JP2000327955A - Primer composition and medical tacky tape or sheet using the same primer composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a primer composition for improving adhesion between a sheet-like substrate and a tacky agent layer in medical tacky tape. SOLUTION: This primer composition is obtained by compounding 100 pts.wt. various polymer binder component such as an urethane-based binder, an ethyleneimine-based binder, an aminoethyl-based binder or a polyester-based binder with 0.3-10 pts.wt. one or two or more kinds of fine particles selected from a group comprising alumina fine particles, silica fine particles and zirconia fine particles having <=100 nm, preferably <=50 nm average particle diameter. This medical tacky tape or sheet is obtained by applying the primer composition on to at least one side of a tape-like or sheet-like substrate to form a primer layer and laminating a natural rubber-based or acrylic tacky agent layer onto the surface of the primer layer.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a primer composition and a medical adhesive tape or sheet using the primer composition. Specifically, the present invention relates to a primer composition suitably used for a medical pressure-sensitive adhesive tape or sheet in which a pressure-sensitive adhesive layer is formed on one surface of a tape-shaped or sheet-shaped base material such as a plaster, a dressing, a transdermal absorption preparation and the like.

[0002]

BACKGROUND OF THE INVENTION Adhesive tapes for medical or hygienic materials (hereinafter referred to as "medical adhesive tapes") are used as bandages, dressings, sports tapes or as transdermal preparations for the purpose of preventing or treating diseases. Is widely used to maintain human health.

[0003] Such a medical adhesive tape is basically made of a film base material such as polyvinyl chloride (PVC), PP (polypropylene), PET (polyethylene terephthalate), or a sheet made of various nonwoven fabrics or cloths. An adhesive layer is laminated on one side of a substrate.
In this case, the quality of the medical pressure-sensitive adhesive sheet is a factor in which the adhesion (anchoring property) between the sheet-shaped substrate and the pressure-sensitive adhesive layer is a heavy factor. For example, when the anchoring property is weak, when the tape is rewound or the tape is peeled off from the adherend, anchoring breakage occurs between the adhesive and the sheet-like base material, causing various troubles such as so-called adhesive residue. Cause. Therefore, it is a well-known fact that various surface treatments and primer compositions are used for the purpose of improving anchoring properties.

[0004] Particularly recently, for the purpose of protecting the global environment,
Polyethylene (PE) or ethylene /
Polyolefin-based substrates such as vinyl acetate copolymer (EVA) and PP are increasingly used. In addition, from the viewpoint that the pressure-sensitive adhesive layer can be laminated without using an organic solvent, a conventional organic solvent-based pressure-sensitive adhesive is changing to a water-based or hot-melt-based pressure-sensitive adhesive. In particular, there has been a strong demand for skin-friendly pressure-sensitive adhesives as medical pressure-sensitive adhesives, which require moderate adhesion to the skin (relatively weak adhesive strength). Materials and hot melt adhesives are often used. Such a medical pressure-sensitive adhesive tape is disclosed in, for example, JP-A-6-319793.

[0005]

However, in these medical pressure-sensitive adhesive tapes, the anchoring property may be very weak, and a primer composition exhibiting an excellent effect for further improving the anchoring property. Is desired.

As a result of the inventor's intensive efforts to develop a new primer composition, a primer composition exhibiting excellent anchoring power is obtained by blending a specific fine particle component with a conventionally used polymer binder. They found something and completed the present invention.

[0007]

The primer composition according to the present invention is obtained by dispersing 0.3 to 10 parts by weight of a particle component having an average particle diameter of 100 nm or less in 100 parts by weight of a polymer binder component. It is characterized by.

The polymer binder used in the present invention is not particularly limited as long as it is used as a conventional primer composition. Urethane-based binder, ethyleneimine-based binder, aminoethyl-based binder, polyester-based binder Binders and the like.
These binders are mainly composed of a polymer component as a binder and a solvent or a dispersion medium and other additives, and the solvent or the dispersion medium is an aqueous substance such as water or alcohol, and benzene or ethyl acetate. And those using organic solvents. More specifically, Mytec NY218A (trade name, manufactured by Mitsubishi Chemical Corporation), Takenate
Solvent-based urethane binder represented by B-800 (Trade name of Takeda Pharmaceutical Co., Ltd.) and water-based urethane binder represented by Takerac W-710 (Trade name of Takeda Pharmaceutical Co., Ltd.), Epomin SP300 (Japan Ethyleneimine binder represented by Catalysts Co., Ltd.), Polyment NK-200
Solvent-based aminoethyl binder represented by (Nippon Shokubai Co., Ltd.), aqueous aminoethyl binder represented by Polyment SK-1000 (Nippon Shokubai Co., Ltd.), Byron 300 (Toyobo Co., Ltd.) And polyester-based binders typified by trade name.

