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IT1391757B1 - Irinotecan cloridrato cristallino e metodi per la sua preparazione - Google Patents

Irinotecan cloridrato cristallino e metodi per la sua preparazione

Info

Publication number
IT1391757B1
IT1391757B1 ITMI2008A001984A ITMI20081984A IT1391757B1 IT 1391757 B1 IT1391757 B1 IT 1391757B1 IT MI2008A001984 A ITMI2008A001984 A IT MI2008A001984A IT MI20081984 A ITMI20081984 A IT MI20081984A IT 1391757 B1 IT1391757 B1 IT 1391757B1
Authority
IT
Italy
Prior art keywords
chloridrate
irinotecan
crystalline
preparation
methods
Prior art date
Application number
ITMI2008A001984A
Other languages
English (en)
Inventor
Roberta Pizzocaro
Ettore Negri
Gaetano Balsamo
Giovanni Pozzi
Angelo Bedeschi
Marco Alpegiani
Paolo Ghetti
Original Assignee
Antibioticos Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos Spa filed Critical Antibioticos Spa
Priority to ITMI2008A001984A priority Critical patent/IT1391757B1/it
Priority to EP09175401A priority patent/EP2189461B1/en
Priority to US12/615,334 priority patent/US8247426B2/en
Publication of ITMI20081984A1 publication Critical patent/ITMI20081984A1/it
Application granted granted Critical
Publication of IT1391757B1 publication Critical patent/IT1391757B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ITMI2008A001984A 2008-11-11 2008-11-11 Irinotecan cloridrato cristallino e metodi per la sua preparazione IT1391757B1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ITMI2008A001984A IT1391757B1 (it) 2008-11-11 2008-11-11 Irinotecan cloridrato cristallino e metodi per la sua preparazione
EP09175401A EP2189461B1 (en) 2008-11-11 2009-11-09 Crystalline irinotecan hydrochloride and methods for the preparation thereof
US12/615,334 US8247426B2 (en) 2008-11-11 2009-11-10 Crystalline irinotecan hydrochloride and methods for its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2008A001984A IT1391757B1 (it) 2008-11-11 2008-11-11 Irinotecan cloridrato cristallino e metodi per la sua preparazione

Publications (2)

Publication Number Publication Date
ITMI20081984A1 ITMI20081984A1 (it) 2010-05-12
IT1391757B1 true IT1391757B1 (it) 2012-01-27

Family

ID=40897397

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2008A001984A IT1391757B1 (it) 2008-11-11 2008-11-11 Irinotecan cloridrato cristallino e metodi per la sua preparazione

Country Status (3)

Country Link
US (1) US8247426B2 (it)
EP (1) EP2189461B1 (it)
IT (1) IT1391757B1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102260272B (zh) * 2011-08-12 2016-01-13 扬子江药业集团有限公司 一种制备盐酸伊立替康的方法
CN102617584B (zh) * 2012-03-14 2013-10-16 海南锦瑞制药股份有限公司 一种盐酸伊立替康化合物及其药物组合物
US10919905B2 (en) 2019-05-16 2021-02-16 Scinopharm Taiwan, Ltd. Polymorphism for irinotecan free base

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1487840B1 (en) * 2002-03-01 2007-06-13 Pfizer Italia S.r.l. Crystalline polymorphic form of irinotecan hydrochloride
CA2516643C (en) * 2003-02-25 2011-04-19 Kabushiki Kaisha Yakult Honsha Method for preparing polymorphism of irinotecan hydrochloride
JP2008509211A (ja) * 2004-08-09 2008-03-27 シルパ・メディケア・リミテッド 塩酸イリノテカン三水和物の改良された製造方法
JP5119153B2 (ja) * 2005-09-20 2013-01-16 シノファーム シンガポール ピーティーイー，リミテッド イリノテカン塩酸塩の新規結晶形

Also Published As

Publication number Publication date
US8247426B2 (en) 2012-08-21
US20100179180A1 (en) 2010-07-15
ITMI20081984A1 (it) 2010-05-12
EP2189461A1 (en) 2010-05-26
EP2189461B1 (en) 2013-04-03

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