IL81933A - Asymmetrical ester derivatives of 1,4-dihydro-2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid,their preparation and pharmaceutical compositions containing them - Google Patents

Asymmetrical ester derivatives of 1,4-dihydro-2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL81933A
Authority: IL; Israel
Prior art keywords: dicarboxylic acid; phenyl; group; dihydro; pyridine
Prior art date: 1986-04-02

Application number

IL81933A

Other languages

English (en)

Other versions

IL81933A0 (en

Original Assignee

Fournier Innovation Synergie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-02

Filing date

1987-03-18

Publication date

1991-06-30

1987-03-18 Application filed by Fournier Innovation Synergie filed Critical Fournier Innovation Synergie

1987-10-20 Publication of IL81933A0 publication Critical patent/IL81933A0/xx

1990-05-25 Priority to IL94503A priority Critical patent/IL94503A0/xx

1990-05-25 Priority to IL94502A priority patent/IL94502A0/xx

1991-06-30 Publication of IL81933A publication Critical patent/IL81933A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Coloring (AREA)
Photoreceptors In Electrophotography (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Laminated Bodies (AREA)
Preventing Corrosion Or Incrustation Of Metals (AREA)
Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

IL81933A 1986-04-02 1987-03-18 Asymmetrical ester derivatives of 1,4-dihydro-2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid,their preparation and pharmaceutical compositions containing them IL81933A (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
IL94503A IL94503A0 (en)	1986-04-02	1990-05-25	Esters of alpha(8-aza-1,4-dioxa-spiro(4,5)decan-2-yl)acetic acid
IL94502A IL94502A0 (en)	1986-04-02	1990-05-25	Preparation of methyl,1,2-dihydroxypropan-3-yl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8604685A FR2596760B1 (fr)	1986-04-02	1986-04-02	Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique

Publications (2)

Publication Number	Publication Date
IL81933A0 IL81933A0 (en)	1987-10-20
IL81933A true IL81933A (en)	1991-06-30

Family

ID=9333794

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL81933A IL81933A (en)	1986-04-02	1987-03-18	Asymmetrical ester derivatives of 1,4-dihydro-2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid,their preparation and pharmaceutical compositions containing them

Country Status (25)

Country	Link
US (2)	US4806544A (xx)
EP (1)	EP0240398B1 (xx)
JP (1)	JPS6317883A (xx)
KR (1)	KR900005956B1 (xx)
CN (1)	CN1015460B (xx)
AT (1)	ATE63555T1 (xx)
AU (2)	AU590690B2 (xx)
CS (1)	CS268828B2 (xx)
DD (2)	DD263291A5 (xx)
DE (1)	DE3770037D1 (xx)
DK (1)	DK161787A (xx)
ES (1)	ES2028886T3 (xx)
FI (1)	FI86302C (xx)
FR (1)	FR2596760B1 (xx)
GR (1)	GR3002267T3 (xx)
HU (2)	HU199479B (xx)
IL (1)	IL81933A (xx)
NO (1)	NO167029C (xx)
NZ (1)	NZ219758A (xx)
OA (1)	OA08508A (xx)
PT (1)	PT84560B (xx)
SU (1)	SU1586515A3 (xx)
TN (1)	TNSN87043A1 (xx)
YU (2)	YU57287A (xx)
ZA (1)	ZA872258B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU7058991A (en) *	1989-12-22	1991-07-24	Byk Gulden Lomberg Chemische Fabrik Gmbh	New dihydropyridines
DE4125271A1 (de) *	1991-07-31	1993-02-11	Bayer Ag	Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester
WO1993006082A1 (en) *	1991-09-13	1993-04-01	Merck & Co., Inc.	Process for the preparation of 4-substituted-1,4-dihydropyridines
AU2010227195B2 (en) *	2009-03-27	2016-04-14	Council Of Scientific And Industrial Research	Substituted 1, 4-dioxa-8-azaspiro [4,5] decanes useful as fungicides and a process for the preparation thereof
WO2012123966A1 (en)	2011-03-04	2012-09-20	Arch Pharmalabs Limited	Process for the preparation of 4 -substituted -1, 4-dihydropyridines
CN102796111B (zh) *	2012-09-10	2014-09-24	贵州大学	氧氮杂螺环酰胺基团的羧(磺)酸酯类化合物及制备方法和用途
CN104860873A (zh) *	2015-05-28	2015-08-26	石家庄学院	一种(s)-1,4-二氢吡啶钙离子拮抗剂的制备方法
CN108430989B (zh) *	2015-10-13	2021-10-08	轩竹生物科技有限公司	1,4-二氢吡啶-3,5-二羧酸酯衍生物的制备方法及中间体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1670824C3 (de) *	1967-03-20	1978-08-03	Bayer Ag, 5090 Leverkusen	1,4-Dihydropyridin-33-dicarbonsäurealkylester
GB1245087A (en) *	1967-10-26	1971-09-02	Wyeth John & Brother Ltd	Heterocyclic compounds
JPS4932542B1 (xx) *	1970-08-17	1974-08-31
GB1591089A (en) *	1976-12-17	1981-06-10	Fujisawa Pharmaceutical Co	1,4-dihydropyridine derivatives and process for preparation thereof
US4250312A (en) *	1979-12-28	1981-02-10	Argus Chemical Corp.	Process for preparing 4-piperidone spiroketal compounds
US4250313A (en) *	1980-02-01	1981-02-10	Argus Chemical Corp.	Process for preparing 4-piperidone spiroketal compounds
DE3208628A1 (de) *	1982-03-10	1983-09-22	Bayer Ag, 5090 Leverkusen	Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS58159462A (ja) *	1982-03-17	1983-09-21	Yoshitomi Pharmaceut Ind Ltd	１，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
WO1983003249A1 (en) *	1982-03-17	1983-09-29	Yoshitomi Pharmaceutical	1,4-dihydropyridine-3,5-dicarboxylate derivatives
FR2577552B1 (fr) *	1985-02-20	1987-09-04	Sori Soc Rech Ind	Esters heterocycliques dissymetriques d'acides 1,4-dihydropyridine-3,5-dicarboxyliques, procede de preparation et utilisation en therapeutique