Among them, an aqueous binder soluble in water or a water-dispersible binder stably dispersed in water is preferably used from the viewpoint of environmental protection. In the present invention, the term “water-based” means both an aqueous solution-based binder and an aqueous dispersion-based binder.

The binder composition of the present invention is obtained by blending a particle component into these various binders. As the particle component, those having extremely high surface adsorption activity are preferable, and examples thereof include alumina, silica, and zirconia. Among them, the average particle size is 100
nm, preferably 50 nm or less. In addition, the said average particle diameter means the value measured using the Coulter counter.

The particle component is used by mixing one or more of alumina fine particles, silica fine particles, and zirconia fine particles. More specifically, Aerosil AER200, Aerosil AER300, Aerosil
Fine powdered silica represented by AEROX050 (trade names of Nippon Aerosil Co., Ltd.), alumina sol 100, alumina sol 2
00, alumina sol, zirconia sol NZS-30 represented by alumina 520 (each trade name of Nissan Chemical Industries, Ltd.)
A, Zirconia sol, Snowtex represented by NZS-30B (each trade name of Nissan Chemical Industries, Ltd.)
30, including water-dispersed particle components such as colloidal silica represented by Snowtex S (trade names of Nissan Chemical Industries, Ltd.), lithium silicate colloid, and IP
Dispersions dispersed in an organic solvent represented by A-ST, MEK-ST, MIBK-ST (trade names of each of Nissan Chemical Industries, Ltd.) may be mentioned. Further, as these particle components, it is preferable to use water-dispersed particle components that are stably dispersed in water, like the binder.

These particle components are added in an amount of 0.3 to 10 parts by weight, preferably 0.5 to 5 parts by weight, based on 100 parts by weight of the polymer binder component. Here, 100 parts by weight of the polymer binder component means 100 parts by weight of the solid content of the polymer binder composition, and when the above-mentioned aqueous and solvent-dispersed polymer binders are used, water is used. Or the residue excluding the solvent. Similarly, for the particle component, 100 parts by weight of the particle component means 100 parts by weight of the solid content, and when an aqueous dispersion system is used, it means a residue obtained by removing water therefrom.

If the particle component is less than 0.3 parts by weight, a sufficient effect of blending the particle component cannot be obtained.
When 10 parts by weight or more is blended, the adhesion may decrease due to the formation of a particle layer that is not sufficiently bonded to the binder on the surface of the coated and laminated primer layer, or the migration of the particle component to the pressure-sensitive adhesive layer may occur. This may cause problems such as a change in the properties of the pressure-sensitive adhesive layer and coloring.

The primer composition of the present invention can be obtained by blending a particle component with the polymer binder and sufficiently dispersing the particle component in the binder. The primer composition thus obtained is applied in a thin layer on one or both surfaces of various tape-like substrates by a known method such as application using a kiss coater, gravure coater, bar coater, spray coater or the like. At this time, of course, various surface treatments such as corona treatment may be applied to the surface of the base material.

The thickness is appropriately selected depending on the application and purpose such as a base material and a pressure-sensitive adhesive layer to be used.
It is adjusted between m ^{2 and} 0.01 g / m ² . In particular, when the polymer binder is an aqueous dispersion, it is necessary to select the amount of coating that can provide a uniform coating, while paying attention to the particle size of the particle components.

The medical pressure-sensitive adhesive tape or sheet according to the present invention is a medical pressure-sensitive adhesive tape or sheet having a primer layer laminated on at least one surface of a tape-shaped or sheet-shaped substrate, and an adhesive layer laminated on the primer layer. It is a tape or a tape, wherein the primer layer is made of the primer composition according to the present invention. That is, the medical pressure-sensitive adhesive tape or the like according to the present invention is obtained by forming a pressure-sensitive adhesive layer after forming a primer layer on the surface of a substrate using the primer composition.

The material of the substrate used in the present invention is not particularly limited as long as it is conventionally used for various medical adhesive tapes and the like. For example, various plastic films and non-woven fabrics such as polyvinyl chloride, polyethylene terephthalate, and other polyolefin-based substrates such as polyethylene, polypropylene, and ethylene / vinyl acetate copolymer, and polyurethane-based substrates, which are being widely used in recent years. it can. These substrates include
Various fillers, antioxidants, vulcanization accelerators,
It does not matter at all if a compound containing a commonly used additive such as an antioxidant is used.

