JP2000198718A - External preparation for promoting blood circulation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an external preparation having excellent promoting action on blood circulation by making the external preparation include a specific adenosine as an active ingredient. SOLUTION: This external preparation comprises adenosine, adenosine 5'-phosphoric acid and/or an adenosine 5'-phosphate as an active ingredient. The amount of the active ingredient in the external preparation mixed is, in the case of the external preparation being a hair tonic, preferably 0.01-20.0 wt.% in the total amount of the hair tonic. Consequently, the external preparation capable of promoting blood circulation in the vicinity of skin (in the skin or in the muscle to be reached by percutaneous absorption) and contributing to beauty and health is obtained. The external preparation can be administered by dermal administration by direct application or spray to skin. The daily dose is 0.01-100.0 mg per kg in the case of human. Preferably, the external preparation is administered once or dividedly twice to four times daily.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin (including a hair nourishing agent) in the technical field. More specifically, the present invention relates to a blood circulation-promoting external preparation capable of promoting blood flow near a point of use by external use. This external preparation for promoting blood circulation is preferably used as a hair restorer or the like capable of exhibiting its excellent blood circulation promoting action as, for example, a hair restoration action such as a hair loss preventing action and a hair growth promoting action.

[0002]

2. Description of the Related Art Promoting blood circulation near the skin is an important matter in various aspects. It is well known that deterioration of blood circulation near the skin causes stiff shoulders, headaches, etc., and is not preferable for health. In addition, it is not preferable that blood circulation deteriorates from the viewpoint of beauty, such as causing dull skin. In addition, poor circulation in the scalp
It is known to be a major cause of hair loss.

[0003] Blood circulation is known to be affected by various causes, but lack of sleep and stress are also common causes in healthy people. Opportunities to be exposed to these causes are increasing in modern society. In other words, it is clear that the tendency of living hours in modern society to shift to late at night is stronger than in the past, and that chronic sleep shortage is increasing. In addition, the modern society is also called a stress society, and various stress factors are increasing.

[0004]

The deterioration of blood circulation near the skin as described above can be recovered by, for example, spa treatment, but this requires a sufficient amount of time and considerable expense. It costs. Therefore, providing a means capable of easily promoting blood circulation is very preferable from a cosmetic and health point of view.

The problem to be solved by the present invention is to find a component capable of promoting blood circulation near the skin by external use, and to provide a skin external preparation containing the active ingredient as an active ingredient, that is, a blood circulation promoting external preparation. Is to do.

[0006]

Means for Solving the Problems In view of the above-mentioned problems, the present inventor examined the effects of promoting blood circulation on various components, and as a result, found that adenosine, adenosine 5'-phosphate, and adenosine 5'-. Phosphoric acid salt has an excellent blood circulation promoting effect, and in combination with this blood circulation promoting effect, it has been found that it has excellent hair growth preventing effects such as hair loss preventing effect and hair growth promoting effect. It has been found that by using the compound as an active ingredient, it is possible to provide a desired external preparation for promoting blood circulation.

That is, the present invention provides an external preparation for promoting blood circulation containing adenosine, adenosine 5'-phosphate and / or adenosine 5'-phosphate as an active ingredient (hereinafter also referred to as the external preparation of the present invention). It is an invention to do.

[0008] The form of the external preparation of the present invention is not particularly limited as long as it can be applied to the outer skin (including the scalp and hair). It is not bound by distinction.

The typical form of the external preparation of the present invention is as follows:
Hair restoration (hereinafter also referred to as the hair restoration of the present invention).
In the present invention, “hair growth” is used in a concept including a hair loss preventing action, a hair growth promoting action, and the like. In addition, the hair restorer of the present invention can be used as a composition for external use on the skin including a cosmeceutical for hair growth of head hair and the like.

[0010]

Embodiments of the present invention will be described below. Active ingredient of the external preparation of the present invention As described above, the active ingredient of the external preparation of the present invention comprises adenosine, adenosine 5′-phosphate and / or adenosine 5 ′.
-Phosphoric acid salts (hereinafter also referred to as adenosines).

Adenosine is one of ribonucleosides and contains adenine which is a purine derivative in the base portion. Adenosine 5'-phosphate is also called 5'-adenylic acid, and is a nucleotide in which one molecule of phosphate binds to the 5'-hydroxyl group of ribose of adenosine.

