[go: up one dir, main page]

IN2012DN00338A - - Google Patents

Download PDF

Info

Publication number
IN2012DN00338A
IN2012DN00338A IN338DEN2012A IN2012DN00338A IN 2012DN00338 A IN2012DN00338 A IN 2012DN00338A IN 338DEN2012 A IN338DEN2012 A IN 338DEN2012A IN 2012DN00338 A IN2012DN00338 A IN 2012DN00338A
Authority
IN
India
Prior art keywords
methods
relates
present
region containing
containing protein
Prior art date
Application number
Other languages
English (en)
Inventor
Soice Neil
Hubbard Dana
Zhang Yu
Harmzik James
Original Assignee
Millipore Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millipore Corp filed Critical Millipore Corp
Publication of IN2012DN00338A publication Critical patent/IN2012DN00338A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
IN338DEN2012 2009-08-07 2010-08-05 IN2012DN00338A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27370909P 2009-08-07 2009-08-07
PCT/US2010/044539 WO2011017514A1 (en) 2009-08-07 2010-08-05 Methods for purifying a target protein from one or more impurities in a sample

Publications (1)

Publication Number Publication Date
IN2012DN00338A true IN2012DN00338A (ja) 2015-05-22

Family

ID=43544660

Family Applications (1)

Application Number Title Priority Date Filing Date
IN338DEN2012 IN2012DN00338A (ja) 2009-08-07 2010-08-05

Country Status (9)

