ECSP19072235A - Anticuerpos anti-ILT4 y fragmentos de unión a antígeno - Google Patents
Anticuerpos anti-ILT4 y fragmentos de unión a antígenoInfo
- Publication number
- ECSP19072235A ECSP19072235A ECSENADI201972235A ECDI201972235A ECSP19072235A EC SP19072235 A ECSP19072235 A EC SP19072235A EC SENADI201972235 A ECSENADI201972235 A EC SENADI201972235A EC DI201972235 A ECDI201972235 A EC DI201972235A EC SP19072235 A ECSP19072235 A EC SP19072235A
- Authority
- EC
- Ecuador
- Prior art keywords
- antigen
- binding fragments
- antibodies
- ilt4 antibodies
- ilt4
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 101000984189 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 2 Proteins 0.000 abstract 2
- 102100025583 Leukocyte immunoglobulin-like receptor subfamily B member 2 Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención proporciona anticuerpos y fragmentos de unión a antígeno de los mismos que se unen a ILT4 (transcrito de tipo inmunoglobulina 4) y combinaciones de los mismos, por ejemplo, con un anticuerpo anti-PD1. También se proporcionan procedimientos de uso de los mismos, por ejemplo, para tratar o prevenir el cáncer en un sujeto; y procedimientos de preparación de dichos anticuerpos y fragmentos
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762483019P | 2017-04-07 | 2017-04-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP19072235A true ECSP19072235A (es) | 2019-12-27 |
Family
ID=62063229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI201972235A ECSP19072235A (es) | 2017-04-07 | 2019-10-04 | Anticuerpos anti-ILT4 y fragmentos de unión a antígeno |
Country Status (27)
Country | Link |
---|---|
US (4) | US11053315B2 (es) |
EP (1) | EP3606958A1 (es) |
JP (2) | JP7045392B2 (es) |
KR (1) | KR102357823B1 (es) |
CN (1) | CN110719917A (es) |
AR (1) | AR111362A1 (es) |
AU (3) | AU2018248294B2 (es) |
BR (1) | BR112019021000A2 (es) |
CA (1) | CA3057378A1 (es) |
CL (1) | CL2019002855A1 (es) |
CO (1) | CO2019011155A2 (es) |
CR (1) | CR20190459A (es) |
DO (1) | DOP2019000253A (es) |
EA (1) | EA201992402A1 (es) |
EC (1) | ECSP19072235A (es) |
GE (1) | GEP20227440B (es) |
IL (1) | IL269593A (es) |
JO (1) | JOP20190236B1 (es) |
MX (1) | MX392369B (es) |
NI (1) | NI201900103A (es) |
PE (1) | PE20191813A1 (es) |
PH (1) | PH12019502275A1 (es) |
SG (1) | SG11201909081YA (es) |
TN (1) | TN2019000272A1 (es) |
TW (1) | TWI796329B (es) |
UA (1) | UA126865C2 (es) |
WO (1) | WO2018187518A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP20131167T1 (hr) | 2007-06-18 | 2014-01-03 | Merck Sharp & Dohme B.V. | Antitijela za humani receptor programirane smrti pd-1 |
TWI796329B (zh) | 2017-04-07 | 2023-03-21 | 美商默沙東有限責任公司 | 抗-ilt4抗體及抗原結合片段 |
TWI833724B (zh) * | 2017-12-22 | 2024-03-01 | 美商永斯醫療股份有限公司 | 抗lilrb2抗體 |
CA3104530A1 (en) | 2018-07-09 | 2020-01-16 | Five Prime Therapeutics, Inc. | Antibodies binding to ilt4 |
WO2020023268A1 (en) * | 2018-07-24 | 2020-01-30 | Amgen Inc. | Combination of lilrb1/2 pathway inhibitors and pd-1 pathway inhibitors |
KR20210108940A (ko) | 2018-09-17 | 2021-09-03 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | 항-lilrb2 항체 및 이의 이용 방법 |
