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JOP20190236A1 - أجسام مضادة لـ ilt4 وشظايا ارتباط بمولد ضد - Google Patents

أجسام مضادة لـ ilt4 وشظايا ارتباط بمولد ضد

Info

Publication number
JOP20190236A1
JOP20190236A1 JOP/2019/0236A JOP20190236A JOP20190236A1 JO P20190236 A1 JOP20190236 A1 JO P20190236A1 JO P20190236 A JOP20190236 A JO P20190236A JO P20190236 A1 JOP20190236 A1 JO P20190236A1
Authority
JO
Jordan
Prior art keywords
antigen
binding fragments
antibodies
ilt4 antibodies
ilt4
Prior art date
Application number
JOP/2019/0236A
Other languages
English (en)
Inventor
Milan Blanusa
Luis Zuniga
Andrea Claudia Schuster
Barbara Joyce-Shaikh
Kornelia Schultze
Original Assignee
Merck Sharp & Dohme
Agenus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Agenus Inc filed Critical Merck Sharp & Dohme
Publication of JOP20190236A1 publication Critical patent/JOP20190236A1/ar
Application granted granted Critical
Publication of JOP20190236B1 publication Critical patent/JOP20190236B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

يوفر الاختراع الحالي أجسام مضادة وشظايا ارتباط بمولد ضد منه ترتبط بـ ILT4 (مستنسخ يشبه الجلوبيولين المناعي 4) وتوليفات منها، على سبيل المثال، مع جسم مضاد لـ-PD1. كما يتم توفير طرق لاستخدامها، على سبيل المثال، لعلاج أو الوقاية من السرطان في خاضع؛ وطرق لتصنيع هذه الأجسام المضادة والشظايا.
JOP/2019/0236A 2017-04-07 2018-04-05 أجسام مضادة لـ ilt4 وشظايا ارتباط بمولد ضد JOP20190236B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762483019P 2017-04-07 2017-04-07
PCT/US2018/026160 WO2018187518A1 (en) 2017-04-07 2018-04-05 Anti-ilt4 antibodies and antigen-binding fragments

Publications (2)

Publication Number Publication Date
JOP20190236A1 true JOP20190236A1 (ar) 2019-10-06
JOP20190236B1 JOP20190236B1 (ar) 2023-09-17

Family

ID=62063229

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2019/0236A JOP20190236B1 (ar) 2017-04-07 2018-04-05 أجسام مضادة لـ ilt4 وشظايا ارتباط بمولد ضد

Country Status (27)

Country Link
US (4) US11053315B2 (ar)
EP (1) EP3606958A1 (ar)
JP (2) JP7045392B2 (ar)
KR (1) KR102357823B1 (ar)
CN (1) CN110719917A (ar)
AR (1) AR111362A1 (ar)
AU (3) AU2018248294B2 (ar)
BR (1) BR112019021000A2 (ar)
CA (1) CA3057378A1 (ar)
CL (1) CL2019002855A1 (ar)
CO (1) CO2019011155A2 (ar)
CR (1) CR20190459A (ar)
DO (1) DOP2019000253A (ar)
EA (1) EA201992402A1 (ar)
EC (1) ECSP19072235A (ar)
GE (1) GEP20227440B (ar)
IL (1) IL269593A (ar)
JO (1) JOP20190236B1 (ar)
MX (1) MX392369B (ar)
NI (1) NI201900103A (ar)
PE (1) PE20191813A1 (ar)
PH (1) PH12019502275A1 (ar)
SG (1) SG11201909081YA (ar)
TN (1) TN2019000272A1 (ar)
TW (1) TWI796329B (ar)
UA (1) UA126865C2 (ar)
WO (1) WO2018187518A1 (ar)

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