IT8519961A0 - Tripeptidi ad azione ipotensiva eprocedimento pr la loro sintesi. - Google Patents
Tripeptidi ad azione ipotensiva eprocedimento pr la loro sintesi.Info
- Publication number
- IT8519961A0 IT8519961A0 IT8519961A IT1996185A IT8519961A0 IT 8519961 A0 IT8519961 A0 IT 8519961A0 IT 8519961 A IT8519961 A IT 8519961A IT 1996185 A IT1996185 A IT 1996185A IT 8519961 A0 IT8519961 A0 IT 8519961A0
- Authority
- IT
- Italy
- Prior art keywords
- tripeptides
- synthesis
- procedure
- hypotensive action
- hypotensive
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 230000001077 hypotensive effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT19961/85A IT1184164B (it) | 1985-03-19 | 1985-03-19 | Triptidi ad azione ipotensiva e procedimento per la loro sintesi |
DE8686200345T DE3674623D1 (de) | 1985-03-19 | 1986-03-07 | Tripeptide mit pharmazeutischer wirksamkeit und verfahren zu ihrer herstellung. |
EP86200345A EP0199379B1 (en) | 1985-03-19 | 1986-03-07 | Pharmacologically active tripeptides and process for their synthesis |
US06/838,120 US4748155A (en) | 1985-03-19 | 1986-03-10 | Pharmacologically active tripeptides and process for their synthesis |
JP61059653A JPH0688968B2 (ja) | 1985-03-19 | 1986-03-19 | トリペプチド及び医薬組成物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT19961/85A IT1184164B (it) | 1985-03-19 | 1985-03-19 | Triptidi ad azione ipotensiva e procedimento per la loro sintesi |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8519961A0 true IT8519961A0 (it) | 1985-03-19 |
IT1184164B IT1184164B (it) | 1987-10-22 |
Family
ID=11162667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT19961/85A IT1184164B (it) | 1985-03-19 | 1985-03-19 | Triptidi ad azione ipotensiva e procedimento per la loro sintesi |
Country Status (5)
Country | Link |
---|---|
US (1) | US4748155A (it) |
EP (1) | EP0199379B1 (it) |
JP (1) | JPH0688968B2 (it) |
DE (1) | DE3674623D1 (it) |
IT (1) | IT1184164B (it) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2060587T3 (es) * | 1986-05-20 | 1994-12-01 | Sankyo Co | Un procedimiento para producir los compuestos llamados mureidomicina a,b,c o d y sus sales y esteres. |
US5213974A (en) * | 1986-05-20 | 1993-05-25 | Sankyo Company, Limited | Fermentation process for preparing antibiotics mureidomycins A, B, C and D |
EP0517345B1 (en) * | 1987-11-20 | 1995-07-19 | Sankyo Company Limited | Intermediates of the mureidomycin group, their preparation, and their use |
US5049548A (en) * | 1989-03-03 | 1991-09-17 | Merck & Co., Inc. | Renin-inhibitory di-, tri-, and tetrapeptides |
FR2649110B1 (fr) * | 1989-06-29 | 1994-10-21 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
IT1261646B (it) * | 1992-08-04 | 1996-05-28 | Ellem Ind Farmaceutica | Derivati peptidici ad attivita' citostimolante e citoprotettiva |
US6261569B1 (en) * | 1992-08-27 | 2001-07-17 | Deakin Research Limited | Retro-, inverso- and retro-inverso synthetic peptide analogues |
ATE533776T1 (de) * | 2004-05-06 | 2011-12-15 | Laboratorios Biosintetica Ltda | Analoge verbindungen analgetischer peptide, abgeleitet vom crotalus durissus terrificus schlangengift, ihre verwendungen, zusammensetzungen und verfahren ihrer herstellung und reinigung |
BR112018068906A2 (pt) | 2016-03-16 | 2019-01-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | composição, método, método de redução de risco, prevenção ou tratamento de um indivíduo que tem uma doença ou distúrbio autoimune, método de indução de degradação de uma proteína-alvo numa célula, método para reduzir o risco, prevenir ou tratar um estado da doença ou afecção num paciente em que a atividade proteica desregulada é responsável pelo referido estado da doença ou afecção, método para reduzir o risco, prevenir ou tratar câncer num indivíduo e método de tratamento de uma doença ou distúrbio genético num indivíduo |
CA3105506A1 (en) | 2018-07-11 | 2020-01-16 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Dimeric immuno-modulatory compounds against cereblon-based mechanisms |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3876624A (en) * | 1973-10-29 | 1975-04-08 | American Home Prod | P-glu' his' n' ala' nh' 2 'and intermediates |
IT1212508B (it) * | 1981-12-22 | 1989-11-22 | Anic Spa | Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori |
IT1164225B (it) * | 1983-05-13 | 1987-04-08 | Anic Spa | Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione |
IT1172391B (it) * | 1983-12-23 | 1987-06-18 | Polifarma Spa | Composti tirpeptidici contenenti acido piroglutaminico e triptofano,procedimentio di produzione ed applicazioni terapeutiche |
IT1206339B (it) * | 1984-01-13 | 1989-04-14 | Anic Spa | Analoghi retro-invertiti esapeptidici c-terminali della sostanza p. |
-
1985
- 1985-03-19 IT IT19961/85A patent/IT1184164B/it active
-
1986
- 1986-03-07 DE DE8686200345T patent/DE3674623D1/de not_active Expired - Lifetime
- 1986-03-07 EP EP86200345A patent/EP0199379B1/en not_active Expired - Lifetime
- 1986-03-10 US US06/838,120 patent/US4748155A/en not_active Expired - Fee Related
- 1986-03-19 JP JP61059653A patent/JPH0688968B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US4748155A (en) | 1988-05-31 |
EP0199379A2 (en) | 1986-10-29 |
EP0199379B1 (en) | 1990-10-03 |
JPH0688968B2 (ja) | 1994-11-09 |
DE3674623D1 (de) | 1990-11-08 |
EP0199379A3 (en) | 1987-05-13 |
JPS61233665A (ja) | 1986-10-17 |
IT1184164B (it) | 1987-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950330 |