JP2001163746A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an oral composition capable of reducing viscosity of saliva, improving stickiness in an oral cavity and giving fresh feeling. SOLUTION: This oral composition is obtained by blending an extract obtained by extracting crude drug such as fruit of Rhus chinensis Mill, root of Rhus punj a bensis Stew, and the like, obtained from plants belonging to the genus Rhus.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition, and more particularly to an oral composition having an effect of improving the stickiness of the oral cavity and giving a refreshing feeling.

[0002]

2. Description of the Related Art As a technique for giving a refreshing sensation to the oral cavity, conventionally, a method using a flavor such as menthol is generally used. For example, in JP-A-8-165228, a specific menthol glycoside is used.
In Japanese Patent No. 3213, attempts have been made to obtain a refreshing sensation with L-menthyl-β-D-maltoside, but these cannot improve the stickiness of the oral cavity.

[0003] Saliva has an action of purifying, antibacterial, buffering, excreting, lubricating, etc., and it requires some fluidity to activate this action and maintain a healthy oral environment.
In addition, if the viscosity of saliva is high, the inside of the mouth becomes sticky and uncomfortable, and it is desirable to reduce the viscosity in order to solve this.

[0004]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a composition for oral cavity which can reduce the viscosity of saliva, improve the stickiness of the oral cavity, and give a refreshing feeling.

[0005]

Means for Solving the Problems In order to solve the above-mentioned problems, the present inventor evaluated the viscosity suppression and the refreshing feeling by using a bovine submandibular gland mucin solution similar to the viscous component of saliva. The present inventors have found that an oral composition containing an extract of a plant belonging to the genus Urushi can reduce the viscosity of saliva, improve the stickiness of the oral cavity, and give a refreshing sensation.

That is, the present invention relates to an urushi (Rh
us) An oral composition comprising an extract of a genus plant.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, as a plant belonging to the genus Rhus in the family Urushi, dry products such as fruits, leaves, roots and bark which are generally used as crude drugs are preferred. Examples of these are Enfushi, Kofuyou, Santsuju, Japanese radish, Yatsuhisayou, and Linhaishi. In particular, Enfushi is Nurde (Rhus chinensis Mill)
It is used as a Chinese medicine and has the effect of "generates sap, moisturizes the lungs, lowers the fire, transforms sputum, squeezes sweat, and stops diarrhea." Kofuyou is the root of Kofuyou and Santsuju is the root and leaf of Sanjutsu. In addition, the radish is the root of the rape, the arboreal is the leaf of the goby, and the linseed is the root or bark of the goby tree.

The extraction may be carried out by using a crude drug of the genus Urushi as it is or by using a pulverized powder as a raw material by a known extraction method. Specifically, an extraction solvent is usually used at room temperature or under heating. 0.5 to 24 hours, especially 1
A method in which extraction is carried out by appropriately stirring under heating for 10 to 10 hours can be suitably adopted. The heating temperature varies depending on the extraction solvent used, but is from room temperature to about the boiling point of the solvent −10 ° C.

The solvent used for the extraction may be a normal polar solvent and is not particularly limited, but specific examples thereof include alcohols such as acetone, ethanol and methanol, water, acetic acid, citric acid and malic acid. And the like, an alkaline solution such as sodium carbonate and sodium acetate, and a salt solution such as common salt. These can be used alone or in combination of two or more.

The solution obtained by extraction with these solvents is obtained by removing the solvent by means of heat evaporation or evaporation under reduced pressure.
Further, if necessary, it can be dried as a powder by drying under reduced pressure or freeze drying. Alternatively, the extract may be directly spray-dried to a powder.

When the extract of the plant belonging to the genus Urushi belonging to the genus Urushi is used for the oral composition of the present invention, the amount of the extract is 0.1% of the total amount of the oral composition on a dry matter basis.
It is preferable that the content be 01 to 5% by weight, particularly 0.1 to 3% by weight. If the amount is less than 0.01% by weight, a satisfactory effect of lowering saliva viscosity and the effect of providing a refreshing feeling cannot be exhibited, while if it exceeds 5% by weight, the stability or flavor of the composition may be impaired.

