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IT1200943B - Composti naftochinonici utili come agenti antimalarici e anticoccidici e procedimento per la loro preparazione - Google Patents

Composti naftochinonici utili come agenti antimalarici e anticoccidici e procedimento per la loro preparazione

Info

Publication number
IT1200943B
IT1200943B IT49275/82A IT4927582A IT1200943B IT 1200943 B IT1200943 B IT 1200943B IT 49275/82 A IT49275/82 A IT 49275/82A IT 4927582 A IT4927582 A IT 4927582A IT 1200943 B IT1200943 B IT 1200943B
Authority
IT
Italy
Prior art keywords
naphtokinonic
malaric
cocidal
agents
procedure
Prior art date
Application number
IT49275/82A
Other languages
English (en)
Other versions
IT8249275A0 (it
Inventor
Alan Thomas Hudson
Anthony Winchester Randall
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IT8249275A0 publication Critical patent/IT8249275A0/it
Application granted granted Critical
Publication of IT1200943B publication Critical patent/IT1200943B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16Unsaturated compounds
    • C07C61/22Unsaturated compounds having a carboxyl group bound to a six-membered ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00Preparation of quinones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00Quinones
    • C07C50/24Quinones containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00Quinones
    • C07C50/26Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/32Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42Separation; Purification; Stabilisation; Use of additives
    • C07C51/487Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C07C53/134Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings monocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/08Saturated compounds having a carboxyl group bound to a six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/15Saturated compounds containing halogen
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT49275/82A 1981-10-16 1982-10-15 Composti naftochinonici utili come agenti antimalarici e anticoccidici e procedimento per la loro preparazione IT1200943B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8131206 1981-10-16

Publications (2)

Publication Number Publication Date
IT8249275A0 IT8249275A0 (it) 1982-10-15
IT1200943B true IT1200943B (it) 1989-01-27

Family

ID=10525197

Family Applications (1)

Application Number Title Priority Date Filing Date
IT49275/82A IT1200943B (it) 1981-10-16 1982-10-15 Composti naftochinonici utili come agenti antimalarici e anticoccidici e procedimento per la loro preparazione

Country Status (8)

Country Link
US (1) US4485117A (it)
EP (1) EP0077551B1 (it)
JP (2) JPS5879945A (it)
CA (1) CA1205083A (it)
DE (1) DE3264133D1 (it)
DK (1) DK164899C (it)
GB (1) GB2107713B (it)
IT (1) IT1200943B (it)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053432A (en) * 1983-04-14 1991-10-01 Burroughs Wellcome Co. Naphthoquinone derivatives
GB8310140D0 (en) * 1983-04-14 1983-05-18 Wellcome Found Antiprotozoal agents
US5175319A (en) * 1983-04-14 1992-12-29 Burroughs Wellcome Co. Naphthoquinone derivatives
US5225436A (en) * 1987-05-15 1993-07-06 Schering Corporation Aryl substituted naphthalene derivatives
US5225184A (en) * 1988-08-16 1993-07-06 Burroughs Wellcome Co. Medicaments
GB8819477D0 (en) * 1988-08-16 1988-09-21 Wellcome Found Medicaments
US5206268A (en) * 1988-08-16 1993-04-27 Burroughs Wellcome Co. Medicaments
CA1329621C (en) * 1988-08-16 1994-05-17 Victoria Susan Latter Naphthoquinones in the treatment or prophylaxis of pneumocystis carinii infections
GB9216859D0 (en) * 1992-08-07 1992-09-23 Wellcome Found Medicaments
GB9224739D0 (en) 1992-11-26 1993-01-13 Wellcome Found Medicaments
GB9226905D0 (en) 1992-12-24 1993-02-17 Wellcome Found Pharmaceutical preparation
US5684035A (en) * 1996-07-17 1997-11-04 Kapadia; Govind J. Antimalarial agents
CA2504388A1 (en) * 2002-10-31 2004-05-13 State Of Israel, Ministry Of Agriculture Quinazolinone compositions for regulation of gene expression related to pathological processes
US7900577B2 (en) * 2004-04-27 2011-03-08 Hewlett-Packard Development Company, L.P. System and a method for starch-based, slow-release oral dosage forms
ITMI20070941A1 (it) * 2007-05-09 2008-11-10 Chimico Internazi0Nale S P A L Procedimento per la preparazione di naftochinoni trans2,3-disostituiti
EP2250145A4 (en) * 2008-03-07 2012-02-22 Alkem Lab Ltd PREPARATION OF NAPHTHOCHINONE COMPOUNDS USING 2,3-DIHALONAPHOCHINONE
EP2307343A1 (en) * 2008-06-30 2011-04-13 Chemagis Ltd. Process for the epimerization of atovaquone isomer, atovaquone intermediates and mixture thereof
WO2012153162A1 (en) * 2011-05-12 2012-11-15 Lupin Limited Novel method for preparation of atovaquone
US8975438B2 (en) * 2011-07-13 2015-03-10 Hoffmann-La Roche Inc. Process for the preparation of cyclohexanecarboxylic acid derivatives
JP2014162752A (ja) * 2013-02-25 2014-09-08 Dic Corp 化合物、液晶組成物、及び表示装置
CN114956972B (zh) * 2022-05-12 2024-10-18 沧州东恩科技有限公司 一种布帕伐醌的合成新方法
CN116874360B (zh) * 2023-09-06 2023-11-24 世华合创生物技术开发(山东)有限公司 一种布帕伐醌的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2553647A (en) * 1946-03-20 1951-05-22 Research Corp Naphthoquinone antimalarials
US2553648A (en) 1948-01-08 1951-05-22 Research Corp Naphthoquinone compounds
US3347742A (en) * 1965-05-28 1967-10-17 Merck & Co Inc 2-(4-cyclohexylcyclohexyl)-3-hydroxy-1, 4-naphthoquinone in controlling coccidiosis in poultry
US3393211A (en) * 1965-09-14 1968-07-16 Merck & Co Inc Naphthoquinone compounds
DE1553666A1 (de) * 1967-11-18 1971-09-16 Balco Filtertechnik Gmbh Scherfolie fuer Trockenrasierer
US3578686A (en) * 1968-04-26 1971-05-11 Sterling Drug Inc 2-hydroxy - 3 -((3,3,5-trimethylcyclohexyl)-alkyl) - 1,4-naphthoquinones and their preparation
US4110473A (en) * 1977-07-14 1978-08-29 E. I. Du Pont De Nemours And Company Miticidal ethers
IL56013A (en) * 1977-11-22 1983-06-15 Wellcome Found 2-cycloalkyl-3-hydroxy-1,4-naphthoquinone derivatives,their preparation and therapeutic compositions containing them

Also Published As

Publication number Publication date
JPS5879945A (ja) 1983-05-13
JPH051250B2 (it) 1993-01-07
DK164899B (da) 1992-09-07
DK164899C (da) 1993-02-01
CA1205083A (en) 1986-05-27
JPH0597765A (ja) 1993-04-20
US4485117A (en) 1984-11-27
JPH0672122B2 (ja) 1994-09-14
DK459682A (da) 1983-04-17
EP0077551A3 (en) 1983-09-14
DE3264133D1 (en) 1985-07-18
EP0077551B1 (en) 1985-06-12
GB2107713B (en) 1985-10-23
EP0077551A2 (en) 1983-04-27
GB2107713A (en) 1983-05-05
IT8249275A0 (it) 1982-10-15

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