[go: up one dir, main page]

IL86013A - N,n-disubstituted-1h-pyrazolo(3,4-d)pyrimidin-4-amines,processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents

N,n-disubstituted-1h-pyrazolo(3,4-d)pyrimidin-4-amines,processes for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
IL86013A
IL86013A IL86013A IL8601388A IL86013A IL 86013 A IL86013 A IL 86013A IL 86013 A IL86013 A IL 86013A IL 8601388 A IL8601388 A IL 8601388A IL 86013 A IL86013 A IL 86013A
Authority
IL
Israel
Prior art keywords
radical
alkyl
pyrazolo
denotes
pyrimidin
Prior art date
Application number
IL86013A
Other languages
English (en)
Other versions
IL86013A0 (en
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of IL86013A0 publication Critical patent/IL86013A0/xx
Publication of IL86013A publication Critical patent/IL86013A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
IL86013A 1987-04-15 1988-04-10 N,n-disubstituted-1h-pyrazolo(3,4-d)pyrimidin-4-amines,processes for the preparation thereof and pharmaceutical compositions containing them IL86013A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873712735 DE3712735A1 (de) 1987-04-15 1987-04-15 Neue pyrazolo(3,4-d)pyrimidine, verfahren zu ihrer herstellung und verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
IL86013A0 IL86013A0 (en) 1988-09-30
IL86013A true IL86013A (en) 1992-02-16

Family

ID=6325658

Family Applications (1)

Application Number Title Priority Date Filing Date
IL86013A IL86013A (en) 1987-04-15 1988-04-10 N,n-disubstituted-1h-pyrazolo(3,4-d)pyrimidin-4-amines,processes for the preparation thereof and pharmaceutical compositions containing them

Country Status (20)