In the salt of adenosine 5'-phosphate, the counter ion forming the salt may be any substance as long as it forms a counter ion with an acid. For example, sodium, potassium, calcium and the like may be used. Can be mentioned. As the salt of adenosine 5′-phosphate, a hydrate thereof can also be used.

In the external preparation of the present invention, as adenosine, adenosine 5'-phosphate and salts of adenosine 5'-phosphate, commercially available reagents can be used. The amount of adenosine in the external preparation of the present invention is,
It should be appropriately selected according to the specific form of the agent and the balance with other components, and is not particularly limited.

For example, when the external preparation of the present invention is a hair restorer, it is generally used in an amount of 0.01 to 20.0% by weight, preferably 0.1 to 10.0% by weight, based on the total amount of the hair restorer. is there. If the amount is less than 0.01% by weight of the total amount of the hair restorer, the active ingredient does not sufficiently exert the hair-growth effect, which is not preferable. If the amount exceeds 20.0% by weight, the formulation tends to be hindered. It becomes remarkable and is not preferable.

Thus, the external preparation of the present invention which promotes blood circulation near the skin (in the skin or in the muscle reached by transdermal absorption) and contributes to beauty and health is provided. Specific form of the external preparation of the present invention The external preparation of the present invention is a skin external preparation that contains an adenosine compound as an active ingredient and exerts a blood circulation promoting action near the skin.

The external preparation of the present invention can contain known components according to the specific form. That is, in a skin external preparation, components that can be generally used can be blended within a range that does not impair the intended effect of the present invention.
For example, oil (solid paraffin, liquid paraffin, silicone oil, squalane, glyceryl monooleate, olive oil, higher alcohol, higher fatty acid, isopropyl myristate, etc.), humectant (polyhydric alcohol such as glycerin, propylene glycol, hyaluronic acid, Maltitol, atelocollagen, sodium lactate, etc.), thickeners (quince, carboxyvinyl polymer, xanthan gum, etc.), antibacterial agents, drugs, antioxidants, UV protection agents, fragrances, coloring agents, surfactants, water, Ethanol and the like can be blended.

The dosage form of the external preparation of the present invention is not particularly limited. For example, an external composition such as an aqueous solution, a solubilizing system, an emulsifying system, a powder dispersing system, a water-oil two-layer system, a water-oil-powder three-layer system, etc. The present invention can be applied to all products.

The external preparation of the present invention can be administered by transdermal administration which is directly applied or sprayed on the skin. Also,
The dose cannot be clearly specified because it varies depending on the specific mode of the external preparation, the age of the user, symptoms, etc., but when administered to humans, adenosines have a body weight of 1 kg.
And an amount that is generally 0.01 to 100.0 mg, preferably 0.1 to 10.0 mg per day,
This amount is preferably administered once a day or divided into 2 to 4 times.

Regarding the hair restoration of the present invention, the most preferred embodiment of the external preparation of the invention is a hair restoration (the hair restoration of the present invention).

In general, the causes of hair loss include the activation of androgens in organs such as hair follicles and sebaceous glands, a decrease in blood flow to the dermal papilla and hair follicles, excessive secretion of sebum, generation of peroxide, and the like. Abnormality, malnutrition, etc. are considered.

For this reason, conventional hair nourishes are generally compounded with components having an action of eliminating or reducing these causes. Nevertheless, nevertheless, conventional hair restorations have not always had sufficient hair restoration effects such as hair loss prevention and hair growth promotion. This is presumably due to various causes of hair loss and the very complex mechanism of hair growth. In view of the variety of causes of such hair loss and the complexity of the hair growth mechanism, it is desired to provide a new hair restorer having an excellent hair restorer action.

The hair restorer of the present invention, by blending adenosines, can promote blood circulation in the scalp due to its excellent blood circulation promoting effect, and can exhibit a hair loss preventing effect, a hair growth promoting effect, and the like.

The dosage form that can be taken by the hair restorer of the present invention is not particularly limited as long as it is a dosage form applicable to the skin, especially the scalp, and for example, liquid, emulsion, ointment and the like can be selected. Further, the form of the hair restorer of the present invention is arbitrary, and for example, a form such as a tonic, a hair cream, a mousse, a shampoo, and a rinse can be employed.

In the hair growth composition of the present invention, among the above-mentioned general ingredients, in particular, known hair growth ingredients which can be blended with existing hair growth compositions can be positively blended. For example, as an antibacterial agent, hinokitiol, hexachlorophen, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide, bithionol and the like can be blended.

