IL75508A - Expression vectors for desulphatohirudin,host cells transformed therewith and the production of desulphatohirudin by means of these host cells - Google Patents

Expression vectors for desulphatohirudin,host cells transformed therewith and the production of desulphatohirudin by means of these host cells

Info

Publication number: IL75508A
Authority: IL; Israel
Prior art keywords: host cells; desulphatohirudin; production; expression vectors; dna sequences
Prior art date: 1984-06-14

Application number

IL75508A

Other languages

English (en)

Other versions

IL75508A0 (en

Original Assignee

Ciba Geigy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-06-14

Filing date

1985-06-13

Publication date

1991-06-10

1985-06-13 Application filed by Ciba Geigy filed Critical Ciba Geigy

1985-10-31 Publication of IL75508A0 publication Critical patent/IL75508A0/xx

1991-06-10 Publication of IL75508A publication Critical patent/IL75508A/xx

Links

XYWBJDRHGNULKG-OUMQNGNKSA-N desirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 XYWBJDRHGNULKG-OUMQNGNKSA-N 0.000 title 2
108010073652 desirudin Proteins 0.000 title 2
239000013604 expression vector Substances 0.000 title 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 3
239000013598 vector Substances 0.000 abstract 3
229940122388 Thrombin inhibitor Drugs 0.000 abstract 2
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 2
239000003868 thrombin inhibitor Substances 0.000 abstract 2
102000007625 Hirudins Human genes 0.000 abstract 1
108010007267 Hirudins Proteins 0.000 abstract 1
101000712605 Theromyzon tessulatum Theromin Proteins 0.000 abstract 1
108090000190 Thrombin Proteins 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
229940006607 hirudin Drugs 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
229960004072 thrombin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Crystallography & Structural Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

IL75508A 1984-06-14 1985-06-13 Expression vectors for desulphatohirudin,host cells transformed therewith and the production of desulphatohirudin by means of these host cells IL75508A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH288284		1984-06-14

Publications (2)

Publication Number	Publication Date
IL75508A0 IL75508A0 (en)	1985-10-31
IL75508A true IL75508A (en)	1991-06-10

Family

ID=4243708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL75508A IL75508A (en)	1984-06-14	1985-06-13	Expression vectors for desulphatohirudin,host cells transformed therewith and the production of desulphatohirudin by means of these host cells

Country Status (23)

