IT1319275B1 - Uso del baclofen nel trattamento dell'astinenza da etanolo. - Google Patents
Uso del baclofen nel trattamento dell'astinenza da etanolo.Info
- Publication number
- IT1319275B1 IT1319275B1 IT1999MI002107A ITMI992107A IT1319275B1 IT 1319275 B1 IT1319275 B1 IT 1319275B1 IT 1999MI002107 A IT1999MI002107 A IT 1999MI002107A IT MI992107 A ITMI992107 A IT MI992107A IT 1319275 B1 IT1319275 B1 IT 1319275B1
- Authority
- IT
- Italy
- Prior art keywords
- baclofen
- treatment
- abstinence
- ethanol
- ethanol abstinence
- Prior art date
Links
- KPYSYYIEGFHWSV-UHFFFAOYSA-N Baclofen Chemical compound OC(=O)CC(CN)C1=CC=C(Cl)C=C1 KPYSYYIEGFHWSV-UHFFFAOYSA-N 0.000 title abstract 2
- 229960000794 baclofen Drugs 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 2
- 206010053164 Alcohol withdrawal syndrome Diseases 0.000 abstract 1
- 208000029650 alcohol withdrawal Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Addiction (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI002107A IT1319275B1 (it) | 1999-10-08 | 1999-10-08 | Uso del baclofen nel trattamento dell'astinenza da etanolo. |
| CA002386817A CA2386817C (en) | 1999-10-08 | 2000-10-05 | The use of baclofen in the treatment of alcoholism |
| DE60021590T DE60021590T2 (de) | 1999-10-08 | 2000-10-05 | Verwendung von baclofen zur behandlung von alkoholismus |
| HK02109321.9A HK1048062A1 (zh) | 1999-10-08 | 2000-10-05 | 巴氯酚(baclofen)在酒精中毒治療中的應用 |
| ES00969423T ES2246900T3 (es) | 1999-10-08 | 2000-10-05 | Uso de baclofeno en el tratamiento del alcoholismo. |
| EP00969423A EP1217999B1 (en) | 1999-10-08 | 2000-10-05 | The use of baclofen in the treatment of alcoholism |
| DK00969423T DK1217999T3 (da) | 1999-10-08 | 2000-10-05 | Anvendelse af baclofen til behandling af alkoholisme |
| PL354083A PL200525B1 (pl) | 1999-10-08 | 2000-10-05 | Zastosowanie baklofenu do wytwarzania leku |
| AT00969423T ATE300295T1 (de) | 1999-10-08 | 2000-10-05 | Verwendung von baclofen zur behandlung von alkoholismus |
| AU79146/00A AU7914600A (en) | 1999-10-08 | 2000-10-05 | The use of baclofen in the treatment of alcohol withdrawal syndrome and to promote alcohol abstinence in alcoholics |
| PCT/EP2000/009750 WO2001026638A2 (en) | 1999-10-08 | 2000-10-05 | The use of baclofen in the treatment of alcoholism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI002107A IT1319275B1 (it) | 1999-10-08 | 1999-10-08 | Uso del baclofen nel trattamento dell'astinenza da etanolo. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI992107A0 ITMI992107A0 (it) | 1999-10-08 |
| ITMI992107A1 ITMI992107A1 (it) | 2001-04-08 |
| IT1319275B1 true IT1319275B1 (it) | 2003-09-26 |
Family
ID=11383744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1999MI002107A IT1319275B1 (it) | 1999-10-08 | 1999-10-08 | Uso del baclofen nel trattamento dell'astinenza da etanolo. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1217999B1 (it) |
| AT (1) | ATE300295T1 (it) |
| AU (1) | AU7914600A (it) |
| CA (1) | CA2386817C (it) |
| DE (1) | DE60021590T2 (it) |
| DK (1) | DK1217999T3 (it) |
| ES (1) | ES2246900T3 (it) |
| HK (1) | HK1048062A1 (it) |
| IT (1) | IT1319275B1 (it) |
| PL (1) | PL200525B1 (it) |