In the oral composition of the present invention, components used in ordinary oral compositions can be used as components other than those described above, and the added amounts of these components do not hinder the effects of the present invention. Normal amounts can be used within the range.

In the case of dentifrices, for example, abrasives, binders,
Thickeners, surfactants, sweeteners, preservatives, flavors, coloring agents,
Various active ingredients other than those described above can be blended, and these ingredients can be mixed with water for production.

Examples of the abrasive include silica-based abrasives such as precipitated silica, silica gel, aluminosilicate and zirconosilicate, dibasic calcium phosphate dihydrate and anhydrate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide , Alumina, magnesium carbonate, tertiary
Magnesium phosphate, zeolite, zirconium silicate, synthetic resin abrasives and the like are preferably used.

As the binder, sodium carboxymethylcellulose, hydroxyethylcellulose, carrageenan, sodium alginate, xanthan gum, carbopol, guar gum, montmorillonite, gelatin and the like are preferably used. As the thickener, glycerin, sorbit, propylene glycol, polyethylene glycol, xylit, maltit, lactit and the like are suitably used.

As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant and the like can be blended, and specific examples thereof include sodium lauryl sulfate, sodium α-olefin sulfonate, and N-acyl sulfonate. Cosinate, N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene hydrogenated castor oil, polyglycerin Fatty acid esters, pluronics, polyoxyethylene sorbitan monostearate and the like are preferably used.

As sweeteners, sodium saccharin,
Examples include stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, and perillartin.

Examples of the preservative include p-hydroxybenzoic acid ester and sodium benzoate. As the flavor, terpenes such as 1-menthol, carvone, anethole, limonene and the like, and derivatives thereof are preferable. As the colorant, blue No. 1, yellow No. 4, titanium dioxide and the like are preferable.

Various active ingredients include fluorides such as sodium fluoride, potassium fluoride, ammonium fluoride, stannous fluoride and sodium monofluorophosphate, and water-soluble compounds such as potassium and sodium orthophosphates. Phosphate compounds, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and salts thereof, sodium chloride, tranexamic acid, epsilon aminocaproic acid, dl-tocopherol acetate, azulene, glycyrrhetinic acid, copper chlorophyllin sodium, copper gluconate Copper compounds such as aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, dextranase, mutanase, amylase, methanase Extracts such as xylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterine, dihydrocholesterol, zinc citrate, corn, oak, clove, rosemary, rosemary, safflower, α-bisabolol, chlorhexidine salts, chloride Cetylpyridinium, benzethonium chloride, trichlorocarbanilide and the like can be mentioned.

[0020]

The oral composition of the present invention can improve the stickiness of the oral cavity and give a refreshing feeling by reducing the viscosity of saliva. Furthermore, the fluidity of saliva increases, and a healthy oral environment can be expected to be maintained. The oral composition of the present invention has high safety and can be usefully used for oral products such as toothpaste, mouthwash, mouthwash, mouth freshener, troche, chewing gum and oral pasta.

[0021]

EXAMPLES The present invention will be described in more detail with reference to the following Examples, but it should not be construed that the present invention is limited thereto.
In Examples,% of the alcohol concentration of the extraction solvent is% by volume, and% of the composition for oral cavity is% by weight.

[Test Example 1] Preparation of an extract from a plant belonging to the genus Urushi 200 g of a dry powder of a crude drug belonging to the genus Urushi shown in Table 1 below and 200 ml of an extraction solvent were placed in a beaker, and firstly 10 to 24 at the temperature shown in Table 1. The extraction was performed twice for 1 hour, and the filtrate was combined and concentrated by a rotary evaporator until water almost disappeared, and lyophilized to obtain a dry powder. Table 1 shows the yield of each crude drug. The obtained dry powder was used in the following evaluation as each extract.