Country Link
US (1) US8536316B2 (ja)
EP (1) EP2462157B1 (ja)
JP (2) JP5791602B2 (ja)
KR (1) KR101415660B1 (ja)
CN (2) CN102574911B (ja)
ES (1) ES2817802T3 (ja)
IN (1) IN2012DN00338A (ja)
SG (1) SG177577A1 (ja)
WO (1) WO2011017514A1 (ja)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3237179B2 (ja) 1992-03-18 2001-12-10 栗田工業株式会社 排超純水中の過酸化水素の除去方法
US20130178608A1 (en) * 2009-12-29 2013-07-11 Samir Kulkarni Protein purification by ion exchange
HRP20241463T1 (hr) 2010-05-25 2025-01-03 F. Hoffmann - La Roche Ag Metode pročišćavanja polipeptida
JP2013535683A (ja) 2010-07-30 2013-09-12 イー・エム・デイー・ミリポア・コーポレイシヨン クロマトグラフィー媒体及び方法
BR102012012673A8 (pt) 2011-05-27 2021-02-17 Abbott Biotherapeutics Corp célula ns0 modificada, métodos de produzir uma proteína recombinante, de obter uma célula hospedeira de mamífero, de sanitizar uma coluna de cromatografia com afinidade para proteína a e de tratar um paciente sofrendo de esclerose múltipla, vetor, composição, processos para colher uma proteína recombinante de uma cultura de célula e para produzir uma composição purificada de daclizumab, meios, e, tampão
AU2012269240B2 (en) 2011-06-16 2016-01-21 Dpx Holdings B.V. Single unit chromatography antibody purification
BR112014000352A2 (pt) 2011-07-08 2017-02-14 Merck Sharp & Dohe Corp método de purificar uma proteína de fusão-fc, proteínas de fusão contendo fc purificada, tnfr:fc purificada, e tnfr:fc elevadamente purificada
CA2842559A1 (en) 2011-07-20 2013-01-24 Zepteon, Incorporated Polypeptide separation methods
EP2739650A4 (en) * 2011-08-01 2015-04-01 Avaxia Biologics Inc SPECIFIC BOVINE POLYCLONAL ANTIBODY OF HUMAN TNF
US9096648B2 (en) 2011-08-19 2015-08-04 Emd Millipore Corporation Methods of reducing level of one or more impurities in a sample during protein purification
RU2014111820A (ru) * 2011-09-01 2015-10-10 Хьюман Дженом Сайенсиз, Инк. Способы элиминации вируса
EP2578286A1 (en) 2011-10-04 2013-04-10 Merck Patent GmbH Method and apparatus for chromatographic purification
SI3257564T2 (sl) * 2011-11-02 2024-10-30 F. Hoffmann-La Roche Ag Izpiralna kromatografija s preobremenitvijo
WO2013075740A1 (en) 2011-11-23 2013-05-30 Sanofi Antibody purification method
CN102492040B (zh) * 2011-12-29 2014-06-25 嘉和生物药业有限公司 一种抗her2或/和抗her3抗体蛋白的纯化方法
SG10201701224UA (en) * 2012-03-12 2017-04-27 Merck Patent Gmbh Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
JP6253584B2 (ja) * 2012-08-27 2017-12-27 旭化成メディカル株式会社 温度応答性クロマトグラフィーによる抗体の精製方法
KR102133699B1 (ko) * 2012-09-11 2020-07-14 코히러스 바이오사이언시즈, 인코포레이티드 고순도 및 탁월한 수율의 정확하게 폴딩된 에타너셉트
AU2013330344B2 (en) 2012-09-17 2018-07-05 W. R. Grace & Co.-Conn. Chromatography media and devices
WO2014099577A1 (en) * 2012-12-17 2014-06-26 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
ES2684527T3 (es) 2013-02-14 2018-10-03 Nanopareil, Llc Fieltro híbrido de nanofibras electrohiladas, método de preparación del mismo y método de purificación de biomoléculas
RU2662668C2 (ru) * 2013-05-06 2018-07-26 Санофи Способ непрерывной многостадийной очистки антител
US20150093800A1 (en) * 2013-09-05 2015-04-02 Genentech, Inc. Method for chromatography reuse
EP3048109A4 (en) * 2013-09-17 2017-04-19 Kaneka Corporation Novel antibody purification method and antibody obtained therefrom, and novel antibody purification method using cation exchanger and antibody obtained therefrom
SG10201804200WA (en) 2013-12-12 2018-07-30 Emd Millipore Corp Protein separations using an acrylamide containing filter
EP3105580B1 (en) * 2014-02-14 2023-10-04 Cytiva Sweden AB Automated multi-step purification system
PT3116891T (pt) 2014-03-10 2020-05-18 Richter Gedeon Nyrt Purificação de imunoglobulina utilizando passos de pré-limpeza
CN104826617B (zh) * 2014-03-25 2017-06-13 西北大学 一种用于蛋白质分离的wax/hic双功能混合模式色谱固定相及其制备方法
PL3137209T3 (pl) 2014-05-02 2023-01-02 W.R. Grace & Co. - Conn. Funkcjonalizowany materiał nośnikowy i sposoby wytwarzania oraz stosowania funkcjonalizowanego materiału nośnikowego
EP3145951A1 (en) * 2014-06-24 2017-03-29 InSight Biopharmaceuticals Ltd. Methods of purifying antibodies
DE102014010353B4 (de) 2014-07-10 2024-09-12 Sartorius Stedim Biotech Gmbh Vorrichtung, Verwendung dieser Vorrichtung und Verfahren für die Stofftrennung mit verbesserter Ausnutzung der Kapazität chromatographischer Medien
EP3230299A1 (en) 2014-12-08 2017-10-18 EMD Millipore Corporation Mixed bed ion exchange adsorber
SG10201911134QA (en) 2015-06-05 2020-01-30 Grace W R & Co Adsorbent bioprocessing clarification agents and methods of making and using the same
CN109071598A (zh) * 2016-04-05 2018-12-21 美国血液技术公司 从血液中富集免疫球蛋白的方法和装置
CN107964044B (zh) * 2016-10-19 2021-11-19 无锡科捷诺生物科技有限责任公司 从乳样中纯化抗cd20单克隆抗体的方法
CN111902720B (zh) 2018-03-21 2025-02-07 沃特世科技公司 基于非抗体高亲和力的样品制备、吸附剂、装置和方法
WO2020125757A1 (en) * 2018-12-21 2020-06-25 Wuxi Biologics (Shanghai) Co., Ltd. A method for improving aggregate removal by protein a chromatography
FR3099066B1 (fr) 2019-07-26 2021-08-13 Novasep Process Procédé de purification d’une substance cible avec inactivation virale
TW202128264A (zh) * 2019-09-25 2021-08-01 瑞士商赫孚孟拉羅股份公司 使用經預測之溶離緩衝鹽濃度的陽離子層析法
CN110724204B (zh) * 2019-11-18 2021-10-22 广东菲鹏制药股份有限公司 Fc融合蛋白的纯化方法
CN113845562A (zh) * 2020-06-28 2021-12-28 佛山汉腾生物科技有限公司 目的蛋白纯化方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490937A (en) 1981-12-07 1985-01-01 Amcor Ltd. Insect electrocution device
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5256694A (en) 1984-09-22 1993-10-26 Basf Aktiengesellschaft Diarylacetylenes, their preparation and their use
US5091178A (en) 1986-02-21 1992-02-25 Oncogen Tumor therapy with biologically active anti-tumor antibodies
US6054051A (en) 1996-01-17 2000-04-25 Genentech, Inc. Tangential-flow filtration system
PT1501369E (pt) 2002-04-26 2015-09-21 Genentech Inc Purificação de proteínas com base na não afinidade
KR101119448B1 (ko) * 2002-09-11 2012-03-15 추가이 세이야쿠 가부시키가이샤 단백질 정제 방법
GB0304576D0 (en) 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
CA2581208A1 (en) * 2004-08-30 2006-03-09 Lonza Biologics Plc. Affinity- plus ion exchange- chromatography for purifying antibodies
WO2009017491A1 (en) 2006-06-14 2009-02-05 Smithkline Beecham Corporation Methods for purifying antibodies using ceramic hydroxyapatite
ES2755386T5 (es) 2006-08-28 2023-04-05 Ares Trading Sa Proceso para la purificación de proteínas que contienen fragmentos Fc
ZA200900836B (en) 2006-08-28 2010-05-26 Ares Trading Sa Process for the purification of FC-fusion proteins
US8168185B2 (en) * 2007-01-17 2012-05-01 Merck Serono Sa Process for the purification of anti CD-25 antibodies
US9433922B2 (en) 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
US20090149638A1 (en) 2007-10-03 2009-06-11 Ley Arthur C Systems and methods for purifying proteins
CN103396480A (zh) 2008-05-15 2013-11-20 诺沃—诺迪斯克有限公司 抗体纯化方法
SG195577A1 (en) * 2008-10-20 2013-12-30 Abbott Lab Viral inactivation during purification of antibodies

