IT1218927B - STABLE PHARMACEUTICAL PREPARATION CONTAINING A STIMULATION FACTOR OF A COLONY OF GRANULOCYTES AND PROCEDURE FOR ITS PREPARATION - Google Patents

STABLE PHARMACEUTICAL PREPARATION CONTAINING A STIMULATION FACTOR OF A COLONY OF GRANULOCYTES AND PROCEDURE FOR ITS PREPARATION

Info

Publication number: IT1218927B
Authority: IT; Italy
Prior art keywords: granulocytes; colony; procedure; preparation; stable pharmaceutical
Prior art date: 1986-07-18

Application number

IT67594/87A

Other languages

Italian (it)

Other versions

IT8767594A0 (en

Inventor

Machida Minoru

Original Assignee

Chugai Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-18

Filing date

1987-07-10

Publication date

1990-04-24

1987-07-10 Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd

1987-07-10 Publication of IT8767594A0 publication Critical patent/IT8767594A0/en

1990-04-24 Application granted granted Critical

1990-04-24 Publication of IT1218927B publication Critical patent/IT1218927B/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Inorganic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

IT67594/87A 1986-07-18 1987-07-10 STABLE PHARMACEUTICAL PREPARATION CONTAINING A STIMULATION FACTOR OF A COLONY OF GRANULOCYTES AND PROCEDURE FOR ITS PREPARATION IT1218927B (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP16948686		1986-07-18
JP16948886		1986-07-18
JP16948786		1986-07-18
JP16948986		1986-07-18

Publications (2)

Publication Number	Publication Date
IT8767594A0 IT8767594A0 (en)	1987-07-10
IT1218927B true IT1218927B (en)	1990-04-24

Family

ID=27474266

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT67594/87A IT1218927B (en)	1986-07-18	1987-07-10	STABLE PHARMACEUTICAL PREPARATION CONTAINING A STIMULATION FACTOR OF A COLONY OF GRANULOCYTES AND PROCEDURE FOR ITS PREPARATION

Country Status (24)

Country	Link
KR (1)	KR930004597B1 (en)
CN (1)	CN1033738C (en)
AT (1)	AT402259B (en)
AU (1)	AU611856B2 (en)
BE (1)	BE1000253A3 (en)
CA (1)	CA1297007C (en)
CH (1)	CH671157A5 (en)
DE (1)	DE3723781C2 (en)
DK (1)	DK171308B1 (en)
ES (1)	ES2010226A6 (en)
FR (1)	FR2601591B1 (en)
GB (1)	GB2193631B (en)
GR (1)	GR871067B (en)
HK (1)	HK64893A (en)
HU (1)	HU198627B (en)
IE (1)	IE60290B1 (en)
IL (1)	IL83220A (en)
IT (1)	IT1218927B (en)
NL (1)	NL192917C (en)
NO (1)	NO171828C (en)
PT (1)	PT85343B (en)
SE (1)	SE503312C2 (en)
SG (1)	SG64393G (en)
YU (1)	YU47543B (en)

Families Citing this family (45)