KR102433076B1 (ko) * | 2019-08-12 | 2022-08-19 | 비온드 바이오로직스 엘티디 | Ilt2에 대한 항체 및 이의 용도 |
CN112442527B (zh) * | 2019-08-27 | 2022-11-11 | 深圳市英马诺生物科技有限公司 | 孤独症诊断试剂盒、基因芯片、基因靶点筛选方法及应用 |
CA3162311A1 (en) * | 2019-12-20 | 2021-06-24 | Philip E. Brandish | Methods for treating cancer using a combination of a pd-1 antagonist, an ilt4 antagonist, and chemotherapeutic agents |
JP2023510199A (ja) * | 2020-01-02 | 2023-03-13 | メルク・シャープ・アンド・ドーム・エルエルシー | Pd-1アンタゴニスト、ilt4アンタゴニストおよびレンバチニブまたはその塩を使用する組合せ癌治療 |
WO2021158413A1 (en) * | 2020-02-05 | 2021-08-12 | The Board Of Regents Of The University Of Texas System | Novel lilrb2 antibodies and uses thereof |
KR20230005978A (ko) | 2020-05-01 | 2023-01-10 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | Ilt-결합제 및 이의 사용 방법 |
KR20230058074A (ko) | 2020-08-12 | 2023-05-02 | 비온드 바이오로직스 엘티디 | Ilt2에 대한 항체 및 이의 용도 |
KR20230069965A (ko) * | 2020-09-17 | 2023-05-19 | 머크 샤프 앤드 돔 엘엘씨 | 암을 치료하기 위한 항-ilt4 항체 또는 그의 항-pd-1 항체와의 조합물의 투여 요법 |
JP2023547380A (ja) * | 2020-10-21 | 2023-11-10 | イミューン-オーエヌシー セラピューティクス,インコーポレーテッド | 新規の抗lilrb2抗体および誘導体生成物 |
CN117545773A (zh) * | 2021-04-09 | 2024-02-09 | 塞德斯医疗公司 | 抗ilt4的抗体、双特异性抗ilt4/pd-l1抗体及其用途 |
JP2024530040A (ja) | 2021-08-05 | 2024-08-14 | イムノス セラピューティクス アーゲー | Hla融合タンパク質を含む併用医薬 |
JP2024530199A (ja) | 2021-08-05 | 2024-08-16 | イムノス セラピューティクス アーゲー | Hla融合タンパク質を含む医薬組成物 |
WO2023077521A1 (en) * | 2021-11-08 | 2023-05-11 | Celldex Therapeutics, Inc | Anti-ilt4 and anti-pd-1 bispecific constructs |
WO2023114346A2 (en) * | 2021-12-16 | 2023-06-22 | Merck Sharp & Dohme Llc | Biomarkers for predicting eligibility for an anti-ilt4 and anti-pd-1 combination therapy |
US20250197491A1 (en) | 2022-03-11 | 2025-06-19 | Macomics Limited | Compositions and methods for modulation of macrophage activity |
WO2023192798A2 (en) * | 2022-03-28 | 2023-10-05 | Coherus Biosciences, Inc. | Anti-ilt4 compositions and methods |
AU2023259127A1 (en) * | 2022-04-29 | 2024-10-31 | Merck Sharp & Dohme Llc | Pharmaceutical formulations of an anti-ilt4 antibody or antigen-binding fragment thererof and methods of use |
KR20250006250A (ko) * | 2022-04-29 | 2025-01-10 | 머크 샤프 앤드 돔 엘엘씨 | 항-pd-1 항체와 조합된 항-ilt4 항체 또는 그의 항원-결합 단편의 안정한 제제 및 그의 사용 방법 |
CN116333127A (zh) * | 2022-06-28 | 2023-06-27 | 北京科诺信诚科技有限公司 | 靶向人lilrb2的纳米抗体及其应用 |
TW202409088A (zh) * | 2022-07-08 | 2024-03-01 | 中國商科望(蘇州)生物醫藥科技有限公司 | 抗lilrb2抗體及其用途 |
WO2024022462A1 (zh) * | 2022-07-29 | 2024-02-01 | 盛禾(中国)生物制药有限公司 | 一种抗ilt4的单域抗体及其应用 |
IL319145A (en) * | 2022-08-22 | 2025-04-01 | Antengene Biologics Ltd | Novel anti-LILRB2 antibodies and their uses |
TW202413414A (zh) * | 2022-09-08 | 2024-04-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗ilt4抗體及其醫藥用途 |
WO2024120526A1 (zh) * | 2022-12-09 | 2024-06-13 | 诺纳生物(苏州)有限公司 | 抗ilt4抗体及其制备方法和应用 |
AU2023410277A1 (en) * | 2022-12-23 | 2025-06-12 | Iomx Therapeutics Ag | Cross-specific antigen binding proteins (abp) targeting leukocyte immunoglobulin-like receptor subfamily b1 (lilrb1) and lilrb2, combinations and uses thereof |
EP4491230A1 (en) * | 2023-07-14 | 2025-01-15 | iOmx Therapeutics AG | Cross-specific antigen binding proteins (abp) targeting leukocyte immunoglobulin-like receptor subfamily b1 (lilrb1) and lilrb2, combinations and uses thereof |