Also Published As

Publication number Publication date
EP2462157B1 (en) 2020-06-17
SG177577A1 (en) 2012-03-29
US20110065901A1 (en) 2011-03-17
WO2011017514A1 (en) 2011-02-10
US8536316B2 (en) 2013-09-17
KR20120089432A (ko) 2012-08-10
JP2015157846A (ja) 2015-09-03
JP6335838B2 (ja) 2018-05-30
KR101415660B1 (ko) 2014-07-16
ES2817802T3 (es) 2021-04-08
CN102574911A (zh) 2012-07-11
EP2462157A4 (en) 2012-12-26
EP2462157A1 (en) 2012-06-13
CN102574911B (zh) 2017-06-06
CN107188960A (zh) 2017-09-22
JP2013501721A (ja) 2013-01-17
JP5791602B2 (ja) 2015-10-07

Similar Documents

Publication Publication Date Title
IN2012DN00338A (ja)
IN2012DN00801A (ja)
MX2009007632A (es) Precipitacion de polielectrolito y purificacion de proteinas.
TW200801262A (en) Method for purifying silicon
BRPI0917993A2 (pt) composições de célula-tronco mesenquimal purificada e métodos de purificação de composições de célula-tronco mesenquimal purificda.
HUE046909T2 (hu) Eljárás rekombináns ADAMTS13 és más proteinek és készítményeik tisztítására
EA201070987A1 (ru) Очищенные гибридные белки иммуноглобулина и способы их очищения
MX336715B (es) Purificacion de iduronato-2-sulfatasa.
UA105785C2 (uk) Спосіб очищення ліпопептидів
EA201270616A1 (ru) Ингибиторы вируса гепатита с
GB2471806A (en) Compositions and methods for treating viral infections
WO2010151799A3 (en) Compounds for modulating rna binding proteins and uses therefor
WO2010151797A3 (en) Compounds for modulating rna binding proteins and uses therefor
MX342920B (es) Metodo para purificar polipeptidos o inmunoconjugados activos.
MX2009010207A (es) Peptidos de hidrazido como inhibidores de proteasa ns3 de virus de hepatitis c.
MX2012002565A (es) Purificacion de proteina mejorada a traves de una elucion de proteina a modificada.
MY188566A (en) Method to improve virus removal in protein purification
WO2011017132A3 (en) Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration
UA108636C2 (xx) Пептид
MX2009010205A (es) Inhibidores de cetoamida p1-no epimerizables de proteasa ns3 de virus de hepatitis c.
MX2011008179A (es) Peptidos para vacuna.
TW200738622A (en) Process for purifying (meth)acrylates
UA103197C2 (uk) Застосування ніфуртимоксу для лікування хвороб, спричинених трихомонадами
PL2286887T3 (pl) Usuwanie endotoksyn ze środków kontrastowych
EA201270403A1 (ru) Способ и система для очистки полипептидов