Further, nicotinamide, benzyl nicotinate, vitamin E or a derivative thereof,
Vasodilators such as, for example, vitamin E acetate, assembly extract, carpronium chloride, acetylcholine derivatives;
Skin function enhancers such as cepharanthin; antiinflammatory agents such as glycyrrhetinic acid or a derivative thereof, purple root extract; female hormones such as estradiol and estrone; amino acids such as serine, methionine, and arginine; vitamin A, vitamin B ₁ , and vitamin B ₆ , Biotin, pantothenic acid or derivatives thereof, and nucleic acids such as adenine, cytosine, thymine, guanine and the like.

Further, if necessary, a drug such as salicylic acid, zinc or a derivative thereof, lactic acid or an alkyl ester thereof, a cooling agent such as menthol, and an organic acid such as citric acid can be added.

The hair restorer of the present invention has an excellent hair loss-promoting action, a hair growth-promoting action and a hair-growth action in mammals including humans, and is useful as a pharmaceutical, quasi-drug or cosmetic for hair care. It is.

[0028]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples, but it should be understood that the technical scope of the present invention is not limited to these Examples. In the following Examples and the like, "%" and the amount indicating the blending amount mean% by weight unless otherwise specified. First, a blood flow increase test was performed to examine the blood circulation promoting action of the active ingredient of the external preparation of the present invention.

1. Blood flow increase test As a test sample, 0.75% adenosine, 0.
A 75% nicotinamide and placebo formulation was prepared. The subjects were healthy panel (16 men and women aged 20 to 60 years).

The panel is placed in a constant temperature / humidity chamber (25 ° C.)
Rested for 30 minutes. Then, 5cm from the side near the wrist
At the above intervals, measurement sites A, B, and C were determined, and the blood flow at each site was measured in advance by a laser Doppler meter (OMEGA-FLOW FLO-N1) (corresponding to data at 0 hours).

In addition, one probe and one blood flow meter were prepared for one measurement site (three devices were prepared according to the number of measurement sites in this test). After the above pre-measurement, each test sample was placed in each of the measurement sites A, B, and C having a diameter of 8 mm.
μL was applied. Next, the blood flow (V: volt) and blood flow velocity (V: volt) were monitored every 5 minutes until one hour after application, and each value was calculated as the average value of all the panels.

The blood flow promoting effect of each test sample was evaluated using the ratio (%) of the blood flow per hour to the above blood flow at 0 hour as an index of the blood flow promoting effect. The result is the first
Shown in the figure.

In FIG. 1, it was found that the blood circulation of the panel was remarkably promoted 30 minutes after the start of the test.
From these results, it has been found that adenosine, an active ingredient according to the present invention, has an excellent blood circulation promoting action.

The same test as described above was conducted for 0.75% adenosine 5'-phosphate. As a result, a remarkable blood circulation promoting effect was also observed for adenosine 5'-phosphate.

Thus, it has been found that an agent exhibiting excellent blood circulation promotion can be provided by using adenosine, adenosine 5'-phosphate and / or adenosine 5'-phosphate as an active ingredient. . 2. Hair Restoration Test Next, examples of usefulness as a hair restorative, which is a typical and preferred embodiment of the external preparation of the present invention, will be described.

First, the formulation of a hair growth sample (liquid hair growth material) used in a hair growth test and the like will be described. [Example 1] Preparation of liquid hair nourishing compounding ingredients (% by weight) adenosine 3.0 70% ethanol 90.0 hydrogenated castor oil ethylene oxide (40 mol) adduct 1.0 ion-exchanged water balance <Production method> Adenosine was dissolved in 70% ethanol, hydrogenated castor oil ethylene oxide (40 mol) adduct and part of ion-exchanged water with stirring. The remaining ion-exchanged water was further added to the obtained solution, and mixed and stirred again to obtain a liquid hair restoration 1.

[0037] Example 2 Preparation Ingredient amount of the liquid hair tonic (% by weight) adenosine 5'-phosphate 0.5 70% Ethanol 90.0 Sodium oleate 0.01 dodecylbenzenesulfonate 0.4 curing Castor oil ethylene oxide (40 mol) adduct 0.5 ion-exchanged water balance <Production method> 70% ethanol, sodium oleate, dodecylbenzenesulfonic acid, hydrogenated castor oil ethylene oxide (40 mol) The adduct and a part of ion-exchanged water were mixed and stirred to dissolve.
To the obtained solution, the remaining ion-exchanged water was further added and mixed and stirred again to obtain a liquid hair restorative 2.