WO2024165671A1 (en) | 2023-02-08 | 2024-08-15 | Immunos Therapeutics Ag | FUSION PROTEINS OF ß2 MICROGLOBULIN, HLA HEAVY CHAIN POLYPEPTIDES, AND INHIBITOR OF CD47-SIRPA |
CN117925759B (zh) * | 2024-01-23 | 2024-07-02 | 通化康元生物科技有限公司 | 林蛙多肽制剂及其在食品和化妆品中的应用 |
Family Cites Families (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
ATE135370T1 (de) | 1988-12-22 | 1996-03-15 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
CA2118508A1 (en) | 1992-04-24 | 1993-11-11 | Elizabeth S. Ward | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
JPH08511420A (ja) | 1993-06-16 | 1996-12-03 | セルテック・セラピューテイクス・リミテッド | 抗 体 |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
US6448035B1 (en) | 1997-04-24 | 2002-09-10 | Immunex Corporation | Family of immunoregulators designated leukocyte immunoglobulin-like receptor (LIR) |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
EP1071700B1 (en) | 1998-04-20 | 2010-02-17 | GlycArt Biotechnology AG | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
GB9818110D0 (en) | 1998-08-19 | 1998-10-14 | Weston Medical Ltd | Needleless injectors and other devices |
US6096002A (en) | 1998-11-18 | 2000-08-01 | Bioject, Inc. | NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method |
AU771908C (en) | 1998-12-09 | 2005-03-10 | Phyton Holdings, Llc | A method for manufacturing glycoproteins having human-type glycosylation |
HU230769B1 (hu) | 1999-01-15 | 2018-03-28 | Genentech Inc. | Módosított effektor-funkciójú polipeptid-változatok |
EP2275541B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
EP1522590B1 (en) | 2000-06-28 | 2009-08-26 | Glycofi, Inc. | Methods for producing modified glycoproteins |
US7795002B2 (en) | 2000-06-28 | 2010-09-14 | Glycofi, Inc. | Production of galactosylated glycoproteins in lower eukaryotes |
US7449308B2 (en) | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
US7632983B2 (en) | 2000-07-31 | 2009-12-15 | Biolex Therapeutics, Inc. | Expression of monoclonal antibodies in duckweed |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
AU2002345878A1 (en) | 2001-06-25 | 2003-01-08 | The Trustees Of Columbia University In The City Of New York | Ilt3 and ilt4-related compositions and methods |
EP1443961B1 (en) | 2001-10-25 | 2009-05-06 | Genentech, Inc. | Glycoprotein compositions |
PL374463A1 (en) | 2001-11-14 | 2005-10-17 | Immunex Corporation | Modulation of lir function to treat rheumatoid arthritis |
CN102911987B (zh) | 2002-04-09 | 2015-09-30 | 协和发酵麒麟株式会社 | 基因组被修饰的细胞 |
WO2003086310A2 (en) | 2002-04-12 | 2003-10-23 | Ramot At Tel Aviv University Ltd. | Prevention of brain inflammation as a result of induced autoimmune response |
US7410483B2 (en) | 2003-05-23 | 2008-08-12 | Novare Surgical Systems, Inc. | Hand-actuated device for remote manipulation of a grasping tool |
CA2532547C (en) | 2003-07-24 | 2020-02-25 | Innate Pharma | Methods and compositions for increasing the efficiency of therapeutic antibodies using nk cell potentiating compounds |
ES2653570T3 (es) | 2004-05-27 | 2018-02-07 | The Trustees Of The University Of Pennsylvania | Células presentadoras de antígeno artificiales novedosas y usos de las mismas |
