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IL93352A - Piperidine compounds, preparations and pharmaceutical preparations containing them - Google Patents

Piperidine compounds, preparations and pharmaceutical preparations containing them

Info

Publication number
IL93352A
IL93352A IL9335290A IL9335290A IL93352A IL 93352 A IL93352 A IL 93352A IL 9335290 A IL9335290 A IL 9335290A IL 9335290 A IL9335290 A IL 9335290A IL 93352 A IL93352 A IL 93352A
Authority
IL
Israel
Prior art keywords
thiadiazol
tetrahydro
methylpyridine
mmol
pyridine
Prior art date
Application number
IL9335290A
Other languages
English (en)
Hebrew (he)
Other versions
IL93352A0 (en
Original Assignee
Novo Nordisk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK82589A external-priority patent/DK82589A/da
Priority claimed from DK231589A external-priority patent/DK231589D0/da
Application filed by Novo Nordisk filed Critical Novo Nordisk
Publication of IL93352A0 publication Critical patent/IL93352A0/xx
Publication of IL93352A publication Critical patent/IL93352A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
IL9335290A 1989-02-22 1990-02-12 Piperidine compounds, preparations and pharmaceutical preparations containing them IL93352A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK82589A DK82589A (da) 1989-02-22 1989-02-22 Piperidinforbindelser, deres fremstilling og anvendelse
DK231589A DK231589D0 (da) 1989-05-12 1989-05-12 Piperidinforbindelser og deres fremstilling og anvendelse

Publications (2)

Publication Number Publication Date
IL93352A0 IL93352A0 (en) 1990-11-29
IL93352A true IL93352A (en) 1994-08-26

Family

ID=26064725

Family Applications (2)

Application Number Title Priority Date Filing Date
IL9335290A IL93352A (en) 1989-02-22 1990-02-12 Piperidine compounds, preparations and pharmaceutical preparations containing them
IL93423A IL93423A0 (en) 1989-02-22 1990-02-16 Piperidine compounds,their preparation and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL93423A IL93423A0 (en) 1989-02-22 1990-02-16 Piperidine compounds,their preparation and pharmaceutical compositions containing them

Country Status (22)