[0023]

[Table 1] Extraction solvent (Temperature) Yield (%) Dried Enfushi powder 50% ethanol (room temperature) 19.3 Dried Enfushi powder Water (70 ° C) 23.8 Dried corn flour powder 80% Ethanol (room temperature) 12.5 Dried salmon powder 30% Ethanol ( 50 ° C) 23.5 Dried radish powder 30% methanol (room temperature) 14.2 Dried palm citrus powder Water (room temperature) 28.6 Dried linden powder 30% methanol (room temperature) 18.0

Evaluation of Exhilaration Feeling of 5 subjects (A, B, C, D, and E) with sticky mouth, water, water flea extract, 50% ethanol flea extract, 80% ethanol fever Extract, 30% ethanol extract of citrus, 30% methanol extract of radish, water extract of palm citrus, 30% methanol extract of linseed
The mouth was washed with 20 ml of a 1% aqueous solution for 30 seconds, and the refreshing feeling in the mouth after 5 minutes was evaluated according to the following four grades. Table 2 shows the results.

◎: Extremely refreshed ○: Refreshed △: Moderately refreshed ×: Not refreshed at all

Evaluation of Viscosity Using Mucin Solution Since the mucus of saliva is mucin, a mucin solution (10 mg / ml) derived from bovine submandibular gland was used as a substitute for saliva. 100 μl of the sample shown in Table 2 was mixed with 500 μl of the mucin solution, allowed to stand at room temperature for 3 minutes, and then the total amount (600 μl) of the viscosity at 37 ° C. was measured with a viscometer (VISCOMETER CONTROLLER RC-105A, Toki Sangyo Co., Ltd.). Manufactured). The results are shown in Table 2.

[0027]

[Table 2] Exhilaration Viscosity (mPa · s, 80rpm ) Water × 2.60 1% aqueous solution of Enfushi water extract ○ 1.05 Enfushi 50% Ethanol extract 1% aqueous solution ◎ 1.04 Koufuyou 80% ethanol extract 1% aqueous solution ◎ 1.17 1% aqueous solution of 30% ethanol extract ◎ 1.04 1% aqueous solution of radish 30% methanol extract ○ 1.28 1% aqueous solution of coconut palm aqueous extract ○ 1.33 Linhaishi 1% aqueous solution of 30% methanol extract ◎ 1.12

[Example 1] Toothpaste Aluminum hydroxide 45% Sorbite 30 Sodium lauryl sulfate 0.8 Sodium alginate 0.6 Saccharin sodium 0.1 Gelatin 0.2 Diethanolamide laurate 1.6 Propylene glycol 5 Fragrance (spearmint) 0.3 Lauroyl sarcosine sodium 0.4 Monofluorophosphine Sodium acid acid 0.75 Enfushi water extract 0.5 Purified water Balance 100%

[Example 2] Toothpaste Calcium carbonate 45% Sorbite 24 Sodium lauryl sulfate 1.3 Carrageenan 0.7 Sodium alginate 0.3 Saccharin sodium 0.1 Gelatin 0.2 Diethanolamide laurate 0.8 Propylene glycol 4 Fragrance (peppermint type) 1 Lauroyl sarcosine sodium 0.4 Monofluoro Sodium phosphate 0.75 Enfushi 50% methanol extract 1 Purified water Balance Total 100%

[Example 3] Toothpaste dibasic calcium phosphate dihydrate 50% sodium lauryl sulfate 1 carrageenan 0.6 xanthan gum 0.3 saccharin sodium 0.1 gelatin 0.2 lauric acid diethanolamide 1 propylene glycol 4 fragrance 1 lauroyl sarcosine sodium 0.4 monofluorophosphate Sodium citrate 0.5 glycerin 0.5 kouyou 80% ethanol extract 1 purified water balance 100%