Country	Link
US (2)	US5422249A (fr)
EP (1)	EP0168342B1 (fr)
JP (1)	JPH0720434B2 (fr)
KR (1)	KR920009522B1 (fr)
AT (1)	ATE64956T1 (fr)
AU (1)	AU591061B2 (fr)
CA (1)	CA1341426C (fr)
CY (1)	CY1782A (fr)
DD (1)	DD240392A5 (fr)
DE (1)	DE3583361D1 (fr)
DK (1)	DK175496B1 (fr)
ES (3)	ES8708012A1 (fr)
FI (1)	FI90787C (fr)
GR (1)	GR851428B (fr)
HK (1)	HK11095A (fr)
HU (1)	HU202288B (fr)
IE (1)	IE57999B1 (fr)
IL (1)	IL75508A (fr)
NO (2)	NO177433C (fr)
NZ (1)	NZ212405A (fr)
PH (1)	PH26867A (fr)
PT (1)	PT80631B (fr)
ZA (1)	ZA854418B (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5705355A (en) *	1984-03-27	1998-01-06	Transgene, S.A.	Hirudin, pharmaceutical compositions comprising it and their use
CA1341414C (fr) *	1984-03-27	2002-12-31	Paul Tolstoshev	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445517C2 (de) *	1984-12-13	1993-11-18	Ciba Geigy	Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
US5821079A (en) *	1985-05-02	1998-10-13	Transgene S.A.	Vectors for the expression and secretion of hirudin by transformed yeasts
FR2593518B1 (fr) *	1985-05-02	1989-09-08	Transgene Sa	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
GB8530631D0 (en)	1985-12-12	1986-01-22	Ciba Geigy Ag	Thrombin inhibitors
MY101203A (en) *	1985-12-12	1991-08-17	Ucp Gen Pharma Ag	Production of thrombin iinhibitors.
GB2188322A (en) *	1986-03-26	1987-09-30	Bayer Ag	Aprotinin and analogues thereof produced by a recombinant host
MC1834A1 (fr) *	1986-07-10	1988-06-03	Transgene Sa	Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation
FR2607516B2 (fr) *	1986-12-01	1989-12-22	Transgene Sa	Vecteurs perfectionnes d'expression d'un variant de l'hirudine dans les levures, procede et produit obtenu
JPH0616716B2 (ja) *	1986-10-14	1994-03-09	塩野義製薬株式会社	酵母におけるヒトｐｓｔｉの製造法
FR2607517B2 (fr) *	1986-12-01	1989-12-22	Transgene Sa	Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu
US5256559A (en) *	1988-03-04	1993-10-26	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation
DE3819079A1 (de) *	1988-06-04	1989-12-07	Hoechst Ag	Hirudin-derivate mit verzoegerter wirkung
GB8817160D0 (en) *	1988-07-19	1988-08-24	Ciba Geigy Ag	Novel proteins
GB8817161D0 (en) *	1988-07-19	1988-08-24	Ciba Geigy Ag	Modified proteins
US5167960A (en) *	1988-08-03	1992-12-01	New England Deaconess Hospital Corporation	Hirudin-coated biocompatible substance
US5112615A (en) *	1988-08-03	1992-05-12	New England Deaconess Hospital Corporation	Soluble hirudin conjugates
DE3835815A1 (de) *	1988-10-21	1990-04-26	Hoechst Ag	Neue isohirudine
ATE119195T1 (de) *	1989-01-25	1995-03-15	Ciba Geigy Ag	Monoklonale antikörper, spezifisch für hirudin.
JPH037583A (ja) *	1989-02-28	1991-01-14	Canon Inc	部分的二本鎖オリゴヌクレオチド及びオリゴヌクレオチドの形成方法
EP0385410B1 (fr) *	1989-02-28	1996-10-02	Canon Kabushiki Kaisha	Oligonucléotide à double brin partiel et son procédé de formation
GB9006400D0 (en)	1990-03-22	1990-05-23	Ciba Geigy Ag	Bacterial vectors
DE4009268A1 (de) *	1990-03-22	1991-09-26	Consortium Elektrochem Ind	Sekretion von hirudinderivaten
US6060451A (en) *	1990-06-15	2000-05-09	The National Research Council Of Canada	Thrombin inhibitors based on the amino acid sequence of hirudin
US5296352A (en) *	1990-10-02	1994-03-22	Ciba-Geigy Corporation	Monoclonal antibodies directed against complexes formed by thrombin and hirudin
US6514730B1 (en)	1991-03-21	2003-02-04	Consortium für elektrochemische Industrie GmbH	Secretion of hirudin derivatives
DE4209110A1 (de) *	1991-11-26	1993-05-27	Basf Ag	Neue thrombininhibitorische proteine aus landblutegeln
DE4140381A1 (de) *	1991-12-07	1993-06-09	Hoechst Ag, 6230 Frankfurt, De	Neue synthetische isohirudine mit verbesserter stabilitaet
HU214698B (hu) *	1992-04-09	1998-06-29	Gyógyszerkutató Intézet Kft.	Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására
DE4404168A1 (de) *	1994-02-10	1995-08-17	Hoechst Ag	Hirudinderivate und Verfahren zu deren Herstellung
US5643580A (en) *	1994-10-17	1997-07-01	Surface Genesis, Inc.	Biocompatible coating, medical device using the same and methods
DE19529997C1 (de) *	1995-08-16	1997-04-10	Hoechst Ag	Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
DE19543737A1 (de) *	1995-11-24	1997-05-28	Hoechst Ag	Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de)	1995-11-28	1997-06-05	Hoechst Ag	Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
EP0985513B1 (fr)	1996-01-31	2003-01-02	Sumitomo Bakelite Company Limited	Procédé d'encapsulation d'un dispositif semi-conducteur par une résine époxy
US6623981B2 (en) *	1998-01-27	2003-09-23	Bristol-Myers Squibb Company	Detection of patients at risk for developing integrin antagonist/agonist mediated disease states
DE10149678A1 (de)	2001-10-09	2009-03-12	Novel Science International Gmbh	Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
US20070016969A1 (en) *	2002-01-18	2007-01-18	Animal Technology Institute Taiwan	Expression vector for hirudin and transformed cells and transgenic animals containing said vector
DE10301255A1 (de)	2003-01-15	2004-07-29	Cpi Creative Pharma International Gmbh	Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
JP3535151B1 (ja) *	2003-07-10	2004-06-07	株式会社ミナキアドバンス	生酵母菌を成分とする液剤の製造方法及びその液剤
US7795205B2 (en)	2004-04-12	2010-09-14	Canyon Pharmaceuticals, Inc.	Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
JP5027310B2 (ja) *	2007-12-28	2012-09-19	バクスター・インターナショナル・インコーポレイテッド	タンパク質の逆圧濾過