Country Link
US (1) US4904666A (pt)
EP (1) EP0287907B1 (pt)
JP (1) JPS63258880A (pt)
KR (1) KR880012605A (pt)
CN (1) CN88102247A (pt)
AT (1) ATE79623T1 (pt)
AU (1) AU613907B2 (pt)
CA (1) CA1308713C (pt)
DD (1) DD274030A5 (pt)
DE (2) DE3712735A1 (pt)
DK (1) DK196888A (pt)
ES (1) ES2052629T3 (pt)
FI (1) FI88163C (pt)
HU (1) HU198493B (pt)
IL (1) IL86013A (pt)
MX (1) MX11090A (pt)
NZ (1) NZ224219A (pt)
PT (1) PT87229B (pt)
SU (1) SU1701111A3 (pt)
ZA (1) ZA882618B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5256650A (en) * 1989-03-29 1993-10-26 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
US5391739A (en) * 1989-03-29 1995-02-21 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
ZA902280B (en) * 1989-03-29 1990-12-28 Merrell Dow Pharma Selective adenosine receptor agents
US5864033A (en) * 1989-09-15 1999-01-26 Metabasis Therapeutics, Inc. Adenosine kinase inhibitors
US5795977A (en) * 1989-09-15 1998-08-18 Metabasis Therapeutics, Inc. Water soluble adenosine kinase inhibitors
US5763597A (en) * 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. Orally active adenosine kinase inhibitors
US5721356A (en) * 1989-09-15 1998-02-24 Gensia, Inc. Orally active adenosine kinase inhibitors
US5674998A (en) * 1989-09-15 1997-10-07 Gensia Inc. C-4' modified adenosine kinase inhibitors
US5726302A (en) * 1989-09-15 1998-03-10 Gensia Inc. Water soluble adenosine kinase inhibitors
US5763596A (en) * 1989-09-15 1998-06-09 Metabasis Therapeutics, Inc. C-4' modified adenosine kinase inhibitors
TW370529B (en) 1992-12-17 1999-09-21 Pfizer Pyrazolopyrimidines
US5368857A (en) * 1993-11-15 1994-11-29 Elizabeth Arden Company, Division Of Conopco, Inc. Ceramide cosmetic compositions
US5646152A (en) * 1994-06-15 1997-07-08 Pfizer Inc. Methods of administering CRF antagonists
US5614530A (en) * 1995-03-10 1997-03-25 Sterling Winthrop Inc. Substituted N-arylmethyl and heterocyclmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines and compositions and methods of use thereof
US6008226A (en) * 1995-03-10 1999-12-28 Sanofi-Synthelabo Substituted N-arylmethyl and heterocylylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines and compositions and methods of use thereof
PT778277E (pt) * 1995-12-08 2003-11-28 Pfizer Derivados heterociclicos substituidos como antagonistas do crf
US6992188B1 (en) 1995-12-08 2006-01-31 Pfizer, Inc. Substituted heterocyclic derivatives
US6051578A (en) * 1996-02-12 2000-04-18 Pfizer Inc. Pyrazolopyrimidines for treatment of CNS disorders
KR100517163B1 (ko) * 2000-02-10 2005-09-26 미쯔이카가쿠 가부시기가이샤 1-인산화 당유도체 아노머의 선택적인 제조방법 및뉴클레오사이드의 제조방법
KR100468352B1 (ko) * 2002-09-24 2005-01-27 한국과학기술연구원 신규 피라졸로피리미딘계 유도체, 그의 제조방법 및 이를 유효성분으로 하는 약학적 조성물
WO2005019222A1 (en) * 2003-08-15 2005-03-03 Merck & Co., Inc. 4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists
WO2005019221A1 (en) * 2003-08-15 2005-03-03 Merck & Co., Inc. 4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists
CA2575430A1 (en) * 2004-08-03 2006-02-16 Merck & Co., Inc. 1,3-disubstituted heteroaryl nmda/nr2b antagonists
US7777035B2 (en) * 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
US20090252779A1 (en) * 2006-06-22 2009-10-08 Chemocentryx, Inc. Azaindazole compounds and methods of use
DE102006029074A1 (de) * 2006-06-22 2007-12-27 Friedrich-Schiller-Universität Jena 4-Amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidin-Derivate, Verfahren zu ihrer Herstellung und deren Verwendung als antivirale Wirkstoffe
EP2766367B1 (de) 2011-10-14 2022-05-18 Scandion Oncology A/S 4-Amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidin-Derivate zur Behandlung von viralen Infekten, insbesondere von Picornavirusinfektionen
DE102012004736A1 (de) 2011-10-20 2013-04-25 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg 4-Amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidin-Derivate und deren Verwendung als antivirale Wirkstoffe
US10647727B2 (en) * 2015-06-25 2020-05-12 Merck Sharp & Dohme Corp. Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551428A (en) * 1956-02-10 1970-12-29 Ciba Geigy Corp New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines
DE1106331B (de) * 1958-05-30 1961-05-10 Ciba Geigy Verfahren zur Herstellung von Pyrazolo[3, 4-d]pyrimidinen
US3399196A (en) * 1959-01-22 1968-08-27 Ciba Geigy Corp Nu-substituted pyrazolo-pyrimidines
US3720674A (en) * 1970-09-02 1973-03-13 Squibb & Sons Inc 4-amino-1h-pyrazolo(3,4-d)pyrimidine derivatives
DE3739366A1 (de) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel
US4885300A (en) * 1988-03-03 1989-12-05 Ortho Pharmaceutical Corporation 4-Substituted pyrazolo[3,4-D]pyrimidine derivatives