US20110142858A1 (en) | 2004-06-07 | 2011-06-16 | Ramot At Tel Aviv University Ltd. | Method of Passsive Immunization Against Disease or Disorder Charcterized by Amyloid Aggregation with Diminished Risk of Neuroinflammation |
DE102004034416A1 (de) | 2004-07-15 | 2006-02-02 | "Stiftung Caesar" (Center Of Advanced European Studies And Research) | Flüssige, strahlunghärtende Zusammensetzungen |
MX2007009935A (es) | 2005-02-18 | 2007-10-10 | Medarex Inc | Anticuerpos monoclonales que carecen de residuos fucosilo contra antigeno membranal especifico de prostata (psma). |
PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
CA3149553C (en) | 2006-06-12 | 2023-11-21 | Aptevo Research And Development Llc | Single-chain multivalent binding proteins with effector function |
JP2010509612A (ja) | 2006-11-14 | 2010-03-25 | ジェネンテック インコーポレイテッド | ニューロン再生の活性調節因子 |
WO2012012716A2 (en) | 2010-07-23 | 2012-01-26 | Regulus Therapeutics, Inc. | Targeting micrornas for the treatment of fibrosis |
TW201247700A (en) | 2011-05-05 | 2012-12-01 | Baylor Res Inst | Immunoglobulin-like transcript (ILT) receptors as CD8 antagonists |
WO2013043569A1 (en) | 2011-09-20 | 2013-03-28 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
WO2013066765A1 (en) | 2011-11-01 | 2013-05-10 | Merck Sharp & Dohme Corp. | Mutation of tup1 in glycoengineered yeast |
EP2798064B1 (en) | 2011-12-30 | 2016-08-31 | Cellscript, Llc | Making and using in vitro-synthesized ssrna for introducing into mammalian cells to induce a biological or biochemical effect |
WO2013181438A2 (en) | 2012-05-30 | 2013-12-05 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for modulating pro-inflammatory immune response |
CA2877441A1 (en) | 2012-07-02 | 2014-01-09 | Medizinische Universitat Wien | Complement split product c4d for the treatment of inflammatory conditions |
EP2730588A1 (en) | 2012-11-12 | 2014-05-14 | Intelectys | Antibodies and fragments thereof raised against the alpha-3 domain of HLA-G protein, methods and means for their preparation, and uses thereof |
EP2940041B1 (en) | 2012-12-28 | 2019-04-10 | Osaka University | Modified laminin containing collagen binding molecule and use thereof |
EP2970373A1 (en) * | 2013-03-12 | 2016-01-20 | The Board of Trustees of The Leland Stanford Junior University | Methods and compositions for inhibiting the effects of amyloid beta oligomers |
SI3021859T1 (en) | 2013-10-25 | 2018-04-30 | Psioxus Therapeutics Limited | Oncolytic adenoviruses equipped with heterologous genes |
CA2948871A1 (en) * | 2014-05-22 | 2015-11-26 | Fred Hutchinson Cancer Research Center | Lilrb2 and notch-mediated expansion of hematopoietic precursor cells |
JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
US20170274003A1 (en) | 2014-09-16 | 2017-09-28 | The Board Of Trustees Of The Leland Stanford Junior University | Blocking pirb upregulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia |
US20160200815A1 (en) * | 2015-01-05 | 2016-07-14 | Jounce Therapeutics, Inc. | Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof |
WO2016127247A1 (en) | 2015-02-11 | 2016-08-18 | University Health Network | Methods and compositions for modulating lilr proteins |
EP3265113A4 (en) * | 2015-03-06 | 2019-02-20 | The Board of Regents of The University of Texas System | ANTI-LRB ANTIBODIES AND THEIR USE FOR THE DETECTION AND TREATMENT OF CANCER |
WO2017042814A1 (en) | 2015-09-10 | 2017-03-16 | Yeda Research And Development Co. Ltd. | Use of perforin positive immature dendritic cells in disease treatment |
US10960008B2 (en) | 2016-07-11 | 2021-03-30 | Dana-Farber Cancer Institute, Inc. | Methods for treating PTEN deficient epithelial cancers using a combination of anti-PI3KBETA and anti-immune checkpoint agents |
US11906519B2 (en) | 2016-07-29 | 2024-02-20 | The Board Of Regents Of The University Of Texas System | Methods for identifying LILRB-blocking antibodies |
AU2017307610B2 (en) | 2016-08-04 | 2023-10-05 | Memorial Sloan-Kettering Cancer Center | Cancer antigen targets and uses thereof |
CN109996880A (zh) | 2016-08-18 | 2019-07-09 | 加利福尼亚大学董事会 | 基于模块化aav递送系统的crispr-cas基因组工程 |
WO2018035710A1 (en) | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anti-ctla4 antibodies |
KR20190052697A (ko) | 2016-09-28 | 2019-05-16 | 가비쉬-가릴리 바이오 어플리케이션스 리미티드. | 암의 신규한 항원 지표를 표적화하는 car 요법을 위한 보편적 플랫폼 |
TWI796329B (zh) | 2017-04-07 | 2023-03-21 | 美商默沙東有限責任公司 | 抗-ilt4抗體及抗原結合片段 |
TWI833724B (zh) | 2017-12-22 | 2024-03-01 | 美商永斯醫療股份有限公司 | 抗lilrb2抗體 |
CA3104530A1 (en) | 2018-07-09 | 2020-01-16 | Five Prime Therapeutics, Inc. | Antibodies binding to ilt4 |
-
2018
- 2018-04-03 TW TW107111860A patent/TWI796329B/zh active
- 2018-04-05 MX MX2019011927A patent/MX392369B/es unknown
- 2018-04-05 AU AU2018248294A patent/AU2018248294B2/en active Active
- 2018-04-05 PE PE2019001999A patent/PE20191813A1/es unknown
- 2018-04-05 US US15/945,779 patent/US11053315B2/en active Active
- 2018-04-05 UA UAA201910947A patent/UA126865C2/uk unknown
- 2018-04-05 JO JOP/2019/0236A patent/JOP20190236B1/ar active
- 2018-04-05 WO PCT/US2018/026160 patent/WO2018187518A1/en active IP Right Grant
- 2018-04-05 CR CR20190459A patent/CR20190459A/es unknown
- 2018-04-05 EP EP18720495.3A patent/EP3606958A1/en active Pending
- 2018-04-05 GE GEAP201815209A patent/GEP20227440B/en unknown
- 2018-04-05 BR BR112019021000A patent/BR112019021000A2/pt unknown
- 2018-04-05 SG SG11201909081Y patent/SG11201909081YA/en unknown
- 2018-04-05 CA CA3057378A patent/CA3057378A1/en active Pending
- 2018-04-05 KR KR1020197032605A patent/KR102357823B1/ko active Active
- 2018-04-05 TN TNP/2019/000272A patent/TN2019000272A1/en unknown
- 2018-04-05 JP JP2019554645A patent/JP7045392B2/ja active Active
- 2018-04-05 EA EA201992402A patent/EA201992402A1/ru unknown
- 2018-04-05 AR ARP180100863A patent/AR111362A1/es unknown
- 2018-04-05 CN CN201880038297.7A patent/CN110719917A/zh active Pending
-
2019
- 2019-09-24 IL IL26959319A patent/IL269593A/en unknown
- 2019-10-02 PH PH12019502275A patent/PH12019502275A1/en unknown
- 2019-10-04 CL CL2019002855A patent/CL2019002855A1/es unknown
- 2019-10-04 NI NI201900103A patent/NI201900103A/es unknown
- 2019-10-04 EC ECSENADI201972235A patent/ECSP19072235A/es unknown