Examples 3 and 4 Preparation of Liquid Hair Restoration Compounding Components (Weight%) Adenosine 5′-disodium phosphate or Adenosine 5′-dipotassium phosphate 1.0 70% Ethanol 90.0 Sesqui Sorbitan oleate 0.4 Hydrogenated castor oil ethylene oxide (40 mol) adduct 0.6 Ion-exchanged water Remaining <Production method> Adenosine 5'-disodium phosphate or adenosine 5'-dipotassium phosphate was treated with 70% ethanol , Sorbitan sesquioleate, hydrogenated castor oil, ethylene oxide (40 mol) adduct, and a portion of ion-exchanged water were mixed and dissolved by stirring. In the resulting solution,
Add the remaining ion-exchanged water and stir to obtain a liquid hair restoration 3
And 4 were obtained.

Example 5 Preparation of Liquid Hair Restoration Ingredients Ingredients (% by weight) Adenosine 5'-sodium phosphate dihydrate 0.3 70% ethanol 90.0 Lauroyltaurine 0.1 Cetylpyridinium chloride 0.01 hydrogenated castor oil ethylene oxide (40 mol) adduct 0.89 ion-exchanged water balance <Production method> Adenosine 5'-sodium phosphate dihydrate was treated with 70% ethanol, lauroyl taurine, cetyl pyridium chloride, Hydrogenated castor oil ethylene oxide (40
Mol) The adduct and a part of ion-exchanged water were mixed and dissolved by stirring. To the resulting solution, the remaining ion-exchanged water was further added and mixed to obtain a liquid hair restorative 5.

Next, the hair growth-promoting effects of the hair nourishes 1 to 5 obtained in Examples 1 to 5 were examined. In addition, hair growth effects of hair growth agents 1 and 3 were examined. As a test animal for hair growth promoting action test , C3H / HeN
Using CrJ mice, the method of Ogawa et al. (Normal and Abnormal Epidermal Differentiati
on), edited by M. Seiji and IA Bernstein, 159-1
70, 1982, The University of Tokyo Press).

That is, six groups of 10 mice were prepared, and the backs of the mice were shaved with a hair clipper and a shaver.
5) Or a control sample (70% ethanol solution)
Each time, 0.1 mL was applied to the shaved back. After 25 days, the regenerated area of the hair was measured.

The results are shown in Table 1 (the numerical values are average values). Table 1 試 料 Sample Hair Regeneration Area (%) Sample Hair Regeneration Area (%) 毛 Hair restoration 1 96 Hair restoration 2 65 Hair restoration 3 75 Hair restorer 4 55 Hair restorer 5 45 Reference 2.0 ──────────────────────────────────── As is clear from Table 1, the hair restoration of the present invention showed a significant effect in a test for promoting hair growth in mice, and it was found that the hair restoration of the present invention had an excellent hair growth promoting action.

Test for Hair Restoration In order to examine the hair restoring effects of the hair restorer of the present invention, such as the hair loss preventing effect and the hair growth promoting effect, a tricogram test was performed on humans by the following method. The test samples are hair restorations 1 and 3 used in the above hair growth test, and the control sample is 70% ethanol.

That is, hair growth products 1 and 3 and 70% ethanol as a control were applied to the scalp of 100 male subjects twice a day, 2 mL at a time, continuously for 6 months. Immediately before application and immediately after completion of application for 6 months, 100 hairs were removed from each test subject, the roots of the removed hairs were observed under a microscope, and the number of telogen hair roots was counted from the form of the hair roots.
The proportion of telogen roots was determined.

The hair growth effects of the test sample (hair growth products 1, 3) and the control sample (70% ethanol) were compared by increasing or decreasing the ratio of the telogen roots. The telogen follicles are hair follicles that have stopped growing, and it has been recognized that humans who complain of hair loss have a higher percentage of these telogen follicles than normal humans.

The evaluation of the hair-growing action was determined according to the following criteria. <Judgment criteria> Effective: When the proportion of the telogen hair root decreased by 20% or more is 40% or more Slightly effective: When the proportion of the telogen hair root decreased by 20% or more is 20% or more Invalid: Pause The results are shown in Table 2 in the case where the proportion of the hair follicles decreased by 20% or more was less than 20%.