1986
- 1986-04-02 FR FR8604685A patent/FR2596760B1/fr not_active Expired
1987
- 1987-03-18 ES ES198787400598T patent/ES2028886T3/es not_active Expired - Lifetime
- 1987-03-18 EP EP87400598A patent/EP0240398B1/fr not_active Expired - Lifetime
- 1987-03-18 DE DE8787400598T patent/DE3770037D1/de not_active Expired - Fee Related
- 1987-03-18 IL IL81933A patent/IL81933A/xx unknown
- 1987-03-18 AT AT87400598T patent/ATE63555T1/de not_active IP Right Cessation
- 1987-03-18 US US07/027,262 patent/US4806544A/en not_active Expired - Fee Related
- 1987-03-19 AU AU70410/87A patent/AU590690B2/en not_active Ceased
- 1987-03-24 NZ NZ219758A patent/NZ219758A/xx unknown
- 1987-03-25 TN TNTNSN87043A patent/TNSN87043A1/fr unknown
- 1987-03-25 FI FI871316A patent/FI86302C/fi not_active IP Right Cessation
- 1987-03-26 PT PT84560A patent/PT84560B/pt not_active IP Right Cessation
- 1987-03-27 ZA ZA872258A patent/ZA872258B/xx unknown
- 1987-03-30 DK DK161787A patent/DK161787A/da not_active IP Right Cessation
- 1987-03-31 OA OA59099A patent/OA08508A/xx unknown
- 1987-03-31 NO NO871339A patent/NO167029C/no unknown
- 1987-04-01 HU HU871403A patent/HU199479B/hu unknown
- 1987-04-01 DD DD87301364A patent/DD263291A5/de not_active IP Right Cessation
- 1987-04-01 SU SU874202348A patent/SU1586515A3/ru active
- 1987-04-01 CN CN87102452A patent/CN1015460B/zh not_active Expired
- 1987-04-01 YU YU00572/87A patent/YU57287A/xx unknown
- 1987-04-01 KR KR1019870003078A patent/KR900005956B1/ko not_active IP Right Cessation
- 1987-04-01 HU HU893897A patent/HUT53080A/hu unknown
- 1987-04-01 DD DD87325139A patent/DD278793A5/de not_active IP Right Cessation
- 1987-04-01 CS CS872292A patent/CS268828B2/cs unknown
- 1987-04-02 JP JP62083694A patent/JPS6317883A/ja active Pending
1988
- 1988-03-09 YU YU480/88A patent/YU44714B/xx unknown
- 1988-09-22 US US07/249,402 patent/US4900833A/en not_active Expired - Fee Related
1989
- 1989-09-11 AU AU41263/89A patent/AU610753B2/en not_active Ceased
1991
- 1991-07-05 GR GR91400959T patent/GR3002267T3/el unknown

Also Published As

Publication number	Publication date
US4806544A (en)	1989-02-21
HUT53080A (en)	1990-09-28
DD263291A5 (de)	1988-12-28
NO167029B (no)	1991-06-17
DE3770037D1 (de)	1991-06-20
TNSN87043A1 (fr)	1990-01-01
NZ219758A (en)	1989-04-26
FI871316A0 (fi)	1987-03-25
IL81933A0 (en)	1987-10-20
FI871316A (fi)	1987-10-03
ATE63555T1 (de)	1991-06-15
DK161787D0 (da)	1987-03-30
AU4126389A (en)	1989-12-21
EP0240398A1 (fr)	1987-10-07
YU48088A (en)	1988-12-31
NO167029C (no)	1991-09-25
AU7041087A (en)	1987-10-08
YU57287A (en)	1988-10-31
FR2596760A1 (fr)	1987-10-09
KR870010055A (ko)	1987-11-30
JPS6317883A (ja)	1988-01-25
AU590690B2 (en)	1989-11-09
EP0240398B1 (fr)	1991-05-15
FI86302B (fi)	1992-04-30
HUT49613A (en)	1989-10-30
HU199479B (en)	1990-02-28
FR2596760B1 (fr)	1988-12-09
CN87102452A (zh)	1987-10-14
GR3002267T3 (en)	1992-12-30
PT84560B (pt)	1989-11-30
CS229287A2 (en)	1989-08-14
CS268828B2 (en)	1990-04-11
SU1586515A3 (ru)	1990-08-15
PT84560A (fr)	1987-04-01
CN1015460B (zh)	1992-02-12
OA08508A (fr)	1988-07-29
NO871339L (no)	1987-10-05
KR900005956B1 (ko)	1990-08-18
FI86302C (fi)	1992-08-10
AU610753B2 (en)	1991-05-23
DD278793A5 (de)	1990-05-16
ZA872258B (en)	1987-11-25
NO871339D0 (no)	1987-03-31
YU44714B (en)	1990-12-31
US4900833A (en)	1990-02-13
ES2028886T3 (es)	1992-07-16
DK161787A (da)	1987-10-03

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