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US4929442A (en) *	1986-09-26	1990-05-29	Exovir, Inc.	Compositions suitable for human topical application including a growth factor and/or related materials
US4847325A (en) *	1988-01-20	1989-07-11	Cetus Corporation	Conjugation of polymer to colony stimulating factor-1
NO179479C (en) *	1988-03-11	1996-10-16	Teikoku Seiyaku Kk	Process for the preparation of an intravaginal pharmaceutical preparation
US5981485A (en)	1997-07-14	1999-11-09	Genentech, Inc.	Human growth hormone aqueous formulation
US5349052A (en) *	1988-10-20	1994-09-20	Royal Free Hospital School Of Medicine	Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor
GB8824591D0 (en) *	1988-10-20	1988-11-23	Royal Free Hosp School Med	Fractionation process
US6132763A (en) *	1988-10-20	2000-10-17	Polymasc Pharmaceuticals Plc	Liposomes
US5104651A (en) *	1988-12-16	1992-04-14	Amgen Inc.	Stabilized hydrophobic protein formulations of g-csf
EP0459516A1 (en) *	1990-06-01	1991-12-04	Kirin-Amgen, Inc.	Oral dosage form of biologically active proteins
JP3249147B2 (en) *	1990-06-01	2002-01-21	キリン−アムジエン・インコーポレーテツド	Oral preparation containing bioactive protein
FR2686899B1 (en)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2686900B1 (en) *	1992-01-31	1995-07-21	Rhone Poulenc Rorer Sa	NOVEL POLYPEPTIDES HAVING GRANULOCYTE COLONY STIMULATION ACTIVITY, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2693907B1 (en) *	1992-07-23	1994-09-02	Rhone Poulenc Rorer Sa	A method of administering granulocyte colony stimulating factor solutions.
EP0582932A1 (en) *	1992-08-11	1994-02-16	F. Hoffmann-La Roche Ag	Therapeutic system for the parenteral administration of hematopoietic growth factors
DE4242863A1 (en) *	1992-12-18	1994-06-23	Boehringer Mannheim Gmbh	Stable lyophilized pharmaceutical preparations of G-CSF
DE4242919A1 (en) *	1992-12-18	1994-06-23	Boehringer Mannheim Gmbh	Process for the preparation of storage-stable aqueous pharmaceutical preparations of G-CSF
US20030053982A1 (en)	1994-09-26	2003-03-20	Kinstler Olaf B.	N-terminally chemically modified protein compositions and methods
US5824784A (en)	1994-10-12	1998-10-20	Amgen Inc.	N-terminally chemically modified protein compositions and methods
AU695129B2 (en) *	1995-02-06	1998-08-06	Genetics Institute, Llc	Formulations for IL-12
TW434020B (en) *	1995-03-15	2001-05-16	Kirin Brewery	Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
TW434021B (en) *	1995-03-15	2001-05-16	Kirin Brewery	Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
GB9526733D0 (en)	1995-12-30	1996-02-28	Delta Biotechnology Ltd	Fusion proteins
US20030190307A1 (en)	1996-12-24	2003-10-09	Biogen, Inc.	Stable liquid interferon formulations
EP1060746A4 (en) *	1998-03-06	2002-06-19	Chugai Pharmaceutical Co Ltd	Protein-free preparations
US6979442B1 (en) *	1998-08-17	2005-12-27	Pfizer Inc.	Stabilized protein compositions
WO2001017542A1 (en) *	1999-09-08	2001-03-15	Chugai Seiyaku Kabushiki Kaisha	Protein solution preparation and method of stabilizing the same
TR200401573T4 (en) *	2000-02-29	2004-08-23	Pfizer Products Inc.	Stabilized granulocyte colony stimulating factor
WO2001064241A1 (en) *	2000-02-29	2001-09-07	Chugai Seiyaku Kabushiki Kaisha	Preparations stabilized over long time
CA2747325A1 (en)	2000-04-12	2001-10-25	Human Genome Sciences, Inc.	Albumin fusion proteins
US6946134B1 (en)	2000-04-12	2005-09-20	Human Genome Sciences, Inc.	Albumin fusion proteins
CA2420850A1 (en)	2000-09-01	2003-02-28	Chugai Seiyaku Kabushiki Kaisha	Solution formulations having long-term stability
US8435939B2 (en)	2000-09-05	2013-05-07	Biokine Therapeutics Ltd.	Polypeptide anti-HIV agent containing the same
US7507413B2 (en)	2001-04-12	2009-03-24	Human Genome Sciences, Inc.	Albumin fusion proteins
CA2471363C (en)	2001-12-21	2014-02-11	Human Genome Sciences, Inc.	Albumin fusion proteins
US7423007B2 (en)	2002-08-27	2008-09-09	Biokine Therapeutics Ltd.	Cxcr4 antagonist and use thereof
EP1598074B1 (en)	2003-02-28	2019-01-02	Chugai Seiyaku Kabushiki Kaisha	Stabilized protein-containing formulations
DE202006020194U1 (en)	2006-03-01	2007-12-06	Bioceuticals Arzneimittel Ag	G-CSF liquid formulation
EP2104507A4 (en)	2006-12-21	2011-05-25	Biokine Therapeutics Ltd	T-140 peptide analogs having cxcr4 super-agonist activity for cancer therapy
WO2010092571A2 (en)	2009-02-11	2010-08-19	Yeda Research And Development Co. Ltd.	Short beta-defensin-derived peptides
CN102740840A (en) *	2010-01-19	2012-10-17	韩美科学株式会社	Liquid formulations for long-acting G-CSF conjugate
EP2399572A1 (en)	2010-06-22	2011-12-28	Sandoz AG	Long-term storage of non-glycosylated recombinant human G-CSF
EP3943098A3 (en)	2015-07-16	2022-05-11	Biokine Therapeutics Ltd.	Compositions and methods for treating cancer
BR112018016924A2 (en)	2016-02-23	2019-01-02	Biokine Therapeutics Ltd	treatment regimen selection method for individual who has acute myeloid leukemia (LMA), acute response myeloid leukemia (LMA) treatment maximization method, lma treatment method, cxcr4 antagonist, and chemotherapeutic agent in the treatment of lma
WO2018138267A1 (en)	2017-01-27	2018-08-02	Cinfa Biotech S.L.	Method for determining the efficacy of a g-csf containing composition
PL3797752T3 (en) *	2018-05-21	2024-10-28	Chugai Seiyaku Kabushiki Kaisha	Lyophilized formulation sealed in glass container