Table 2 割 合 Ratio of test subjects (%) ──毛 Sample of hair-growing action Evaluation of the ratio of hair roots in the telogen phase decreased by 20% or more Reduced by less than 20% Increased by 20% or more ２０20% Less than increase 毛 Hair restoration 1 42 33 25 Effective hair restoration 3 35 30 35 Somewhat effective Reference 10 50 40 Invalid のFrom the results, adenosine or adenosine 5 ′
-It was revealed that a hair growth effect of the present invention containing a phosphoric acid salt was found to be significant in a human trichogram test.

Also, the hair restoration of the present invention containing adenosine 5'-phosphate (hair restoration 2) was confirmed to have a hair growth promoting effect. It is clear that the same hair-growing action is observed.

In addition to Examples 1 to 5, the formulation of another embodiment of a hair restorer according to the present invention is further illustrated as an example. In all of the hair restorations obtained in the following examples, hair growth promoting action and hair restoration action almost similar to those of the liquid hair restorations 1 to 5 were observed.

In addition, Examples 9 and later, which will be described later, show examples of formulations of the external preparation of the present invention other than the hair restorer. The blood flow increase test described above was also performed on the examples of these formulations, and the blood circulation near the skin of the subject was clearly promoted.

Example 6 Preparation of Emulsion-Type Hair Restoration Compounding Components (Weight%) (A phase) Adenosine 5′-disodium phosphate 1.0 Hardened castor oil ethylene oxide (60 mol) adduct 2.0 Glycerin 10.0 Dipropylene glycol 10.0 1,3-butylene glycol 5.0 Polyethylene glycol 1500 5.0 (Phase B) Cetyl isooctanoate 10.0 Squalane 5.0 Vaseline 2.0 Propylparaben 2.0 ( C phase) 1% aqueous solution of carboxyvinyl polymer 30.0 Sodium hexametaphosphate 0.03 Ion exchange water 8.35 (D phase) Ion exchange water 4.5 (E phase) Potassium hydroxide 0.12 Ion exchange water 5.0 <Production method> A phase and B phase were each heated and dissolved at 60 ° C, mixed, and homomixed to form a gel. Phase D was gradually added thereto and dispersed with a homomixer.

Next, the dissolved C phase was added thereto, and finally the dissolved E phase was added and emulsified with a homomixer to obtain an O / W emulsion type hair restorer. [Example 7] Preparation of creamy hair restorer Component blending amount (% by weight) (A phase) Liquid paraffin 5.0 cetostearyl alcohol 5.5 glyceryl monostearate 3.0 EO (20 mol) -2-octyl Dodecyl ether 3.0 Propylparaben 0.3 Fragrance 0.1 (Phase B) Adenosine 5.0 Glycerin 8.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium dodecyl sulfate 0.1 Sodium hexametaphosphate 0.005 Ion-exchanged water balance <Production method> A phase and B phase were each heated and dissolved, mixed, and emulsified with a homomixer to obtain a creamy hair restorer.

Example 8 Preparation of Liquid Hair Restoration Compounding Components (% by weight) Adenosine 5′-potassium phosphate 0.5 Stearyl dimethylamine oxide 0.5 Hardened castor oil ethylene oxide (40 mol) adduct 1. 0 95% ethanol 54.0 Ion-exchanged water balance <Production method> Ion-exchanged water was added to 95% ethanol,
After adding hydrogenated castor oil ethylene oxide (40 mol) adduct and stearyl dimethylamine oxide to this,
Adenosine 5'-potassium phosphate was added, and the mixture was stirred and dissolved to obtain a liquid hair restoration.

Example 9 Preparation of Liquid Hair Restoration Ingredients Incorporation Amount (% by weight) N-cocolauryl-β-aminopropionate sodium 0.2 adenosine 5′-disodium phosphate hydrate 1.0 dodecylbenzene Sodium sulfonate 0.5 hydrogenated castor oil ethylene oxide (40 mol) adduct 1.0 95% ethanol 54.0 ion-exchanged water balance <Production method> Add ion-exchanged water to 95% ethanol,
After addition of hydrogenated castor oil ethylene oxide (40 mol) adduct, sodium dodecylbenzenesulfonate and sodium N-cocolauryl-β-aminopropionate, adenosine 5′-disodium phosphate hydrate was added, followed by stirring and dissolution. Thus, a liquid hair restoration was obtained.

