXRYWOJYVGJZLE-UHFFFAOYSA-N 0.000 claims 1
- YEYAKZXEBSVURO-UHFFFAOYSA-N 4-amino-3-chloro-n-[2-(diethylamino)ethyl]benzamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C(Cl)=C1 YEYAKZXEBSVURO-UHFFFAOYSA-N 0.000 claims 1
- 150000003857 carboxamides Chemical class 0.000 claims 1
- 229950008176 declopramide Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000017128 negative regulation of NF-kappaB transcription factor activity Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Claims (5)
- ドライアイおよび眼の湿潤を必要とする他の障害の処置のための組成物であって、薬学的受容可能なキャリアおよび薬学的有効量の１種以上のＮＦ−κＢインヒビターを含む、組成物。
- 請求項１に記載の組成物であって、前記１種以上のＮＦ−κＢインヒビターの薬学的有効量が、０．００１〜１．０％（ｗ／ｖ）である、組成物。
- 請求項１に記載の組成物であって、前記ＮＦ−κＢインヒビターが、２−クロロ−Ｎ−［３，５−ジ（トリフルオロメチル）フェニル］−４−（トリフルオロメチル）ピリミジン−５−カルボキサミド；３，４−ジヒドロ−４，４−ジメチル−２Ｈ−１，２−ベンゾセレナジン；デクロプラミド；およびデキシリポタムからなる群より選択される、組成物。
- 請求項１に記載の組成物であって、前記組成物が、前記眼への局所的投与のために処方されている、組成物。
- 請求項１に記載の組成物であって、前記ドライアイおよび眼の湿潤を必要とする他の障害が、屈折手術に関連するドライアイの症状である、組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29249501P | 2001-05-21 | 2001-05-21 | |
| PCT/US2002/015859 WO2002095704A1 (en) | 2001-05-21 | 2002-05-17 | Use of nf-kappa-b inhibitors to treat dry eye disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004527578A JP2004527578A (ja) | 2004-09-09 |
| JP2004527578A5 true JP2004527578A5 (ja) | 2005-12-22 |
Family
ID=23124921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002592087A Pending JP2004527578A (ja) | 2001-05-21 | 2002-05-17 | ドライアイ障害を処置するためのＮＦ−κＢインヒビターの使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6696453B2 (ja) |
| EP (1) | EP1393277B1 (ja) |
| JP (1) | JP2004527578A (ja) |
| CN (1) | CN1509462A (ja) |
| AT (1) | ATE333273T1 (ja) |
| AU (1) | AU2002309963B2 (ja) |
| BR (1) | BR0209965A (ja) |
| CA (1) | CA2447883A1 (ja) |
| CY (1) | CY1105220T1 (ja) |
| DE (1) | DE60213230T2 (ja) |
| DK (1) | DK1393277T3 (ja) |
| ES (1) | ES2263785T3 (ja) |
| MX (1) | MXPA03010632A (ja) |
| PL (1) | PL367286A1 (ja) |
| PT (1) | PT1393277E (ja) |
| WO (1) | WO2002095704A1 (ja) |
| ZA (1) | ZA200308769B (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05003063A (es) * | 2002-09-20 | 2005-05-27 | Alcon Inc | Uso de inhibidores de la sintesis de citosina para el tratamiento de trastornos de ojos secos. |
| CN112263672A (zh) | 2020-11-04 | 2021-01-26 | 武汉益承生物科技有限公司 | 一种p55pik抑制剂在制备干眼治疗药物中的应用 |
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| US3991759A (en) | 1975-10-28 | 1976-11-16 | Alza Corporation | Method and therapeutic system for treating aqueous deficient dry eye |
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| US4370325A (en) | 1979-03-30 | 1983-01-25 | Dermik Laboratories | Pharmaceutical compositions and method of treatment |
| US6410516B1 (en) | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
| US4744980A (en) | 1986-04-28 | 1988-05-17 | Holly Frank J | Ophthalmic solution for treatment of dry eye syndrome |
| US4883658A (en) | 1986-04-28 | 1989-11-28 | Holly Frank J | Ophthalmic solution for treatment of dry-eye syndrome |
| US4804539A (en) | 1986-07-28 | 1989-02-14 | Liposome Technology, Inc. | Ophthalmic liposomes |
| US4818537A (en) | 1986-10-21 | 1989-04-04 | Liposome Technology, Inc. | Liposome composition for treating dry eye |
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| US5278151A (en) | 1987-04-02 | 1994-01-11 | Ocular Research Of Boston, Inc. | Dry eye treatment solution |
| US4914088A (en) | 1987-04-02 | 1990-04-03 | Thomas Glonek | Dry eye treatment solution and method |
| US4996209A (en) | 1988-06-20 | 1991-02-26 | Alcon Laboratories, Inc. | Ophthalmic antiinflammatory compositions comprising S(+)-flurbiprofen |
| US5075104A (en) | 1989-03-31 | 1991-12-24 | Alcon Laboratories, Inc. | Ophthalmic carboxy vinyl polymer gel for dry eye syndrome |
| US5174988A (en) | 1989-07-27 | 1992-12-29 | Scientific Development & Research, Inc. | Phospholipid delivery system |
| US5583150A (en) | 1989-08-18 | 1996-12-10 | Alcon Laboratories, Inc. | 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases |
| US5041434A (en) | 1991-08-17 | 1991-08-20 | Virginia Lubkin | Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application |
| ZA912797B (en) | 1990-05-29 | 1992-12-30 | Boston Ocular Res | Dry eye treatment process and solution |
| ATE132366T1 (de) | 1990-05-29 | 1996-01-15 | Boston Ocular Res | Zusammensetzung zur behandlung von dry eye erkrankungen |
| DE4028906A1 (de) | 1990-09-12 | 1992-03-19 | Paz Arzneimittelentwicklung | Arzneimittel sowie deren herstellung und deren verwendung bei der bekaempfung von schmerzen und/oder entzuendungen und/oder fieber an tieren und menschen |