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3432596A (en) *	1967-10-13	1969-03-11	Dresden Arzneimittel	Method for producing highly pure hirudine
US4704362A (en) *	1977-11-08	1987-11-03	Genentech, Inc.	Recombinant cloning vehicle microbial polypeptide expression
US4517294A (en) *	1982-03-03	1985-05-14	Genentech, Inc.	Human antithrombin III
GR79124B (fr) *	1982-12-22	1984-10-02	Genentech Inc
WO1985000831A1 (fr) *	1983-08-10	1985-02-28	Amgen	Expression microbienne d'un facteur de croissance semblable a l'insuline
DE3342139A1 (de) *	1983-11-22	1985-05-30	Ciba-Geigy Ag, Basel	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
FR2562088B1 (fr) *	1984-03-27	1987-11-13	Transgene Sa	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
CA1341414C (fr) *	1984-03-27	2002-12-31	Paul Tolstoshev	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
DE3438296A1 (de) *	1984-04-18	1985-11-07	Hoechst Ag, 6230 Frankfurt	Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3689525D1 (de) *	1985-07-17	1994-02-24	Hoechst Ag	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
DE3541856A1 (de) *	1985-11-27	1987-06-04	Hoechst Ag	Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
MY101203A (en) *	1985-12-12	1991-08-17	Ucp Gen Pharma Ag	Production of thrombin iinhibitors.
FR2645175B1 (fr) *	1989-03-31	1994-02-18	Transgene Sa	Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche

1985
- 1985-06-10 EP EP85810268A patent/EP0168342B1/fr not_active Expired - Lifetime
- 1985-06-10 DE DE8585810268T patent/DE3583361D1/de not_active Expired - Lifetime
- 1985-06-10 AT AT85810268T patent/ATE64956T1/de not_active IP Right Cessation
- 1985-06-11 PH PH32401A patent/PH26867A/en unknown
- 1985-06-12 GR GR851428A patent/GR851428B/el unknown
- 1985-06-12 PT PT80631A patent/PT80631B/pt unknown
- 1985-06-12 CA CA000483736A patent/CA1341426C/fr not_active Expired - Fee Related
- 1985-06-12 FI FI852342A patent/FI90787C/fi not_active IP Right Cessation
- 1985-06-12 ZA ZA854418A patent/ZA854418B/xx unknown
- 1985-06-12 DD DD85277301A patent/DD240392A5/de not_active IP Right Cessation
- 1985-06-13 JP JP60127266A patent/JPH0720434B2/ja not_active Expired - Lifetime
- 1985-06-13 NO NO852389A patent/NO177433C/no unknown
- 1985-06-13 DK DK198502656A patent/DK175496B1/da not_active IP Right Cessation
- 1985-06-13 AU AU43655/85A patent/AU591061B2/en not_active Expired
- 1985-06-13 HU HU852340A patent/HU202288B/hu unknown
- 1985-06-13 NZ NZ212405A patent/NZ212405A/xx unknown
- 1985-06-13 IL IL75508A patent/IL75508A/xx not_active IP Right Cessation
- 1985-06-13 ES ES544126A patent/ES8708012A1/es not_active Expired
- 1985-06-13 IE IE1475/85A patent/IE57999B1/en not_active IP Right Cessation
- 1985-06-14 KR KR1019850004195A patent/KR920009522B1/ko not_active IP Right Cessation
1986
- 1986-10-01 ES ES557116A patent/ES8707766A1/es not_active Expired
- 1986-10-01 ES ES557115A patent/ES8707765A1/es not_active Expired
1993
- 1993-09-15 US US08/121,974 patent/US5422249A/en not_active Expired - Lifetime
1995
- 1995-01-26 HK HK11095A patent/HK11095A/xx not_active IP Right Cessation
- 1995-03-03 US US08/398,416 patent/US5728549A/en not_active Expired - Lifetime
- 1995-10-20 CY CY178295A patent/CY1782A/xx unknown
1999
- 1999-11-17 NO NO1999023C patent/NO1999023I1/no unknown