The pressure-sensitive adhesive is not particularly limited, and various pressure-sensitive adhesives conventionally used for medical pressure-sensitive adhesive tapes can be used. For example, a natural rubber-based adhesive, a synthetic rubber-based adhesive such as polyisoprene, SIS, SBS, and polyisobutylene, and an acrylic-based adhesive such as acrylic acid and acrylate ester may be used. They are,
Although it can be appropriately selected according to the substrate and the purpose of use, a natural rubber-based pressure-sensitive adhesive or an acrylic pressure-sensitive adhesive is particularly preferably used.

If necessary, various tackifiers such as rosin-based, terpene-based, and petroleum-based pressure-sensitive adhesives, and esters of monobasic acids or polybasic acids with branched alcohols and / or unsaturated fatty acids or softeners as softeners. An ester of a branched acid and a tetravalent or lower alcohol may be used, and an isocyanate-based, epoxy-based, or metal-ion-based cross-linking agent may be used alone or in combination. Further, depending on the application such as a medical adhesive tape, various pharmaceutical components, cosmetic components and the like can be blended.

These pressure-sensitive adhesives are laminated on the primer layer formed and laminated on at least one surface of the tape-shaped substrate by the above method. For example, the pressure-sensitive adhesive can be laminated by directly applying the pressure-sensitive adhesive on the primer layer, or by applying the pressure-sensitive adhesive to a process paper or the like that has been subjected to a release treatment and transferring the pressure-sensitive adhesive to the primer layer.

Thus, the medical pressure-sensitive adhesive tape or sheet of the present invention can be obtained. Examples of the medical pressure-sensitive adhesive tape or sheet include a bandage, a so-called cut bun cut into a predetermined shape, a low skin irritating oily gel pressure-sensitive adhesive tape. It is supplied as medical aids such as medical supplies, pharmaceuticals such as transdermal preparations, and cosmetics.

[0022]

EXAMPLES Next, an adhesion test was carried out using the primer compositions of Examples of the present invention to confirm the effects of the present invention. In the adhesion test, a commercially available pressure-sensitive adhesive tape was applied to each base material surface coated with the primer composition to be evaluated at 23 ° C and 65 ° C.
In an atmosphere of% RH, a 5 kgf pressure-sensitive adhesive roll was reciprocated once and bonded, and after 20 minutes, the peeling force when peeling the pressure-sensitive adhesive tape was measured. The peeling was performed at a peel of 180 ° and a peeling speed of 300 mm / min.

(Experimental Example 1) Snowtex 30 (aqueous colloidal silica as a particle component) was added to 100 parts by weight of solids of Polyment SK-1000 (manufactured by Nippon Shokubai Co., Ltd.) as an aqueous ethylamino binder as a polymer binder. A particle size of 10 to 20 nm, manufactured by Nissan Chemical Industry Co., Ltd.) was added while changing the solid content in the range of 0 to 50 parts by weight as shown in Table 1, and added to the corona-treated surface of the EVA film as the base material. The primer layer was formed evenly by coating. Next, a commercially available pressure-sensitive adhesive tape in which an acrylate-based pressure-sensitive adhesive layer was laminated on a substrate made of an EVA film was adhered to the surface of the primer layer, and an adhesion test was performed. The results are shown in Table 1.

[0024]

[Table 1]

As can be seen from Table 1, the particle component was 0.3
By adding it in the range of 50 to 50 parts by weight, the adhesion was greatly improved, but when 10 parts or more of the particle component was added, transparency was lowered and coloring was observed.

(Experimental Example 2) An adhesion test was performed in the same manner as in Experimental Example 1 except that the average particle size of colloidal silica was changed from 10 to 80 nm as shown in Table 2. In addition, the addition amount of the particle component was fixed to 3 parts by weight of the solid content with respect to 100 parts by weight of the solid content of the polymer binder. The results are shown in Table 2.

[0027]

[Table 2]

As can be seen from Table 2, excellent adhesion was exhibited by setting the average particle size of the particles to 50 nm or less.

(Experimental Example 3) As a polymer binder, 100 parts by weight of solids of Polyment NK350 (manufactured by Nippon Shokubai Co., Ltd.), which is a solution dispersion type binder, was mixed with silica particles of XBA-ST (average particle diameter) as a particle component. 4 parts by weight of 13 nm (manufactured by Nissan Chemical Industries, Ltd.) was added as a solid content, and the mixture was uniformly applied to the corona-treated surface of a polypropylene film as a substrate to form a primer layer. Next, a commercially available pressure-sensitive adhesive tape in which an acrylate pressure-sensitive adhesive layer was laminated on a substrate made of an EVA film was adhered to the surface of the primer layer, and an adhesion test was performed. In addition, as a comparative example, an adhesion test was similarly performed for an untreated polyethylene film.