| ATE141502T1 (de) | 1991-01-15 | 1996-09-15 | Alcon Lab Inc | Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen |
| ZA927277B (en) | 1991-10-02 | 1993-05-19 | Boston Ocular Res | Dry eye treatment process and solution. |
| DE4140184C2 (de) | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Akutform für ein Flurbiprofen enthaltendes Arzneimittel |
| WO1993020823A1 (en) | 1992-04-21 | 1993-10-28 | The Schepens Eye Research Institute, Inc. | Ocular androgen therapy in sjögren's syndrome |
| US5958912A (en) * | 1992-04-21 | 1999-09-28 | The Schepens Eye Research Institute, Inc. | Ocular therapy in keratoconjunctivitis sicca using topically applied androgens of TGF-β |
| US5290572A (en) | 1992-08-06 | 1994-03-01 | Deo Corporation | Opthalmic composition for treating dry eye |
| US5686436A (en) | 1993-05-13 | 1997-11-11 | Hiv Diagnostics, Inc. | Multi-faceted method to repress reproduction of latent viruses in humans and animals |
| US5561161A (en) | 1994-03-25 | 1996-10-01 | Oxigene, Inc. | Methods of administering and pharmaceutical formulations containing n-substituted benzamides and/or acid addition salts thereof |
| FR2718441B1 (fr) * | 1994-04-07 | 1996-06-28 | Bioxytech | Nouveaux composés de structure benzisoséléna-zoline et -zine, leur procédé de préparation et leurs applications thérapeutiques. |
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| US6335358B1 (en) | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
| DE69634404T2 (de) | 1995-08-14 | 2005-12-29 | Optigenex, Inc. | Caroteinoid-nicotinamid-zink zusammensetzungen und verfahren zur behandlung unter verwendung derselben |
| US5696166A (en) | 1995-10-31 | 1997-12-09 | Yanni; John M. | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders |
| WO1997020578A1 (en) | 1995-12-04 | 1997-06-12 | University Of Miami | Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance |
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| US6046185A (en) | 1996-07-11 | 2000-04-04 | Inflazyme Pharmaceuticals Ltd. | 6,7-oxygenated steroids and uses related thereto |
| US6071904A (en) | 1996-12-11 | 2000-06-06 | Alcon Laboratories, Inc. | Process for manufacturing ophthalmic suspensions |
| US5800807A (en) | 1997-01-29 | 1998-09-01 | Bausch & Lomb Incorporated | Ophthalmic compositions including glycerin and propylene glycol |
| US6043083A (en) | 1997-04-28 | 2000-03-28 | Davis; Roger J. | Inhibitors of the JNK signal transduction pathway and methods of use |
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| US6207458B1 (en) | 1998-05-07 | 2001-03-27 | University Of Washigton/Stowers Insitute For Medical Research | Proteins capable of regulating NF-κB JNK and apoptosis pathways and methods of using the same |
| EP1037627B1 (en) * | 1998-07-14 | 2001-08-01 | Alcon Laboratories, Inc. | Use of 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid and of pharmaceutically acceptable salts thereof for the manufacture of a medicament for the treatment of non-allergic ophthalmic inflammatory disorders and for the prevention of ocular neovascularization |
| EP1166781A4 (en) | 1999-01-20 | 2002-08-21 | Kyowa Hakko Kogyo Kk | proteasome |
| US6254860B1 (en) | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
| ES2223512T3 (es) | 1999-04-27 | 2005-03-01 | Novartis Ag | Uso de derivados de acidos 2,4-diamino-3-hidroxicarboxilicos como inhibidores de la proteasoma. |
-
2002
- 2002-05-17 WO PCT/US2002/015859 patent/WO2002095704A1/en active IP Right Grant
- 2002-05-17 CN CNA028102061A patent/CN1509462A/zh active Pending
- 2002-05-17 DK DK02736994T patent/DK1393277T3/da active
- 2002-05-17 EP EP02736994A patent/EP1393277B1/en not_active Expired - Lifetime
- 2002-05-17 US US10/150,219 patent/US6696453B2/en not_active Expired - Lifetime
- 2002-05-17 ES ES02736994T patent/ES2263785T3/es not_active Expired - Lifetime
- 2002-05-17 PT PT02736994T patent/PT1393277E/pt unknown
- 2002-05-17 BR BR0209965-9A patent/BR0209965A/pt not_active IP Right Cessation
- 2002-05-17 PL PL02367286A patent/PL367286A1/xx not_active Application Discontinuation
- 2002-05-17 DE DE60213230T patent/DE60213230T2/de not_active Expired - Lifetime
- 2002-05-17 JP JP2002592087A patent/JP2004527578A/ja active Pending
- 2002-05-17 CA CA002447883A patent/CA2447883A1/en not_active Abandoned
- 2002-05-17 MX MXPA03010632A patent/MXPA03010632A/es active IP Right Grant
- 2002-05-17 AT AT02736994T patent/ATE333273T1/de active
- 2002-05-17 AU AU2002309963A patent/AU2002309963B2/en not_active Ceased
-
2003
- 2003-11-11 ZA ZA2003/08769A patent/ZA200308769B/en unknown
-
2006
- 2006-09-14 CY CY20061101314T patent/CY1105220T1/el unknown
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