- 2019-10-04 DO DO2019000253A patent/DOP2019000253A/es unknown
- 2019-10-07 CO CONC2019/0011155A patent/CO2019011155A2/es unknown
-
2021
- 2021-06-03 US US17/338,566 patent/US11897956B2/en active Active
- 2021-06-03 US US17/338,597 patent/US11897957B2/en active Active
- 2021-08-30 AU AU2021225143A patent/AU2021225143A1/en not_active Abandoned
-
2022
- 2022-03-18 JP JP2022043279A patent/JP7394160B2/ja active Active
-
2023
- 2023-12-20 US US18/389,914 patent/US12344670B2/en active Active
-
2024
- 2024-12-11 AU AU2024278314A patent/AU2024278314A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP19072235A (es) | Anticuerpos anti-ILT4 y fragmentos de unión a antígeno | |
CO2018010538A2 (es) | Anticuerpos específicos del receptor de poliovirus humano (rvp) | |
CL2019001198A1 (es) | Anticuerpo bioespecífico contra bcma y cd3 y un fármaco inmunológico para uso combinado en el tratamiento de mieloma múltiple. | |
CL2017003021A1 (es) | Agentes de unión a inmunorreceptor de células t con dominios ig y motivo de inhibición basado en tirosina de inmunorreceptor (tigit) y usos de los mismos. | |
CL2019003093A1 (es) | Anticuerpos anti-trem2 y métodos para utilizarlos. | |
UY37928A (es) | Anticuerpos anti-cd38 y métodos de uso | |
CL2018000744A1 (es) | Anticuerpos anti-tigit (inmunoreceptor de linfocitos t con dominios ig e itim) y metodos de uso. | |
CO2020000214A2 (es) | Anticuerpos agonistas que se unen a cd137 humano y sus usos | |
CL2017003195A1 (es) | Anticuerpos madurados por afinidad y humanizados para fcrh5 y métodos para su uso. | |
CL2017001866A1 (es) | Anticuerpos anti-cd3, anticuerpos anti-cd123 y anticuerpos biespecíficos que se unen específicamente a cd3 y/o cd123 | |
AR107442A1 (es) | Anticuerpos contra el receptor huérfano similar al receptor tirosina quinasa 1 (anti-ror1), anticuerpos biespecíficos que se unen a ror1 y al antígeno cd3, y métodos para el tratamiento del cáncer | |
CO2020010277A2 (es) | Moléculas de unión a antígeno dirigidas a her2 que comprenden 4-1bbl | |
MX2022000132A (es) | Inmunoreceptores especificos de claudina-18.2 y epitopos de celulas t. | |
BR112018014016A2 (pt) | combinação de um agonista de ox40 e um agonista de anticorpo monoclonal 4-1bb para tratamento de câncer | |
MX2017012802A (es) | Anticuerpos antisortilina y métodos para su uso. | |
CL2017000278A1 (es) | Moléculas biespecíficas de unión a antígeno activadoras de células t | |
AR108468A1 (es) | POLIPÉPTIDOS DE FUSIÓN CD40L-Fc Y MÉTODOS DE USO DE LOS MISMOS | |
CL2017000250A1 (es) | Anticuerpo monoclonal anti-ctla4 o su fragmento de unión a antígeno, una composición farmacéutica y uso | |
MX2017001597A (es) | Anticuerpos anti-pd-l1. | |
BR112016030740A2 (pt) | diacorpos heterodiméricos biespecíficos e seus usos | |
CL2017001217A1 (es) | Conjugados de droga de anticuerpos. | |
BR112017020054A2 (pt) | anticorpos para icos | |
CO2018013298A2 (es) | Anticuerpos anti-gitr y sus usos. | |
BR112017006468A2 (pt) | anticorpo biespecífico, composição farmacêutica, kit, uso de uma combinação de um anticorpo biespecífico e método de tratamento de câncer | |
CO2018012497A2 (es) | Anticuerpos de interferón beta y usos de los mismos |