As a result, the adhesion was 250 g / 20 mm in the comparative example, but 580 g / 2 in the example.
0 mm, and the adhesion was more than doubled.

(Experimental Example 4) Snowtex 30 which is water-based colloidal silica as a particle component was added to 100 parts by weight of solids of Polyment SK-1000 (manufactured by Nippon Shokubai Co., Ltd.) which is an aqueous ethylamino binder as a polymer binder.
(Particle size: 10 to 20 nm, manufactured by Nissan Chemical Industries, Ltd.) was added in an amount of 0.5 parts by weight in terms of solid content so that the amount of application was 0.3 g / m ^{2 on} the corona-treated surface of the EVA film as the base material. The primer layer was formed evenly by coating. Next, on the surface of this primer layer, a base made of an EVA film
An adhesive material was applied to an external medical material (adhesive tape) coated with an acrylic pressure-sensitive adhesive described in Japanese Patent Application Publication No. 19793, and an adhesion test was performed. As a comparative example, untreated E
An adhesion test was similarly performed for the case where a VA film was used.

As a result, the adhesion was 250 g / 20 mm in the comparative example, but 580 g / 20 mm in the example.
20 mm, and the adhesion was more than doubled.

(Experimental Example 5) A water-based alumina sol 100 (particle size: 10 nm or less, Nissan) was used as a particle component in 100 parts by weight of solids of Polyment NK200PN (manufactured by Nippon Shokubai Co., Ltd.) as a solution-dispersed binder. 1 part by weight of a chemical industry (manufactured by Chemical Industry Co., Ltd.) was added, and a coating amount of 0.1% was applied to the corona-treated surface of a polypropylene film as a base material.
The primer layer was formed by applying the solution uniformly at 3 g / m ² . Separately, 3 parts by weight of zirconia sol NZS-30B (particle size: 70 nm or less, manufactured by Nissan Chemical Industries, Ltd.) was added as a particle component to form a primer layer in the same manner. Next, on the surface of these primer layers,
A commercially available pressure-sensitive adhesive tape in which an acrylate pressure-sensitive adhesive layer was laminated on a substrate made of an EVA film was adhered to perform an adhesion test. In addition, as a comparative example, an adhesion test was similarly performed for an untreated polyethylene film.

As a result, the adhesion was 220 g / 20 mm in the comparative example, but was 630 g / 20 mm and 500 g / 20 mm in each of the primer layers in the example, and the adhesion was more than doubled. Became.

(Experimental Example 6) An acrylic pressure-sensitive adhesive layer composed of 2-ethylhexyl acrylate and acrylic acid was laminated on the surfaces of the two types of primer layers obtained in Experimental Example 5, to form a medical pressure-sensitive adhesive tape of the present invention. It was created. In these medical pressure-sensitive adhesive tapes, excellent adhesion was obtained without coloring and without change in the adhesive properties.

[0036]

According to the present invention, the anchoring force between the pressure-sensitive adhesive layer and the substrate can be improved without being affected by the material of the substrate layer.

Continued on the front page F term (reference) 4C076 AA74 BB31 DD29 EE03 EE07 EE10 EE13 EE48 FF01 FF70 4J004 AA04 AA05 AA07 AA10 AA11 AA14 AA15 AA18 AB01 CA04 CA05 CA06 CB01 CC02 CD06 CE01 FA09 4J038 EA01 MA011

Claims (7)

[Claims] 1. 100 parts by weight of a polymer binder component,
A primer composition comprising 0.3 to 10 parts by weight of a particle component having an average particle diameter of 100 nm or less. 2. The primer composition according to claim 1, wherein the particle component has an average particle size of 50 nm or less. 3. The particle component is selected from the group consisting of alumina fine particles, silica fine particles, and zirconia fine particles.
The primer composition according to claim 1, wherein the primer composition is a kind or two or more kinds. 4. An aqueous binder composition is used as the polymer binder.
The primer composition according to any one of the preceding claims. 5. The primer composition according to claim 1, wherein a water-dispersed particle composition is used as the particle component. 6. A medical pressure-sensitive adhesive tape or sheet having a primer layer laminated on at least one surface of a tape-shaped or sheet-shaped substrate, and a pressure-sensitive adhesive layer laminated on the primer layer, wherein the primer layer is A medical pressure-sensitive adhesive tape or sheet comprising the primer composition according to claim 1, 2, 3, 4, or 5. 7. The medical adhesive tape or sheet according to claim 6, wherein the base material is an ethylene / vinyl acetate copolymer.