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IT8519961A0 - Tripeptidi ad azione ipotensiva eprocedimento pr la loro sintesi. - Google Patents

Tripeptidi ad azione ipotensiva eprocedimento pr la loro sintesi.

Info

Publication number
IT8519961A0
IT8519961A0 IT8519961A IT1996185A IT8519961A0 IT 8519961 A0 IT8519961 A0 IT 8519961A0 IT 8519961 A IT8519961 A IT 8519961A IT 1996185 A IT1996185 A IT 1996185A IT 8519961 A0 IT8519961 A0 IT 8519961A0
Authority
IT
Italy
Prior art keywords
tripeptides
synthesis
procedure
hypotensive action
hypotensive
Prior art date
Application number
IT8519961A
Other languages
English (en)
Other versions
IT1184164B (it
Inventor
Alessandro Sisto
Antonio Silvio Verdini
Antonino Virdia
Giovanna De Luca
Giovanni Di Stazio
Vincenzo Politi
Original Assignee
Eniricerche Spa
Polifarma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche Spa, Polifarma Spa filed Critical Eniricerche Spa
Priority to IT19961/85A priority Critical patent/IT1184164B/it
Publication of IT8519961A0 publication Critical patent/IT8519961A0/it
Priority to DE8686200345T priority patent/DE3674623D1/de
Priority to EP86200345A priority patent/EP0199379B1/en
Priority to US06/838,120 priority patent/US4748155A/en
Priority to JP61059653A priority patent/JPH0688968B2/ja
Application granted granted Critical
Publication of IT1184164B publication Critical patent/IT1184164B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2732-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2732-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/282-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IT19961/85A 1985-03-19 1985-03-19 Triptidi ad azione ipotensiva e procedimento per la loro sintesi IT1184164B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT19961/85A IT1184164B (it) 1985-03-19 1985-03-19 Triptidi ad azione ipotensiva e procedimento per la loro sintesi
DE8686200345T DE3674623D1 (de) 1985-03-19 1986-03-07 Tripeptide mit pharmazeutischer wirksamkeit und verfahren zu ihrer herstellung.
EP86200345A EP0199379B1 (en) 1985-03-19 1986-03-07 Pharmacologically active tripeptides and process for their synthesis
US06/838,120 US4748155A (en) 1985-03-19 1986-03-10 Pharmacologically active tripeptides and process for their synthesis
JP61059653A JPH0688968B2 (ja) 1985-03-19 1986-03-19 トリペプチド及び医薬組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19961/85A IT1184164B (it) 1985-03-19 1985-03-19 Triptidi ad azione ipotensiva e procedimento per la loro sintesi

Publications (2)

Publication Number Publication Date
IT8519961A0 true IT8519961A0 (it) 1985-03-19
IT1184164B IT1184164B (it) 1987-10-22

Family

ID=11162667

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19961/85A IT1184164B (it) 1985-03-19 1985-03-19 Triptidi ad azione ipotensiva e procedimento per la loro sintesi

Country Status (5)

Country Link
US (1) US4748155A (it)
EP (1) EP0199379B1 (it)
JP (1) JPH0688968B2 (it)
DE (1) DE3674623D1 (it)
IT (1) IT1184164B (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2060587T3 (es) * 1986-05-20 1994-12-01 Sankyo Co Un procedimiento para producir los compuestos llamados mureidomicina a,b,c o d y sus sales y esteres.
US5213974A (en) * 1986-05-20 1993-05-25 Sankyo Company, Limited Fermentation process for preparing antibiotics mureidomycins A, B, C and D
EP0517345B1 (en) * 1987-11-20 1995-07-19 Sankyo Company Limited Intermediates of the mureidomycin group, their preparation, and their use
US5049548A (en) * 1989-03-03 1991-09-17 Merck & Co., Inc. Renin-inhibitory di-, tri-, and tetrapeptides
FR2649110B1 (fr) * 1989-06-29 1994-10-21 Adir Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1261646B (it) * 1992-08-04 1996-05-28 Ellem Ind Farmaceutica Derivati peptidici ad attivita' citostimolante e citoprotettiva
US6261569B1 (en) * 1992-08-27 2001-07-17 Deakin Research Limited Retro-, inverso- and retro-inverso synthetic peptide analogues
ATE533776T1 (de) * 2004-05-06 2011-12-15 Laboratorios Biosintetica Ltda Analoge verbindungen analgetischer peptide, abgeleitet vom crotalus durissus terrificus schlangengift, ihre verwendungen, zusammensetzungen und verfahren ihrer herstellung und reinigung
BR112018068906A2 (pt) 2016-03-16 2019-01-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. composição, método, método de redução de risco, prevenção ou tratamento de um indivíduo que tem uma doença ou distúrbio autoimune, método de indução de degradação de uma proteína-alvo numa célula, método para reduzir o risco, prevenir ou tratar um estado da doença ou afecção num paciente em que a atividade proteica desregulada é responsável pelo referido estado da doença ou afecção, método para reduzir o risco, prevenir ou tratar câncer num indivíduo e método de tratamento de uma doença ou distúrbio genético num indivíduo
CA3105506A1 (en) 2018-07-11 2020-01-16 H. Lee Moffitt Cancer Center And Research Institute, Inc. Dimeric immuno-modulatory compounds against cereblon-based mechanisms

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876624A (en) * 1973-10-29 1975-04-08 American Home Prod P-glu' his' n' ala' nh' 2 'and intermediates
IT1212508B (it) * 1981-12-22 1989-11-22 Anic Spa Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori
IT1164225B (it) * 1983-05-13 1987-04-08 Anic Spa Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
IT1172391B (it) * 1983-12-23 1987-06-18 Polifarma Spa Composti tirpeptidici contenenti acido piroglutaminico e triptofano,procedimentio di produzione ed applicazioni terapeutiche
IT1206339B (it) * 1984-01-13 1989-04-14 Anic Spa Analoghi retro-invertiti esapeptidici c-terminali della sostanza p.

Also Published As

Publication number Publication date
US4748155A (en) 1988-05-31
EP0199379A2 (en) 1986-10-29
EP0199379B1 (en) 1990-10-03
JPH0688968B2 (ja) 1994-11-09
DE3674623D1 (de) 1990-11-08
EP0199379A3 (en) 1987-05-13
JPS61233665A (ja) 1986-10-17
IT1184164B (it) 1987-10-22

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950330