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IT1283650B1 - Chelati paramagnetici ad alta relassivita' in siero - Google Patents

Chelati paramagnetici ad alta relassivita' in siero

Info

Publication number
IT1283650B1
IT1283650B1 IT96MI001684A ITMI961684A IT1283650B1 IT 1283650 B1 IT1283650 B1 IT 1283650B1 IT 96MI001684 A IT96MI001684 A IT 96MI001684A IT MI961684 A ITMI961684 A IT MI961684A IT 1283650 B1 IT1283650 B1 IT 1283650B1
Authority
IT
Italy
Prior art keywords
serum
high relaxation
paramagnetic chelates
chelates
paramagnetic
Prior art date
Application number
IT96MI001684A
Other languages
English (en)
Inventor
Marco Lolli
Luisella Calabi
Alessanfro Maiocchi
Fabrizio Rebasti
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa filed Critical Bracco Spa
Priority to IT96MI001684A priority Critical patent/IT1283650B1/it
Publication of ITMI961684A0 publication Critical patent/ITMI961684A0/it
Priority to PCT/EP1997/004096 priority patent/WO1998005625A1/en
Priority to EP97940037A priority patent/EP0915829A1/en
Priority to AU42029/97A priority patent/AU4202997A/en
Priority to JP50542598A priority patent/JP4225573B2/ja
Priority to ZA9706891A priority patent/ZA976891B/xx
Publication of ITMI961684A1 publication Critical patent/ITMI961684A1/it
Application granted granted Critical
Publication of IT1283650B1 publication Critical patent/IT1283650B1/it
Priority to US09/612,392 priority patent/US6403055B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76Metal complexes of amino carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IT96MI001684A 1996-08-02 1996-08-02 Chelati paramagnetici ad alta relassivita' in siero IT1283650B1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT96MI001684A IT1283650B1 (it) 1996-08-02 1996-08-02 Chelati paramagnetici ad alta relassivita' in siero
PCT/EP1997/004096 WO1998005625A1 (en) 1996-08-02 1997-07-28 Diagnostic imaging contrast agent with improved in-serum-relaxivity
EP97940037A EP0915829A1 (en) 1996-08-02 1997-07-28 Diagnostic imaging contrast agent with improved in-serum-relaxivity
AU42029/97A AU4202997A (en) 1996-08-02 1997-07-28 Diagnostic imaging contrast agent with improved in-serum-relaxivity
JP50542598A JP4225573B2 (ja) 1996-08-02 1997-07-28 改善された血清緩和を有する診断用画像造影剤
ZA9706891A ZA976891B (en) 1996-08-02 1997-08-01 Diagnostic imaging contrast agent.
US09/612,392 US6403055B1 (en) 1996-08-02 2000-07-07 Diagnostic imaging contrast agent with improved in serum relaxivity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI001684A IT1283650B1 (it) 1996-08-02 1996-08-02 Chelati paramagnetici ad alta relassivita' in siero

Publications (3)

Publication Number Publication Date
ITMI961684A0 ITMI961684A0 (it) 1996-08-02
ITMI961684A1 ITMI961684A1 (it) 1998-02-02
IT1283650B1 true IT1283650B1 (it) 1998-04-23

Family

ID=11374755

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI001684A IT1283650B1 (it) 1996-08-02 1996-08-02 Chelati paramagnetici ad alta relassivita' in siero

Country Status (6)

Country Link
EP (1) EP0915829A1 (it)
JP (1) JP4225573B2 (it)
AU (1) AU4202997A (it)
IT (1) IT1283650B1 (it)
WO (1) WO1998005625A1 (it)
ZA (1) ZA976891B (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW319763B (it) 1995-02-01 1997-11-11 Epix Medical Inc
CA2303426C (en) 1997-10-02 2008-09-23 Epix Medical, Inc. Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
IT1298614B1 (it) * 1998-03-10 2000-01-12 Bracco Spa Chelati complessi di manganese ad alta relassivita' in siero
IT1298613B1 (it) * 1998-03-10 2000-01-12 Bracco Spa Chelati complessi di manganese ad alta relassivita' in siero
GB9911681D0 (en) * 1999-05-19 1999-07-21 Nycomed Imaging As Process
US7081472B2 (en) 2000-11-08 2006-07-25 K. U. Leuven Research & Development Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them
US6549798B2 (en) 2001-02-07 2003-04-15 Epix Medical, Inc. Magnetic resonance angiography data
ITMI20011518A1 (it) * 2001-07-17 2003-01-17 Bracco Imaging Spa Leganti azotati multidentati capaci di complessare ioni metallici e loro uso in diagnostica e in terapia
US7893223B2 (en) 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
CN115611757A (zh) * 2021-07-16 2023-01-17 江苏慧聚药业股份有限公司 mRNA传递剂的合成

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57183471A (en) * 1981-04-30 1982-11-11 Takemoto Oil & Fat Co Ltd Synthetic fiber treating oil agent
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
EP0713139B1 (en) * 1994-10-20 1998-06-03 Fuji Photo Film Co., Ltd. Novel, iron complex, process for producing the same, photographic processing composition and processing process using the same
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
IT1290417B1 (it) * 1996-08-02 1998-12-03 Bracco Spa Composti chelanti derivati di acidi poliamminopolicarbossilici, loro chelati con ioni metallici paramagnetici, loro preparazione ed

Also Published As

Publication number Publication date
JP4225573B2 (ja) 2009-02-18
ITMI961684A1 (it) 1998-02-02
JP2000516915A (ja) 2000-12-19
AU4202997A (en) 1998-02-25
EP0915829A1 (en) 1999-05-19
ZA976891B (en) 1998-05-11
ITMI961684A0 (it) 1996-08-02
WO1998005625A1 (en) 1998-02-12

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