| WO (1) | WO2001026638A2 (it) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| AU2004267100B2 (en) | 2003-08-20 | 2010-10-07 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| EP2354120A1 (en) | 2003-08-20 | 2011-08-10 | XenoPort, Inc. | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
| US7494985B2 (en) | 2004-11-03 | 2009-02-24 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use |
| US7566738B2 (en) | 2004-11-03 | 2009-07-28 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use |
| WO2008033572A1 (en) | 2006-09-15 | 2008-03-20 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| US8062870B2 (en) | 2008-01-25 | 2011-11-22 | Xenoport, Inc. | Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs |
| WO2009094577A2 (en) | 2008-01-25 | 2009-07-30 | Xenoport, Inc. | Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| EP2250148B1 (en) | 2008-01-25 | 2016-08-17 | XenoPort, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use |
| US8299291B2 (en) | 2008-08-07 | 2012-10-30 | Xenoport, Inc. | Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs |
| WO2010017498A1 (en) | 2008-08-07 | 2010-02-11 | Xenoport, Inc. | Methods of synthesizing n-hydroxysuccinimidyl carbonates |
| US10071068B2 (en) | 2009-03-03 | 2018-09-11 | Xenoport, Inc. | Sustained release oral dosage forms of an R-baclofen prodrug |
| WO2010120370A2 (en) | 2009-04-17 | 2010-10-21 | Xenoport, Inc. | Gamma-amino-butyric acid derivatives as gabab receptor ligands |
| DE102010011069A1 (de) | 2010-03-11 | 2011-09-15 | Susanne Haamann | Verfahren zur gezielten pharmakologischen und co-psychotherapeutischen Behandlung der Alkoholabhängigkeit mit Baclofen und Nalmefen |
| US8580850B2 (en) | 2011-08-11 | 2013-11-12 | Xenoport, Inc. | Anhydrous and hemihydrate crystalline forms of an (R)-baclofen prodrug, methods of synthesis and methods of use |
| WO2016115504A1 (en) * | 2015-01-15 | 2016-07-21 | Allaysis, Llc | Intravenous baclofen formulations and treatment methods |
-
1999
- 1999-10-08 IT IT1999MI002107A patent/IT1319275B1/it active
-
2000
- 2000-10-05 CA CA002386817A patent/CA2386817C/en not_active Expired - Fee Related
- 2000-10-05 AT AT00969423T patent/ATE300295T1/de active
- 2000-10-05 EP EP00969423A patent/EP1217999B1/en not_active Expired - Lifetime
- 2000-10-05 DE DE60021590T patent/DE60021590T2/de not_active Expired - Lifetime
- 2000-10-05 WO PCT/EP2000/009750 patent/WO2001026638A2/en active IP Right Grant
- 2000-10-05 HK HK02109321.9A patent/HK1048062A1/zh unknown
- 2000-10-05 DK DK00969423T patent/DK1217999T3/da active
- 2000-10-05 AU AU79146/00A patent/AU7914600A/en not_active Abandoned
- 2000-10-05 ES ES00969423T patent/ES2246900T3/es not_active Expired - Lifetime
- 2000-10-05 PL PL354083A patent/PL200525B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE300295T1 (de) | 2005-08-15 |
| CA2386817A1 (en) | 2001-04-19 |
| ITMI992107A1 (it) | 2001-04-08 |
| CA2386817C (en) | 2009-05-12 |
| ES2246900T3 (es) | 2006-03-01 |
| HK1048062A1 (zh) | 2003-03-21 |
| WO2001026638A3 (en) | 2002-02-28 |
| DE60021590D1 (de) | 2005-09-01 |
| EP1217999B1 (en) | 2005-07-27 |
| ITMI992107A0 (it) | 1999-10-08 |
| WO2001026638A2 (en) | 2001-04-19 |
| PL200525B1 (pl) | 2009-01-30 |
| AU7914600A (en) | 2001-04-23 |
| PL354083A1 (en) | 2003-12-29 |
| EP1217999A2 (en) | 2002-07-03 |
| DE60021590T2 (de) | 2006-05-24 |
| DK1217999T3 (da) | 2005-11-28 |
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