Example 10 Preparation of Cream Ingredients Components (Weight%) Stearic Acid 5.0 Stearyl Alcohol 4.0 Isopropyl Myristate 18.0 Glycerin Monostearate 3.0 Propylene Glycol 10.0 Adenosine 3 0.0 Potassium hydroxide 0.2 Sodium bisulfite 0.01 Preservatives Appropriate amount Fragrance Appropriate amount Ion-exchanged water balance <Production method> Add propylene glycol, adenosine and potassium hydroxide to ion-exchanged water and heat to 70%. C. (aqueous phase). The other components were mixed and melted and kept at 70 ° C. (oil phase). The water phase was gradually added to the oil phase, and after the addition was completed, the temperature was maintained for a while to cause a reaction. Thereafter, the mixture was uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well to obtain a cream.

Example 11 Preparation of Cream Blending Components (% by Weight) Stearic Acid 2.0 Stearyl Alcohol 7.0 Hydrogenated Lanolin 2.0 Squalane 5.0 2-Octyldodecyl Alcohol 3.0 Polyoxyethylene (25 mol) Cetyl alcohol ether 3.0 Glycerin monostearate 2.0 Propylene glycol 5.0 Adenosine 5'-phosphate 0.75 Sodium bisulfite 0.03 Ethyl paraben 0.3 Perfume Appropriate amount Ion-exchanged water residue <Production method> Propylene glycol was added to ion-exchanged water, and heated to 70 ° C (aqueous phase). The other components were mixed, melted by heating, and kept at 70 ° C. (oil phase). The oil phase was added to the water phase, preliminarily emulsified, uniformly emulsified by a homomixer, and then cooled to 30 ° C. while stirring well to obtain a cream.

Example 12 Preparation of Emulsion Compounding Components (% by weight) Stearic Acid 2.5 Cetyl Alcohol 1.5 Vaseline 5.0 Liquid Paraffin 10.0 Polyoxyethylene (10 mol) Monooleate 2 0.0 Polyethylene glycol 1500 3.0 Adenosine 0.75 Triethanolamine 1.0 Carboxyvinyl polymer 0.05 Adenosine 5'-phosphate 0.02 Sodium bisulfite 0.01 Ethylparaben 0.3 Perfume Appropriate amount Ion-exchanged water Residue <Production method> Propylene glycol was added to a small amount of ion-exchanged water, and this was heated and maintained at 70 ° C (aqueous phase). The other components were mixed, melted by heating, and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase was gradually added thereto, and the mixture was uniformly emulsified with a homomixer. After emulsification, the mixture was cooled to 30 ° C. while stirring well to obtain an emulsion.

Example 13 Preparation of Emulsion Formulation Components (% by weight) Microcrystalline wax 1.0 Beeswax 2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan sesquioleate 4.0 Polyoxyethylene (20 mol) Sorbitan sesquioleate 1.0 Propylene glycol 7.0 Disodium adenosine-5 'phosphate or dipotassium adenosine-5' phosphate 5.0 Sodium bisulfite 0.01 Ethyl paraben 0.0 3 Appropriate amount of perfume Ion-exchanged water balance <Production method> Propylene glycol was added to ion-exchanged water, and heated to 70 ° C (aqueous phase). The other components were mixed, melted by heating and kept at 70 ° C. (oil phase). While stirring the oil phase, the aqueous phase was gradually added thereto, and the mixture was uniformly emulsified with a homomixer. After emulsification, 30 ° C with good stirring
Cooled to give an emulsion.

[0059] Example 14 Preparation Ingredient of serums (wt%) (A phase) Ethyl alcohol (95%) 10.0 Polyoxyethylene (20 moles) octyldodecanol 1.0 Pantothenyl ethyl ether 0.1 Adenosine 2.0 Methyl paraben 0.15 (B phase) Potassium hydroxide 0.1 (C phase) Glycerin 5.0 Dipropylene glycol 10.0 Sodium bisulfite 0.03 Carboxyvinyl polymer 0.2 Ion exchange water Remaining part <Production method> A phase and C phase are each dissolved uniformly,
Phase A was added to solubilize. Next, the phase B was added thereto to obtain a serum.

[0060]

According to the present invention, there is provided an external preparation for promoting blood circulation, which exhibits an excellent blood circulation promoting effect near the skin of mammals such as humans, and further has an effect of preventing hair loss and promoting hair growth. A hair restorer having an excellent hair restorer action is also provided.

[Brief description of the drawings]

FIG. 1 is a drawing showing the results of a blood flow promotion test.

Claims (2)

[Claims] An external preparation for promoting blood circulation containing adenosine, adenosine 5'-phosphate and / or adenosine 5'-phosphate as an active ingredient. 2. The external preparation for promoting blood circulation according to claim 1, wherein the preparation is in the form of a hair nourishing agent.