Family Cites Families (9)

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DE2652636A1 (en) *	1976-11-19	1978-05-24	Hans Uwe Dr Rer Nat Wolf	Stabilising protein during separation, purification and storage - by adding amphiphilic cpds., esp. lipid(s), ionic and or nonionic detergents
SE451844B (en) *	1978-03-20	1987-11-02	Morinaga Milk Industry Co Ltd	GLYCOPROTEIN, PROCEDURE FOR PREPARING THEREOF AND THERAPEUTIC AGENTS INCLUDING THE GLYCOPROTEIN
DE3380726D1 (en) *	1982-06-24	1989-11-23	Japan Chem Res	Long-acting composition
JPS60228422A (en) *	1984-04-26	1985-11-13	Suntory Ltd	Stabilized preparation of physiologically active substance
JPS61227526A (en) *	1984-07-25	1986-10-09	Chugai Pharmaceut Co Ltd	Novel csf and method of collecting same
JPS6191131A (en) *	1984-10-09	1986-05-09	Chugai Pharmaceut Co Ltd	Method and composition for preventing adsorption of pharmaceutical
ATE80894T1 (en) *	1985-02-05	1992-10-15	Cetus Oncology Corp	PURIFICATION OF NATURAL COLONY STIMULATING FACTOR-1.
US4810643A (en) *	1985-08-23	1989-03-07	Kirin- Amgen Inc.	Production of pluripotent granulocyte colony-stimulating factor
JPH0618778B2 (en) *	1985-10-04	1994-03-16	中外製薬株式会社	Leukopenia treatment

1987
- 1987-07-08 GR GR871067A patent/GR871067B/en unknown
- 1987-07-10 IT IT67594/87A patent/IT1218927B/en active
- 1987-07-13 NL NL8701640A patent/NL192917C/en not_active IP Right Cessation
- 1987-07-14 AT AT0177587A patent/AT402259B/en not_active IP Right Cessation
- 1987-07-15 BE BE8700787A patent/BE1000253A3/en not_active IP Right Cessation
- 1987-07-15 DK DK368387A patent/DK171308B1/en not_active IP Right Cessation
- 1987-07-15 AU AU75665/87A patent/AU611856B2/en not_active Expired
- 1987-07-15 CA CA000542239A patent/CA1297007C/en not_active Expired - Lifetime
- 1987-07-16 PT PT85343A patent/PT85343B/en unknown
- 1987-07-16 NO NO872966A patent/NO171828C/en not_active IP Right Cessation
- 1987-07-16 CH CH2727/87A patent/CH671157A5/en not_active IP Right Cessation
- 1987-07-17 IE IE193387A patent/IE60290B1/en not_active IP Right Cessation
- 1987-07-17 DE DE3723781A patent/DE3723781C2/en not_active Expired - Lifetime
- 1987-07-17 SE SE8702907A patent/SE503312C2/en not_active IP Right Cessation
- 1987-07-17 IL IL83220A patent/IL83220A/en not_active IP Right Cessation
- 1987-07-17 ES ES8702106A patent/ES2010226A6/en not_active Expired
- 1987-07-17 FR FR878710156A patent/FR2601591B1/en not_active Expired - Lifetime
- 1987-07-17 YU YU134287A patent/YU47543B/en unknown
- 1987-07-17 HU HU873268A patent/HU198627B/en unknown
- 1987-07-17 GB GB8716904A patent/GB2193631B/en not_active Expired - Lifetime
- 1987-07-18 CN CN87104963A patent/CN1033738C/en not_active Expired - Lifetime
- 1987-07-18 KR KR1019870007804A patent/KR930004597B1/en not_active IP Right Cessation
1993
- 1993-05-18 SG SG64393A patent/SG64393G/en unknown
- 1993-07-08 HK HK648/93A patent/HK64893A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
YU47543B (en)	1995-10-03
FR2601591A1 (en)	1988-01-22
SE503312C2 (en)	1996-05-13
FR2601591B1 (en)	1991-04-26
DK171308B1 (en)	1996-09-02
IL83220A0 (en)	1987-12-31
KR930004597B1 (en)	1993-06-01
CA1297007C (en)	1992-03-10
IE60290B1 (en)	1994-06-29
NL8701640A (en)	1988-02-16
IT8767594A0 (en)	1987-07-10
PT85343B (en)	1990-04-30
CH671157A5 (en)	1989-08-15
NO872966D0 (en)	1987-07-16
ES2010226A6 (en)	1989-11-01
HK64893A (en)	1993-07-16
YU134287A (en)	1989-06-30
NL192917C (en)	1998-05-07
AU611856B2 (en)	1991-06-27
GR871067B (en)	1987-11-19
BE1000253A3 (en)	1988-09-27
DK368387D0 (en)	1987-07-15
HU198627B (en)	1989-11-28
AU7566587A (en)	1988-01-21
NL192917B (en)	1998-01-05
AT402259B (en)	1997-03-25
IE871933L (en)	1988-01-18
GB2193631A (en)	1988-02-17
GB8716904D0 (en)	1987-08-26
ATA177587A (en)	1996-08-15
DE3723781A1 (en)	1988-01-21
DK368387A (en)	1988-01-19
KR880001297A (en)	1988-04-22
NO872966L (en)	1988-01-19
CN87104963A (en)	1988-02-24
DE3723781C2 (en)	1999-09-02
NO171828B (en)	1993-02-01
SE8702907D0 (en)	1987-07-17
HUT44941A (en)	1988-05-30
IL83220A (en)	1993-01-31
SE8702907L (en)	1988-01-19
SG64393G (en)	1993-08-06
PT85343A (en)	1987-08-01
GB2193631B (en)	1990-11-21
CN1033738C (en)	1997-01-08
NO171828C (en)	1993-05-12

