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JOP20210107A1 - مضمنات التعبير عن foxp3 - Google Patents

مضمنات التعبير عن foxp3

Info

Publication number
JOP20210107A1
JOP20210107A1 JOP/2021/0107A JOP20210107A JOP20210107A1 JO P20210107 A1 JOP20210107 A1 JO P20210107A1 JO P20210107 A JOP20210107 A JO P20210107A JO P20210107 A1 JOP20210107 A1 JO P20210107A1
Authority
JO
Jordan
Prior art keywords
modulators
foxp3 expression
useful
expression
treating
Prior art date
Application number
JOP/2021/0107A
Other languages
English (en)
Inventor
Susan M Freier
Alexey Revenko
Robert A Macleod
Original Assignee
Ionis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionis Pharmaceuticals Inc filed Critical Ionis Pharmaceuticals Inc
Publication of JOP20210107A1 publication Critical patent/JOP20210107A1/ar

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
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    • C12N2310/30—Chemical structure
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy

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  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

تقدم النماذج الحالية طرق، مركبات، وتركيبات مفيدة لتثبيط التعبير عن FOXP3، والتي يمكن أن تكون مفيدة لعلاج، الوقاية من، أو تخفيف السرطان. يتم توجيه تجسيدات معينة تم توفيرها في الاختراع الحالي إلى مركبات وتركيبات قوية ومقبولة مفيدة لتثبيط التعبير عن FOXP3، والتي يمكن أن تكون مفيدة في علاج أو منع أو تخفيف أو إبطاء تقدم السرطان. في نماذج معينة، يرتبط السرطان ببيئة مكروية أو سدى مثبط للمناعة.
JOP/2021/0107A 2018-11-14 2019-11-14 مضمنات التعبير عن foxp3 JOP20210107A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862767123P 2018-11-14 2018-11-14
US201962924001P 2019-10-21 2019-10-21
PCT/US2019/061508 WO2020102558A1 (en) 2018-11-14 2019-11-14 Modulators of foxp3 expression

Publications (1)

Publication Number Publication Date
JOP20210107A1 true JOP20210107A1 (ar) 2023-01-30

Family

ID=70731746

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0107A JOP20210107A1 (ar) 2018-11-14 2019-11-14 مضمنات التعبير عن foxp3

Country Status (22)

Country Link
US (2) US11547718B2 (ar)
EP (1) EP3880211A4 (ar)
JP (1) JP2022507425A (ar)
KR (1) KR20210091197A (ar)
CN (1) CN113286601A (ar)
AU (1) AU2019378026A1 (ar)
BR (1) BR112021009209B1 (ar)
CA (1) CA3118507A1 (ar)
CL (1) CL2021001227A1 (ar)
CO (1) CO2021007303A2 (ar)
CR (1) CR20210304A (ar)
DO (1) DOP2021000092A (ar)
EC (1) ECSP21040508A (ar)
IL (1) IL283083A (ar)
JO (1) JOP20210107A1 (ar)
MX (1) MX2021005599A (ar)
PE (1) PE20211656A1 (ar)
PH (1) PH12021551093A1 (ar)
SG (1) SG11202104859WA (ar)
TW (1) TW202028222A (ar)
UY (1) UY38472A (ar)
WO (1) WO2020102558A1 (ar)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3845646A1 (en) * 2019-12-30 2021-07-07 Secarna Pharmaceuticals GmbH & Co. KG Modified antisense oligonucleotide for inhibition of foxp3 expression
US12194057B2 (en) * 2020-12-17 2025-01-14 Washington University NXTAR-derived oligonucleotides and uses thereof

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