[go: up one dir, main page]

IL36189A0 - 1-(substituted benzyl)-tetrahydro-2-(1h)-pyrimidones and their preparation - Google Patents

1-(substituted benzyl)-tetrahydro-2-(1h)-pyrimidones and their preparation

Info

Publication number
IL36189A0
IL36189A0 IL36189A IL3618971A IL36189A0 IL 36189 A0 IL36189 A0 IL 36189A0 IL 36189 A IL36189 A IL 36189A IL 3618971 A IL3618971 A IL 3618971A IL 36189 A0 IL36189 A0 IL 36189A0
Authority
IL
Israel
Prior art keywords
pyrimidones
tetrahydro
preparation
substituted benzyl
benzyl
Prior art date
Application number
IL36189A
Other languages
English (en)
Original Assignee
Norwich Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norwich Pharma Co filed Critical Norwich Pharma Co
Publication of IL36189A0 publication Critical patent/IL36189A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Joining Of Building Structures In Genera (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL36189A 1970-03-05 1971-02-15 1-(substituted benzyl)-tetrahydro-2-(1h)-pyrimidones and their preparation IL36189A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1698270A 1970-03-05 1970-03-05

Publications (1)

Publication Number Publication Date
IL36189A0 true IL36189A0 (en) 1971-04-28

Family

ID=21780073

Family Applications (1)

Application Number Title Priority Date Filing Date
IL36189A IL36189A0 (en) 1970-03-05 1971-02-15 1-(substituted benzyl)-tetrahydro-2-(1h)-pyrimidones and their preparation

Country Status (14)

Country Link
US (1) US3681349A (de)
AT (1) AT305288B (de)
BE (1) BE763745A (de)
CH (1) CH555343A (de)
DE (1) DE2110445C3 (de)
DK (1) DK127427B (de)
ES (1) ES388780A1 (de)
FR (1) FR2085673B1 (de)
GB (1) GB1294626A (de)
IL (1) IL36189A0 (de)
NL (1) NL7102519A (de)
NO (1) NO130728C (de)
SE (1) SE376420B (de)
ZA (1) ZA71928B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL39003A (en) * 1971-03-25 1975-02-10 Morton Norwich Products Inc 1-(substituted benzyl)tetrahydro-2-(1h)-pyrimidones and their preparation
US3957785A (en) * 1971-12-02 1976-05-18 Societa' Farmaceutici Italia S.P.A. Bβ-Pyrimidino-aminomethyl-10α-ergoline and 10α-methoxyergoline derivatives
US3956325A (en) * 1974-01-21 1976-05-11 Smithkline Corporation 5-Heterocyclic-1,2,3,6-tetrahydro-4(5H) pyrimidinone
US4003900A (en) * 1976-03-11 1977-01-18 Morton-Norwich Products, Inc. 1-Benzyl-5-chloro-2-(1H)-pyrimidone
US4002627A (en) * 1976-03-26 1977-01-11 Morton-Norwich Products, Inc. 1-Benzyl-3-methyl-3,4,5,6-tetrahydro-2(1H) pyrimidone
US4052399A (en) * 1976-09-13 1977-10-04 Morton-Norwich Products, Inc. 1-[2-(Hexahydro-1H-azepino)ethyl]-2(1H)pyrimidone dihydrochloride
US4052400A (en) * 1976-10-29 1977-10-04 Morton-Norwich Products, Inc. Hypertensive 1-substituted 2(1h)-pyrimidones
US8835426B2 (en) * 2007-02-26 2014-09-16 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1
EP2183228B1 (de) * 2007-07-26 2014-08-20 Vitae Pharmaceuticals, Inc. ZYKLISCHE 11ß-HYDROXYSTEROID-DEHYDROGENASE-1-HEMMER
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2714532A1 (en) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
CA2715290A1 (en) * 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5538356B2 (ja) * 2008-03-18 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤
TW200946520A (en) * 2008-05-01 2009-11-16 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2723039A1 (en) * 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291370B1 (de) * 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Cyclische inhibitoren von 11beta-hydroxysteroiddehydrogenase 1
WO2009134384A1 (en) * 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
KR20110050459A (ko) * 2008-07-25 2011-05-13 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
WO2010127237A2 (en) * 2009-04-30 2010-11-04 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CN102105454A (zh) 2008-07-25 2011-06-22 贝林格尔.英格海姆国际有限公司 合成1型11β-羟基类固醇脱氢酶的抑制剂
WO2010010157A2 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
EP2393807B1 (de) 2009-02-04 2013-08-14 Boehringer Ingelheim International GmbH Zyklische 11beta-hydroxysteroid-dehydrogenase-1-hemmer
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
JP5656986B2 (ja) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
WO2011002910A1 (en) 2009-07-01 2011-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8552212B2 (en) 2009-11-05 2013-10-08 Boehringer Ingelheim International Gmbh Chiral phosphorus ligands
AR078887A1 (es) * 2009-11-06 2011-12-07 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
US8648192B2 (en) 2010-05-26 2014-02-11 Boehringer Ingelheim International Gmbh 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
JP5813106B2 (ja) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン
KR20130137628A (ko) 2010-11-02 2013-12-17 베링거 인겔하임 인터내셔날 게엠베하 대사 장애를 치료하기 위한 약제학적 병용물
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE562987A (de) * 1956-12-05
DE1121617B (de) * 1959-05-26 1962-01-11 Huels Chemische Werke Ag Verfahren zur Herstellung von Tetrahydropyrimidin-2-onderivaten
DE1545601A1 (de) * 1965-07-22 1969-08-07 Basf Ag Verfahren zur Herstellung von Hexahydro-pyrimidinderivaten
DE1670368A1 (de) * 1966-07-16 1970-11-05 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung aralkylsubstituierter Lactame und Cyclischer Harnstoffe
DE1670241A1 (de) * 1967-07-01 1971-01-28 Basf Ag Verfahren zur Herstellung von 2-Oxohexahydropyrimidinen