Publication	Publication Date	Title
IT1218927B (en)	1990-04-24	STABLE PHARMACEUTICAL PREPARATION CONTAINING A STIMULATION FACTOR OF A COLONY OF GRANULOCYTES AND PROCEDURE FOR ITS PREPARATION
IT1206827B (en)	1989-05-03	COMPOSITION FOR COSMETIC OR PHARMACEUTICAL USE CONTAINING NIOSOMES AND AT LEAST A WATER SOLUBLE POLYAMIDE AND PROCEDURE FOR ITS PREPARATION
FI102182B1 (en)	1998-10-30	Method for the preparation of human insulin analogs
DE3665608D1 (en)	1989-10-19	Disposable sterilization biological test pack
GB2176711B (en)	1988-12-07	Blood sample syringe
GR860342B (en)	1986-06-03	11b- phenyl-gonane their preparation and pharmaceutical preparations containing them
MC1782A1 (en)	1987-09-02	PHARMACEUTICAL PREPARATION
GB8723504D0 (en)	1987-11-11	Medical syringe
IT8967528A0 (en)	1989-06-28	CARBOXYAMIDE COMPOUNDS PROCEDURES FOR THE PREPARATION OF THE MEDIA AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
DK433786A (en)	1987-03-12	PHARMACEUTICAL PREPARATIONS AND MEDICAL APPLICATIONS OF DIOXOPIPERIDE INGREDIENTS
PH24517A (en)	1990-07-18	Di-t-butyl compounds,their pharmaceutical formulations and a method of use thereof
DK51493A (en)	1993-05-05	MEDICINAL CONTAINING HUMANT INTERLEUKIN-1ALFA AND USE OF INTERLEUKIN-1ALFA FOR THE PREPARATION OF SUCH MEDICINAL PRODUCTS
MC1695A1 (en)	1986-07-18	PROCESSES FOR THE PREPARATION OF NEW COMPOUNDS AND PHARMACEUTICAL FORMS CONTAINING THEM
NO171345C (en)	1993-03-03	PROCEDURE FOR THE PREPARATION OF PHARMACEUTICAL PREPARATIONS CONTAINING Tissue PLASMINOGEN ACTIVATOR
IT8922164A0 (en)	1989-10-27	PHARMACEUTICAL COMPOSITION AND PROCEDURE FOR ITS PREPARATION
IT8622122A0 (en)	1986-10-24	ADHESIVE FOR OSIMILAR DENTAL PROSTHESES AND PROCEDURE FOR ITS MANUFACTURE.
GR860870B (en)	1986-07-23	Novel benzisolelenazolonyl derivatives method for their preparation and pharmaceutical preparation containing them
IT1242724B (en)	1994-05-17	INJECTABLE SOLUTION CONTAINING A BIS-INDOLIC ALCALOID AND PROCEDURE FOR ITS PREPARATION
IL71470A (en)	1987-07-31	Pharmaceutical forms of sulpiride suitable for oral administration and their preparation
IL78779A (en)	1990-01-18	Derivatives of 2-hydroxyalkyl-4-phenyl-5-alkenyl-1,3-dioxane,their preparation and pharmaceutical compositions containing them
PT82853A (en)	1986-07-01	PROCESS FOR THE PREPARATION OF NEW BENZAMIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
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