Example 4 Toothpaste Silica 20% Sorbit 60 Sodium Lauryl Sulfate 0.9 Sodium Saccharin 0.15 Gelatin 0.3 Lauric Diethanolamide 1.5 Propylene Glycol 5 Flavor 1.5 Sodium Lauroyl Sarcosine 0.5 Sodium Fluoride 0.2 Xanthan Gum 0.5 Polyethylene Glycol # 4000 0.5 80% ethanol extract 1 Purified water Balance Total 100%

Example 5 Toothpaste Modified aluminum hydroxide 50% sodium lauryl sulfate 1.5 carrageenan 0.5 sodium saccharin 0.14 propylene glycol 5 fragrance 1.3 myristoyl sarcosine sodium 0.3 sodium monofluorophosphate 0.5 glycerin 20 anhydrous silicic acid 5 titanium oxide 0.5 Sodium carboxymethylcellulose 0.1 Sansiju 30% ethanol extract 0.8 Purified water Balance 100%

Example 6 Toothpaste Modified Aluminum Hydroxide 50% Sodium Lauryl Sulfate 1.5 Carrageenan 0.5 Xanthan Gum 0.5 Saccharin Sodium 0.14 Propylene Glycol 5 Fragrance 1 Myristoyl Sarcosine Sodium 0.3 Sodium Fluoride 0.5 Glycerin 20 Silicic Anhydride 5 Titanium Oxide 0.5 Sodium carboxymethylcellulose 0.1 30% methanol extract of radish 0.5 Purified water Balance 100%

Example 7 Toothpaste Silicic anhydride 20% Sodium polyacrylate 0.5 Xanthan gum 0.5 Propylene glycol 5 70% sorbite solution 20 Saccharin sodium 0.1 Sodium benzoate 0.3 Sodium lauryl sulfate 1.5 Fragrance 1 Palm oil extract 0.5 Purified water Balance 100% in total

Example 8 Toothpaste Calcium hydrogen phosphate dihydrate 45% Silicic anhydride 2 Carboxymethylcellulose sodium 1 Carrageenan 0.1 Propylene glycol 3 60% sorbite solution 25 Methyl parahydroxybenzoate 0.2 Sodium benzoate 0.5 Saccharin sodium 0.2 Sodium monofluorophosphate 0.73 Tranexamic acid 0.05 Isopropylmethylphenol 0.1 Sodium lauryl sulfate 1.2 Sodium lauroyl sarcosine 0.3 Fragrance 1 Phosphorus 30% methanol extract 1 Purified water Balance 100%

Example 9 Toothpaste 40% calcium carbonate igneous silica 2 sodium polyacrylate 0.5 carrageenan 0.5 propylene glycol 3 glycerin 30 ethyl parahydroxybenzoate 0.1 propyl paraoxybenzoate 0.1 sodium saccharin 0.2 sodium lauryl monofluorophosphate 0.76 lauryl Sodium sulfate 1.4 Sodium lauroyl sarcosine 0.1 Fragrance 1 Phosphorus 30% methanol extract 1 Purified water Balance Total 100%

[Example 10] Liquid dentifrice silica 18% sorbitol 55 sodium lauryl sulfate 1 sodium saccharin 0.1 gelatin 0.2 lauric acid diethanolamide 1.2 propylene glycol 2 flavor (spearmint type) 1.5 palmitoyl sarcosine sodium 0.4 sodium fluoride 0.2 glycerin 18 xanthan gum 0.1 Decaglyceryl laurate 0.5 Sodium sulfate (anhydrous) 0.3 Palm leaf extract 1 Purified water Balance 100%

Example 11 Liquid Dentifrice Precipitable Silica 20% Butyl Paraoxybenzoate 0.01 Xanthan Gum 0.2 Sodium Polyacrylate 0.15 Propylene Glycol 2 Sorbit 35 Glycerin 25 Saccharin Sodium 0.1 Fragrance 1 Dye (Brilliant Blue) 0.001 Sodium Lauryl Sulfate 1.5 Monolauric Acid Decaglyceryl 4 30% methanol extract of radish 1 Purified water Balance 100%