Also Published As

Publication number Publication date
DK127427B (da) 1973-11-05
SE376420B (de) 1975-05-26
BE763745A (fr) 1971-09-03
ES388780A1 (es) 1975-03-01
NL7102519A (de) 1971-09-07
FR2085673B1 (de) 1974-09-06
CH555343A (de) 1974-10-31
DE2110445C3 (de) 1975-05-28
FR2085673A1 (de) 1971-12-31
ZA71928B (en) 1972-09-27
US3681349A (en) 1972-08-01
DE2110445B2 (de) 1974-10-10
GB1294626A (en) 1972-11-01
DE2110445A1 (de) 1971-11-04
AT305288B (de) 1973-02-26
NO130728C (de) 1975-01-29
NO130728B (de) 1974-10-21

Similar Documents

Publication Publication Date Title
IL36189A0 (en) 1-(substituted benzyl)-tetrahydro-2-(1h)-pyrimidones and their preparation
ZA71682B (en) New phenoxy-hydroxypropylamines and their preparation
ZA711269B (en) New substituted biguanides and their pharmaceutical use
HK34379A (en) Tetrahydronaphthyloxyaminopropanols and related compounds
GB1323371A (en) Heterocyclized polydiynylenes and methods for their preparation
IL36462A (en) 2-benzothiazolylurea derivatives and their use as herbicides
IL37706A0 (en) New biscarbamates and their use as herbicides
IL37563A0 (en) 8-cyano-5-octanolide and its preparation
IL37971A (en) 2-amino-4-thiocyanatobenzothiazoles and their preparation
CA946390A (en) Heterocyclic compounds and their preparation
CY779A (en) 1-substituted-6-7-methylenedioxy-4(1h)-oxocinnoline-3-carbonitriles and their preparation
IL39003A (en) 1-(substituted benzyl)tetrahydro-2-(1h)-pyrimidones and their preparation
IL36085A0 (en) Benzocycloheptaisoquinoline derivatives and their preparation
ZA708554B (en) New cresol derivatives and their use
ZA711607B (en) New n-vinyl-quinolones and the preparation thereof
IL38281A (en) Substituted ypsilon-phenyl-butyronitriles and their preparation
IL36728A0 (en) Substituted pyrrolylmethylamines and their preparation
ZA717413B (en) Heterocyclic compounds and their preparation
IL37932A (en) 2-amino-4-thiocyanatobenzothiazoles and their preparation
IL37008A0 (en) Cyclophosphates and their preparation
ZA715706B (en) Herbicidally-active substituted phenyl-thiocarbamates and their manufacture and use
ZA711467B (en) Thioxsanthene derivatives and their preparation
IL36984A0 (en) Substituted dehydroabietylamines and preparation thereof
CA947314A (en) 1-(para-methylsulfinylbenzylidene)-2-methyl-5-fluoro-3-indenylacetic acid and preparation
AU450369B2 (en) Substituted pyrrolemethylamines and their preparation