Also Published As

Publication number Publication date
FI881760A0 (fi) 1988-04-14
DE3873807D1 (de) 1992-09-24
HUT47578A (en) 1989-03-28
PT87229A (pt) 1988-05-01
FI88163C (fi) 1993-04-13
SU1701111A3 (ru) 1991-12-23
AU1450688A (en) 1988-10-20
ATE79623T1 (de) 1992-09-15
DK196888D0 (da) 1988-04-11
CN88102247A (zh) 1988-11-02
ZA882618B (en) 1988-10-17
ES2052629T3 (es) 1994-07-16
MX11090A (es) 1993-11-01
DK196888A (da) 1988-10-16
FI881760A (fi) 1988-10-16
US4904666A (en) 1990-02-27
CA1308713C (en) 1992-10-13
EP0287907A1 (de) 1988-10-26
DE3712735A1 (de) 1988-11-10
JPS63258880A (ja) 1988-10-26
KR880012605A (ko) 1988-11-28
IL86013A0 (en) 1988-09-30
FI88163B (fi) 1992-12-31
AU613907B2 (en) 1991-08-15
HU198493B (en) 1989-10-30
EP0287907B1 (de) 1992-08-19
NZ224219A (en) 1990-11-27
DD274030A5 (de) 1989-12-06
PT87229B (pt) 1992-08-31

Similar Documents

Publication Publication Date Title
IL86013A (en) N,n-disubstituted-1h-pyrazolo(3,4-d)pyrimidin-4-amines,processes for the preparation thereof and pharmaceutical compositions containing them
ATE74603T1 (de) Derivate von purin, verfahren zu ihrer herstellung und pharmazeutische zubereitung.
ES8303355A1 (es) Procedimiento para la obtencion de nuevos derivados de mer- captoimidazoles.
ES8701773A1 (es) Procedimiento de preparar derivados de nucleosidos y purinas8-substituidos
ES2013379A6 (es) Procedimiento para preparar 6-sulfenamido-6, sulfinamido- y 6-sulfonamido-purinas, nucleosidos de purinas y nucleotidos de purinas antitumorales.
IE44339L (en) Piperazine derivatives.
SE8700555D0 (sv) Purine derivatives, their production and medicaments containing them
ES8406495A1 (es) Un procedimiento para la produccion de nuevos compuestos de 2-fenilimidazo 2,1-b)benzotiazol
ES8201955A1 (es) Un procedimiento de produccion de derivados del acido 2-hi- droxioxanilico
HUT46329A (en) Process for producing substituted amino-methane-diphosphonic acid derivatives
ES8300776A1 (es) Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina
ES2038600T3 (es) Composiciones para uso terapeutico comprendiendo compuestos organo-siliceos.
ES8706682A1 (es) Metodo para la fabricacion de nuevas triazolopirimidinas.
FR2703048B1 (fr) Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
IL86169A (en) Substituted quinoxalyl-imidazolidine-2,4-diones,processes for their preparation and pharmaceutical compositions containing them
DE3269505D1 (en) Substituted 1-benzoyl-2-phenylimino-imidazolidines, their acid addition salts, process for their preparation and pharmaceutical compositions containing them
JPS5795995A (en) Phosphonoformaldehyde, manufacture and use as intermediate product for producing drug
EP0280868A3 (en) Imidazo- and triazolothiadiazines, process for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds
GR3002560T3 (en) 2-selenomethyl-1, 4-dihydropyridines, a process for the preparation thereof and pharmaceutical compositions containing them
ES482469A1 (es) Procedimiento para la preparacion de 2-fenilamino-imidazoli-nas-(2) sustituidas.
ES407775A1 (es) Procedimiento para la preparacion de sulfonilaminopirimidi-nas que disminuyen el azucar en la sangre.
ATE110078T1 (de) Substituierte thienoimidazol-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensäuresekretionshemmer.
MY105044A (en) Thieno (3', 4' -4, 5)imidazo(2,1-b)thiazole derivatives, a process for their preparation and their use in medicaments.
SE8400451D0 (sv) Bronchodilatory azepino /1,2-a/pyrimidine derivatives and acid addition salts thereof and pharmaceutical compositions containig same
GB2006765A (en) Tricyclic purine derivatives, their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
RH Patent void