Country Link
US (5) US5043345A (sv)
EP (2) EP0384285A3 (sv)
JP (2) JPH02255680A (sv)
KR (1) KR0163763B1 (sv)
CN (1) CN1028105C (sv)
AR (1) AR247565A1 (sv)
AT (1) ATE123030T1 (sv)
AU (2) AU629302B2 (sv)
CA (2) CA2010579A1 (sv)
DE (1) DE69019550T2 (sv)
DK (1) DK0384288T3 (sv)
ES (1) ES2072323T3 (sv)
FI (2) FI900887A0 (sv)
GR (1) GR3017062T3 (sv)
HU (2) HU221623B1 (sv)
IE (1) IE69672B1 (sv)
IL (2) IL93352A (sv)
NO (2) NO900831L (sv)
NZ (1) NZ232615A (sv)
PH (1) PH26465A (sv)
PT (2) PT93241B (sv)
RU (1) RU2042676C1 (sv)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
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EP0372125A1 (en) * 1988-11-08 1990-06-13 Akzo N.V. Oxazole and thiazole derivatives
US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
US5264444A (en) * 1989-02-22 1993-11-23 Novo Nordisk A/S Piperidine compounds and use
US5328925A (en) * 1989-02-22 1994-07-12 Novo Nordisk A/S Piperidine compounds and their use
EP0459568A3 (en) * 1990-05-31 1992-09-30 Merck Sharp & Dohme Ltd. Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
USRE35822E (en) * 1990-08-21 1998-06-09 Novo Nordisk A/S Heterocyclic compounds
EP0561913B1 (en) * 1990-11-29 1998-04-01 Allergan, Inc. Use of pyridine derivatives in the treatment of ocular hypertension
EP0492903A1 (en) * 1990-12-21 1992-07-01 MERCK SHARP & DOHME LTD. Substituted pyrazines, pyrimidines and pyridazines for use in the treatment of glaucoma
IE922270A1 (en) * 1991-07-26 1993-01-27 Akzo Nv Pyrazole derivatives
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
US5175166A (en) * 1991-08-27 1992-12-29 The University Of Toledo Muscarinic agonists
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5244906A (en) * 1992-01-23 1993-09-14 Dowelanco Insect control with substituted oxadiazole and thiadiazole compounds
CA2146019A1 (en) * 1992-10-23 1994-05-11 Howard B. Broughton Dopamine receptor subtype ligands
DE69426021T2 (de) * 1993-06-04 2001-05-17 Novo Nordisk A/S, Bagsvaerd Xamonelin-Tartrat
CA2169839C (en) * 1993-08-19 2002-06-11 Franklin Porter Bymaster Antipsychotic method
US5753683A (en) * 1993-08-19 1998-05-19 Novo Nordisk A/S Antipsychotic method
US5545638A (en) * 1993-12-21 1996-08-13 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
IL112024A (en) * 1993-12-21 1999-07-14 Novo Nordisk As Pharmaceutical compositions comprising tetrahydropyridine derivatives substituted with oxadiazole or thiadiazole for treating gastrointestinal motility disorders
US5605908A (en) * 1994-10-24 1997-02-25 Eli Lilly And Company Heterocyclic compounds and their use
US5672709A (en) * 1994-10-24 1997-09-30 Eli Lilly And Company Heterocyclic compounds and their preparation and use
US5998404A (en) * 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5484794A (en) * 1994-11-09 1996-01-16 Eli Lilly And Company Method for treating anxiety
US5488056A (en) * 1994-10-31 1996-01-30 Eli Lilly And Company Method for treating anxiety
US5726193A (en) * 1994-10-31 1998-03-10 Eli Lilly And Company Method for treating anxiety
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
WO1996013167A1 (en) * 1994-10-31 1996-05-09 Eli Lilly And Company Method for treating anxiety
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
US5565475A (en) * 1994-11-08 1996-10-15 Muhlhauser; Mark A. Method of treating urinary bladder dysfunctions with 3-tetrahydropyridine derivatives
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US5605701A (en) * 1995-02-17 1997-02-25 Eli Lilly And Company Transdermal formulation
US5852037A (en) * 1995-11-13 1998-12-22 Eli Lilly And Company Method for treating anxiety
US5763457A (en) * 1995-11-13 1998-06-09 Eli Lilly And Company Method for treating anxiety
US5998434A (en) * 1995-12-06 1999-12-07 Eli Lilly And Company Composition for treating pain
PL327144A1 (en) * 1995-12-07 1998-11-23 Lilly Co Eli Method of relieving paints
GB9603755D0 (en) * 1996-02-22 1996-04-24 Pfizer Ltd Therapeutic agents
AU2991397A (en) * 1996-04-23 1997-11-12 Eli Lilly And Company Heterocyclic compounds
CA2252573A1 (en) * 1996-04-23 1997-10-30 Celia Ann Whitesitt Heterocyclic compounds
EP0910566B1 (en) * 1996-04-24 2003-09-17 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
PT821955E (pt) * 1996-08-01 2002-07-31 Lilly Co Eli Uso de 3-(4-hexiloxi-1,2,5-tiadiazol-3-il)-1,2,5,6-tetrahidro-1-metilpiridina (xanomelina) para o tratamento da doenca bipolar
EP0821954A1 (en) * 1996-08-01 1998-02-04 Eli Lilly And Company Method for treating mental retardation
EP0821956A1 (en) * 1996-08-01 1998-02-04 Eli Lilly And Company Method for treating disruptive behavior disorders
US6043258A (en) * 1996-08-01 2000-03-28 Eli Lilly And Company Method for treating disruptive behavior disorders with xanomeline
US6090829A (en) * 1996-08-01 2000-07-18 Eli Lilly And Company Method for treating excessive aggression
EP0821957A3 (en) * 1996-08-01 1998-04-22 Eli Lilly And Company Use of 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine (xanomeline) for treating substance abuse
EP0821959A3 (en) * 1996-08-01 1998-09-16 Eli Lilly And Company Use of 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine for treating nicotine withdrawal
EP0821958A3 (en) * 1996-08-01 1998-07-08 Eli Lilly And Company Use of 3-(4-hexyloxy-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyridine (xanomeline) for treating excessive aggression
US6117890A (en) * 1996-08-01 2000-09-12 Eli Lilly And Company Method for treating bipolar disorder
CA2269506A1 (en) * 1996-10-23 1998-04-30 Eli Lilly And Company Method for treating dementia due to aids
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US6034108A (en) * 1997-07-28 2000-03-07 Eli Lilly And Company Method for treating mental retardation
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
US6096767A (en) 1999-01-22 2000-08-01 The University Of Toledo Muscarinic receptor agonists
US6376675B2 (en) * 1999-01-22 2002-04-23 The University Of Toledo Muscarinic receptor agonists
US6211204B1 (en) 1999-01-22 2001-04-03 University Of Toledo Muscarinic receptor agonists
US20040023951A1 (en) * 2001-06-18 2004-02-05 Bymaster Franklin Porter Combination therapy for treatment of psychoses
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US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
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US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
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US10815242B2 (en) 2015-06-19 2020-10-27 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
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NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
IL83275A (en) * 1986-09-08 1994-02-27 Novo Nordisk As Compounds 1,2, 4-Oxadiazolyl Pipridine Transformed, their preparation and pharmaceutical preparations containing them
US5017618A (en) * 1987-03-16 1991-05-21 University Of Florida Labile derivatives of ketone analogs of 3-substituted-1-alkylamino-2-propanols and their use as beta-adrenergic blockers
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
DK162892C (da) * 1988-07-04 1992-05-11 Novo Nordisk As 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
US5264444A (en) * 1989-02-22 1993-11-23 Novo Nordisk A/S Piperidine compounds and use
US5328925A (en) * 1989-02-22 1994-07-12 Novo Nordisk A/S Piperidine compounds and their use
US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5175166A (en) * 1991-08-27 1992-12-29 The University Of Toledo Muscarinic agonists