Also Published As

Publication number	Publication date
EP0168342B1 (fr)	1991-07-03
DE3583361D1 (de)	1991-08-08
EP0168342A1 (fr)	1986-01-15
IL75508A0 (en)	1985-10-31
PT80631A (de)	1985-07-01
CY1782A (en)	1995-10-20
HK11095A (en)	1995-02-03
GR851428B (fr)	1985-11-25
ES557116A0 (es)	1987-08-16
ZA854418B (en)	1986-02-26
DD240392A5 (de)	1986-10-29
FI852342L (fi)	1985-12-15
DK175496B1 (da)	2004-11-08
US5728549A (en)	1998-03-17
HUT38674A (en)	1986-06-30
ES8708012A1 (es)	1987-09-01
AU591061B2 (en)	1989-11-30
ATE64956T1 (de)	1991-07-15
JPS6119492A (ja)	1986-01-28
NO852389L (no)	1985-12-16
JPH0720434B2 (ja)	1995-03-08
US5422249A (en)	1995-06-06
AU4365585A (en)	1985-12-19
NO1999023I1 (no)	1999-11-17
PH26867A (en)	1992-11-16
NO177433B (no)	1995-06-06
NZ212405A (en)	1989-01-06
ES557115A0 (es)	1987-08-16
DK265685A (da)	1985-12-15
FI90787C (fi)	1994-03-25
FI90787B (fi)	1993-12-15
CA1341426C (fr)	2003-04-01
ES544126A0 (es)	1987-09-01
PT80631B (de)	1987-04-28
ES8707765A1 (es)	1987-08-16
IE57999B1 (en)	1993-06-02
NO177433C (no)	1995-09-13
HU202288B (en)	1991-02-28
IE851475L (en)	1985-12-14
KR860000381A (ko)	1986-01-28
KR920009522B1 (ko)	1992-10-17
DK265685D0 (da)	1985-06-13
FI852342A0 (fi)	1985-06-12
ES8707766A1 (es)	1987-08-16

Publication	Publication Date	Title
IL75508A (en)	1991-06-10	Expression vectors for desulphatohirudin,host cells transformed therewith and the production of desulphatohirudin by means of these host cells
HUT46061A (en)	1988-09-28	Dna sequences encoding hirudin-like protein and process for producing such proteins
LTIP828A (en)	1995-02-27	Nucleic acid fragment which codes for human proapolipoprotein a-1
EP0185444A3 (en)	1986-08-13	Cloning and expression of htlv-iii dna
ATE469228T1 (de)	2010-06-15	Dns, die für phosphodiesterasen von säugetieren kodiert
CA2141060A1 (fr)	1994-12-08	Insertion de gmp cyclique; phosphodiesterase et methodes specifiques pour gmp cyclique
AU4554396A (en)	1996-04-26	Superior thrombomodulin analogs for pharmaceutical use
ATE173762T1 (de)	1998-12-15	Klonierung der n-methylhydantoinase

Legal Events

Date	Code	Title
1998-11-26	HP	Change in proprietorship
1999-11-30	KB	Patent renewed
2003-07-31	KB	Patent renewed
2005-09-25	EXP	Patent expired