IL44165A - Method for fluorescently labelling a material with a furanone derivative and products formed by reacting such a material with the furanone derivative - Google Patents
Method for fluorescently labelling a material with a furanone derivative and products formed by reacting such a material with the furanone derivativeInfo
- Publication number
- IL44165A IL44165A IL44165A IL4416574A IL44165A IL 44165 A IL44165 A IL 44165A IL 44165 A IL44165 A IL 44165A IL 4416574 A IL4416574 A IL 4416574A IL 44165 A IL44165 A IL 44165A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- phenyl
- compound
- lower alkyl
- labeled
- Prior art date
Links
- 239000000463 material Substances 0.000 title claims description 42
- 238000000034 method Methods 0.000 title claims description 32
- 238000002372 labelling Methods 0.000 title claims description 22
- 150000002241 furanones Chemical class 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims description 35
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 22
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 claims description 17
- 235000018102 proteins Nutrition 0.000 claims description 17
- 102000004169 proteins and genes Human genes 0.000 claims description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 17
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- 239000007787 solid Substances 0.000 claims description 11
- 241000700605 Viruses Species 0.000 claims description 10
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- 229910052736 halogen Inorganic materials 0.000 claims description 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 7
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 7
- 235000001014 amino acid Nutrition 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- BLWINLJDTOJSRU-UHFFFAOYSA-N 2-methoxy-2,4-diphenylfuran-3-one Chemical compound O=C1C(OC)(C=2C=CC=CC=2)OC=C1C1=CC=CC=C1 BLWINLJDTOJSRU-UHFFFAOYSA-N 0.000 claims description 4
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- BEAWFNYWFJIVNJ-UHFFFAOYSA-N 2,4-diphenyl-2-phenylmethoxyfuran-3-one Chemical compound O=C1C(C=2C=CC=CC=2)=COC1(C=1C=CC=CC=1)OCC1=CC=CC=C1 BEAWFNYWFJIVNJ-UHFFFAOYSA-N 0.000 claims description 2
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
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- 238000002955 isolation Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 206010028417 myasthenia gravis Diseases 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- MUMVIYLVHVCYGI-UHFFFAOYSA-N n,n,n',n',n",n"-hexamethylmethanetriamine Chemical compound CN(C)C(N(C)C)N(C)C MUMVIYLVHVCYGI-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000003589 nefrotoxic effect Effects 0.000 description 1
- 231100000381 nephrotoxic Toxicity 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 201000000901 ornithosis Diseases 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229940067107 phenylethyl alcohol Drugs 0.000 description 1
- 125000004344 phenylpropyl group Chemical group 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 229960005235 piperonyl butoxide Drugs 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- WBQTXTBONIWRGK-UHFFFAOYSA-N sodium;propan-2-olate Chemical compound [Na+].CC(C)[O-] WBQTXTBONIWRGK-UHFFFAOYSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 229940118376 tetanus toxin Drugs 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical compound C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 description 1
- 210000002993 trophoblast Anatomy 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/12—Nitrate to nitrite reducing bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Luminescent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33801973A | 1973-03-05 | 1973-03-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL44165A0 IL44165A0 (en) | 1974-05-16 |
| IL44165A true IL44165A (en) | 1977-06-30 |
Family
ID=23323052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44165A IL44165A (en) | 1973-03-05 | 1974-02-07 | Method for fluorescently labelling a material with a furanone derivative and products formed by reacting such a material with the furanone derivative |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5443571B2 (xx) |
| AT (1) | AT332545B (xx) |
| AU (1) | AU473159B2 (xx) |
| BE (1) | BE811825A (xx) |
| CA (1) | CA1022483A (xx) |
| CH (1) | CH602905A5 (xx) |
| DD (1) | DD111374A5 (xx) |
| DE (1) | DE2407899C3 (xx) |
| ES (1) | ES423853A1 (xx) |
| FR (1) | FR2221728B1 (xx) |
| GB (1) | GB1433093A (xx) |
| IL (1) | IL44165A (xx) |
| IT (1) | IT1015815B (xx) |
| NL (1) | NL156509B (xx) |
| NO (1) | NO750485L (xx) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1573212A (en) * | 1976-04-15 | 1980-08-20 | Technicon Instr | Immunoassay for gentamicin |
| DE2965740D1 (en) * | 1978-11-10 | 1983-07-28 | Hoffmann La Roche | Method for the determination of an amino acid or an amino sulfonic acid |
| KR102385099B1 (ko) | 2017-06-30 | 2022-04-12 | 주식회사 만도 | 전자식 브레이크 시스템 및 제어 방법 |
-
1974
- 1974-02-07 IL IL44165A patent/IL44165A/en unknown
- 1974-02-07 AU AU65340/74A patent/AU473159B2/en not_active Expired
- 1974-02-19 DE DE2407899A patent/DE2407899C3/de not_active Expired
- 1974-02-20 CH CH234074A patent/CH602905A5/xx not_active IP Right Cessation
- 1974-02-20 IT IT48594/74A patent/IT1015815B/it active
- 1974-02-27 NL NL7402645.A patent/NL156509B/xx not_active IP Right Cessation
- 1974-03-01 DD DD176901A patent/DD111374A5/xx unknown
- 1974-03-01 JP JP2348574A patent/JPS5443571B2/ja not_active Expired
- 1974-03-04 GB GB959274A patent/GB1433093A/en not_active Expired
- 1974-03-04 ES ES423853A patent/ES423853A1/es not_active Expired
- 1974-03-04 FR FR7407245A patent/FR2221728B1/fr not_active Expired
- 1974-03-04 AT AT174174A patent/AT332545B/de not_active IP Right Cessation
- 1974-03-04 BE BE141602A patent/BE811825A/xx unknown
- 1974-03-04 CA CA194,030A patent/CA1022483A/en not_active Expired
-
1975
- 1975-02-14 NO NO740485A patent/NO750485L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO750485L (xx) | 1974-09-06 |
| AU473159B2 (en) | 1976-06-17 |
| CH602905A5 (xx) | 1978-08-15 |
| DD111374A5 (xx) | 1975-02-12 |
| NL7402645A (xx) | 1974-09-09 |
| NL156509B (nl) | 1978-04-17 |
| DE2407899B2 (de) | 1978-02-16 |
| JPS49134670A (xx) | 1974-12-25 |
| JPS5443571B2 (xx) | 1979-12-20 |
| FR2221728B1 (xx) | 1976-10-15 |
| GB1433093A (en) | 1976-04-22 |
| DE2407899A1 (de) | 1974-09-19 |
| ATA174174A (de) | 1976-01-15 |
| CA1022483A (en) | 1977-12-13 |
| IL44165A0 (en) | 1974-05-16 |
| DE2407899C3 (de) | 1978-09-28 |
| BE811825A (fr) | 1974-09-04 |
| AU6534074A (en) | 1975-08-07 |
| FR2221728A1 (xx) | 1974-10-11 |
| IT1015815B (it) | 1977-05-20 |
| ES423853A1 (es) | 1976-03-16 |
| AT332545B (de) | 1976-10-11 |
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