Also Published As

Publication number Publication date
GR3017062T3 (en) 1995-11-30
FI95704B (sv) 1995-11-30
JPH02255679A (ja) 1990-10-16
FI95704C (sv) 1996-03-11
FI900886A0 (sv) 1990-02-22
CN1045104A (zh) 1990-09-05
EP0384288B1 (en) 1995-05-24
FI900887A0 (fi) 1990-02-22
DE69019550D1 (de) 1995-06-29
PH26465A (en) 1992-07-27
KR0163763B1 (ko) 1998-12-01
NO900830L (no) 1990-08-23
JPH02255680A (ja) 1990-10-16
DE69019550T2 (de) 1995-10-05
PT93241B (pt) 1996-01-31
CA2010578C (en) 2000-05-23
AR247565A1 (es) 1995-01-31
NZ232615A (en) 1992-06-25
US5284859A (en) 1994-02-08
EP0384285A3 (en) 1991-04-24
IL93423A0 (en) 1990-11-29
US5041455A (en) 1991-08-20
DK0384288T3 (da) 1995-10-02
HUT58326A (en) 1992-02-28
KR910015569A (ko) 1991-09-30
IL93352A0 (en) 1990-11-29
NO900831L (no) 1990-08-23
IE69672B1 (en) 1996-10-02
HU900884D0 (en) 1990-05-28
ATE123030T1 (de) 1995-06-15
JP2921578B2 (ja) 1999-07-19
CA2010578A1 (en) 1990-08-22
NO900830D0 (no) 1990-02-21
RU2042676C1 (ru) 1995-08-27
NO900831D0 (no) 1990-02-21
AU629302B2 (en) 1992-10-01
HU211705A9 (en) 1995-12-28
NO179639C (no) 1996-11-20
AU4999690A (en) 1990-08-30
PT93241A (pt) 1990-08-31
HU221623B1 (hu) 2002-12-28
EP0384288A2 (en) 1990-08-29
PT93242A (pt) 1990-08-31
CN1028105C (zh) 1995-04-05
CA2010579A1 (en) 1990-08-22
US5043345A (en) 1991-08-27
ES2072323T3 (es) 1995-07-16
AU4999790A (en) 1990-08-30
EP0384288A3 (en) 1991-04-10
US5559138A (en) 1996-09-24
IE900504L (en) 1990-08-22
NO179639B (no) 1996-08-12
US5712297A (en) 1998-01-27
EP0384285A2 (en) 1990-08-29

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