[Example 12] Liquid dentifrice Aluminum hydroxide 25% Sodium polyacrylate 0.1 Sodium carboxymethylcellulose 0.2 Propylene glycol 2 Sorbit 15 Glycerin 40 Sodium saccharin 0.1 Perfume 1 Sodium lauryl sulfate 1.5 Decaglyceryl monolaurate 1 30% ethanol extract 1 Purified water balance Total 100%

Example 13 Toothpaste Sodium Lauryl Sulfate 0.2% POE (60) hydrogenated castor oil 1 2-Alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine 0.06 Glycerin (85%) 10 Propylene glycol 1 Xanthan gum 0.1 Polyvinylpyrrolidone 0.5 Xylitol 1 Citric acid 0.08 Sodium citrate 0.2 Sodium benzoate 0.3 Methyl paraben 0.2 Perfume (peppermint type) 0.5 Kouyou 80% ethanol extract 1 Purified water Balance 100%

Example 14 Mouthwash 99.5% Ethanol 1.6% Polyoxyethylene hydrogenated castor oil 2 Citric acid 0.01 Trisodium citrate 0.3 Perfume (spearmint type) 0.5 Lauroyl sarcosine sodium 0.1 Sodium fluoride 0.08 Glycerin 10 DL-alanine 1 80% ethanol extract 0.8 Purified water Balance Total 100%

Example 15 Mouthwash 90% ethanol 20% polyoxyethylene (80 mol) sorbitan monotaurate 0.5 Perfume (spearmint type) 1.5 Sodium monofluorophosphate 0.15 Lauroyl sarcosine sodium 0.1 Enfushi 50% ethanol extract 1 Purified water balance Total 100%

Example 16 Mouthwash 99.5% Ethanol 10% Glycerin 10P. O. E (60) hydrogenated castor oil 5 sodium saccharin 0.7 sodium benzoate 0.1 flavor 1 Enfushi 50% ethanol extract 1 purified water balance 100%

Example 17 Oral Freshener 99.5% Ethanol 50% Glycerin 15P. O. E (60) hydrogenated castor oil 3 l-menthol 1 fragrance (peppermint) 0.3 Enfushi 50% ethanol extract 1 purified water balance 100%

[Example 18] Lozenge gum arabic 6% Fragrance (spearmint) 1 Sodium monofluorophosphate 0.05 Sodium lauroyl sarcosine 0.01 Glucose 36 Palatinose 36 Phosphorus cinnamon 30% methanol extract 0.8 Purified water Balance 100%

Example 19 Lozenge lactose 97% O. E (60) monostearate 0.2 Sodium lauryl sulfate 0.05 Chlorhexidine gluconate 0.02 Stevia extract 0.2 Methyl salicylate 0.2 Isoeugenol 0.05 Flavor 0.02 Sansijutsu 30% ethanol extract 1 Hydroxyethylcellulose Balance 100%

[Example 20] Chewing gum Gum base 20% Flavor (peppermint type) 1 Sodium monofluorophosphate 0.1 Sodium lauroyl sarcosine 0.01 Calcium carbonate 2 Saccharose 15 Powdered sugar 58 Sansiju 30% Ethanol extract 1 Purified water Balance 100%

Example 21 Oral Pasta Cetanol 10% Squalane 20 Precipitated Silica 5 O. E (40) Hardened castor oil 0.1 Sorbitan monooleate 1 Sodium lauryl sulfate 0.2 Glycyrrhetinic acid 0.1 Saccharin sodium 0.6 ε-Aminocaproic acid 0.5 Ethyl salicylate 0.2 Isoeugenol 0.1 Menthone 0.05 Perfume (spearmint) 0.6 Enfushi 50% ethanol extract 1 Purification Water balance total 100%

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Claims (1)

[Claims] 1. A composition for oral cavity, comprising an extract of a plant belonging to the genus Urushi (Rhus).