IL75179A - (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide,its preparation and pharmaceutical compositions containing it - Google Patents
(s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide,its preparation and pharmaceutical compositions containing itInfo
- Publication number
- IL75179A IL75179A IL75179A IL7517985A IL75179A IL 75179 A IL75179 A IL 75179A IL 75179 A IL75179 A IL 75179A IL 7517985 A IL7517985 A IL 7517985A IL 75179 A IL75179 A IL 75179A
- Authority
- IL
- Israel
- Prior art keywords
- radical
- oxo
- alpha
- ethyl
- pyrrolidineacetamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Detergent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Seasonings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848412357A GB8412357D0 (en) | 1984-05-15 | 1984-05-15 | Pharmaceutical composition |
Publications (2)
Publication Number | Publication Date |
---|---|
IL75179A0 IL75179A0 (en) | 1985-09-29 |
IL75179A true IL75179A (en) | 1988-05-31 |
Family
ID=10560974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL75179A IL75179A (en) | 1984-05-15 | 1985-05-13 | (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide,its preparation and pharmaceutical compositions containing it |
Country Status (33)
Country | Link |
---|---|
US (3) | US4696943A (pl) |
EP (1) | EP0162036B1 (pl) |
JP (1) | JPH0629186B2 (pl) |
KR (1) | KR920003819B1 (pl) |
CN (1) | CN1015541B (pl) |
AT (1) | ATE45567T1 (pl) |
AU (1) | AU574465B2 (pl) |
BG (2) | BG50156A3 (pl) |
CA (1) | CA1235129A (pl) |
CY (2) | CY1567A (pl) |
DE (3) | DE3572348D1 (pl) |
DK (1) | DK163501C (pl) |
ES (2) | ES8608485A1 (pl) |
FI (1) | FI80673C (pl) |
GB (1) | GB8412357D0 (pl) |
GE (1) | GEP20002001B (pl) |
GR (1) | GR851155B (pl) |
HK (1) | HK52391A (pl) |
IE (1) | IE59950B1 (pl) |
IL (1) | IL75179A (pl) |
LT (1) | LT2584B (pl) |
LU (2) | LU90615I2 (pl) |
LV (1) | LV5233A3 (pl) |
MY (2) | MY101726A (pl) |
NL (1) | NL300028I2 (pl) |
NO (2) | NO164534C (pl) |
PL (2) | PL144346B1 (pl) |
PT (1) | PT80460B (pl) |
SA (1) | SA01210656A (pl) |
SG (1) | SG80090G (pl) |
SU (3) | SU1402260A3 (pl) |
UA (1) | UA6158A1 (pl) |
ZA (1) | ZA853635B (pl) |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8827389D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
IT1231477B (it) * | 1989-07-12 | 1991-12-07 | Sigma Tau Ind Farmaceuti | (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti |
GB9319732D0 (en) | 1993-09-24 | 1993-11-10 | Ucb Sa | Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety |
US6124473A (en) * | 1998-05-08 | 2000-09-26 | Ucb, S.A. | Process for preparing (s)- and (R)-α-ethyl-2-oxo-1-pyrrolidineacetamide |
US6107492A (en) * | 1998-05-08 | 2000-08-22 | Ucb, S.A. | Process for the preparation of levetiracetam |
EA002380B1 (ru) * | 1999-07-21 | 2002-04-25 | Российский Государственный Педагогический Университет Им. А.И.Герцена | Антиишемическое средство |
EA002379B1 (ru) * | 1999-07-21 | 2002-04-25 | Российский Государственный Педагогический Университет Им. А.И.Герцена | Средство, обладающее антиишемической, гипотензивной и антигипоксической активностью |
AR026610A1 (es) | 1999-12-01 | 2003-02-19 | Ucb Sa | Un derivado pirrolidinacetamida solo o en combinacion para tratamiento de desordenes del sistema nervioso central |
GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
US6686477B2 (en) * | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
US7112612B2 (en) | 2000-11-21 | 2006-09-26 | Ucb S.A. | N-alkylated GABA compounds, processes for their preparation and their use as medicaments |
CN1484527A (zh) * | 2000-12-28 | 2004-03-24 | ��һ��������ҩ��ʽ���� | 神经性疼痛治疗和预防药 |
JP2004523557A (ja) * | 2001-02-23 | 2004-08-05 | ジョンズ・ホプキンス・ユニバーシティ | チック、振せん、および関連疾患の治療 |
IL160045A0 (en) * | 2001-08-10 | 2004-06-20 | Ucb Sa | Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues |
JP4351909B2 (ja) * | 2001-10-08 | 2009-10-28 | ユセベ ファルマ ソシエテ アノニム | 薬剤を調製するための、2−オキソ−1−ピロリジン誘導体の使用 |
AU2003242538A1 (en) * | 2002-05-14 | 2003-11-11 | Ucb, S.A. | Use of 2-oxo-1-pyrrolidone derivatives for the preparation of a drug |
WO2004069796A2 (en) * | 2003-02-03 | 2004-08-19 | Teva Pharmaceutical Industries Ltd. | Process for producing levetiracetam |
ES2214147B1 (es) | 2003-02-28 | 2005-10-01 | Farma-Lepori S.A. | Procedimiento de obtencion de un agente antiepileptico. |
WO2004083180A1 (en) * | 2003-03-18 | 2004-09-30 | Hetero Drugs Limited | Novel crystalline forms of levetiracetam |
EP1663968A1 (en) * | 2003-09-05 | 2006-06-07 | Ranbaxy Laboratories Limited | Process for the preparation of pure levetiracetam |
EA010306B1 (ru) * | 2003-09-24 | 2008-08-29 | Юсб, С.А. | Способ получения производных 2-оксо-1-пирролидина |
CA2546970C (en) | 2003-12-02 | 2011-04-26 | Ucb, S.A. | Imidazole derivatives, processes for preparing them and their uses |
US7531673B2 (en) | 2004-02-18 | 2009-05-12 | Dr. Reddy's Laboratories Limited | Preparation of amino acid amides |
CA2488325C (en) * | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
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EP1879861A2 (en) * | 2005-04-01 | 2008-01-23 | Rubamin Laboratories Limited | Process for preparing levetiracetam and racemization of (r)- and (s)-2-amino butynamide and the corresponding acid derivatives |
JP2008542322A (ja) | 2005-06-01 | 2008-11-27 | ユセベ ファルマ ソシエテ アノニム | 2−オキソ−1−ピロリジン誘導体 |
PL1909764T3 (pl) * | 2005-07-26 | 2015-03-31 | Ucb Pharma Sa | Kompozycje farmaceutyczne zawierające lewetyracetam i sposób ich wytwarzania |
US8338621B2 (en) | 2005-12-21 | 2012-12-25 | Ucb S.A. | Process for the preparation of 2-oxo-1-pyrrolidine derivatives |
CA2637925A1 (en) * | 2006-01-24 | 2007-08-02 | Teva Pharmaceutical Industries Ltd. | Levetiracetam formulations and methods for their manufacture |
US20080014264A1 (en) * | 2006-07-13 | 2008-01-17 | Ucb, S.A. | Novel pharmaceutical compositions comprising levetiracetam |
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US20240368082A1 (en) * | 2023-05-05 | 2024-11-07 | Suzhou Brighthope Pharmatech Co., Ltd | Process for the production of levetiracetam and intermediate thereof |
US20240368080A1 (en) * | 2023-05-05 | 2024-11-07 | Suzhou Brighthope Pharmatech Co., Ltd | Process for the production of levetiracetam and intermediate thereof |
US20240368081A1 (en) * | 2023-05-05 | 2024-11-07 | Suzhou Brighthope Pharmatech Co., Ltd | Process for the production of levetiracetam and intermediate thereof |
US20240409511A1 (en) * | 2023-06-12 | 2024-12-12 | Suzhou Brighthope Pharmatech Co., Ltd | Process for the production of levetiracetam and intermediates thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1309692A (en) * | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
GB1583871A (en) * | 1976-10-19 | 1981-02-04 | Ucb Sa | Anti-aggregants |
FR2418790A1 (fr) * | 1978-03-02 | 1979-09-28 | Philagro Sa | Nouveaux derives de pyrrolidinone-2 et compositions herbicides les contenant |
GB8412358D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
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1984
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1985
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1986
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1987
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1989
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1990
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1991
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1993
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1999
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2000
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2001
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2004
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